The genetics of MLL leukemogenesis
In the November 1st issue of G&D, Dr. Michael Cleary (Stanford University School of Medicine) and colleagues identify the gene Meis1 as a critical player in the establishment of leukemia stem cells, and the development of MLL
Mixed lineage leukemia (MLL) is a distinctive type of leuke...
Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease
...ventional testing. Downing said the analysis identified focal CNAs adjacent to genes previously linked to chromosomal translocations. Those genes are mll
, MLLT4 , NUP98 and NSD1 . These data suggest that chromosomal translocations are more frequent in AML than was previously thought. Identifying th...
Universal Music Enterprises (UMe) and Body By Jake Global Create the World's First Digital Fitness Music Label
... the nation's first "Fitness State." Jake is also the founder of Major League Lacrosse (MLL), the nation's first professional outdoor lacrosse league, mll
is now entering its ninth successful season with ten teams throughout the country. Jake created his Don't Quit! Foundation to support and educate the ...
Mouse model highlights histone methylation as distinguishing feature for leukemia subtypes
... a strategy for distinguishing cancer subtypes.
rearrangements have been observed in some cases of...eloid leukemia (AML). ALL patients with rearranged mll
have a relatively poor prognosis when compared wit...difficult. Recent studies have suggested that some mll
fusion proteins enhance gene expression by recruit...
New leukemia signal could point way to better treatment, Stanford researchers find
...nhibiting GSK3 combats leukemias caused by mutated mll
genes. MLL, an acronym for "mixed-lineage leukemia...to see which genes are driving the cancer. Mutated mll
genes are viewed as a bad prognostic marker, Clear... When a GSK3 inhibitor clobbered cells with mutant mll
genes, Wang realized his work was cut out for him....
Microenvironment a main driver of aggressive multi-lineage leukemia disease type
... allow testing of novel therapeutic strategies for mll
patients. They will also yield information that ma...L) results when chromosome mutations involving the mll
gene fuse with certain partner genes. These so-called translocations result in the mll
gene being rearranged to send instructions to crea...
Advances in Blood Cancer Therapy to be Highlighted at American Society of Hematology Conference
...argets for new drug development.
-- Targeting RUNX1 in Leukemia, John H. Bushweller, Ph.D., University of Virginia, Charlottesville; Targeting mll
Fusion Genes in Leukemia, Michael Thirman, M.D., University of Chicago. (Same session: Dec. 8, 2 p.m., and Dec. 9, 7:30 a.m.). Personalized m...
Unique role for blood formation gene identified
... cannot work properly, and leukemia can ensue.
is the most commonly affected gene in childhood le..., said Ernst, who first helped clarify the role of mll
as a postdoctoral fellow at Harvard.
Many child... In infant leukemia, the chromosome containing the mll
gene breaks within...
Mouse Gene With Gene Stutter Will Help Leukemia Research
...al tandem duplication, is located in a gene called mll
(for mixed-lineage leukemia). A partial tandem dup...ferently. In this case, the duplication within the mll
gene contributes to an aggressive form of AML. Thi...nd Carlo M. Croce, discovered this mutation in the mll
CSHL team develops mouse models of leukemia that predict response to chemotherapy
...me in people, while fusion oncogenes involving the mll
gene have been associated with an adverse outcome....and is commonly found in concert with AML1/ETO and mll
These altered stem cells were tr...odels suggest that AML patients diagnosed with the mll
chromosome rearrangement will not show durable res...
Tracking the molecular pathway to mixed-lineage leukemia
...ost cases are caused by a fusion of two genes, the mll
and the AF4 genes.
When the mll
gene is fused to the AF4 gene, a potent cancer-cau... to cancer and to leukemia disease progression. In mll
patients, it seems the MLL-AF4 protein alters the ...
Syracuse University researchers discover new way to attack some forms of leukemia
...neage Leukemia (MLL) protein. In normal cells, the mll
protein, which contains 3,969 amino acids, combine... white blood cells. In some types of leukemia, the mll
switch is broken, which prevents white blood cells...Cosgrove's team identified a tiny component of the mll
proteina peptide sequence that contains just six a...
Stowers Institute's Shilatifard Lab identifies new role for factor critical to transcription
... required for the regulation of the temporary interruptions of Pol II transcription in a living organism."
"ELL is found in translocation with the mll
gene in childhood leukemia," said Edwin Smith, Ph.D., Research Scientist in the Shilatifard Lab. "We know very little about the role of these factors ...
Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
...PASS examines the yeast homologue of the mammalian mll
complex, a histone methylase involved in the devel...east. Soon thereafter, it was established that the mll
protein in humans also existed in a COMPASS-like c...Given the importance of histone methylation by the mll
complex and leukemia pathogenesis, defining the mo...