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Lymphocytes in Medical News

Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis

..., please visit www.lexpharma.com . About Rheumatoid Arthritis lymphocytes are a type of white blood cell that play an important role in the immune system. Inappropriate activation of lymphocytes is often associated with autoimmune diseases, a spectrum of disorders in wh...

Critical link in cell death pathway revealed

... that, depending on the cell type, the way the killing of the cell happens is substantially different," he said. "In so-called type I cells, such as lymphocytes (white blood cells involved in the immune response), the killing is very direct. When FAS is activated a protein-destroying enzyme called caspase-8 is...

Cell division find prompts overhaul of immune response modeling

...tigating the proliferation and survival of T and B lymphocytes white blood cells that are crucial to the body's ability to generate immunity. When lymphocytes are exposed to pathogens they are stimulated to un...s of cell divisions, which increases the number of lymphocytes many hundredfold. After a period the cells stop di...

Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Inc's. GCS-100 Molecule

...ound that human tumors contain a large number of T lymphocytes which are directed against specific antigens of the tumor cells, but that these lymphocytes are in a state of paralysis. An important compone...tice on the cell surface. The function of these T lymphocytes could readily be restored in vitro by addition o...

Ortho Biotech Oncology Research & Development Announces Collaboration with National Cancer Institute to Develop Novel Cell Therapies to Treat Cancer

...mmunotherapy of cancer for decades. His group developed Tumor Infiltrating lymphocytes (TILs), T cells obtained from a patient's tumor, expanded and then re-admin...materials to stimulate T cells from a patient's blood to become Cytotoxic T lymphocytes (CTLs), which recognize and attack tumor cells. Early clinical results show...

UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage

...ory disorders, some of which increase risk for several types of cancer. Researchers found that local intestinal inflammation induced DNA damage to lymphocytes of the peripheral blood circulating throughout the body. This means that chromosome damage was not limited to the intestine, but involved tissues of t...
Lymphocytes in Medical Technology

TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)

SAN MARINO, Calif., May 27 /PRNewswire/ -- Epeius Biotechnologies ( http://www.epeiusbiotech.com ) announced today that the results of a Phase I Feasibility Study of sequential targeted gene delivery -- using Rexin-G followed by Reximmune-C -- for cancer vaccination will be presented at the AS...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

...pment for the treatment of individuals with recent-onset type 1 diabetes, is a humanized monoclonal antibody engineered to alter the function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon cha...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

...he course of four to 12 weeks. Beginning with the 0.1 mg/kg dose, evidence of biologic activity was observed. The median reduction in peripheral lymphocytes was 67% and was as high as 98%. Two patients with leukemia cutis had complete or partial clearance of skin lesions. One patient had a 36% reduction in...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

...ion. Following maturation, these dendritic cells activate Natural Killer (NK) and Natural Killer T-cells (NK-T) of the innate immune pathway and CD8+ lymphocytes of the adaptive immune pathway. Initiating the immune response in the GALT, and away from the tumor, reduces the effect of anti-immune factors produc...

Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells

...opulation; DC2). Other parameters measured included mixed-leukocyte reaction (MLR), natural killer (NK) cell activity, the proliferative response of T lymphocytes toward mitogen (phytohemagglutinin [PHA]) and cytokine production of interleukin (IL)-2, IL-4, IL-6, IL-10, interferon gamma-gamma, and (alpha)-tumor ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

...ed by the accumulation of functionally immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue and other organs. Two types of lymphocytes are present in the blood, B cells and T cells. The majority of this patient population (90 percent) suffers from a subtype called B-cell chronic lymph...
Lymphocytes in Medical Products

Mitogen Proliferation, Lymphocytes

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Antigen & Mitogen Proliferation Panel, Lymphocytes

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Antigen Proliferation, Lymphocytes

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Lymphocytes in Medical Definition

Central tolerance

...ponent self antigens of the host). In mammals the process occurs in the thymus (T cells) [2] [3] and bone marrow (B cells), when maturing lymphocytes are exposed to self antigens. Self antigens are present in both organs due to endogenous expression within the organ and importation of antigen due t...
Lymphocytes in Medical Dictionary

Thymus

... the soul The thymus sits just in front of and above the heart. ... T lymphocytes develop in the thymus and then travel to lymph nodes (bean-sized ... ...ionary and glossary with medical definitions ... It is in the thymus that lymphocytes mature, multiply, and become ... The T is for thymus . ... Much of the...

