Immune-Based Lymphoma Treatment Shows Promise
...rted on a possible biomarker -- a protein known as msh2
-- that might predict which patients with non-smal...l fare better on cisplatin-based chemotherapy.
is one of a family of DNA repair genes, the irony ...risingly, then, patients with either low levels of msh2
or none at all respond better to cisplatin treatme...
Model Predicts Colon Cancer Inheritable Genetic Defects
Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is characterized by the inheritance of defects in the MLH1, msh2
and MSH6 genes. These three genes help repair mismatches that can occur during the duplication of the genetic code when new cells are made, and are kn...
A New Test Developed to Identify Suspected Bowel Cancer Patients
...explained that the team had developed the test in a long-term study that involved 870 patients, primarily focusing on the faults in three genes, MLH1, msh2
and MSH6, which are considered responsible for proteins that help to prevent the DNA damage that are linked with tumour development.
MSH2 in Biological News
Inherited cancer mutation is widespread in America
The initial study of nine families showed that the American Founder Mutation results in the loss of a very specific piece of a gene called msh2
(although many other mutations also cause Lynch syndrome).
The new study linked 27 of the 41 families into seven groups through genealogic studies.
MSH2 in Biological Technology
Tools for Detecting MSH2 Expression in Chinese Hamster Ovary Cells
Integrated system simplifies and improves Northern blot analysis
Karen Dolter Jeff Braman
Streamline RNA analysis with a whole host of products from Stratagene.
First, the StrataPrep total RNA miniprep kit is
used to isolate ample yields of high-quality RNA...
MSH2 in Biological Dictionary
is a gene commonly associated with Hereditary nonpolyposis colorectal cancer. ... MSH2
and ATR form a signaling module and regulate two branches of the damage ... ... homologs form two major heterodimers: Msh2
/Msh6 (MutSα) and Msh2
/Msh3 (MutSβ) ... the MutS and MutL homo...
...ropean Bioinformatics Institute ... MutS and MutL are involved in ... DNA mismatch repair protein MutS , type 1. DNA mismatch repair protein, msh2
... The European Bioinformatics Institute ... MutS and MutL are involved in preventing recombination between partially ... MutS can also coll...