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MELANOCYTE in Medical News

UBC researchers discover gene mutation that causes eye cancer

...published today in Nature , will allow researchers to develop therapeutic interventions against some melanomas. "We discovered that GNAQ regulates melanocyte survival," says Van Raamsdonk. "When the GNAQ gene is mutated it leads to unregulated growth of melanocytes. Since cancer is a disease of unregulated ...

FDR Might Have Had Melanoma

...ck to the 1930s and '40s, no one knew what it was." Melanoma is a cancer of the thin top layer of the skin, called the epidermis, which strikes the melanocyte cells that are responsible for the brown protective pigmentation that emerges following sun exposure. According to the American Cancer Society, melano...

Genome-wide survey nets key melanoma gene

...it a tale of two melanocytes. Given the same genetic mutation, why does one melanocyte shut down growth and become a relatively benign mole, while another rages o...cause its presence suggested something intriguing: If one otherwise healthy melanocyte begins expressing BRAF, the IGFBP7 it produces can enter cells around it, p...

Fish Give Clues to Human Skin Color Changes

...re very different from each other," Kingsley said in a prepared statement. The Kit ligand gene makes a protein that plays a role in maintaining the melanocyte skin cells that control pigmentation. While this gene isn't the only factor that determines skin color, it does seem to account for about 20 percen...

Why Don’t All Moles Progress to Melanoma

...ciated with diseases like diabetes and Alzheimer’s disease.” “In our study, we found that the ER senses the activity of certain oncogenes in the melanocyte and triggers a response that prevents the malignant transformation of these cells,” Soengas adds. According to Soengas, the tumor suppressive me...

Insight Into Tanning Process Suggests Novel Way to Prevent Skin Cancer

...in of red hair and pale skin in humans is found in a tiny pouch-like receptor, called MC1R, on the surface of melanocytes. When the hormone MSH -- for melanocyte Stimulating Hormone -- drops into the pouch, it causes a surge in the melanocyte’s production of the chemical cAMP. cAMP then stimulates melanocytes t...

Varied Applications of Adult Stem Cells to Treat Host of Disorders in Human

...kers and demonstrated appropriate functions in tissue culture, according to each cell type. For example, after 14 days, 20% to 40% of the cells in the melanocyte media took on a weblike shape typical of melanocytes. The new cells also expressed biomarkers typical of pigment cells and when placed in an artificia...

Prevent Skin Cancer with Lifestyle Changes

...h light-colored skin that is prone to freckles. Skin cancer, which develops in the epidermal layer, is known as non-melanoma whereas cancer of the melanocyte is known as melanoma with non-melanomas more common in parts of body such as the face, which is more frequently exposed to sunlight. Melanoma, rarer,...
MELANOCYTE in Medical Dictionary

Skin

...Prosanol products for contact dermatitis, dandruff, psoriasis, and irritations of the skin . (Click to enlarge) skin cutaway of human skin A. melanocyte B. muscle C. sebaceous gland D. hair shaft E ... outer covering); peel off: skin off the thin bark. ... BORBA's skin ... Drinkable Skin...

Melanoma

...s of the skin, hair and nails and educational ... melanoma n. , pl. -mas or -mata . A dark-pigmented, usually malignant tumor arising from a melanocyte and occurring most commonly in the Information about melanoma ... Although melanoma is the least common type of skin cancer, it is the most ...

Malignant melanoma

...malignant melanoma in Hutchinson melanotic ... melanoma n. , pl. -mas or -mata . A dark-pigmented, usually malignant tumor arising from a melanocyte and occurring most commonly in the More about Malignant Melanoma : Causes and symptoms Diagnosis Treatment Alternative treatment Prognosis Co...
MELANOCYTE in Biological News

The genetics of the white horse unraveled

...t may lead to tumour development. We propose that the Grey mutation stimulates growth of melanocytes and that this leads to a premature loss of the melanocyte stem cells needed for hair pigmentation whereas the mutation promotes an expansion of some of the melanocytes causing skin pigmentation, says Leif And...

Why don't all moles progress to melanoma?

...sociated with diseases like diabetes and Alzheimer's disease." "In our study, we found that the ER senses the activity of certain oncogenes in the melanocyte and triggers a response that prevents the malignant transformation of these cells," Soengas adds. According to Soengas, the tumor suppressive mec...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...e hair, are specialized cells spawned by colorless melanocyte stem cells. These cells were discovered by Nishimura in 2002. A pool of undifferentiated melanocyte stem cells resides in the hair follicle, and durin...s gene. In a dramatic fashion, the mice lost their melanocyte stem cells shortly after birth and quickly went gr...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...e hair, are specialized cells spawned by colorless melanocyte stem cells. These cells were discovered by Nishimura in 2002. A pool of undifferentiated melanocyte stem cells resides in the hair follicle, and durin...s gene. In a dramatic fashion, the mice lost their melanocyte stem cells shortly after birth and quickly went gr...

Scientists discover the cellular roots of graying hair

...e hair, are specialized cells spawned by colorless melanocyte stem cells. These cells were discovered by Nishimura in 2002. A pool of undifferentiated melanocyte stem cells resides in the hair follicle, and durin...s gene. In a dramatic fashion, the mice lost their melanocyte stem cells shortly after birth and quickly went gr...
MELANOCYTE in Biological Technology

The development of a melanocortin MC5 receptor binding assay using the LEADseeker Multimodality Imaging System

...nto three major peptide hormone fragments: adrenocorticotrophin (ACTH), the melanocyte stimulating hormones, and β-endorphin. The various melanocyte stimulating hormones are known to activate the MC 5 (melanocortin subtype ...

The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System

...nto three major peptide hormone fragments: adrenocorticotrophin (ACTH), the melanocyte stimulating hormones, and β-endorphin. The various melanocyte stimulating hormones are known to activate the MC 4 (melanocortin subtype ...
MELANOCYTE in Biological Definition

Hormone

...in (hCG) growth hormone (GH or hGH) insulin insulin-like growth factor (IGF, also somatomedin) leptin luteinizing hormone (LH) melanocyte stimulating hormone (MSH or α-MSH) neuropeptide Y oxytocin parathyroid hormone (PTH) prolactin (PRL) renin secretin s...
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