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Lymphocytic in Medical News

Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia

FRAZER, Pa., Aug. 3 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH ) today announced that the Journal of Clinical Oncology has published data from a pivotal phase 3 study demonstrating that TREANDA(R) (bendamustine HCl) for Injection improved clinical outcomes when compared to chl...

FDA Accepts Genta's NDA Amendment as Complete Response for Genasense(R) Treatment of Chronic Lymphocytic Leukemia

Submission Based on Increased 5-Year Survival in Responding Patients BERKELEY HEIGHTS, N.J., July 14 /PRNewswire-FirstCall/ -- Genta Incorporated (OTC Bulletin Board: GNTA) announced that the Food and Drug Administration (FDA) has accepted the Company's amendment to its New Drug Application ...

TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA

FRAZER, Pa., Dec. 3 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) today announced that the U.S. Food and Drug Administration (FDA) has accepted and granted priority review designation to the TREANDA(R) (bendamustine HCl) New Drug Application (NDA) for the first-line treatment of pati...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia

FRAZER, Pa., Sept. 21 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) today announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) requesting approval of TREANDA(R) (bendamustine HCl) for the treatment of patients with chronic lympho...

New Engineered Drug Shows Promise in Treating Lymphocytic Leukaemia

A recent research has found that a new type of engineered drug may have the potential to treat chronic lymphocytic leukaemia. The study by researchers at the Ohio State University Comprehensive Cancer Center was published online in the journal Blood. The research has established t...

Gene Mutation That Increases the Risk of Chronic Lymphocytic Leukaemia Found

Scientists at Ohio State University Comprehensive Cancer Center have discovered an inherited gene mutation that makes a person more vulnerable to chronic lymphocytic leukaemia (CLL). The study shows that the inherited mutation greatly reduces the gene's protective activity. Furthermore, a...

Lenalidomide Gives New Hope To Chronic Lymphocytic Leukemia Patients

According to a phase II study conducted by Asher Chanan-Khan, MD, Department of Medicine, Roswell Park Cancer Institute (RPCI), patients treated with lenalidomide// for relapsed chronic lymphocytic leukemia (CLL) or diseases that no longer responded to chemotherapy have experienced a major response...

Sagent Pharmaceuticals Announces Launch of First Two Oncolytic Products: Fludarabine Phosphate for Injection, USP and Epirubicin Hydrochloride Injection

...eneric equivalent to Fludara(R), distributed by Bayer HealthCare Pharmaceuticals) is indicated for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regim...

Silenced genes as a warning sign of blood cancer

...uestion is when the first labels occur in the development of cancer. In their recently published study the investigators used mice affected by chronic lymphocytic leukemia as a model for studying the disease. The researchers investigated the genetic material of these mice at regular intervals from birth. They...

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

...eater than 12 months. A Phase 2 single-arm, open-label study evaluating 200 mg of forodesine twice-daily in patients with chronic lymphocytic leukemia is ongoing, and the Company expects to provide an update on this study by the end of 2009. Conference Call and Web Cast ...
Lymphocytic in Medical Technology

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

SEATTLE and ORLANDO, Fla., June 1 /PRNewswire-FirstCall/ -- Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN ) announced today the presentation of encouraging Phase 1 safety and efficacy results following administration of low doses of TRU-016 in heavily pre-treated patients with high-risk genomic fa...

New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia

US Oncology Affiliated Physicians Participate in ASH Conference SAN FRANCISCO, Dec. 8 /PRNewswire/ -- A leading cancer researcher affiliated with the US Oncology Research Network will present findings from a randomized, multicenter Phase III trial that compared FCR and PCR in patients wit...

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

Data from a pivotal trial suggests that ofatumumab has activity in heavily pre-treated patients who have failed standard treatments PHILADELPHIA, Dec. 8 /PRNewswire-USNewswire/ -- GlaxoSmithKline (GSK) and Genmab A/S (OMX: GEN) announced today positive results from a pivotal trial pr...