Mycosis

...aused by a fungus. fungal infection ... General Information About Mycosis Fungoides and the S├ęzary Syndrome ... In mycosis fungoides, T-cell lymphocytes become cancerous and affect the skin. ... Recurrent Mycosis Fungoides / Sezary Syndrome. To Learn More. Overview Of PDQ ... Stages of mycosis ...

Lymphocyte

..., B cells and natural killer (NK) cells ... B lymphocytes from early vertebrates have potent phagocytic and...hage ... More often, though, the Env-binding lymphocytes were admixed with nonstaining cells. ... Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. ... CD4+ T lym...

Lymphoma

... Lymphoma is a type of cancer that originates in lymphocytes of the immune system. They often originate in lymph nodes, presenting as an enlargement of the node (a tumor). Lymphomas are closely related to ...

Lymph

...infections, the lymph nodes swell with billions of white ... The filtered lymph then flows back into the blood stream at certain points. ... lymphocytes are carried throughout the body in a colorless fluid called lymph . The lymph system is a network of thin tubes that reach into all parts of the .....

Immunology

...tions in several disciplines of science, and as ... The Lymphocyte Biology Section (LBS) studies basic aspects of how white blood cells called T lymphocytes ... Immunology > Lymphocyte Biology. Immunology ... Located in Cleveland, OH, Case Western Reserve University is one of the nation's leadin...
Lymphocytes in Biological News

How T lymphocytes attack

Our immune system finds it difficult to eliminate tumours effectively. Deciphering the strategies it implements may increase the immune system's effect on tumour cells and thus improve the clinical perspectives for anticancer immune therapy. At the Institut Curie, INSERM and CNRS researchers have...

Stop and smell the flowers -- the scent really can soothe stress

...entists exposed lab rats to stressful conditions while inhaling and not inhaling linalool. Linalool returned stress-elevated levels of neutrophils and lymphocytes key parts of the immune system to near-normal levels. Inhaling linalool also reduced the activity of more than 100 genes that go into overdrive in s...

'First aid' for brain cells comes from blood

...lberg University Hospital have shown that certain immune cells in the blood inhibit inflammation after a stroke. These cells are known as regulatory T lymphocytes (Treg). The regulator cytokine Interleukin 10 plays an important role in this protection, perhaps offering a new approach to stroke therapy. The stud...

Researchers explore new driver of transplant rejection: Platelets

...hit the general that initiates acute rejection, it would put the troops in disarray," says Rabb. "Traditional therapies therefore inhibit or deplete T lymphocytes and other white blood cell components of the immune system. The newest kid on the block is the platelet and it represents an opportunity to target the...

Researchers identify a cell type that limits stroke damage

...stroke is caused by the body's immune response. Cells such as microglia and lymphocytes provoke harmful effects similar to those observed during nervous system inf...mage by blocking the production of neurotoxins and modulating the action of lymphocytes and microglia in the brain. ...

Seemingly suicidal stunt is normal rite of passage for immune cells

...induced breaks in the DNA of immune cells known as lymphocytes activate genes that cause the cells to travel from...Scientists have known for two decades or more that lymphocytes can break their own DNA in this fashion, creating ...ll's ability to repair DNA damage slowed down, the lymphocytes can't activate the genes that get them to where th...
Lymphocytes in Biological Technology

R-Tech Ueno Notifies R&D Items

...ing type present in the vascular endothelium and the free type present in the serum. The former serves as a molecule adherent to white blood cells and lymphocytes and is involved in inflammation while the latter detoxifies amine in the living body by its amine oxidase activity. In other words, VAP-1 is a protein...

