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MTHFR in Medical News

Gene Could Boost Stroke Risk for Migraine Sufferers

... reviewed the data to see which women carried a particular form of the gene mthfr 677C -- a gene that had been suggested by prior research as a possible link...1 percent of the study population carried this gene variant. Alone, the mthfr 677C variant doesn't appear to raise the risk of cardiovascular disease. H...

Same drug, different results: MUHC researcher on the path to personalized medicine

...he metabolism of folate -- on mice with an altered mthfr gene, which is a gene crucial for folate metabolis...to humans because a parallel mutation in the human mthfr gene affects human folate metabolism similarly. Th... In earlier studies, Rozen's laboratory cloned the mthfr gene and identified the common variant which inter...

NARSAD researchers identify specific genes and family traits linked to mental illnesses

...may be deficient in people with schizophrenia, and mthfr (methylenetetrahydrofolate reductase), which activ...e, Dr. Roffman and his colleagues started with the mthfr gene and found that one variant increases the seve...r. Roffman's team is looking at the combination of mthfr and another gene -- COMT (catechol-O-methyltransfe...

Genes May Explain Role of Race in Colon Cancer Risk

...han 25,000 people. They found that people who have two "T" copies of the mthfr gene that metabolizes folate -- a chemical needed to produce and maintain n...th, said in a prepared statement. The finding that two "T" copies of the mthfr gene may help protect against colorectal cancer in certain racial/ethnic gr...

Genetic differences point to ethnic and racial disparities in colorectal cancer risk

...homocysteine,a chemical byproduct that is toxic to cells. The CC version of mthfr is considered the wild type the version most common in the population as a...gs warrant larger studies to evaluate gene-environment interactions for the mthfr polymorphism and colorectal cancer risk in different racial or ethnic popul...
MTHFR in Medical Technology

NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression

...r. Roffman's team is looking at the combination of mthfr and another gene -- COMT (catechol-O-methyltransfe...In individuals who carry the risk variants of both mthfr and COMT, lower-than-normal levels of dopamine in ...colleagues also found that the same combination of mthfr and COMT variants were associated with abnormally ...
MTHFR in Medical Products

Methotrexate Sensitivity by MTHFR Genotyping

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
MTHFR in Biological News

In lung cancer, silencing one crucial gene disrupts normal functioning of genome

...five cancer-associated genes (CDH1, CDKN2A, GSTP1, mthfr and RASSF1A) in tumor samples from 209 lung patien... to be inactivated in lung cancer. But the role of mthfr has been less clear, he said. The enzyme produced ...ed risk of cardiovascular disease. "Because the mthfr gene product plays a role in the maintenance of th...

SNPs affect folate metabolism in study of Puerto-Rican adults

...that may increase the risk for cancer," Crott said. With respect to the mthfr 677C>T SNP, those with two copies of the variant gene (TT genotype) display... After correcting for other potentially confounding factors, those with the mthfr 677TT genotype displayed folate concentrations 4.6% lower than CC genotypes...

Interaction between gene variants may alter brain function in schizophrenia

...during working memory. Although the schizophrenia-associated variant of mthfr was found in both patients and controls, when the working memory task becom...ion in cortical function seen in patients with the schizophrenia-associated mthfr variant was even more pronounced in patients who also had a COMT variant pr...

At Boston symposium, NARSAD researchers report on genes and family traits

...may be deficient in people with schizophrenia, and mthfr (methylenetetrahydrofolate reductase), which activ...e, Dr. Roffman and his colleagues started with the mthfr gene and found that one variant increases the seve...r. Roffman's team is looking at the combination of mthfr and another gene -- COMT (catechol-O-methyltransfe...

MUHC researchers make cancer target breakthrough

...olate reductase, or MTHFR. Researchers were able to inhibit the function of the gene by creating antisense--an exact opposite of a tiny section of the mthfr gene. "MTHFR is involved in the synthesis of methionine--a critical nutrient necessary for growth of cancer cells," explains Dr. Rima Rozen, principal...
MTHFR in Biological Technology

Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits

...n CCR2 (64I), Factor V (Leiden), SDF-1(3 A), and mthfr (C677T) genes, as well as of a 32-base-pair deleti...us thrombosis (Table 1). The mthfr (C677T) allelic discrimination kit is used to dete...n thrombosis 11 mthfr (Methylene-tetrahydrofolate reduc...
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