The Leukemia & Lymphoma Society and Memgen Announce New Chronic Lymphocytic Leukemia Clinical Trial

WHITE PLAINS, N.Y., Dec. 3 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) and Memgen, LLC jointly announce the beginning of a new clinical trial of ISF35, a cancer vaccine, at the University of California, San Diego (UCSD). LLS is collaborating on this trial in the hopes th...

Genmab and GlaxoSmithKline Announce Positive Top-Line Results in Ofatumumab Chronic Lymphocytic Leukemia Pivotal Study

Summary: Phase III Pivotal Study of Ofatumumab in Refractory CLL Meets Primary Endpoint COPENHAGEN, July 31 /PRNewswire-FirstCall/ -- Genmab A/S (OMX: GEN) and GlaxoSmithKline (LSE and NYSE: GSK) announced today positive top-line results from an interim analysis of ...

FDA Indicates That Genasense(R) Approval in Chronic Lymphocytic Leukemia Will Require Additional Confirmatory Data

Approval Dependent on Outcomes of New Analyses or Confirmatory Trial Conference Call to Discuss Strategy Scheduled for Tuesday March 18, 2008 BERKELEY HEIGHTS, N.J., March 17 /PRNewswire-FirstCall/ -- Genta Incorporated (Nasdaq: GNTA ) announced that the Food and Drug Administration's (FD...

FDA Extends Review of Genasense(R) NDA Appeal in Chronic Lymphocytic Leukemia

BERKELEY HEIGHTS, N.J., Jan. 14 /PRNewswire-FirstCall/ -- Genta Incorporated (Nasdaq: GNTA ) announced today that the Food and Drug Administration (FDA) has extended its review of Genta's appeal of the non- approvable decision for a New Drug Application (NDA) that proposed the use of Genasens...

TREANDA Significantly Improves Clinical Outcomes in Patients with Chronic Lymphocytic Leukemia Compared to Chlorambucil

Data from Pivotal Study Show Bendamustine Produced a Significant Increase in Overall Response Rate and Progression Free Survival FRAZER, Pa., Dec. 10 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) announced today that in a pivotal study of treatment-naive patients with chronic ...

ZymoGenetics Reports Results From Atacicept Phase 1b Clinical Trial in B-Cell Chronic Lymphocytic Leukemia

SEATTLE, June 04, 2007 /PRNewswire-FirstCall/ -- ZymoGenetics, Inc. today announced that interim findings were presented from a Phase 1b clinical trial with atacicept in B-cell chronic lymphocytic leukemia (B-CLL) at the American Society of Clinical Oncology (ASCO) 2007 annual meeting. The study i...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

First RNA Antagonist Medicine to Be Tested in Patients Reduces Severity of Adult Leukaemia Copenhagen, 6th June 2007 - Santaris Pharma, the Danish biopharmaceutical company, announced today that SPC2996, the Company's new RNA Antagonist of Bcl-2, has shown early evidence of efficacy in an initia...
Lymphocytic in Medical Products

Chronic Lymphocytic Leukemia (CLL)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Chromosome Analysis, Chronic Lymphocytic Leukemia (CLL) Panel by FISH

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Lymphocytic in Medical Definition

Hematopathology

...o many mature blood cells , and is called that because it is a chronic process clinically. Examples are chronic myelogenous leukemia and chronic lymphocytic leukemia . Acute leukemia is the proliferation of too many immature blood cells, called myeloblasts , which have lost the ability to become mature ...
Lymphocytic in Medical Dictionary

Subacute thyroiditis

...s/Candler, Savannah ... prominent feature of subacute thyroiditis is gradual or ... THYROIDITIS ... THYROIDITIS , SUBACUTE THYROIDITIS , lymphocytic ... Chronic inflammation (granulomatous or subacute thyroiditis ) Prevention: Not known ... Subacute thyroiditis often follows a viral ...

