Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal
... Colitis, or Autoimmune Hepatitis), in the case of mtx
therapy for JIA, a continuation of mtx
for 12 to 24 months after induction of remission h...hers.1
The risk of relapse in JIA patients, once mtx
is discontinued, is approximately 50%.2 However, ...
ACTEMRA(R) (tocilizumab) Studies to be Featured at the European League Against Rheumatism (EULAR) Congress
...in the Bella Center.
"Efficacy of Tocilizumab (TCZ) vs Methotrexate (MTX) Monotherapy in Patients with Rheumatoid Arthritis (RA) with No Prior mtx
or DMARD Exposure," results from the AMBITION study, will be highlighted in a poster presentation by lead investigator Graeme Jones, M.D., Professor a...
UCB's CIMZIA(R) (certolizumab pegol) Approved by the U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis
...l responses within one to two weeks, compared with mtx
alone. Additionally, radiographic data showed Cimz...SS) at 24 and 52 weeks of treatment, compared with mtx
"The approval of Cimzia(R... two or four weeks, and administered together with mtx
or as monotherapy.
In the pivotal clinical t...
Wide variability in rheumatoid arthritis drug suggests alternative dosing should be considered
...derstanding the time it takes for stable levels of mtx
to be reached could be useful in effectively contr... long-term damage. A new study examining levels of mtx
metabolites in red blood cells was published in th...interscience.wiley.com/journal/76509746/home ).
is normally taken orally and is rapidly taken up i...
Centocor, Inc. Submits Application to FDA Requesting Approval of Golimumab for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
... as the First-line Option in the
treatment of Rheumatoid arthritis of Early onset (GO-BEFORE) study; the
GOlimumab FOR subjects With Active RA Despite mtx
(GO-FORWARD) study; and A
Multicenter, Randomized, Double-blind, Placebo-controlled Trial of
Golimumab, a Human Anti-TNF-alpha Monoclonal Antibody, Ad...
Rheumatoid Arthritis Drug Boosts Melanoma Incidence
...ts (309 women, 150 men) who started treatment with mtx
prior to June 1986. During a total of 4,273 person...esearchers found that the RA patients who received mtx
were 50 percent more likely than people in the gen... risk of melanoma in patients with RA treated with mtx
compared with the general population," lead author...
HUMIRA(R) (adalimumab) Data Show That Treating Early Rheumatoid Arthritis With Combination Treatment Resulted in Cost Savings From Improved Work Productivity
compared the effectiveness of HUMIRA and mtx
alone in treating early
RA. At baseline, a total o... patients with early RA treated with HUMIRA plus mtx
Increased incidence of melanoma found in rheumatoid arthritis patients treated with methotrexate
... Numerous case reports of RA patients treated with mtx
developing lymphoma and, even more strikingly, tum... drug was discontinued, have prompted concern that mtx
itself may be carcinogenic. So far, however, stud...d the cancer incidence in RA patients treated with mtx
by local doctors. Their findings, featured in the...
Study affirms effectiveness of medication for juvenile rheumatoid arthritis
...etween the ages of 4 and 17 years. Treatment with mtx
and other DMARDs was discontinued a minimum of 2 w... year, participants were permitted to add low-dose mtx
if recommended by their physician. At every 3 mon...percent) and white (74 percent), and all had taken mtx
prior to the study. At baseline, the mean age of ...
Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis
...s. HUMIRA can be used alone or in
combination with mtx
or other DMARDs. HUMIRA is indicted for reducing s...ult patients when the
response to DMARDs including mtx
has been inadequate, and for the treatment
of seve... be given as monotherapy in case of intolerance to mtx
when continued treatment with...
