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Lysine in Medical News

Wistar Institute team finds key target of aging regulator

...ins, these results clarify a key role of Sir2 protein in control of lifespan. "Some modifications on histones, like this acetylation on histone H4 lysine 16, are persistent and are maintained through generations of cell divisions. This DNA-independent inheritance is called epigenetics," Berger says. "Ch...

Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth

...sion (switching on) or silencing (switching off) of certain genes. Progen and its collaborators have focused their research on an enzyme known as lysine specific demethylase 1(LSD1), which contributes to the silencing of important tumor suppressor genes. They have successfully developed PG11144 that i...

Xanodyne's New Drug Application for the Treatment of Heavy Menstrual Bleeding (Menorrhagia) Accepted for Filing with a Priority Review Classification

...he New Drug Application (NDA) for XP12B, a unique oral therapy which acts as a competitive plasmin inhibitor to prevent fibrinolysis by binding to the lysine receptor sites of plasminogen. This helps to normalize the hyperfibrinolytic activity often present in women with HMB. "We are pleased with the ...

Understanding mental illness through gene-environment interactions

... this issue of Biological Psychiatry. In another Review, Akbarian and Huang discuss mutations of genes that are involved in the regulation of histone lysine methylation, a type of epigenetic modification, that are associated with neurodevelopmental diseases, including mental retardation, autism and schizop...

Work with fungus uncovering keys to DNA methylation

...tdoctoral research associate Hisashi Tamaru. They found that a protein required for DNA methylation, DIM-5, is an enzyme that adds a methyl group onto lysine 9 of histone H3. "This was the first solid indication that chromatin is important for DNA methylation," Selker said. The new paper by Adhvaryu and ...

Another Study Warns of Risk From Cardiac Surgery Drug

... a higher risk of death for patients than other anti-bleeding drugs, called lysine analogues. While Trasylol was somewhat more effective at controlling blood loss and transfusions than lysine analogues, its higher risk of death and significantly higher price are dete...

Risk of death may be higher with drug commonly used during cardiac surgery

...o control blood loss and transfusions during cardiac surgery, compared with lysine analogues, according to a study http://www.cmaj.ca//cgi/rapidpdf/cmaj.0811...study, a systematic review of 49 randomized trials, compared aprotinin with lysine analogues. It includes new information from The Blood Conservation Using An...

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

...ved in the chemistry of rapid replication. The Doctors Bogoch called them "Replikins", and they are strictly defined by the concentration of lysine and histidine residues and the spacing between them. To demonstrate the correlation between the concentration of replikins and the lethality of influ...

Scientists identify proteins that help bacteria put up a fight

...a and Roy found that both MprF1 and MprF2 perform this same function, but they use different amino acids that lead to the modification. The amino acid lysine has already been identified as a player in this modification, and is used by MprF2. Ibba and Roy found that MprF1, however, uses the amino acid alanin...

AMAS Test Measures Lethal Replikin Gene Activity in Lung and Other Cancers

...wly identified gene has been named the Replikin Peak Gene (RPG). "Replikins(TM)" are a class of proteins containing high concentrations of amino acids lysine and histidine that have been previously determined to be related to rapid replication and virulence. Using proprietary computer algorithms constructed...
Lysine in Medical Technology

PARI's eFlow Included in Gilead's NDA Submission for Aztreonam Lysine for Inhalation

MONTEREY, Calif., Nov. 26 /PRNewswire/ -- PARI Pharma's eFlow electronic nebulizer was included in Gilead's (Nasdaq: GILD ) recent New Drug Application (NDA) submittal to the U.S. Food and Drug Administration (FDA) for marketing approval of aztreonam lysine for inhalation (75 mg three times d...

Gilead Announces Presentation of Positive Phase III Data on Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis

SEATTLE--(BUSINESS WIRE)--Apr 19, 2007 - Gilead Sciences, Inc. (Nasdaq:GILD) today announced detailed results of its Phase III AIR-CF2 study evaluating aztreonam lysine for inhalation, an antibiotic, in patients with cystic fibrosis (CF) who have pulmonary Pseudomonas aeruginosa (P. aeruginosa). In...

Gilead Announces Achievement of Primary Efficacy Endpoint in Second Phase III Study of Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis

FOSTER CITY, Calif.--(BUSINESS WIRE)--May 29, 2007 - Gilead Sciences, Inc. (Nasdaq:GILD) today announced that its Phase III AIR-CF1 (CP-AI-007) study of aztreonam lysine for inhalation for the treatment of people with cystic fibrosis (CF) who have pulmonary Pseudomonas aeruginosa (P. aeruginosa) me...

Peptimmune Announces Grant of United States Patent for PI-2301 Peptide Copolymer for Multiple Sclerosis

...e body is disrupted. The '790 patent claims "A linear random copolymer YFAK comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K)," )." which was licensed from Harvard University. The copolymer technology was developed in conjunction with Professor Jack L. Strominger M.D., Hi...

