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Lymphocyte in Medical News

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

New York May 18, 2009: A new study published online in Nature Immunology ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus at stages that coincide with V(D)J recombination of the heavy and light chain (Igh and Igk) loci. Researche...

AAI honors Chen Dong for breakthrough T lymphocyte research

HOUSTON - Back when scientists viewed immune response as an either-or process strictly divided between two pathways, each driven by a separate T helper cell, Chen Dong, Ph.D., and colleagues at The University of Texas M. D. Anderson Cancer Center helped uncover a surprising and pivotal third path ...

Cell division find prompts overhaul of immune response modeling

...r deaths. They also recorded how this variation in lymphocyte behaviour was transmitted through cell generations..." Professor Hodgkin said it appeared that when a lymphocyte first divided chemicals were produced that were pr...th accurate information on the time it takes for a lymphocyte to divide, the time taken to die and the number of...

Blood Test Shows Statistically Significant Association With Alzheimer's Disease (AD), May Predict Conversion of Mild Cognitive Impairment to AD

...elopment of the characteristic pathologies of the disease, the amyloid plaques and tau tangles. Most importantly, the findings validate the use of our lymphocyte test as a biomarker of Alzheimer's disease and suggest that the test is predictive of cognitive deficit developing in MCI patients." About Un...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...y II-34 Targeted Therapy II-34 Gene Therapy II-34 Immunotherapy II-34 Monoclonal Antibody Treatment II-35 Vaccines II-35 Donor lymphocyte Infusion II-35 Hematological Cancer Drug Classes II-35 Hypomethylating Agents & Antimetabolites II-35 Bisphosphonates II-36 Alkyla...

Early treatment of systemic onset JIA with anakinra restores the IL-18 response

...ed to normal, as observed in healthy controls. During follow-up, two patients flared following anakinra treatment. *NK cells are a type of cytotoxic lymphocyte that constitute a major component of the innate immune system. NK cells play a major role in the rejection of tumors and cells infected by viruses. Th...
Lymphocyte in Medical Technology

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

...umab is a novel monoclonal antibody being developed for the treatment of type 1 diabetes and other autoimmune diseases. Otelixizumab targets CD3, a T lymphocyte receptor involved in normal cell signaling. Otelixizumab has not yet been approved for marketing. Data suggest that the antibody may work in patient...

New Hope to Beat Cancer

...ient's immune system to kill cancer cells. (Logo: http://www.newscom.com/cgi-bin/prnh/20090303/CG78204LOGO-b ) The Young Tumor-Infiltrating lymphocyte (Y-TIL) trial is a phase 2 clinical trial being offered with technical support from the National Cancer Institute (NCI) in Bethesda, Md. Milwaukee nat...

GeneThera Announces it is Set to Begin Commercial Testing for Johne's Disease as Soon as January, 2009.

...ection, the microorganism elicits a cell-mediated response by the host that can be characterized by strong delayed-type IV hypersensitivity reactions, lymphocyte proliferative responses to mitogens, and production of cytokines by stimulated T lymphocytes. As the disease progresses from sub clinical to clinical ...

Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's

...ledge about dementia and fostering a vital, collegial research community. -- Thomas Arendt. "Diagnosis Of Alzheimer's Disease Using Peripheral Blood lymphocyte Expression Of CD-69 Following A Mitogenic Stimulus." (Funders: National Institutes of Health, GW Medical, Provista Life Sciences) -- Anne M. Fagan. ...

IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients

...unced follow-up results from the Phase 2 study of IDM-2101 showing that the product candidate was well tolerated, induced broadly specific cytotoxic T lymphocyte (CTL) responses, and showed a positive survival trend in HLA-A2 positive patients with non-small cell lung cancer (NSCLC) who were treated with IDM-21...

Pixantrone to be Studied in Phase I/II Trial for Aggressive Multiple Sclerosis

...e included. The objectives of the study are to determine the efficacy of pixantrone as an immunosuppressive agent based on its ability to decrease the lymphocyte count and to evaluate efficacy in MS based on gadolinium enhanced magnetic resonance imaging. This trial is an open-label, multi-center, non-comparati...
Lymphocyte in Medical Products

Lymphocyte Subset Panel 6-Total Lymphocyte Enumeration with CD45RA & CD45RO

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Lymphocyte Subset Panel 5-Total Lymphocyte Enumeration

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Giemsa Stain

Description:...exhibiting a very light, pale pink. Leukocyte nuclear chromatin stains magenta-purple, monocyte cytoplasm stains the classical "ground glass" blue and lymphocyte cytoplasm stains clear, sky blue....
Company:Richard-Allan Scientific

Particle Analysing System PAS

Description:... Multiparameter laser and arc lamp flow cytometer for all applications in immunology, microbiology, cell biology, pathology, hematology, lymphocyte dubset and cell analysis....
Company:Partec GmbH

