Navigation Links
MEK1 in Medical News

Combination targets: some drugs may work best when they work together

... with a lack of oxygen, a state called hypoxia, they report. AZD6244 is a small molecule inhibitor developed by AstraZeneca to bind to and inhibit mek1 and MEK2 proteins, which together form a critical point on the pathway that controls the ongoing survival of cells. Defects along the pathway can lead...
MEK1 in Medical Technology

Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at American College of Gastroenterology Annual Scientific Meeting

...details are as follows: Date/Time: Tuesday, October 7, 2008 from 10:30 a.m. - 4:00 p.m. EDT Abstract Title: "RDEA119, a Potent and Highly Selective mek1 / 2 Inhibitor is Beneficial in Dextran Sulfate Sodium (DSS)-Induced Chronic Colitis in Mice" Poster Number: P1050 ...

New Data for XL880, XL647 and XL184 to Be Presented at AACR-NCI-EORTC

...f cytotoxic therapy by XL844, an orally bioavailable inhibitor of Chk1 and Chk2 (Abstract #B228) -- XL518, a Potent Selective Orally Bioavailable mek1 Inhibitor, Downregulates the RAS/RAF/MEK/ERK Pathway In Vivo, Resulting in Tumor Growth Inhibition and Regression in Pre-Clinical Models (Abst...
MEK1 in Biological Technology

New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways

...ctivates the GAL4-c-Fos fusion protein expressed from the pFA-cFos plasmid. The mechanism of this activation is not yet characterized. PKA, mek1 and other extracellular stimuli failed to activate the GAL4-c-Fos fusion protein (data not shown). ...

Improved Vectors for PathDetect Trans-Reporting Systems

...smids with either the pFC-dbd or pFC2-dbd plasmids yielded similar background levels of luciferase activity. Since the mek1 protein is a known upstream activator of the Elk1 protein, the pFC-MEK1 plasmid was used to compare the activity of the pFA-Elk1 and ...

In Vivo Signal Transduction Pathway Reporting Systems

...lk1 is phosphorylated and activated by MAPK. 10,11 The MEKK and mek1 proteins are both known activators of the Elk1 protein. Cotransf... of luciferase. These data are consistent with reports that both mek1 and MEKK proteins are known activators of the MAPK pathway. 16-...

Yeast Protein Production System Features High Yields and One-Step Purification

...s, including the rat c-Jun N-terminal kinase (JNK) and the human mek1 gene products ( figure 4 ). Yield for these proteins ...K1 fusion protein. The GST tag was efficiently detached from the mek1 moiety by digesting the purified GST-MEK1 fusion protein with en...

Production of Full-Length, Biologically Active MEK1WT and MEK1CA

...ressed and purified recombinant, wild-type human mek1 WT and a constitutively active mutant (MEK1 CA ) ...d in E. coli are significantly degraded. Wild-type mek1 WT can be used as a substrate for upstream MEK ... MEKK or mos. The uses for constitutively active mek1 CA include identifying potential substrates, ma...

Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems

... In a similar fashion, the specificity of the pFA2-Elk1 fusion activator plasmid is demonstrated ( Figure 2 C). Since the mek1 protein is a known upstream activator of the Elk1 protein 12 the pFC-MEK1 plasmid, constitutively expressing this kinase, was u...
MEK1 in Biological Dictionary

SiRNA

...ly inhibit Akt expression using RNA interference, a ... SignalSilence® mek1 siRNA from Cell Signaling Technology allows the researcher to specifically inhibit mek1 expression using RNA interference, a method in which ... siRNA Produ...

Pachytene

... In addition, the pachytene checkpoint requires the chromatin silencing factor ... Pachytene arrest also requires the meiosis-specific Red1 and mek1 proteins (14) ... Meiotic pachytene bivalents are much longer than somatic metaphase chromosomes ... Detailed pachytene BAC-FISH analys...
Other Tags
(Date:10/1/2014)... First Warning Systems, a pioneer in early ... the body, announced the company is changing its name ... breadth of upcoming product releases. The initial focus will ... “Our initial focus will be an ‘Internet of Everthing,’ ... cellular changes over time,” said Rob Royea, president and ...
(Date:10/1/2014)... D.C. and ATLANTA (PRWEB) October 01, 2014 ... information security executive networking and relationship-marketing firm, ... 2014 Information Security Executive® and Project of ... include top-ranking decision makers representing organizations in ... academics. Projects include large-scale technology endeavors that ...
(Date:10/1/2014)... MO (PRWEB) October 01, 2014 Join the ... Castlewood Eating Disorder Treatment Center’s first ever charity golf tournament ... for people with eating disorders who cannot afford treatment. The ... Golf Club in Eureka, Mo. , The day-long event ... noon. A reception and award dinner will begin at 5 ...
(Date:10/1/2014)... Beverly Hills licensed Clinical Psychologist and nationally ... years of private practice in her Beverly Hills office ... greater joy and fulfillment in their relationships. Dr. Mojas ... suggestions for anyone who suspects they are in a ... or not, it’s not always easy to know when ...
(Date:10/1/2014)... Innovations announces the upcoming airing of ... Monday, October 20, 2014 at 7:30 a.m. EST/PT via ... behind the scenes to learn about Break the Cycle’s ... the practical help and information Break the Cycle provides ... signs of abuse, how to navigate the legal system, ...
Breaking Medicine News(10 mins):Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 2Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 3Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2
(Date:9/30/2014)... using marijuana, new research, involving mice and published in ... of Leukocyte Biology , suggests that just because ... That,s because a team of Italian scientists have found ... damage to the immune system. This damage may result ... multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis in ...
(Date:9/30/2014)... Sept. 30, 2014  Spectra Automation, a ... the biotech and power generation industries, announced ... Bioprocess Manager, an easy-to-use and cost-effective data ... bioprocess development laboratories. Most ... and analyzer systems. Accessing and consolidating data ...
(Date:9/29/2014)... A new study confirms that the exposure to tar ... than of regular cigarettes. Similarly, exposure to nicotine ... increasingly popular type of cigarette in several countries around ... of certain toxic chemicals in the smoke of these ... because lower levels of chemicals in the smoke are ...
Breaking Biology News(10 mins):Adolescent exposure to thc may cause immune systems to go up in smoke 2Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2
Other Contents