MSH2

Immune-Based Lymphoma Treatment Shows Promise

...rted on a possible biomarker -- a protein known as msh2 -- that might predict which patients with non-smal...l fare better on cisplatin-based chemotherapy. msh2 is one of a family of DNA repair genes, the irony ...risingly, then, patients with either low levels of msh2 or none at all respond better to cisplatin treatme...

Model Predicts Colon Cancer Inheritable Genetic Defects

...th Sciences. Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is characterized by the inheritance of defects in the MLH1, msh2 and MSH6 genes. These three genes help repair mismatches that can occur during the duplication of the genetic code when new cells are made, and are kn...

A New Test Developed to Identify Suspected Bowel Cancer Patients

...explained that the team had developed the test in a long-term study that involved 870 patients, primarily focusing on the faults in three genes, MLH1, msh2 and MSH6, which are considered responsible for proteins that help to prevent the DNA damage that are linked with tumour development. The finding...

MSH2 in Biological News

Inherited cancer mutation is widespread in America

...d States. The initial study of nine families showed that the American Founder Mutation results in the loss of a very specific piece of a gene called msh2 (although many other mutations also cause Lynch syndrome). The new study linked 27 of the 41 families into seven groups through genealogic studies. ...

MSH2 in Biological Technology

Tools for Detecting MSH2 Expression in Chinese Hamster Ovary Cells

Integrated system simplifies and improves Northern blot analysis Karen Dolter Jeff Braman Stratagene Streamline RNA analysis with a whole host of products from Stratagene. First, the StrataPrep total RNA miniprep kit is used to isolate ample yields of high-quality RNA...

MSH2 in Biological Dictionary

MSH2

MSH2 is a gene commonly associated with Hereditary nonpolyposis colorectal cancer. ... MSH2 and ATR form a signaling module and regulate two branches of the damage ... ... homologs form two major heterodimers: Msh2 /Msh6 (MutSα) and Msh2 /Msh3 (MutSβ) ... the MutS and MutL homo...

MutS

...ropean Bioinformatics Institute ... MutS and MutL are involved in ... DNA mismatch repair protein MutS , type 1. DNA mismatch repair protein, msh2 ... The European Bioinformatics Institute ... MutS and MutL are involved in preventing recombination between partially ... MutS can also coll...