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MDM2 in Medical News

Gene Test May ID Younger Women at Risk for Melanoma

... Identification of this variation in a gene called mdm2 could lead to a screening test to identify women a... further studies, the increased risk caused by the mdm2 variation "is higher than a lot of the other clini...percent of female patients younger than 50 had the mdm2 genetic variation, compared with about 16 percent ...

NYU study finds new risk factor for melanoma in younger women

...rongly, resulting in far greater production of the mdm2 protein. Women with higher estrogen levels an... would be expected to have higher estrogen-related mdm2 protein that could increase their melanoma risk, explains Dr. Polsky. The mdm2 genetic variant appears in the gene's promoter, a ...

Stabilizing cancer-fighting p53 can also shield a metastasis-promoter

... job is to degrade p53 when it's no longer needed. mdm2 also degrades the mutated version of the p53 prote.... Mice with the double-mutant p53 that also had no mdm2 died sooner and developed more aggressive metastat...mal Mdm2, to 9 percent in mice lacking one copy of mdm2 to 17 percent in mice with no Mdm2. Metastasis - t...

Effect of mutant p53 stability on tumorigenesis and drug design

...nesis, and lends startling new insight into the potential pitfalls of using mdm2 inhibitors for cancer therapy. "Our data are both exciting and sobering:... interaction will also disrupt the Mdm2/mutant-p53 interaction. Thus, these mdm2 inhibitors will succeed in stabilizing mutant p53, and fail in preventing t...

Researchers Design Promising Cancer Drug

... of cancer, according to the researchers. In almost all types of human cancer, p53 is inactivated. About half the time, this is because the protein mdm2 binds to p53 and inhibits the tumor-suppressor function of p53. In other cases, p53 dysfunction is due to a missing or mutated gene. "Many traditio...

U-M researchers ID promising new cancer drug

... Using a computer-assisted approach, U-M researchers designed a small molecule, called MI-219, that is highly effective in blocking the interaction of mdm2 and p53. MI-219 specifically kills tumor cells by harnessing the power of p53. In animal models of human cancer, MI-219 completely inhibited tumor gro...

AACR's Seventh Annual Landon Awards

... in preventing the development of cancer. Furthering his study of p53, Levine discovered another piece of the puzzle with the identification of the mdm2 oncoprotein as a potent inhibitor of p53. The milestone discovery of the Mdm2-p53 interaction has become, in recent years, a target for drug developm...

Oncoproteins double-team and destroy vital tumor-suppressor

...ubiquitins to the phosphorylated tumor suppressor, mdm2 marks it for destruction by the ubiquitin-proteasome degradation pathway. "Both ERK and mdm2 are well-known oncoproteins, but their collaborati...ast cancer tumors, the researchers found that high mdm2 expression and low FOXO3a expression are associate...

Advances in Blood Cancer Therapy to be Highlighted at American Society of Hematology Conference

...ncer Center, (Monday, Dec. 10, 8 a.m.). -- Comprehensive Biomarker and Genomic Analysis Identifies p53 Status as Major Determinant of Response to mdm2 Inhibitors in Chronic Lymphocytic Leukemia, Shaomeng Wang, Ph.D., University of Michigan, (Dec. 10, 7:45 a.m.). -- IgVH Mutational Status Doe...

Advances in drug screening: building a better haystack for the needles of tomorrow

...s Foundation. Identification of inhibitors for mdm2 ubiquitin ligase activity from natural products by... for a molecule that inhibits the known ability of mdm2 to signal for the destruction of the pro-apoptosis (cell suicide) protein p53. In normal cells, mdm2 and p53 exist in a state of benign equilibrium ba...
MDM2 in Medical Technology

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

...(AACR), to be held in Los Angeles, California April 14-18, 2007. Ascenta's mdm2 program has been selected for presentation at the "High Impact Late-Breakin...and General Manager of Ascenta's R&D Subsidiary in Shanghai, China. The mdm2 program will also be featured in a talk on Saturday, April 14 (Petree D at ...
MDM2 in Biological News

Study of placenta unexpectedly leads to cancer gene

...rectly regulates p53 activity through another protein called Mdm2, which was already known to be involved in some cancers. In cells lacking SENP2, the mdm2 becomes trapped in the nucleus, and is unable to halt p53, allowing it to accumulate within the cell. This disruption leads to distinct problems in ce...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...during PEL tumorigenesis. The results of this study demonstrate binding of the KSHV latency associated antigen LANA to both p53 and MDM2, and that the mdm2 inhibitor Nutlin-3a disrupts the p53-MDM2-LANA complex and selectively induces massive apoptosis in PEL cells. The cytotoxic effect of Nutlin-3a was s...

St. Jude announces breakthrough in eye cancer treatment

...s in mouse models. The molecule was originally developed by Roche Pharmaceuticals (Nutley, N.J.) for a similar use against a related target called mdm2 in adult cancer cells. The success in knocking out MDMX with nutlin-3 represents the first example of local delivery of a targeted chemotherapy drug f...

Study pinpoints protein's role in cancer spread

...of the body's cells, the biochemical ratio between mdm2 and p53 can become unbalanced causing mdm2 to act as a cancer-promoting agent. The proje...her at the University, explains: "One way in which mdm2 controls the p53 protein is by activating its dest...

p53, tumor suppression and aging

... to activate p53 in order to curb tumor formation. mdm2 is a key inhibitor of p53 and therefore an attract...erated aging. To analyze the effects of reduced mdm2 levels on tumorigenesis ?as well as the potential ...team used mdm2-hypomorphic mice (that express less mdm2 protein than normal mice) which have elevated leve...

Loosen leash on cancer protein 'watchdog,' researchers say

...ease p53's activity without completely cutting its mdm2 leash." The scientists spent three years creati... produced about 20 percent of the normal amount of mdm2 protein, which is far less than they would have pr...cer toolkit. "Essentially, this study validates mdm2 as a potentially powerful chemopreventative for so...
MDM2 in Biological Technology

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

...SJ, Strong LC, Lozano G, Levine AJ. A Single Nucleotide Polymorphism in the mdm2 Promoter Attenuates the p53 Tumour Suppressor Pathway and Accelerates Tumou...ath and Differentiation; 2006, 13(6), 1027-1036. (iii) Toledo F, Wahl GM. mdm2 and MDM4: p53 regulators as targets in anticancer therapy. International Jo...
MDM2 in Biological Products

Rabbit Anti-MDM2, phospho (Ser185) Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to mdm2 (phospho S185) ( Abpromise for all tested applications). entrezGeneID: 4193 SwissProtID: Q00987...
Company:Abcam

Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

Description:...cycle in a p53-dependent manner. p14^ARF^ binds to mdm2 and promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and ...
Company:Lab Vision
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