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MAb in Medical News

Crucell's Rabies MAb Enters Phase I Trial in India

Dutch biotechnology company, Crucell N V’s Rabies monoclonal antibody (mAb) product has entered a phase I clinical study in India, four months after launching// a similar study in the US. Crucell has developed a human monoclonal antibody product for the post-exposure prophylaxis of rabies, u...

Enhanced Vision Supports America's Leading Event for Blind and Visually Impaired

...alk event proceeds will benefit the following outstanding groups that support the blind and visually impaired, including Carroll Center for the Blind, mab Community Services, National Braille Press, and Perkins School for the Blind. For more information, call 888-811-3161 or visit www.EnhancedVision.c...

Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program

... Cotara Presentation Details : Reference #: 150240 Publication No.: 445 Abstract Title: Dosimetry of phase I interstitial 131I-chTNT-1/B mab (Cotara) for the treatment of recurrent glioma Accepted to: ISRTRD Integrated Session (Oral) Session Info: Dosimetry/Radiobiology IV: Targeted, ...

Novel Treatments Demonstrate Improvements in Overall Survival and Response Rates in Difficult-To-Treat Forms of Leukemia and Lymphoma

...s (14 percent), anemia (12 percent), and neutropenia (11 percent). Immunochemotherapy With Fludarabine, Cyclophosphamide, and Ritux i mab Versus Fludarabine and Cyclophosphamide I m proves R e sponse Rates and Progression-Free Survival of Pr e viously Untreated Patients With ...

EMS Magazine Announces Top Innovation Awards for 2008

...Nonin Medical Inc. LifeSense -- PerSys Medical Blizzard Heat Casualty Blanket -- Sartin Services, Inc. mab -- Medical Ambulance/Evacuation Bus -- Serenity Safety Products Guardian Safety Seat -- Siemens Ultrasound Acuson P10 ...

Biosimilar Monoclonal Antibodies in Oncology Will Approach Blockbuster Status by 2017

...ers of biosimilar drugs, and the high turnover of oncology patients will accelerate growth and penetration within the relatively un-crowded biosimilar mab market. Although oncology will prove to be a robust market, the opportunity for biosimilars varies significantly by therapeutic area, according to t...

Centocor, Inc. Submits Application to FDA Requesting Approval of Golimumab for the Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...g a Human Anti-TNF Monoclonal Antibody (GO-REVEAL) trial and the Golimumab - A Randomized Study in Ankylosing Spondylitis Subjects of a Novel Anti-TNF mab Injection (SC) Given Every Four Weeks (GO-RAISE) trial were reported at the American College of Rheumatology Annual Scientific Meeting. About Rheuma...

Combination targets: some drugs may work best when they work together

...research toward a specific treatment for this disease, the researchers contend. This pre-clinical data supports potential clinical trials of a TRAIL-R mab and chemotherapy combination in CCA, Humphreys says. ...

Avastin Dropped Out Of Funded Drugs List

...ris D'Entremont says Oxaliplatin, a drug that treats colorectal cancer, and mab Campath, a drug that treats chronic lymphocytic leukemia have been added to... a cost of $2.6 million. The province will also pay for a drug called mab Campath, used to treat chronic lymphocytic leukemia, at an estimated cost o...

International Collaboration Takes Aim at Rabies

...7 to assess the safety and tolerability of the new mab in people, with hopes of having the new, lower-cos...sues, the CDC and MBL launched an effort to find a mab that could be used in place of hRIG. The work used... virus strains in culture. That research found one mab in particular, now called HuMAB 17 C7, which worke...

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MAb in Medical Technology

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

...se." In the open-label, uncontrolled extension of the Go limumab - A R andomized Study in A nkylosing Spondylitis Subjects of a Novel Anti-TNF mab I njection ( S C) Given E very Four Weeks (GO-RAISE) study, patients receiving every-four-week subcutaneous treatment with SIMPONI experienced susta...

Data To Be Presented at ASCO Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

...: 2072: S. Shen, R. Lustig, K.D. Judy, J.B. Fiveash, J. S. Shan, "Open-label, dose confirmation and dosimetry study of Interstitial I 131 I-chTNT-1/ B mab for the treatment of recurrent glioblastoma multiforme (GBM)." Sunday, June 1, 2008 2:00 PM - 6:00 PM CDT. About Peregrine Pharmaceuticals Peregri...

