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MMP in Medical News

Patriot Scientific Corporation Announces Cardiac Science Corporation's Purchase of a Moore Microprocessor Patent(TM) Portfolio License

...ns over 60 other global companies that have become mmp licensees. The mmp Portfolio patents cover techniques that enable hig...sor-based features and benefits. About the mmp Portfolio The Moore Microprocessor Patent ...

Study in Nature Medicine establishes major new treatment target in diseased arteries

... Mice lacking CypA saw greater than 75 percent decreases in ROS production, mmp activation and inflammatory cell influx compared to normal mice, with the o...s that, if interfered with, would shut down ROS production, CypA secretion, mmp activation and inflammatory cell recruitment in AAA. Also in the next phase...

Durability of dental fillings improves if the enzyme activity of teeth is inhibited

... team has shown that human dentin contains the key mmp for breaking down collagen. The bonding of composi...e bond has been more or less completely prevented. mmp enzyme activity in the tooth can be rapidly and ea... research in question also strongly indicates that mmp inhibitors might help slow down tooth decay. These...

Skin color studies on tadpoles lead to cancer advance

...s unconventional study, which was initiated with funding from the UK Medical Research Council, identifies for the first time an effective new man-made mmp (metalloproteinase) inhibitor, known as 'NSC 84093'. The work was led by the University of East Anglia, in partnership with the John Innes Centre ...

Study Questions Value of Anti-Meth Campaign

...said the graphic ads exaggerated the dangers of meth use. Initially, the mmp was privately funded, but it has since received millions of dollars in stat...makers and the media. However, the review found that those in charge of the mmp emphasized only positive findings and overlooked the numerous negative resu...

Success of anti-meth ads questioned by study

...ons of dollars in state and federal support as the mmp has promoted the ad campaign as a resounding succe...he risks of using meth. The review found that the mmp overlooked these unflattering results when promoti...dings to policymakers and the media. Instead, the mmp focused on select positive findings. The author o...

Study provides clues to preventing and treating cancer spread

... these cells induced MMP9, an enzyme that is known to promote cancer. The researchers considered this good news, since drugs are available that block mmp enzymes and have proven beneficial in treating cancer. Still, many basic questions remain to be answered. How do cancers promote the formation o...

JCI online early table of contents: March 13, 2008

...y role for the protein MMP-2 in this process, leading to the suggestion that some women with ovarian cancer might benefit from early treatment with an mmp inhibitor. In the study, expression of MMP-2 was upregulated in human ovarian tumor cells when they attached to stromal cells in culture. Further, ...

Viral Therapy Slows Pediatric Tumors in Mice

...p break down molecules that are important for the structural support and normal development of cells, organs and maintenance of tissues. However, when mmp activity becomes unbalanced, the enzyme plays a well-documented role in the formation of invasive and metastatic cancers, including pediatric neurobla...

Bad Enzymes Found To Enable Brain Recovery Following Stroke

... episode, to prevent irreversible damage to the brain. Rats that were designed to mimic human models of stroke were given different doses of the mmp inhibitor, at different intervals. Administration of the inhibitor immediately following the stroke showed smaller brain damaged areas. No effect was ...
MMP in Biological News

Skin cancer study uncovers new tumor suppressor gene

...e individualized cancer treatment strategies where mmp and other key enzymes play a functional role in tu...ance of drugs designed to treat cancer by blocking mmp enzymes. Because members of the mmp gene family were thought to be oncogenes and many ...

Researchers isolate protein domain linked to tumor progression

...ting drugs that inactivate a different part of the mmp enzyme could have the capacity to target the tumor...o determine the functions of different parts of an mmp enzyme. These parts, known as domains, usually cor...gnificant and unknown consequences. To determine mmp domain function, the researchers used a simple mod...

UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome

...t. But minocycline, they found, reduces these mmp levels in the mice, allowing the synapses to matur...minister minocycline. They will also explore other mmp inhibitors that may be more effective than minocyc.... "We will investigate whether a combination of mmp inhibitors with other drugs, such as fenobam, can ...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

... MMPs help break down molecules that are important for the structural support and normal development of cells, organs and maintenance of tissues. When mmp activity becomes unbalanced, the enzyme plays a well-documented role in the formation of invasive and metastatic cancers, including pediatric neurobla...

New molecular pathway could reveal how cells stick together

...on of that protein. She has previously done similar work knocking out mmp in flies. "One of the defects in mmp mutants is in their ability to control cell adhesion," she said. Many tissu...

'Bad' enzymes may wear white hats after stroke

...m induced stroke in rats and injected some with an mmp inhibitor at different times after the stroke. Whe... and blood vessel regrowth. Rats that received an mmp inhibitor seven days after stroke had much lower l... behavioral task than rats that did not receive an mmp inhibitor. While current efforts to design MMP-...
MMP in Biological Technology

VisEn Launches Next-Generation Fast ('Fluorescence Activatible Sensor Technology') Agent Platform for Expanded Performance in Imaging Disease Biomarkers In Vivo

...e 750 FAST as a fast-acting, near-infrared imaging agent to measure tumor mmp activity in vivo and monitor treatment efficacy. In the study, administration of the agent allowed the non-invasive measurement of mmp inhibition using two different chemotherapy regimes. Using the VisEn FMT 2...

ThromboGenics N.V.: Business Update

...t in the level of damage to the blood brain barrier compared to placebo-treated patients, measured using the marker of matrix metalloproteinase (MMP). mmp activation plays a crucial role in the pathogenesis of brain edema and hemorrhagic transformation after ischemic stroke. It remains ThromboGenics' i...
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(Date:10/15/2014)... awarded the 44th Rosenstiel Award for Distinguished Work in ... exploring the mechanisms of genomic instability and its implications ... the second alumnus to win the Rosenstiel Award; the ... , Alt is the Charles A. Janeway Professor of ... and an investigator at the Howard Hughes Medical Institute ...
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