Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal

... Colitis, or Autoimmune Hepatitis), in the case of mtx therapy for JIA, a continuation of mtx for 12 to 24 months after induction of remission h...hers.1 The risk of relapse in JIA patients, once mtx is discontinued, is approximately 50%.2 However, ...

ACTEMRA(R) (tocilizumab) Studies to be Featured at the European League Against Rheumatism (EULAR) Congress

...in the Bella Center. "Efficacy of Tocilizumab (TCZ) vs Methotrexate (MTX) Monotherapy in Patients with Rheumatoid Arthritis (RA) with No Prior mtx or DMARD Exposure," results from the AMBITION study, will be highlighted in a poster presentation by lead investigator Graeme Jones, M.D., Professor a...

UCB's CIMZIA(R) (certolizumab pegol) Approved by the U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis

...l responses within one to two weeks, compared with mtx alone. Additionally, radiographic data showed Cimz...SS) at 24 and 52 weeks of treatment, compared with mtx alone (p<0.001). "The approval of Cimzia(R... two or four weeks, and administered together with mtx or as monotherapy. In the pivotal clinical t...

Wide variability in rheumatoid arthritis drug suggests alternative dosing should be considered

...derstanding the time it takes for stable levels of mtx to be reached could be useful in effectively contr... long-term damage. A new study examining levels of mtx metabolites in red blood cells was published in th...interscience.wiley.com/journal/76509746/home ). mtx is normally taken orally and is rapidly taken up i...

Centocor, Inc. Submits Application to FDA Requesting Approval of Golimumab for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... as the First-line Option in the treatment of Rheumatoid arthritis of Early onset (GO-BEFORE) study; the GOlimumab FOR subjects With Active RA Despite mtx (GO-FORWARD) study; and A Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Golimumab, a Human Anti-TNF-alpha Monoclonal Antibody, Ad...

Rheumatoid Arthritis Drug Boosts Melanoma Incidence

...ts (309 women, 150 men) who started treatment with mtx prior to June 1986. During a total of 4,273 person...esearchers found that the RA patients who received mtx were 50 percent more likely than people in the gen... risk of melanoma in patients with RA treated with mtx compared with the general population," lead author...

HUMIRA(R) (adalimumab) Data Show That Treating Early Rheumatoid Arthritis With Combination Treatment Resulted in Cost Savings From Improved Work Productivity

...tudy that compared the effectiveness of HUMIRA and mtx to mtx alone in treating early RA. At baseline, a total o... patients with early RA treated with HUMIRA plus mtx (compared to...

Increased incidence of melanoma found in rheumatoid arthritis patients treated with methotrexate

... Numerous case reports of RA patients treated with mtx developing lymphoma and, even more strikingly, tum... drug was discontinued, have prompted concern that mtx itself may be carcinogenic. So far, however, stud...d the cancer incidence in RA patients treated with mtx by local doctors. Their findings, featured in the...

Study affirms effectiveness of medication for juvenile rheumatoid arthritis

...etween the ages of 4 and 17 years. Treatment with mtx and other DMARDs was discontinued a minimum of 2 w... year, participants were permitted to add low-dose mtx if recommended by their physician. At every 3 mon...percent) and white (74 percent), and all had taken mtx prior to the study. At baseline, the mean age of ...

Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis

...s. HUMIRA can be used alone or in combination with mtx or other DMARDs. HUMIRA is indicted for reducing s...ult patients when the response to DMARDs including mtx has been inadequate, and for the treatment of seve... be given as monotherapy in case of intolerance to mtx or when continued treatment with...

MTX in Medical Technology

CIMZIA(R) (Certolizumab Pegol) Provides Rapid and Sustained Relief from Signs and Symptoms of Rheumatoid Arthritis for Two Years

...IA as a monotherapy (FAST 4WARD) and together with mtx (RAPID 1) was presented at the meeting. Both studi...ercent) of patients receiving CIMZIA together with mtx (RAPID 1) achieving an ACR20 response within one w... the effect of treatment with CIMZIA together with mtx in quality of life measurements. In RAPID 1, nearl...

Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment

...ated with MTX. HUMIRA can be given as monotherapy in case of intolerance to mtx or when continued treatment with mtx is inappropriate. HUMIRA has been shown to reduce the rate of progression o...

Data From Two Phase 3 Studies Show Anti-TNF Golimumab Significantly Improved Signs and Symptoms of Rheumatoid Arthritis

...percent of patients receiving golimumab 50 mg plus mtx and 56 percent receiving golimumab 100 mg plus mtx achieved at least 20 percent improvement in signs ...ed to 33 percent of patients receiving placebo and mtx (p<0.01 and p<0.001, respectively). Improvements w...