Phase 3 Data Regarding Anti-RSV Antibody To Be Presented at Pediatric Academic Societies (PAS) Annual Meeting

...se among children with underlying medical conditions in the general U.S. population. About Motavizumab Motavizumab is an investigational humanized mab being evaluated for its potential to prevent serious lower respiratory tract disease caused by RSV in pediatric patients at high risk of RSV disease. ...

MedImmune Advances Asthma Program with Start of a Phase 2 Trial in Europe and Australia and First U.S.-Based Clinical Trial for Antibody Targeting IL-13

...ting interleukin-13 (IL-13). One of the studies is a Phase 2 clinical trial in Europe and Australia designed to assess the potential of the anti-IL-13 mab in patients with uncontrolled asthma despite optimal treatment. The company has also begun dosing patients in the first U.S.-based clinical trial of t...

Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma

... Two phase 1 single-dose, dose-escalation studies were previously conducted to evaluate the safety, tolerability and pharmacokinetics of the anti-IL-9 mab in healthy volunteers. In addition, preclinical data suggest that blocking IL-9 may provide clinical benefit for patients with asthma. "We continue ...

Ception Therapeutics Initiates Phase II/III Clinical Trial for Its Lead Product Reslizumab in Eosinophilic Esophagitis (EE) in Children

...rmation on this clinical trial, please visit http://www.clinicaltrials.gov [Identifier: NCT00538434]. About Reslizumab Reslizumab is a humanized mab against IL-5. IL-5 plays a crucial role in the maturation, growth and chemotaxis of eosinophils, inflammatory cells implicated in a number of allergic...

Tolerx Achieves Milestone with Completion of Phase Ib Clinical Study of TRX1 in Cutaneous Lupus Erythematosus

...xizumab, an anti-CD3 MAb, in type 1 diabetes with its collaboration partner, GlaxoSmithKline. Tolerx is also engaged in preclinical development of new mab product candidates that engage the body's immune system and further promote and enhance immune responses. This type of therapy is being researched for...

Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint

...sdaq: UTHR ) and its wholly- owned subsidiary, Unither Pharmaceuticals, Inc., announced today the completion of their two pivotal trials of OvaRex(R) mab for the treatment of advanced ovarian cancer. Preliminary analysis demonstrates that the studies failed to reach statistical significance. The ident...

New Anti-TNF Golimumab Significantly Reduced Signs and Symptoms of Ankylosing Spondylitis According to Phase 3 Study Findings

...nti-TNF-alpha treatment option." According to findings from the Golimumab - A Randomized Study in Ankylosing Spondylitis Subjects of a Novel Anti-TNF mab Injection (SC) Given Every Four Weeks (GO-RAISE) trial, 59 percent of patients receiving golimumab 50 mg and 60 percent of patients receiving golimuma...

MedImmune Presents New Pharmaco-Economic Data at American Academy of Pediatrics Regarding Infants at High Risk for RSV

...Synagis, which was a significant product improvement as a monthly intramuscular injection for the prevention of severe RSV, as well as being the first mab to receive U.S. Food and Drug Administration (FDA) approval for an infectious disease. MedImmune continues to reinforce its commitment to developing a...

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MAb in Biological News

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

...uman antibody phage display library to identify 10 mab that bind to the stem of H5 type HA, the influenza...ists determined the X-ray crystal structure of the mab bound to the H5N1 HA, which showed that the heavy chain of the mab inserts into a highly conserved pocket in the HA s...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

...uman antibody phage display library to identify 10 mab that bind to the stem of H5 type HA, the influenza...ists determined the X-ray crystal structure of the mab bound to the H5N1 HA, which showed that the heavy chain of the mab inserts into a highly conserved pocket in the HA s...

JCI online early table of contents: Jan. 19, 2009

...he researchers therefore suggest that using antibodies that target Pim-1 might of benefit to individuals with prostate cancer. TITLE: Pim-1specific mab suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis AUTHOR CONTACT: Pei Xia...