MTX in Medical Technology
CIMZIA(R) (Certolizumab Pegol) Provides Rapid and Sustained Relief from Signs and Symptoms of Rheumatoid Arthritis for Two Years
...IA as a
monotherapy (FAST 4WARD) and together with mtx
(RAPID 1) was presented at
the meeting. Both studi...ercent) of
patients receiving CIMZIA together with mtx
(RAPID 1) achieving an ACR20
response within one w... the effect of treatment with
CIMZIA together with mtx
in quality of life measurements. In RAPID 1,
Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment
...ated with MTX. HUMIRA can be
given as monotherapy in case of intolerance to mtx
or when continued
treatment with mtx
is inappropriate. HUMIRA has been shown to reduce the
rate of progression o...
Data From Two Phase 3 Studies Show Anti-TNF Golimumab Significantly Improved Signs and Symptoms of Rheumatoid Arthritis
...percent of patients receiving golimumab 50 mg plus mtx
percent receiving golimumab 100 mg plus mtx
achieved at least 20 percent
improvement in signs ...ed to 33 percent of
patients receiving placebo and mtx
(p<0.01 and p<0.001, respectively).
U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older
...e-modifying anti-rheumatic drugs
(DMARDs), such as mtx
or TNF antagonists.
"Juvenile idiopathic arthrit...who were inadequate
responders to DMARDs including mtx
and were new to biologic treatment,
ORENCIA demons...A may be used as monotherapy or
concomitantly with mtx
in pediatric patients. ORENCIA should not be
Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept)
... AIM was a Phase III multi-center, randomized, double-blind, placebo-
controlled trial with 652 patients treated at baseline who had active RA
therapy (638 included in efficacy analyses). The study was
double-blind through one year, followed by an ongoing, open-label,
long-term extension stud...
Five-Year Data Demonstrate Long-Term Efficacy and Safety with ORENCIA(R) (abatacept) in Adults with Rheumatoid Arthritis Who had an Inadequate Response to Methotrexate
...dequate response to
methotrexate." Details of the Study Patients in the initial one-year, double-blind, placebo-controlled
randomized trial received mtx
and either ORENCIA (10 mg/kg or 2 mg/kg) or
placebo administered as a 30-minute intravenous infusion on Days 1, 15 and
30, and every four weeks therea...
CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year
... pegol) Placebo & mtx
200mg & mtx
400mg & mtx
Six months ACR 20 13...
ORENCIA(R) (abatacept) Supplemental Biologics License Application for Juvenile Idiopathic Arthritis Accepted by FDA for Filing and Review
...rrently approved for use in adults with moderate to severe rheumatoid
arthritis (RA) who have had an inadequate response to one or more DMARDs
such as mtx
or TNF antagonists. ORENCIA is a selective modulator of a co-
stimulatory signal required for full T-cell activation. About Juvenile Idiopathic Arthr...
Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid
| (certolizumab pegol) |
pegol) 200mg & mtx
Anti-TNF Golimumab Continues to Show Promise in Phase II Rheumatoid
...t significantly greater
percentages of patients treated with golimumab plus mtx
ACR 20, 50 and 70 responses (marked improvement in arthritis
criteria) at Week 16 compared with patients treated with
placebo plus mtx
group. Adults with active RA for at
least three months' duration despite ...
MTX in Medical Products
Coag-A-Mate MTX II
Description: This is the comprehensive, simple and flexible solution. The Coag-A-Mate MTX
II has a compact, bench-top design, but offers full automation and many features previously only found in high-volume systems. It is an easy to learn, cost-effective solution and can also be used as a back-up for larger sy...
Finstruments 96 well washer and Cellwasher
Features:...eight, onboard pump provides gentle dispensing and agitation. Perfect for cell washings, overcomes the limitations of gravity feed systems, comes with mtx
Labs upgrade 2 liter supply reservoir(s), external pump and waste reservoir. Easy user maintenance....
Company:MTX Labs Inc.
MTX in Biological News
Fruit fly research set to revolutionize study of birth defects
...ted use of MTX," says Affleck.
Many of the genes found to be affected by mtx
are involved in cell cycle regulation, signal transduction, transport, defe... transcription, or various aspects of metabolism.
"This study shows that mtx
treatment has multiple targets," says Affleck. "And this provides us with a...
MTX in Biological Technology