U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older

...e-modifying anti-rheumatic drugs (DMARDs), such as mtx or TNF antagonists. "Juvenile idiopathic arthrit...who were inadequate responders to DMARDs including mtx and were new to biologic treatment, ORENCIA demons...A may be used as monotherapy or concomitantly with mtx in pediatric patients. ORENCIA should not be admin...

Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept)

... AIM was a Phase III multi-center, randomized, double-blind, placebo- controlled trial with 652 patients treated at baseline who had active RA despite mtx therapy (638 included in efficacy analyses). The study was double-blind through one year, followed by an ongoing, open-label, long-term extension stud...

Five-Year Data Demonstrate Long-Term Efficacy and Safety with ORENCIA(R) (abatacept) in Adults with Rheumatoid Arthritis Who had an Inadequate Response to Methotrexate

...dequate response to methotrexate." Details of the Study Patients in the initial one-year, double-blind, placebo-controlled randomized trial received mtx and either ORENCIA (10 mg/kg or 2 mg/kg) or placebo administered as a 30-minute intravenous infusion on Days 1, 15 and 30, and every four weeks therea...

CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year

... pegol) Placebo & mtx 200mg & mtx 400mg & mtx Six months ACR 20 13...

ORENCIA(R) (abatacept) Supplemental Biologics License Application for Juvenile Idiopathic Arthritis Accepted by FDA for Filing and Review

...rrently approved for use in adults with moderate to severe rheumatoid arthritis (RA) who have had an inadequate response to one or more DMARDs such as mtx or TNF antagonists. ORENCIA is a selective modulator of a co- stimulatory signal required for full T-cell activation. About Juvenile Idiopathic Arthr...

Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid Arthritis

...b | (certolizumab pegol) | | | | pegol) 200mg & mtx | 400mg & mtx | |--------+-----------+--------------------+-----------------------...

Anti-TNF Golimumab Continues to Show Promise in Phase II Rheumatoid Arthritis Study

...t significantly greater percentages of patients treated with golimumab plus mtx achieved ACR 20, 50 and 70 responses (marked improvement in arthritis sympt...ring criteria) at Week 16 compared with patients treated with placebo plus mtx group. Adults with active RA for at least three months' duration despite ...

MTX in Medical Products

Coag-A-Mate MTX II

Description: This is the comprehensive, simple and flexible solution. The Coag-A-Mate MTX II has a compact, bench-top design, but offers full automation and many features previously only found in high-volume systems. It is an easy to learn, cost-effective solution and can also be used as a back-up for larger sy...
Company:bioMerieux, Inc.

Finstruments 96 well washer and Cellwasher

Features:...eight, onboard pump provides gentle dispensing and agitation. Perfect for cell washings, overcomes the limitations of gravity feed systems, comes with mtx Labs upgrade 2 liter supply reservoir(s), external pump and waste reservoir. Easy user maintenance....
Company:MTX Labs Inc.

MTX in Biological News

Fruit fly research set to revolutionize study of birth defects

...ted use of MTX," says Affleck. Many of the genes found to be affected by mtx are involved in cell cycle regulation, signal transduction, transport, defe... transcription, or various aspects of metabolism. "This study shows that mtx treatment has multiple targets," says Affleck. "And this provides us with a...

MTX in Biological Technology

Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... or in combination with MTX. SIMPONI can be used in combination with mtx in patients who do not respond adequately to mtx alone. -- Reducing signs and symptoms in adult patients with active ank...

Phase 3 studies show golimumab significantly improved signs and symptoms of rheumatoid arthritis

...udy, GOlimumab FOR subjects With Active RA Despite mtx (GO-FORWARD), both the 50 mg and 100 mg doses of g...percent of patients receiving golimumab 50 mg plus mtx and 56 percent receiving golimumab 100 mg plus mtx achieved at least 20 percent improvement in signs ...

Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis

...ated with MTX. HUMIRA can be given as monotherapy in case of intolerance to mtx or when continued treatment with mtx is inappropriate. HUMIRA has been shown to reduce the rate of progression o...

Three PDX (Pralatrexate) Studies Presented at the 2007 AACR-NCI-EORTC Conference

...antifolates. The results suggest that PDX is mechanistically different from mtx and Alimta and that these differences may be due to enhanced uptake of PDX ...ctase (DHFR). In addition, PDX induced greater tumor regression compared to mtx or Alimta in two human NSCLC xenograft models, including the highly aggress...

Electroporation of Primary Bone Marrow Cells

...ions required when an adherent cell rather than a nonadherent one was the target. These cells were cultured in medium containing mtx to determine the percentage of cells expressing the mutant enzyme. The use of the phosphate buffered sucrose (272 mM sucrose, 7 ...