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MMP2 in Medical News

Study Finds direct link Between stress And Ovarian Cancer

...s the tiny blood vessels that tumors need to nourish themselves. They found that not only had VEGF activated, but also were two other compounds called mmp2 and MMP9, which were involved in sustaining tumors. Dr Sood said, “This study provides a new understanding of how chronic stress and stress fact...

Identification Of Gene Sequence To Promote Growth Of New Arteries

...new arteries // . He demonstrated in mice that the mmp2 gene is the key factor for the development of new ...en detailed information on the DNA sequence of the mmp2 gene, which encodes an enzyme believed to promote ...e having the intact gene and the other lacking the mmp2 gene. In about three weeks, the normal mice develo...
MMP2 in Medical Technology

Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy

... a common problem in diabetic patients, often leading to the need for hemodialysis or kidney transplant. XL784 is a potent small molecule inhibitor of mmp2 and ADAM10, metalloprotease enzymes that may play a role in renal fibrosis and impairment. "We obviously are disappointed that this trial did not mee...
MMP2 in Biological News

Genes set scene for metastasis

...ls from the bloodstream into the lung. The gene set comprises EREG (an epidermal growth factor receptor ligand), the cyclooxygenase COX2, and MMP1 and mmp2 (matrix enzymes that are expressed in human breast cancer cells). The researchers conclude that drug combinations that target one or more of the...

Genetic key to growth of new arteries is identified

...Sarkar, MD, PhD, has demonstrated in mice that the mmp2 gene is essential for the growth of new arteries w... the first time, the specific DNA sequences of the mmp2 gene that are expressed when new arteries are grow...rteries of normal mice and of mice that lacked the mmp2 gene, which encodes an enzyme that promotes the gr...
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