Promising Cystic Fibrosis Compound on Track for Development

... Pharmaceutical Company last year, acquired the rights to develop aztreonam lysine as an inhalation product to treat Pseudomonas aeruginosa infections. The company has said it will submit its new drug application (NDA) for aztreonam lysine to the FDA by the end of 2007. In the meantime, Gilead recently announced i...
Lysine in Medical Products

EnteroScreen 4™

Description:...e differentiation of Salmonella and Shigella species. Three media, Modified lysine Iron Agar, lysine Iron Agar (LIA), and Urea Agar, are used to screen non-lactose fermentors i...
Company:Hardy Diagnostics
Lysine in Biological News

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

...hyl groups that get attached to the tail of one of the histones, histone H3, at a specific spot the ninth residue, which happens to be the amino acid lysine (K). This mark is therefore called H3K9me. In fission yeast, a model system used for studying heterochromatin mechanisms because of its comparativ...

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

...ts of chromosomes are opened, making them susceptible to inappropriate use. Cells mark transcribed regions of chromosomes with a "landmark," called H3 lysine 36 methylation (H3K36), to direct appropriate use. Working in fruit flies, the Workman Lab investigated how cells direct dKDM4A, a novel histone ...

Epigenetic research uncovers new targets for modification enzymes

...arch is reported online in the journal Nature Chemical Biology. These modification enzymes, called protein methyltransferases, add methyl groups to lysine amino acids within the histones and change their influence on gene expression. The newly identified non-histone targets add yet another influence on g...

Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk

... methylation and this modification is an essential part of gene expression. Several years ago, the Shilatifard Lab identified the first histone H3 lysine 4 (H3K4) methyltransferase, known as COMPASS, in yeast. Soon thereafter, it was established that the MLL protein in humans also existed in a COMPASS-l...

Discovery may help defang viruses

... tests suggest that some viral strains with specific mutation patterns lead to a form of the virus that cannot sustain itself. "By altering a single lysine residue, you not only affect the virus' replication, but also the accuracy with which it is copied," he said. "A virus replication speed and accuracy ...

Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia

...ns. Scientists have known the specific pathways of lysine production in bacteria for more than a half-centur...y. They also have known some of the steps by which lysine is produced in plants, but they didn't really have...y found that the pathway used by plants to produce lysine is probably used by Chlamydia to synthesize a chem...

Researchers uncover new mechanism of tumor suppressor

...udies were accomplished by Gozani's group, and are the subject of the second report that will appear in Nature titled ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. "Our findings have established the mechanistic principles by which the inhibitor of growth 2 tumor suppres...

UCR chemist part of team identifying new areas of gene regulation

... chromatin remodeling complex to the location of acetylation. "In this paper, we used mass spectrometry to identify a novel acetylation site at the lysine 56 of yeast histone H3," said Zhang, referring to the previously unknown location of a chemical opening to allow genetic transfers to occur. "We fo...
Lysine in Biological Technology

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

...n to be involved in the chemistry of rapid replication. The Drs. Bogoch called them "Replikins," and they are strictly defined by the concentration of lysine and histidine residues and the spacing between them. To demonstrate the correlation between the concentration of replikins and the lethality of influe...

Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated

... software method, called FluForecast(R), has been designed to measure Replikins(TM), a class of proteins containing high concentrations of amino acids lysine and histidine, that have been determined to be related to rapid replication and virulence. Rather than being evenly distributed in the virus genome, r...
Lysine in Biological Products

Rabbit Anti-Human acetyl-Histone H3 (Lys 4) Antibody, Unconjugated from Upstate

Description:...yl-Histone H3 (Lys 4) Immunogen: KLH-conjugated, synthetic peptide containing the sequence ...RT[ Ac K]Q... in which [ Ac K] corresponds to acetyl lysine 4 of human histone H3 Accession Number: NM_003493 Molecular Weight: Mr ~17kDa Quality Assurance: Routinely evaluated by immunoblot....
Company:Upstate

Rabbit Anti-Human Histone H3, acetyl Polyclonal Antibody, Unconjugated from Lake Placid Biologicals

Description:... Antibody specific for histone H3 acetylated at any of the five N-terminal lysine residues. Rabbit polyclonal serum. Antigen: Synthetic peptide derived from histone H3 N-terminal region, mulitpliy acetylated...
Company:Lake Placid Biologicals

Mouse Anti-Human Histone H3, trimethyl (Lys27) Monoclonal Antibody, Unconjugated from Lake Placid Biologicals

Description:... Antibody specific for trimethyl-Lys27 of histone H3. Mouse monoclonal. Antigen: Synthetic peptide derived from histone H3, trimethylated at lysine 27...
Company:Lake Placid Biologicals

Keyhole Limpet Hemocyanin NP-KLH (Keyhole Limpet Hemocyanin), Unconjugated from Biosearch Technologies

Description:... 4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to KLH (Keyhole Limpet Hemocyanin) lysine through amide bonds....
Company:Biosearch Technologies

Sheep NP-SSA (Sheep Serum Albumin), Unconjugated from Biosearch Technologies

Description:... 4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
Company:Biosearch Technologies

