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MIF in Medical News

Anemia from Malaria Linked to a Protein MIF

Scientists at Johns Hopkins, Yale and other institutions have conducted a joint cell and animal study that has revealed one important contributor to the severe anemia// that result from malaria, often causing death. The culprit is a protein cells make in response to inflammation called MIF, whic...

Blocking protein leads to fewer, smaller skin cancer tumors

...tion against some pathogens. But in this research, mif emerged as a contributor to the chronic inflammati...erm sun exposure. Previous studies have implicated mif in other cancers, as well. "Our data show that mif appears to be affecting multiple pathways that are...

Gene predicts heart attack response and cardiac damage

...dys response to infection. We found that when mif is released in response to a lack of oxygen, it ca... The researchers discovered that mice lacking the mif gene had a deficient AMPK response and suffered more severe heart attacks than mice with an intact mif gene. A common variation in the...

Immune Substance in Semen may Help Determine Male Fertility

...ealthy controls. It was observed that the mif levels in men with infertility problems were eithe... levels that were just right. Upon adding mif into lab dishes filled with healthy sperm, the res...ity impaired. Dr. Al-Abed wonders whether mif can work as a form of male contraceptive, if it ha...

Immune System Protein Could Be the Key Infertility

...is colleagues say. They first isolated the mif contained in semen samples collected from 68 infe... The researchers found that the infertile men had mif levels that were either too high or too low. When the scientists added mif into lab dishes filled with healthy sperm, it decr...

Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression

... used in finding drugs which reduces the amount of mif // in a way progression of Multiple Sclerosis is h...lammation-producing chemicals. Conversely, lack of mif seems to trigger the release of other immune syste... Caroline Whitacre said, "Our results suggest that mif may be less important for initiating MS, but that ...

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MIF in Medical Technology

Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors

KING OF PRUSSIA, Pa., Aug. 2 /PRNewswire/ -- Cytokine PharmaSciences, Inc. (CPSI) today revealed that recent experiments with its small-molecule MIF inhibitors showed oral efficacy in animal models. Based on these results, the Company announced that it is advancing one of these compounds into ...
MIF in Medical Products

Lymphogranuloma Venereum (LGV), Differentiation Antibody Panel, MIF

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
MIF in Biological News

Intervention method reduces binge drinking

... reduced drinking among a group of heavy-drinking college students. The mif intervention includes a personalized feedback profile and a 45-minute couns...AC that was 0.039 lower than that of assessment-only participants. Finally, mif group participants reported a mean alcohol problem score that was 2.32 poin...

How bad is malaria anemia? It may depend on your genes

... anemia. A number of human proteins, including mif (which stands for migration inhibitory factor), we...wn in a dish, the research team showed that adding mif to the cells decreases both the final number and m...th plasmodium, mice genetically engineered to lack mif experience less severe anemia and are more likely ...

Towards precise classification of cancers based on robust gene functional expression profiles

...y, the researchers focused on the formation of the mif protein (macrophage migration inhibitory factor), ... associated with obesity. "We've shown that the mif gene is crucial for the development of type 1 diab..., specially bred mice that lacked the gene for the mif protein failed to develop diabetes compared to mic...

Chemists identify key gene in development of type 1 diabetes

...y, the researchers focused on the formation of the mif protein (macrophage migration inhibitory factor), ... associated with obesity. "We've shown that the mif gene is crucial for the development of type 1 diab..., specially bred mice that lacked the gene for the mif protein failed to develop diabetes compared to mic...
MIF in Biological Technology

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

...has a second drug discovery program targeting the pro-inflammatory cytokine mif (Macrophage Migration Inhibitory Factor), which has emerged as a critical m...s for MIF. Identification of structural motifs for high affinity binding of mif to its target receptors ( Weber et al., PNAS, 2008 ) enables Carolus Therap...
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