Epstein-Barr Virus (EBV) VCA IFA IgG

Features:... The recombinant substrate eliminates the problem of interference from early antigen expression which occurs in substrate slides prepared with a human lymphocyte line. ...
Company:Focus Diagnostics

Epstein-Barr Virus (EBV) VCA IgM Recombinant IFA (RIFA)

Features:... The recombinant substrate eliminates the problem of interference from early antigen expression which occurs in substrate slides prepared with a human lymphocyte line. ...
Company:Focus Diagnostics

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Lymphocyte in Medical Definition

Hematopathology

...odes . Hematopathologists have named different lymphomas after the type of lymphocyte that has become malignant . Thus there are B cell lymphomas , T cell ...chemistry and flow cytometry , techniques using antibodies to specific lymphocyte surface markers , to determine the type of lymphoma in the pathology ...

Thymocyte

...y cytokine and chemokine receptors. J Immunol. 2007 Feb 15;178(4):2008-17. http://www.jimmunol.org/cgi/content/full/178/4/2008 ] ^ Sleckman BP, lymphocyte antigen receptor gene assembly: multiple layers of regulation. Immunol Res 32:153-8, 2005. full text ^ Baldwin TA, Hogquist KA, Jameson SC, ...
Lymphocyte in Medical Dictionary

Lymphocyte

A scanning electron microscope (SEM) image of a single human lymphocyte . ... The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells ... B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities" ... B Cell Development a...

Thymus

... located in the upper anterior portion of the chest cavity just behind the sternum. The main function of the thymus is to provide an area for T lymphocyte maturation, and is vital in... thymus n. , pl. -muses . A small glandular organ that is situated behind the top of the breastbone, consisting...

Peripheral smear

...he Test Is Performed ... Peripheral Smear , Peripheral Blood Film, Blood Film ... Leukocyte Morphology on Peripheral Smear . Leukocytosis. lymphocyte Count ... Blood smear . Definition: ... Peripheral smear . How the test is performed: ... The smear shows the relative number and kinds of w...

Immunology

... various applications in several disciplines of science, and as ... The lymphocyte Biology Section (LBS) studies basic aspects of how white blood cells called T lymphocytes ... Immunology > lymphocyte Biology. Immunology ... Located in Cleveland, OH, Case Western Reserv...

Immune response

...esponse happens the first time that the body encounters a ... The Immune Response . Lecture Notes Rewrite and Notes ... cells – Nonspecific lymphocyte involved in the Innate Immune Response . ... secondary immune response . ... ... the nonspecific and then specific response of the immun...

Hyaline Membrane Disease

... treatment complications, and prevention hyaline membrane disease n. See respiratory distress syndrome. ... What are the effects of low lymphocyte level on Hyaline Membrane Disease ? ... RDS in newborn infants used to be called hyaline membrane disease . — David A. Cramer, MD ......
Lymphocyte in Biological News

Researchers explore new driver of transplant rejection: Platelets

...pportunities for attacking organ injury and rejection head-on, says Rabb. The traditional target of current anti-rejection medicine is the so-called T lymphocyte a white blood cell believed to be the major orchestrator of the immune response against any foreign tissues, including transplants. "The thought w...

Seemingly suicidal stunt is normal rite of passage for immune cells

..., that normally helps the cell sense DNA damage. "This explains why the lymphocyte counts in these patients drop so sharply," Sleckman says. "Not only is the ...ll line developed in his lab, researchers induced double-stranded breaks in lymphocyte DNA using the same enzymes the cells normally use to create the breaks. The...

UC Davis researchers discover how HIV turns food-poisoning into lethal infection

... revealed that viral infection of the intestine results in the depletion of a type of white blood cell, called Th-17, in the gut mucosa. This T helper lymphocyte produces IL-17, a cytokine or chemical messenger that plays a crucial role in the inflammatory response, recruiting other immune system cells to the s...

Glue inside the cell

...his process of de-ubiquitination is constantly happening in cells and it could contribute to prevent an over-shooting activation of T cells. Unopposed lymphocyte activity is responsible for many chronic diseases, autoimmunity or even lymphoma development. Future work must address the status of Malt1 ubiquitinat...

3 Columbia University Medical Center faculty elected to Institute of Medicine

... and her laboratory work focuses primarily on transcriptional regulation of lymphocyte development. A major focus of her current work is an unusual transcriptional repressor called Blimp-1 (B lymphocyte induced maturation protein). Her studies on Blimp-1 are revealing important...