Sheep NP-SGG (Sheep Gamma Globulin), Unconjugated from Biosearch Technologies

Description:... 4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SGG (Sheep gamma globulin) lysine through amide bonds. This product is homologous to NP-BSA....
Company:Biosearch Technologies

Bovine NIP-BSA (Bovine Serum Albumin), BSA (Bovine Serum Albumin) conjugated/tagged from Biosearch Technologies

Description:... 4-Hydroxy-3-iodo-5-nitrophenylacetyl hapten is conjugated to BSA protein through lysine by amide bonds....
Company:Biosearch Technologies

Bovine TNP-BSA (Bovine Serum Albumin), BSA (Bovine Serum Albumin) conjugated/tagged from Biosearch Technologies

Description:... 2,4,6-Trinitrophenyl hapten is conjugated to Bovine Serum Albumin protein through lysine by amide bonds....
Company:Biosearch Technologies

Bovine TNP-BGG (Bovine Gamma Globulin), BGG (Bovine Gamma Globulin) conjugated/tagged from Biosearch Technologies

Description:... 2,4,6-Trinitrophenyl hapten is conjugated to Bovine Gamma Globulin (BGG) through lysine by amide bonds....
Company:Biosearch Technologies

Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex

Description:...matin remodeling, and post translational modifications of histones, which include the dynamic acetylation and deacetylation of epsilon-amino groups of lysine residues present in the tail of core histones. The enzymes responsible for reversible acetylation/deacetylation processes are histone acetyltransferas...
Company:GeneTex
Lysine in Biological Definition

Alpha helix

...glutamic acid ) in order to stabilise the helix dipole. Less common (and less effective) is C-terminal capping with a positively charged protein like lysine . α helices have particular significance in DNA binding motifs, including helix-turn-helix motifs, leucine zipper motifs and zinc finger...

Amino acid

...ad must be taken in with food. In humans , the essential amino acids are lysine , leucine , isoleucine , methionine , phenylalanine , threonine , try... hydrophobic 131.17 6.05 2.32 9.76 K Lys lysine basic 146.19 9.60 2.16 9.06 10.54 L Leu ...

Genetic code

...e AAU (Asn/N) Asparagine AAC (Asn/N) Asparagine AAA (Lys/K) lysine AAG (Lys/K) lysine AGU (Ser/S) Serine AGC (Ser/S) Serine AGA (Arg/R) Arginine ...

Collagen

...proline and hydroxylysine – the former composing a rather large percentage of the total amino acids. They are derivatised from proline and lysine in enzymatic processes of post translational modification, for which vitamin C is required. This is related to why vitamin C deficiencies can cau...

Genetic code

...e AAU (Asn/N) Asparagine AAC (Asn/N) Asparagine AAA (Lys/K) lysine AAG (Lys/K) lysine AGU (Ser/S) Serine AGC (Ser/S) Serine AGA (Arg/R) Arginine ...

Histone

...fications can play a role in gene regulation in an epigenetic manner. Regulation occurs at the TATA box . Structure Histones are rich in lysine and arginine and are water-soluble. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but al...

Protein

...proteins come in two forms: complete proteins contain all eight of the amino acids ( threonine , valine , tryptophan , isoleucine , leucine , lysine , phenylalanine , and methionine ) that humans cannot produce themselves, while incomplete proteins lack or contain only a very small proportion o...
Lysine in Biological Dictionary

Ubiquitin

...aryotes Ubiquitin ligase A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that covalently attaches ubiquitin to a lysine on a target Ubiquitin (Ub) is a small protein that is composed of 76 amino acids. ... Among eukaryotes, ubiquitin is highly conserved, meanin...

Histones

...somes. ... An important feature about histones is that they contain a few lysine (K) ... Histones are proteins around which DNA can wind for compacti...ETYLTRANSFERASES (HATS) NUCLEOSOME-ACETYLATING NATIVE COMPLEXES ... certain lysine side chains within a histone's basic N-terminal tail region (149) ... ...

Histone

...tween the histone and deoxyribose sugars ... Histone H3 This article does not cite any references or sources. ... Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins" ... Elucidating the histone code -- The Judd Rice laboratory studies the epigenetic regulation o...

Heterochromatin

...ooks like Silencing Heterochromatin and DNA Double Strand Break Repair 7th edition by Kevin D Mills from Springer... Sir2 Deacetylates Histone H3 lysine 56 to Regulate Telomeric Heterochromatin Structure in Yeast ... Formation of Facultative Heterochromatin and Onset of Cell ... ...

Glycosylation

...·a·tion/ (gli-ko′′sĭ-la'shun) the ... Proteomics articles relating to ' glycosylation ' ... Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous d ... Lectins and also bacteria modify the glycosylation of gut surface receptors in the rat. ... It uses material ...

C Terminus

...limited proteolysis with subtilisin enhances ... Only the β-tubulin C terminus needs to be removed to achieve these changes and ... Since the lysine residues at the C terminus might be ubiquitinated by Mdm2, two ... Acetylation of p53 at the C terminus has been thought to recruit coactivato...
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