Carbon Design Innovations, Inc. Introduces Carbon Nanotube Probe Technology for Atomic Force Microscopy, CNT-Probes Deliver New Level of AFM Imaging Performance

... "The carbon nanotube AFM probes from C|D|I reveal the most accurate surface morphology, especially for cellular samples such as rat basophilic lymphocytes cells," states Dr. G. Y. Liu, University of California, Davis. "All observations reflect upon the superior geometry of these CCHAR probes, ...

Micromet Presents Update at ASCO 2009 on a Phase 1b Combination Study of Adecatumumab and Docetaxel

...uded nausea, vomiting, stomatitis, constipation, fatigue, fever and chills. Laboratory abnormalities included reduction in various blood cells such as lymphocytes and neutrophils comparable to what is typically observed with docetaxel monotherapy. The overall response rate according to RECIST [version 1.0]...

OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer

...e of mild fever, chills and creatinine levels (a laboratory measure for reduced kidney function) and a moderate to significant decrease in circulating lymphocytes in the blood (another laboratory measure) without any increase in infection rate compared to the docetaxel arm. The investigators concluded that the c...

Novavax Announces Enrollment in the Second Phase II Study of its Seasonal Influenza VLP Vaccine Candidate

...tralize influenza virus and prevent spread throughout the cells of the respiratory tract -- and the matrix 1 or "M1" virus that stimulates cytotoxic T lymphocytes to kill cells that may already be infected. This three-pronged approach may offer an advantage over existing vaccines which contain mostly HA with va...

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

...e system. Fragments of these proteins, such as chemoattractant complement fragment C5a, work to recruit immune system cells including neutrophils and lymphocytes to the site of inflammation. The C5a receptor is highly expressed on innate immune cells, making it an attractive target for small molecule therapeut...
Lymphocytes in Biological Products

Rat Anti-Gamma delta T Lymphocytes Monoclonal Antibody, Unconjugated, Clone MAC320 from BD Biosciences Pharmingen

Description: Gamma delta T Lymphocytes Purified Anti-Porcine clone MAC320, Isotype Rat IgG 2a , kappa, 0.1 mg Consult technical datasheet for details....
Company:BD Biosciences Pharmingen

Mouse Anti-Rabbit T LYMPHOCYTES Monoclonal Antibody, Unconjugated, Clone KEN-5 from AbD Serotec

Description: MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
Company:AbD Serotec

Human Genetic Cell Bank Service from European Collection of Cell Cultures (ECACC)

Description:... Genetic Cell Bank Service The Human Genetic Cell Bank Serviceat ECACC is based on Epstein-Barr Virus (EBV) immortalisation of human peripheral blood lymphocytes (PBLs) resulting in the production of lymphoblastoid cell lines (LCLs). These cell lines are subsequently banked, providing a renewable and expandable...
Company:European Collection of Cell Cultures (ECACC)
Lymphocytes in Biological Definition

Antibody

...egawa showed in 1976, portions of the genome in B lymphocytes can recombine to form all the variation seen in ...ication or antigen affinity chromatography. If the lymphocytes that produce the antibodies can be isolated and im...al links Lymphomation: Immunoglobulins How lymphocytes Produce Antibody PLOS primer: V(D)J Recombinat...

Antigen

...so they start to secrete cytokines . The cytokines then activate cytotoxic lymphocytes T (CTL), antibodies secreting lymphocytes B , macrophages and other cells. Endogenous antigens Endogenous...

B cell

... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response ). The abbreviation "B" stands for the burs...

Full blood count

...mber per litre. A complete blood count with differential will also include: Neutrophil granulocytes - May indicate bacterial infection. lymphocytes - Higher with some viral infections such as glandular fever . Also raised in lymphocytic leukaemia CLL . Monocytes - May be raised in bacteri...

Cartilage

...ptures the cartilage ring, causing tissue to herniate into the spinal canal . The matrix of cartilage acts as a barrier, preventing the entry of lymphocytes or diffusion of immunoglobins . This property allows for the transplantation of cartilage from one individual to another without fear of tissue rej...