How 'memory' T cells curb the spread of viruses throughout the body

...through the blood to kill infected cells at the site where the virus entered the body (most commonly the skin, the lungs or the gut). This process of lymphocyte multiplication and migration may take several days while viruses multiply and spread quicker. Sigal’s work shows the CD8 T cells can protect from vir...
Lymphocyte in Biological Technology

BD IMag Human Regulatory T Lymphocyte Separation Set for Isolation of Treg Cells

BD Biosciences is pleased to introduce the BD IMag Human Regulatory T Lymphocyte Separation Set DM (Cat. No. 558142) for the isolation of Treg cells from peripheral blood mononuclear cells (PBMC). The reagent set isolates Treg cells in two stages. First, negative selection is performed u...

Sunesis Reports Financial Results for the Second Quarter 2009

...4.9 million for the same periods in 2008. Sunesis recognized $2.0 million in the second quarter of 2009 for the sale to SARcode of its interest in the lymphocyte function-associated antigen-1, or LFA-1, patents and related know-how that had previously been the subject of a license agreement with them, and $1.5 ...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

...ety and early signs of efficacy of TRU-016 as shown by a reduction in tumor lymphocyte blood counts, reduction in lymph node and spleen size, and/or an improvemen...of leukemia cutis, and the other six had 27% to 94% reduction in peripheral lymphocyte count. One patient had an increase in hemoglobin of 40% and a reduction in ...

Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology

...a - Poster discussion from 2:00 p.m. to 6:00 p.m. local time on Sunday, May 31, 2009. "Association of peripheral blood lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab" (Abstract #3020, Developmental Therapeutics: Immun...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

...d in vivo in the mouse. Dendritic cells direct the subsequent immune response to a vaccine by presenting the vaccine's antigen(s) to the appropriate T lymphocyte and then deliver specific cytokine proteins to the T cell to determine the immune response outcome to the specific vaccine. Each L.E.A.P.S. const...

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

...l characteristics. Dendritic cells direct the subsequent immune response to a vaccine by presenting the vaccine's antigen(s) to the appropriate T lymphocyte and then deliver specific cytokine proteins to the T cell to determine the immune response outcome to the specific vaccine. "L.E.A.P.S. vaccines are ...
Lymphocyte in Biological Definition

Antibody

...xpress on its surface. The antibodies a single B lymphocyte produces can differ in their heavy chain and the B...cell membrane , where it can be recognized by a T lymphocyte , which compares it to similar structures on the cell membrane of a B lymphocyte . If it finds a matching pair, the T...

B cell

... Prize in Physiology or Medicine for demonstrating how B cells create the enormous diversity of antibodies from only a few genes. See also T lymphocyte Antibody ...

Immune system

...r /CD8 receptor / perforin / apoptosis /clonal selection immunosuppression immunosuppressive drug immunotherapy lymphatic system / lymphocyte macrophage major histocompatibility complex / class I MHC /class II MHC monoclonal antibody / polyclonal antibody ...

Synapse

...action of the enzyme acetylcholinesterase . By analogy to true synapses described above, the interface between an antigen presenting cell and lymphocyte is sometimes called an immunological synapse . References M.F. Bear, B.W. Conners, and M.A. Paradiso. 2001. Neuroscience: Exploring the Bra...

T cell

...s (CD4 + ) are "middlemen" in the immune response. When they get activated, they proliferate and secrete cytokines, that regulate or 'help' effector lymphocyte function. They are known as one of the targets of HIV infection, and the decrease of CD4 + T cells results in AIDS . Some helper T cells secrete c...
Lymphocyte in Biological Dictionary

Uropod

...and a uropod -specific marker, CD44. ... Figure 2. MTs reorient toward the uropod after polarization by fMLF in suspended ... Microspikes on the lymphocyte Uropod . William McFarland 1 ... Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions. ... The number of uropo...

Thymus gland

...rgan located in the upper anterior portion of the chest cavity just behind the sternum. The main function of the thymus is to provide an area for T lymphocyte maturation. The thymus also... thymus n. , pl. -muses . A small glandular organ that is situated behind the top of the breastbone, ... The t...

Thylakoid

...und compartment inside chloroplasts and cyanobacteria. ... The word " thylakoid " is derived from the Greek thylakos, meaning "sac" ... A type of lymphocyte responsible for cell-mediated immunity that differentiates ... thylakoid (thy-luh-koid) [Gk. thylakos, a small bag] ... The term thylakoid is...

T lymphocytes

...ted immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells...tes count measurement . Information about T lymphocyte in the free online English ... T cell. lymph cell, lymphocyte - an agranulocytic leukocyte that normally makes ...

T cell

...tral role in cell -mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells by the presence of a sp...English dictionary and encyclopedia. cytotoxic t ... T cell - a small lymphocyte developed in the thymus; it ... However, the precursors of T cells l...

Sister chromatid

...mes show sister chromatids ... The maintenance of sister - chromatid cohesion is essential to ... the sister chromatids separate and ... lymphocyte sister chromatid exchange: A similar 0.4-mL sample of blood was ... Sister chromatid differentiation on staining was performed by the FPG te...
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