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MDR1 in Medical Technology

Alfacell Provides Shareholder Update

...nticipate results shortly. Other studies will be conducted in order to elucidate if Onconase is able to down regulate the protein produced by the mdr1 gene. There is ample evidence this may be the case, and if so, as previously mentioned, Onconase would be a strong candidate to be used as an adjunct ...

Tapestry Pharmaceuticals Presents Data on TPI 287 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

...ation Taxane Derivative, Functionally Modulates mdr1 P-glycoprotein Drug Transport Pump and is Active i...ess sensitive in a variety of cancer cell lines to mdr1 mediated efflux than other approved taxanes. mdr1 mediated drug efflux may be a primary cause of res...
MDR1 in Biological Technology

Tapestry Reports Third Quarter 2007 Financial Results and Preliminary Data From Its Phase 2 Prostate Cancer Trial

...tant cancer cell lines to MDR1 mediated efflux than other approved taxanes. mdr1 mediated drug efflux may be a primary cause of resistance to chemotherapy w...itaxel or IDN 5109, another taxane in development purported to be active in mdr1 expressing tumors. In addition, data was presented that demonstrated tumor ...

Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio

...t cytochrome P450 drug metabolizing genes, such as CYP2B6(4) and CYP2D6(5). mdr1 encodes P-glycoprotein, a key protein involved in drug transport that is kn...sive and complex disease areas. Hence, genes for drug transporters, such as mdr1 and OCT1 will prove to be as important as the Cytochrome P450 system in det...
MDR1 in Biological Products

MDR1 Shift Assay from CHEMICON

Description:... The CHEMICON mdr1 Shift Assay provides a convenient method to probe conformational changes in mdr1 that occur upon transport of mdr1 substrates. Thus, the kit may be used to determine...
Company:CHEMICON
MDR1 in Biological Dictionary

Glycoprotein

...mation about Glycoprotein . ... Human metapneumovirus glycoprotein G is an important virulence factor ... P Glycoprotein , the product of the mdr1 gene, is expressed in distinct non ... Elevated levels of P Glycoprotein have also been reported in multidrug-resistant ... Upregulation of P-gly...

Gene amplification

.... MTX-resistance in a tumor can occur by gene amplification of dhfr (but not often documented) ... Gene amplification ® overproduction of mdr1 ® drug resistance: ... ...
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