Smithsonian scientists discover new bird species

...onal Museum of Natural History and a member of the mab program's team, returned to Washington, D.C., from...the conservation importance of the area." The mab program is part of the Center for Conservation Edu... olive-backed forest robin was not the goal of the mab project," Schmidt said, "it is definitely a remind...
MAb in Biological Technology

Gram Quantities of MAb Produced with Simple Bioreactor in Serum-Free Perfusion Culture Replacing Ascitic Fluid Production

By J. Doyle, L. Johnstone and L. Cottis AGEN Biomedical Ltd. Queensland, Australia http://www.agen.com.au The CelliGen Plus immobilized-bed perfusion was investigated as a means for producing large quantities of MAb from a hyb...

Regado Biosciences Expands Medical Advisory Board

...entin of Sweden) join the original members bringing the current size of the mab to twelve. Regado's mab comprises leaders in the fields of cardiology, thrombosis/coagulation and c...

Data Presented at Society of Nuclear Medicine 2009 Annual Meeting Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

...stig(2), K. Judy(2), W. Shapiro(3), K. Spicer(4), S. Patel(4), J. Fiveash(1), J. Lai(5), J. Shan(5), "Dosimetry of phase I interstitial 131I-chTNT-1/B mab (Cotara) for the treatment of recurrent glioma." (1)U Alabama, Birmingham, AL; (2)U Penn, Philadelphia, PA; (3)BNI St. Joseph's MedCtr, Phoenix...

Regado Biosciences Establishes Medical Advisory Board

... announced the establishment of its Medical Advisory Board (MAB). Regado's mab is comprised of leaders in the fields of cardiology, thrombosis and coagula...ficer of Regado, stated, "We are delighted to announce the formation of our mab and look forward to the knowledge, guidance and creativity that they will b...

Transgenomic, Inc. Announces Appointment of New Board Members

...n technology, the STI technology, which applies RNA transcription rather than PCR for the amplification of variable lgG domains to yield high fidelity mab libraries. Prior to STI, Dr. Schuh was the Founding Chief Executive Officer and Director of AviaraDx, Inc. AviaraDx was a molecular diagnostics labor...

OriGene Technologies, Inc. Establishes High Throughput Monoclonal Antibody Production Outsourcing Center in China

...hese unique genome-wide resources OriGene believes it can produce several thousand high quality monoclonal antibodies per year. This genome-wide mab production capacity is available to all commercial and academic partners with a long-term goal to providing high quality monoclonal antibodies for eve...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

...active dermatomyositis and polymyositis. The company has also conducted clinical trials in psoriasis with MEDI-545. -- CAM-3001 - CAM-3001 is a mab with potential to help patients with rheumatoid arthritis. The antibody targets the alpha sub-unit of the granulocyte-macrophage colony sti...

Laureate Announces Manufacturing Agreement with Tolerx

...ent of various autoimmune indications, these are: otelixizumab, an anti-CD3 mab that is being developed in collaboration with GlaxoSmithKline and MTRX1011A a modified form of TRX1, an anti-CD4 mab that is being developed in collaboration with Genentech, Inc. In addition t...

Expert Neurology Panel Weighs Impact of New Reports of PML in Multiple Sclerosis Patients on Tysabri

...g: -- New interferons, integrin inhibitors, B-cell inhibitors, S1Ps, fumarates, neuroprotection/neuroregeneration. -- The potential for vaccine or mab approaches for the treatment or prevention of multiple sclerosis. -- Which therapeutics in development to provide symptomatic benefits in MS are the...

3SBio Inc. Announces Second Quarter 2008 Results

....9 million, representing 4.4% of total net revenues, in the second quarter 2007. This increase was mainly due to expenses associated with our anti-TNF mab and HPV vaccine programs. Sales, marketing and distribution expense, representing 44.6% of total net revenues, increased by 31.9% to RMB26.6 million...
MAb in Biological Products

Mouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4 from MitoScience LLC

Description:...rticularly ones that result in an absence or near absence of the polypeptide, are the leading cause of cytochrome c oxidase deficiency. The anti-SURF1 mab reacts specifically in human and bovine tissues. The levels of SURF1 are low even in rapidly dividing fibroblast cell cultures (as well as in mature t...
Company:MitoScience LLC

Mouse Anti-Hamartin Monoclonal Antibody, Unconjugated, Clone 1B2 from Cell Signaling Technology

