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MEK1 in Medical News

Combination targets: some drugs may work best when they work together

... with a lack of oxygen, a state called hypoxia, they report. AZD6244 is a small molecule inhibitor developed by AstraZeneca to bind to and inhibit mek1 and MEK2 proteins, which together form a critical point on the pathway that controls the ongoing survival of cells. Defects along the pathway can lead...
MEK1 in Medical Technology

Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at American College of Gastroenterology Annual Scientific Meeting

...details are as follows: Date/Time: Tuesday, October 7, 2008 from 10:30 a.m. - 4:00 p.m. EDT Abstract Title: "RDEA119, a Potent and Highly Selective mek1 / 2 Inhibitor is Beneficial in Dextran Sulfate Sodium (DSS)-Induced Chronic Colitis in Mice" Poster Number: P1050 ...

New Data for XL880, XL647 and XL184 to Be Presented at AACR-NCI-EORTC

...f cytotoxic therapy by XL844, an orally bioavailable inhibitor of Chk1 and Chk2 (Abstract #B228) -- XL518, a Potent Selective Orally Bioavailable mek1 Inhibitor, Downregulates the RAS/RAF/MEK/ERK Pathway In Vivo, Resulting in Tumor Growth Inhibition and Regression in Pre-Clinical Models (Abst...
MEK1 in Biological Technology

New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways

...ctivates the GAL4-c-Fos fusion protein expressed from the pFA-cFos plasmid. The mechanism of this activation is not yet characterized. PKA, mek1 and other extracellular stimuli failed to activate the GAL4-c-Fos fusion protein (data not shown). ...

Improved Vectors for PathDetect Trans-Reporting Systems

...smids with either the pFC-dbd or pFC2-dbd plasmids yielded similar background levels of luciferase activity. Since the mek1 protein is a known upstream activator of the Elk1 protein, the pFC-MEK1 plasmid was used to compare the activity of the pFA-Elk1 and ...

In Vivo Signal Transduction Pathway Reporting Systems

...lk1 is phosphorylated and activated by MAPK. 10,11 The MEKK and mek1 proteins are both known activators of the Elk1 protein. Cotransf... of luciferase. These data are consistent with reports that both mek1 and MEKK proteins are known activators of the MAPK pathway. 16-...

Yeast Protein Production System Features High Yields and One-Step Purification

...s, including the rat c-Jun N-terminal kinase (JNK) and the human mek1 gene products ( figure 4 ). Yield for these proteins ...K1 fusion protein. The GST tag was efficiently detached from the mek1 moiety by digesting the purified GST-MEK1 fusion protein with en...

Production of Full-Length, Biologically Active MEK1WT and MEK1CA

...ressed and purified recombinant, wild-type human mek1 WT and a constitutively active mutant (MEK1 CA ) ...d in E. coli are significantly degraded. Wild-type mek1 WT can be used as a substrate for upstream MEK ... MEKK or mos. The uses for constitutively active mek1 CA include identifying potential substrates, ma...

Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems

... In a similar fashion, the specificity of the pFA2-Elk1 fusion activator plasmid is demonstrated ( Figure 2 C). Since the mek1 protein is a known upstream activator of the Elk1 protein 12 the pFC-MEK1 plasmid, constitutively expressing this kinase, was u...
MEK1 in Biological Dictionary

SiRNA

...ly inhibit Akt expression using RNA interference, a ... SignalSilence® mek1 siRNA from Cell Signaling Technology allows the researcher to specifically inhibit mek1 expression using RNA interference, a method in which ... siRNA Produ...

Pachytene

... In addition, the pachytene checkpoint requires the chromatin silencing factor ... Pachytene arrest also requires the meiosis-specific Red1 and mek1 proteins (14) ... Meiotic pachytene bivalents are much longer than somatic metaphase chromosomes ... Detailed pachytene BAC-FISH analys...
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(Date:4/16/2014)... Ariz. April 15, 2014 The Translational Genomics ... at their annual Founders Dinner for their support of ... event took place March 28 in Scottsdale. , Catherine ... Ivy Foundation, received TGen,s John S. McCain Leadership Award, ...
(Date:4/15/2014)... and pre-diabetes in the United States have nearly doubled since ... of Public Health, with obesity apparently to blame for the ... disease has not hit all groups equally, with alarming increases ... to new research reported in the April 15, 2014 issue ...
(Date:4/14/2014)... , Significant advances have been made in chemotherapy over ... while avoiding healthy tissues continues to be a major ... targeted drug delivery, including the use of nanocarriers, or ... specific locations in the body. , The catch? These ...
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(Date:4/14/2014)... that the molecule, called microRNA 135b, is a vital ... the growth of bowel cancers. , Drugs targeted at ... cancer-causing mutations at once, while tests for it could ... believe. , The research was carried out by an ...
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(Date:4/17/2014)... such as heart disease, epilepsy and pain, making them ... is still much scientists do not know about the ... into the structure of sodium channels and, specifically, one ... responsible for ,fine-tuning, the activity of the channel. The ... the Journal of Biological Chemistry . , Nerves ...
(Date:4/17/2014)... journal Current Biology on April 17 have ... The Brazilian insects, which represent four distinct but related ... first example of an animal with sex-reversed genitalia. ... different animals, Neotrogla is the only example ... Kazunori Yoshizawa from Hokkaido University in Japan. , During ...
(Date:4/17/2014)... the genetic information of DNA is used to ... numerous different functions in living organisms. Messenger RNA ... expression, by relating the genetic information of DNA ... , By examining the different types and ... at a given time, researchers can determine which ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2In sex-reversed cave insects, females have the penises 2Rapid and accurate mRNA detection in plant tissues 2
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