Marrow

...ramming and more to ... Get the facts on leukemia (cancer of the bone marrow , blood) causes, symptoms, signs, types (hairy cell, chronic/acute lymphocytic or myeloid), research, treatment ... What is bone marrow ? Why are marrow transplants used? What role does chemotherapy or radiation thera...

Lymph

...nformation and news resource. ... Exercising After Mastectomy and Lymph Node Removal. Additional Resources and References ... Leukemia - Chronic lymphocytic - CLL | Cancer.Net - The American Society of Clinical ... Swelling of lymph nodes in the neck, under the arms, or in the groin. ... When you get...

Leukemia

...curs, Find information on leukemia including lymphocytic leukemia , myeloid leukemia , hairy cell leuk...et Printer-Friendly Document: Leukemia - Chronic lymphocytic (CLL) Detailed Guide ... Do We Know What Causes Chronic lymphocytic Leukemia ? ... Leukemia can be either acut...

Chronic thyroiditis

...isiana ... disease ( chronic thyroiditis ) Thyroid ... Tells about the causes, symptoms, diagnosis, risk factor, and treatment for chronic lymphocytic thyroiditis , also known as Hashimoto's Thyroiditis . Home > Health Encyclopedia > Chronic thyroiditis (Hashimoto?s disease) ... Chro...

Burkitt lymphoma

... Information about non-Hodgkin lymphoma treatment, clinical trials, research, ... non-Hodgkin lymphomas include Burkitt lymphoma , chronic lymphocytic leukemia ... Burkitt's lymphoma tends to occur most often in children and in adults with ... Endemic Burkitt lymphoma is seen among the ...

Autoimmune thyroiditis

...hyroiditis , also called autoimmune or chronic lymphocytic thyroiditis , is ... Article on thyroiditis ...oimmune thyroiditis is characterized by diffuse lymphocytic ... The Johns Hopkins Autoimmune Disease Res...... What is Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease? ... ...

Acute lymphoblastic

...mphoblastic leukemia definition ... acute lymphocytic leukemia ( ə′kyüt limfə′sidik lü′kēmēə ) ( medic...mphoblastic Leukemia (ALL) (also known as Acute lymphocytic Leukemia - ALL), leukemia information, and risk ...cute lymphoblastic leukemia (ALL) 4.2 Chronic lymphocytic leukemia (CLL) ... ALL (Precursor T acute lym...

Acute lymphocytic leukemia

...in's ... Information > Leukemia > Acute lymphocytic Leukemia . print page ... Acute lymphocytic leukemia (ALL) is a type ... Advances in the treatment of acute lymphocytic leukemia (ALL) have ... ...
Lymphocytic in Biological News

Study validates means to measure possible leukemia marker

...hich are spool-like proteins that help support and store DNA. The technology accurately detected differences in the composition of histones in chronic lymphocytic leukemia (CLL) cells compared with their healthy counterparts, immune cells called B lymphocytes. These variations are a promising molecular biomar...

Peering inside the skull of a mouse to solve meningitis mystery

...rmed many critical experiments that supported the unexpected findings of the study. A Disease Driven by the Immune System The scientists used lymphocytic choriomeningitis virus (LCMV), which is relatively harmless in humans with a healthy immune system. Other viruses that cause meningitis usually are as...

Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

... selectively rearm T cells while generally reinvigorating them." The researchers made their discoveries in a mouse model of chronic infection with lymphocytic choriomeningitis virus. They had earlier found that a receptor known as programmed death-1 (PD-1) was highly expressed by exhausted T cells from chron...

Scripps research team sheds light on immune system suppression

...sion of this immune response in mice infected with lymphocytic choriomeningitis virus, pointing to potential new ...ifornia, San Diego, worked with mice infected with lymphocytic choriomeningitis virus, a model Oldstone describes... then triggers other immune responses. But the lymphocytic choriomeningits virus, and presumably other immuno...

