Bio-imaging mass spectrometry techniques reveal molecular details about complex systems

... sphingolipids that accumulate in the brain when there is a genetic defect. This research was funded by the National Institutes of Health. While maldi samples must be analyzed in a vacuum, recent advances allow samples to be studied under ambient conditions. Facundo Fernandez, an assistant professor ...

Bruker Daltonics Showcasing Novel Proteomics Solutions Based on Mass Spectrometry at the 7th HUPO World Congress 2008

...informatics. The high sensitivity SmartBeam™ maldi ion funnel source has now been coupled with the ul...ra™ FTMS, representing a 'perfect match' for maldi small molecule tissue imaging, including drugs and..., the cluttered spectra produced in small molecule maldi imaging of tissue samples are readily resolved, al...

Thermo Fisher Scientific Showcases Product Innovation at PITTCON 2008

...ientific LTQ Orbitrap XL ETD and Thermo Scientific maldi LTQ Orbitrap -- these advancements bring electr...in definitive protein characterization. The new maldi LTQ Orbitrap series accelerates the analysis of...ss Orbitrap capabilities. Thermo Scientific maldi LTQ XL(TM) mass spectrometer with ImageQuest(TM) ...

Vanderbilt University Medical Center and Waters Collaborate on Tissue Imaging Research Using SYNAPT HDMS

...nce collaborative research efforts using Waters(R) maldi SYNAPT(TM) High Definition MS(TM) (HDMS(TM)) Syste...to evaluating the use of ion mobility for enhanced maldi imaging combined with high resolution, high sensit...ct to derive significant insight into the power of maldi tissue imaging for biological applications and its...

MALDI in Biological News

An easy way to find a needle in a haystack by removing the haystack

...atrix subsequently irradiated with a laser leads to the formation of protein ions which can be analyzed and detected. However, matrices used in the maldi technique have a substantial disadvantage: the laser beam not only forms ions from the substances of interest; it also forms low-mass ions ( Instea...

Story ideas from Molecular & Cellular Proteomics

...ovement disorders such as Parkinsons disease. Article: Proteomics Identification of Proteins in Human Cortex Using Multidimensional Separations and maldi Tandem Mass Spectrometer, by Sheng Pan, Min Shi, Jinghua Jin, Roger L. Albin, Andy Lieberman, Marla Gearing, Biaoyang Lin, Catherine Pan, Xiaowei Yan,...

Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor

...proteins and other macromolecular complexes. Bier conducted his studies using a top-down approach of the intact complex using a cryodetector-based maldi TOF mass spectrometer (Macromizer) equipped with 16 superconducting tunnel junctions. Carnegie Mellon houses the only two of these instruments in the ...

MALDI in Biological Technology

Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer

...aters also offers a high performance, exchangeable maldi source for the SYNAPT G2 system with broad applications. For example, by combining maldi with ion mobility separations, Waters High Definition Imaging maldi (HDI MALDI) solution enables researchers to better...

Thermo Fisher Scientific Unveils New Laboratory Technologies at Analytica 2008

...etry Thermo Scientific LTQ Orbitrap(R) XL(TM) ETD and Thermo Scientific maldi LTQ Orbitrap -- these advancements bring electron transfer dissociation ...s, enabling the ultimate in definitive protein characterization. The new maldi LTQ Orbitrap series accelerates the analysis of whole tissue, biological...

Bruker Announces Availability of New HUPO World Congress Proteomics Posters on Web Site

...Biomarker Proteomics -- A New Sensor-Controlled Preparation Technique for maldi Tissue Imaging Poster M102 -- Towards Stable Diagnostic Setups in Clin... Poster T11 -- Class Imaging: Classification of Breast Cancer Sections by maldi Tissue Imaging Poster T175 Glycoproteomics -- Relative Quantificat...

Americas Third Coast nurtures biotechnology

...ilson recently introduced the new MALDILC System, a tool designed to perform nano, capillary, and micro HPLC with fraction collection directly sent to maldi plates. The plated fractions can then be analyzed repeatedly by MALDI-TOF MS. The MALDILC Systems HPLC-coupled fraction collection simplifies complex ...

LC-MALDI and MALDI-MS/MS for the Analysis of Complex Peptide Mixtures

...ctra are generated from different positions on the maldi target and sample depletion is less of an issue. ...nd the resulting peptides are separated prior to maldi analysis (see Figure 1). Automated maldi time-of-fl ight (TOF) mass spectrometric (MS) anal...

Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry

...1% TFA was passed up and down the tip ten times and finally eluted onto the maldi plate and mixed with matrix or eluted into a buffered solution of trypsin a...vernight at 37C. An aliquot was mixed with CHCA matrix and deposited on the maldi plate. Results and Discussion After acid elution fro...

Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS

...h 4 μl of a 10 mg/ml solution of alpha cyano 4-hydroxy cinnamic acid in 60% ethanol and 40% acetonitrile. A 0.5 μl droplet was placed on the maldi target, air-dried and the target inserted into the instrument. Results Figure 1 shows the progress of the synthesis of the 21 m...

Sample Preparation Solutions for Cellular Protein Fractionation Poster, Rev A

...ractions among other functions. 2DE and maldi peptide mass fingerprinting data will b...botics system for protein digestion and maldi target spotting. Gel spots were destained, reduced...es were then automatically spotted onto maldi target plates mixed with a matrix solut...

MALDI in Biological Products

AXIMA-CFRplus MALDI TOF from Shimadzu Biotech

Description: The nature of proteomics demands the detection of very small amounts of sample. The superior performance of the AXIMA-CFRplus with improved resolution (20,000) and mass accuracy (less than 5 ppm) provides increased confidence in protein identification. The AXIMA-CFRplus also includes beam blanking ...
Company:Shimadzu Biotech

AXIMA-CFR MALDI TOF from Shimadzu Biotech

Description: The standard of the Axima range, the AXIMA-CFR provides a combination of high mass accuracy, resolution, sensitivity and mass range, and offers excellent versatility with both linear and reflectron time-of-flight analysis. The unique patented curved field reflectron enables the generation of seamle...
Company:Shimadzu Biotech

AXIMA-LNR Linear MALDI TOF from Shimadzu Biotech

Description: Intended for users requiring mass detection but not structural information the AXIMA-LNR linear MALDI TOF Mass spectrometer is ideally suited for high throughput QA/QC applications and for high performance mass analysis. Typical applications include oligonucleotide QA/QC, SNP analysis, protein det...
Company:Shimadzu Biotech

prOTOF 2000 MALDI O-TOF Mass Spectrometer from PerkinElmer

Description: The new MALDI O-TOF creates a new category for MALDI. It is based on an orthogonal platform that has been licensed to the PerkinElmerSCIEX joint venture from the University of Manitoba. As the first single MALDI-TOF mass spectrometer with an orthogonal design and collisional cooling, the prO...
Company:PerkinElmer

Protein Identification Service via MALDI MS/MS from Protagen AG

Description: This protein identification Service includes 1. Scanning of gel(s) 2. Excision/picking of protein spots 3. High-sensitive tryptic in-gel digestion and peptide extraction 4. Preparation of samples for MALDI-MS 5. Acquisition of PMF (Peptide Mass Fingerprint) spectra via MALDI-MS (Bruker ultraflex TO...
Company:Protagen AG

Labware Carriers from Tecan

Description:...er tubes such as Eppendorf tubes, cryovials and PCR tubes. Any microplate-based footprint, usually 24-, 96- or 384-well plates. Reagent troughs, maldi targets and microscope slide adapters. High density formats such as 1536-well plates and crystallography plates. Temperature-controlled carriers...
Company:Tecan

BD 96-well format from BD Biosciences - Discovery Labware

Description:... 96-well format (For processing samples on microplate-size maldi target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
Company:BD Biosciences - Discovery Labware

Freedom EVO 150 from Tecan

Description:... in situ hybridization (ISH), fluorescence in situ hybridization (FISH), immunohistochemistry (IHC) applications Proteomics Protein digestion and maldi spotting Protein crystallization and crystallization set-up Protein solubility Recombinant protein purification Drug Discovery Compound syn...
Company:Tecan

Chemical Inkjet Printer from Shimadzu Biotech

Description:...nd ink-jet technology enables precise and reproducible delivery of reagents Critical samples can be archived Direct analysis by Shimadzu Biotech AXIMA maldi TOF analysis for high confidence protein identification Multiple chemistry support for higher protein coverage ...
Company:Shimadzu Biotech

Xcise automated robotic system for Gel Processing from Shimadzu Biotech

Description:...s. It combines the functions of high-resolution gel imaging, precision spot cutting, protein digestion and peptide purification, and deposition onto a maldi plate into a single integrated benchtop instrument. The Xcise is the first commercial offering from the collaboration between Shimadzu Biotech and Pr...
Company:Shimadzu Biotech

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MALDI in Biological Dictionary

Mass spectrometry

...pectrometry can not ... Mass spectrometry is a tool that could expand the disorders screened for in ... TOD 10:10 – Bioaerosol Detection Using maldi Ion Mobility and Mass Spectrometry ... WP 682 – Is Wikipedia the Public Face of Mass Spectrometry ? ... ...