Description:... Hamartin/TSC1 (1B2) Mouse mab Ship: Hot Store: -20 C...
Company:Cell Signaling Technology

Rabbit Anti-4E-BP1, phospho (Thr37 / Thr46) Monoclonal Antibody, Unconjugated, Clone 236B4 from Cell Signaling Technology

Description:... Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mab Shipping Temperature: Cold Storage Temperature: -20C...
Company:Cell Signaling Technology

Rabbit Anti-TAK1, phospho (Thr184 / Thr187) Monoclonal Antibody, Unconjugated, Clone 90C7 from Cell Signaling Technology

Description:... Phospho-TAK1 (Thr184/187) (90C7) Rabbit mab Shipping Temperature: Cold Storage Temperature: -20C...
Company:Cell Signaling Technology

Anti-Mouse H60 Monoclonal Antibody, Allophycocyanin Conjugated, Clone 205326 from R&D Systems

Description:... Mouse H60 Allophycocyanin mab (Clone 205326) ENTREZ GeneID: 15101...
Company:R&D Systems

Mouse Anti-Human VEGF-D Monoclonal Antibody, Biotin Conjugated, Clone 78923 from R&D Systems

Description:... Human VEGF-D Biotinylated mab (Clone 78923)...
Company:R&D Systems

Rat Anti-Mouse Limitin Monoclonal Antibody, Unconjugated, Clone 183727 from R&D Systems

Description:... Mouse Limitin mab (Clone 183727)...
Company:R&D Systems

Mouse Anti-Oligodendrocyte Marker O1 Monoclonal Antibody, Unconjugated, Clone O1 from R&D Systems

Description:... Oligodendrocyte Marker O1 mab (Clone O1)...
Company:R&D Systems

Mouse Anti-Human HVEM Cell Surface Staining Monoclonal Antibodies, Allophycocyanin Conjugated, 94801 from R&D Systems

Description:... Human HVEM/TNFRSF14 Allophycocyanin mab (Clone 94801)...
Company:R&D Systems

Mouse Anti-Human PDGF R beta Monoclonal Antibody, Unconjugated, Clone PR7212 from R&D Systems

Description:... Human PDGF R beta mab (Clone # PR7212)...
Company:R&D Systems

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MAb in Biological Definition

Monoclonal antibody

... Monoclonal antibodies ( mab ) are antibodies that are identical because they were produced by one typ...tigen and induce an immunological response on the target cancer cell. Such mab could also be modificated for delivery of a toxin , radioisotope , cytok...
MAb in Biological Dictionary

Tubulin

... of polymerisation into microtubules, tubulin requires GTP. ... Confocal immunofluorescent analysis of HeLa cells, using β- Tubulin (9F3) Rabbit mab (green) ... 2148 α/β- Tubulin Antibody ... 1032 β- Tubulin Blocking Peptide ... Western blot analysis of extracts from CAD and C6 cells, using β-...

Sequential Epitope

...al or linear) epitope is a sequential fragment from the ... Epitope B is sequential , conserved among isolates, and not immunodominant. ... mab (40) directed against a sequential epitope on GP5, as demonstrated by the ... (C) Distribution of the maximum length of a sequential stretch ...

MSH2

...fo ... Biomolecule Products : MSH2 (clear filter) Type : Proteins (clear filter) ... ... analysis of HeLa cells using MSH2 (D24B5) XP™ Rabbit mab (green) ... MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential ... Feedback / suggest a new topic for MSH2 . Search...

His tag

... 2372 β-Gal (14B7) Mouse mAb. 2396 MBP (8G1) Mouse mab ... Product Pathways - Related Products. His - Tag (27E8) Mouse mab #2366 ... 2367 HA- Tag (6E2) Mouse mAb. 2372 β-Gal (14B7) Mouse mAb. 2396 MBP (8G1) Mouse mab ... Problem with His Tag purification - usi...

DNA gyrase

...resent in prokaryotes and is essential ... The analysis of DNA gyrase from mycobacteria, which are gram-positive acid-fast ... Binding of the mab did not affect either GyrA–GyrB or gyrase – DNA interactions. ... DNA gyrase purified from fluoroquinolone-resistant strains of M.tuberculosis a...
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