The IMF says journal editorial documents dramatic increase in survival since the 1980s

...es these achievements with myeloma are now benefiting a wide range of blood cancers as these drugs are being tested in non-Hodgkin's lymphoma, chronic lymphocytic leukemia and other blood cancers. In the editorial he says the next step is to identify new agents with "greater efficacy or lesser toxicities" in thi...

Researchers find way to make tumor cells easier to destroy

...icancer therapeutic, and it recently received clearance by the U.S. Food and Drug Administration to enter human phase I/II clinical testing in chronic lymphocytic leukemia. In some preliminary studies, GRN163L has been shown to be additive when used in combination with existing cancer drugs or radiation. Next...

Two suppressor molecules affect 70 genes in leukemia

...olecules that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model. The research, using human chronic lymphocytic leukemia (CLL) cells, also showed that loss of the two molecules affects 70 genes, most of which are involved in critical functions such as cell growt...

Gene therapy protocol at UCSD activates immune system in patients with leukemia

... A research team at the Moores Cancer Center at University of California, San Diego (UCSD) reports that patients with chronic lymphocytic leukemia (CLL) who were treated with a gene therapy protocol began making antibodies that reacted against their own leukemia cells. The study will be ...

NCI renewal grant to develop new cancer therapies

...cently received approval to lead a multi-institutional trial of vorinostat and bortezomib, a proteasome inhibitor, in patients with refractory diffuse lymphocytic B-cell lymphoma or mantle cell lymphoma. ...

University of Pennsylvania researchers develop formula to gauge risk of disease clusters

...f eight cases of leukemia in Niles, Ill., in 1956-1960, which was reasonably assessed as a chance, random event. On the other hand, 12 cases of acute lymphocytic leukemia in Churchill County, Nev., in 1999-2001 was assessed not to be a chance event but due to a common, possibly environmental cause. Multiple ...
Lymphocytic in Biological Technology

Sanofi-aventis U.S. to Acquire Oral Chronic Lymphocytic Leukemia Treatment

BRIDGEWATER, N.J., May 11 /PRNewswire-FirstCall/ -- Sanofi-aventis U.S. announced today that it has acquired from biotechnology company Antisoma plc the U.S. commercial rights to Oforta(TM) (fludarabine phosphate film-coated tablets), an oral B-cell chronic lymphocytic leukemia (CLL) drug. Ofort...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

Published in the Journal Blood for the American Society of Hematology Annual Meeting SOMERSET, N.J., Dec. 10 /PRNewswire-FirstCall/ -- Alfacell Corporation (Nasdaq: ACEL ) today announced that American Society of Hematology (ASH) annual meeting abstracts in Blood (2008 112: Abstract 4...

Genta Submits NDA Amendment to FDA for Genasense as Treatment of Chronic Lymphocytic Leukemia

Submission Based on Increased 5-Year Survival Data for Responding Patients BERKELEY HEIGHTS, N.J., June 6 /PRNewswire-FirstCall/ -- Genta Incorporated (OTC Bulletin Board: GNTA) announced that the Company has submitted an amendment to the Food and Drug Administration (FDA) for its New Drug Appl...

Cephalon Receives FDA Approval for TREANDA, a Novel Chemotherapy for Chronic Lymphocytic Leukemia

- First New Agent for CLL Patients Approved by the FDA since 2001 - FRAZER, Pa., March 20 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) today announced that the U.S. Food and Drug Administration (FDA) has approved TREANDA(R) (bendamustine hydrochloride) for Injection for the treatm...

Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia

FRAZER, Pa., Sept. 21 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) today announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) requesting approval of TREANDA(R) (bendamustine HCl) for the treatment of patients with chronic lympho...

FDA Grants Orphan Drug Designation to TREANDA, an Investigational Treatment for Chronic Lymphocytic Leukemia

FRAZER, Pa., Aug. 29 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) announced today that the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development granted orphan drug designation for the company's investigational therapy, TREANDA(R) (bendamustine HCl), for the ...