Cloning

...ning is the process of creating an identical copy of an original. A clone in the biological sense, therefore, is a single cell (like bacteria , lymphocytes etc.) or multi-cellular organism that is genetically identical to another living organism. Sometimes this can refer to "natural" clones made eith...
Lymphocytes in Biological Dictionary

Lymphocytes

Functionally distinct subsets of lymphocytes correlate with their appearance. Most, but not all large granular lymphocytes are more commonly known as the ... B cells are lymphocytes that play a large role in the humoral immune response . The principal functions of B cells are to ...

T lymphocytes

T cells belong to a group of white blood cells known as lymphocytes , and play a central role in cell-mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells by the presence of a special receptor on their cell... The small l...

B lymphocytes

B cells are lymphocytes that play a large role in the humoral immune response . The principal functions of B cells are to make antibodies against antigens, perform the role of Antigen... The small lymphocytes are the T cells and B cells. ... The lymphocytes involved in ad...

White blood cells

...r ... The nongranuloctye white blood cells , lymphocytes and monocytes, do not have ... White blood ...rks. Red Blood Cells . White Blood Cells . lymphocytes and ... five kinds of white blood cells (... and other diseases. Granulocytes, monocytes, and lymphocytes are white blood cells . Also called leukocyt...

Venules

...s cells found in regular venules . HEVs enable lymphocytes circulating in the blood to directly enter a lym... pia venules in the cerebral cortex. ... ... lymphocytes at specialized high endothelial venules within lymph nodes and other ... of Rolling T lymphocytes in Peripheral Lymph Node High Endothelial Venules...

T cell

...ial receptor on their cell ... T helper cells are a sub-group of lymphocytes that play an important role in establishing and maximizing the capabilitie...stem. ... T cells belong to a group of white blood cells known as lymphocytes and play a ... Their major role is to shut down T cell mediated immuni...
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(Date:4/18/2014)... have made a brain-related discovery that could revolutionize ... This discovery opens up the possibility that environmental ... specific brain activity that the researchers have identified ... Journal of Neuroscience has just published a ... associate professor of psychology and his doctoral student ...
(Date:4/18/2014)... to potential new treatments for breaking the cycle of ... or scarring, is a hallmark of the disease, and ... to serious organ damage and, in some cases, death. ... findings made by Swati Bhattacharyya, PhD, research assistant professor ... protein plays in promoting fibrosis. , "Our results ...
(Date:4/17/2014)... have identified the first genetic variant specifically associated ... accounting for around 10-15 per cent of all ... of the breast cancer sub-type, called invasive lobular ... causes of this particular kind of breast cancer, ... research, published today (Thursday) in the journal ...
(Date:4/17/2014)... According to a study published today in PLOS ... world where malaria is common can mount an immune ... them to avoid repeated bouts of high fever and ... in their bloodstream. The findings may help researchers develop ... by the malaria parasite. , Each year, approximately 200 ...
(Date:4/17/2014)... Two recent papers by a University of Colorado ... scientists develop treatments or vaccines for Dengue fever, ... other disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, ... the School of Medicine and an early career ... colleagues recently published articles in the scholarly journals ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:New clues on tissue scarring in scleroderma 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:CU researchers discover target for treating dengue fever 2
(Date:4/17/2014)... consumption advisories for expecting mothers are ineffective in ... organic pollutants (POPs). , The study, performed ... Toronto Scarborough PhD student Matt Binnington and Professor ... environmental contamination, a mother,s compliance with advisories, and ... exposure in her children. , Their model estimates ...
(Date:4/17/2014)... A Kansas State University engineer has developed ... remotely detects improvised explosive devices. The same technique ... Dunn, the Steven M. and Kay L. Theede ... and nuclear engineering, and his research team have ... underground or in car trunks. The distance detection ...
(Date:4/17/2014)... Europe, Asia and the United States are spreading across ... native honeybee populations at this time, according to an ... Nosema microsporidia and Varroa mites., ... these invasive pests, which suggests to us that the ... the United States currently are not necessary in East ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
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