Cephalon Appoints Craig C. Phillips as Vice President and General Manager of Oncology Business Unit

...herapeutic portfolio in the United States includes two marketed products: TREANDA, which is approved in the United States for the treatment of chronic lymphocytic leukemia (CLL) and for the treatment of patients with indolent B-cell non-Hodgkin's lymphoma (NHL) that has progressed during or within six months of ...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

...ical trial of TRU-016 for the treatment of chronic lymphocytic leukemia (CLL), a preclinical study demonstrating ...6 in patients with previously treated CLL or small lymphocytic lymphoma (SLL). Abstract 8571 (May 30, ...armaceutical (SMIP) on direct apoptosis in chronic lymphocytic leukemia cells via transcriptional up-regulation o...

AACR 100th Annual Meeting Highlights Superior Ability of InNexus' DXL-Modified Anti-CD20 Antibody to Attach and Kill NHL With Safety Comparable to Approved Antibody Therapies in Preclinical Studies

...leted its comprehensive review of the development plans for DXL625 (CD20) for the prospective treatment of Non-Hodgkin's Lymphoma (NHL) and/or Chronic lymphocytic Leukemia (CLL). InNexus' submission included detailed information on plans for a Phase I clinical program, preclinical pharmacology and toxicology dat...

FDA Provides A Positive Review of InNexus Biotechnology Development Plan for Lead Product

... development plans for InNexus' lead preclinical candidate, DXL625 (CD20) for the prospective treatment of Non-Hodgkin's Lymphoma (NHL) and/or Chronic lymphocytic Leukemia (CLL). InNexus' submission included detailed information on plans for a Phase I clinical program, preclinical pharmacology and toxicolog...
Lymphocytic in Biological Products

L1210 cell line slides ( mouse: lymphocytic leukemia ) from GeneTex

Description: Mouse L1210 cells were cultured in DMEM and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each wells surface specifically treated to enhance cel...
Company:GeneTex
Lymphocytic in Biological Definition

Full blood count

...il granulocytes - May indicate bacterial infection. Lymphocytes - Higher with some viral infections such as glandular fever . Also raised in lymphocytic leukaemia CLL . Monocytes - May be raised in bacterial infection Eosinophil granulocytes - Increased in parasitic infections. Basophil g...

Stem cell

...f adult stem cells. Since 1988 these cord blood stem cells have been used to treat Gunther's disease , Hunter syndrome , Hurler syndrome , Acute lymphocytic leukaemia and many more problems occurring mostly in children. It is collected by removing the umbilical cord, cleansing it and withdrawing blood fro...
Lymphocytic in Biological Dictionary

Monoclonal Antibody

...ered by ... CLL Topics - Patients dedicated to the fight against chronic lymphocytic leukemia ... Related Articles: Review of Monoclonal Antibodies in Development ... CLL Topics - Patients dedicated to the fight against chronic lymphocytic leukemia ... Read about a new CD20 monoclonal antibody , HuMax-CD20 from...

Monoclonal antibodies

...nancies ... CLL Topics - Patients dedicated to the fight against chronic lymphocytic ... The monoclonal antibodies Rituxan and Campath have changed the land...for CLL ... CLL Topics - Patients dedicated to the fight against chronic lymphocytic leukemia ... Related Articles: Review of Monoclonal Antibodies in Devel...

Lymphocytes

...ut Lymphocytes in the free online English ... Lymphocytes . lymphocytic. lymphocytic choriomeningitis. lymphocytic choriomeningitis virus ... Lymphocytes are formed from lymphoblasts....

Gene therapy

... method of gene therapy has been the work of many labs in ... gene therapy ... CLL Topics - Patients dedicated to the fight against chronic lymphocytic leukemia ... Gene Therapy is the title that was chosen to describe a ... ...
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