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Locus in Medical News

Deaths, Injuries Increase With Higher Speed Limits

...United States. The largest increase -- 9.1 percent -- was on rural interstates, followed by urban interstates at 4 percent. "These roads were the main locus of raised speed limits," they noted. Some states had imposed a 65 mph limit. Others went to 70, and still others, 75. The solution, said Friedman...

Gum Disease, Heart Disease Share Genetic Link

...tions hadn't been confirmed. The University of Kiel team found that the two diseases share a genetic variant on chromosome 9. "We studied a genetic locus on chromosome 9p21.3 that had previously been identified to be associated with myocardial infarction [heart attack], in a group of 151 patients suffer...

Scientists find shared genetic link between the dental disease periodontitis and heart attack

...many, said that his team had discovered a genetic variant situated on chromosome 9 which was shared between the two diseases. "We studied a genetic locus on chromosome 9p21.3 that had previously been identified to be associated with myocardial infarction, in a group of 151 patients suffering from the mo...

New study evaluates community response to personally controlled health information

...ties associated with sharing health information A need for help understanding technical or clinical issues Concerns about quality, accuracy and locus of responsibility for maintaining records Uncertainty about appropriate and safe read/edit access policies Consumer demands of the technology ...

Einstein scientists propose new theory of autism

...ntal disorder caused by impaired regulation of the locus coeruleus, a bundle of neurons in the brain stem t...nd that scientific evidence directly points to the locus coeruleusnoradrenergic (LC-NA) system as being inv...hed professor of neuroscience at Einstein. The locus coeruleus has widespread connections to brain regi...

Study IDs Variations in Black, White Genomes

...es, which in turn could result in neurological disease. It is also interesting to find out whether the type of mental retardation associated with this locus is more common in whites than in Africans or African-Americans. If this is true, then it might be one of the first reported diseases with differing et...
Locus in Medical Technology

A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer

...re help to tag major biological mechanisms underlying cancer susceptibility more generally. The paper, entitled "Sequence variants at the TERT-CLPTM1L locus associate with many cancer types," is published today in the online edition of Nature Genetics at www.nature.com/ng , and will appear in an upcoming ...

Findings on Bladder-Brain Link May Point to Better Treatments for Problems in Sleep, Attention

...brain structures, the Barrington's nucleus and the locus ceruleus, developed abnormal activity as a result of the bladder obstruction. In particular, the locus ceruleus showed persistently high activity, and th...s, but added that the brain circuits involving the locus ceruleus might be a useful target for drugs to imp...

EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha-7 Nicotinic Agonist, EVP-6124, in Patients with Schizophrenia

... to suppress the response to a second stimulus. Sensory gating abnormalities in Schizophrenia have been linked to an allele on chromosome 15, the gene locus for the alpha-7 receptor. Alpha-7 nicotinic agonists have been recently shown to improve cognition and the P50 response in patients with Schizophrenia...

Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers

... a patented microarray-based approach to map tumor associated changes in DNA methylation, alterations that can affect normal gene expression. A single locus associated with the GHSR gene was the most powerful biomarker in the study, with a clinical sensitivity of 90% and a specificity of 96% for infiltrati...

Researchers Discover a Common Variation in a Gene Segment that Increases the Risk for Prostate Cancer

...----------------------------------- Resource: Yeager M, Orr N, Hayes RB, et al. Genome-wide association study of prostate cancer identifies a second locus at 8q24. Nature Genetics. Online April 1, 2007. -------------------------------------------------------------------------------- CONTACT: NCI Of...

The Past, Present and Future of HLA Typing

...trast, the Class II proteins, which associate with and present exogenous antigens to CD4+ T-cells, are expressed by the HLA DR, -DQ and DP loci. Each locus is highly polymorphic; for example, there appear to be 300+ alleles in the HLA-B or DRB1 loci. A clear understanding of the differences between HLA p...
Locus in Medical Products

B Locus High Res SSP UniTray®

Description: Our Class I Direct to High Res SSP kits provide high resolution typing of the entire locus with a single tray. Locus specific typing on a single tray reduces QC and testing costs while saving time. Straight from genomic DNA to high resolution results, no need for initial low resolution typing ...
Company:Dynal Biotech, LLC

A Locus High Res SSP UniTray®

Description: Our Class I Direct to High Res SSP kits provide high resolution typing of the entire locus with a single tray. Locus specific typing on a single tray reduces QC and testing costs while saving time. Straight from genomic DNA to high resolution results, no need for initial low resolution typing ...
Company:Dynal Biotech, LLC

DPB1 SSP UniTray®

Description:...II Direct to High Res SSP kits provide high resolution typing of the entire locus with a single tray. locus specific typing on a single tray reduces QC and testing costs while saving ...
Company:Dynal Biotech, LLC

DQB1 SSP UniTray®

Description:...II Direct to High Res SSP kits provide high resolution typing of the entire locus with a single tray. locus specific typing on a single tray reduces QC and testing costs while saving ...
Company:Dynal Biotech, LLC

DQA1 SSP UniTray®

Description:...II Direct to High Res SSP kits provide high resolution typing of the entire locus with a single tray. locus specific typing on a single tray reduces QC and testing costs while saving ...
Company:Dynal Biotech, LLC

DRB96 SSP UniTray

Description:...II Direct to High Res SSP kits provide high resolution typing of the entire locus with a single tray. locus specific typing on a single tray reduces QC and testing costs while saving ...
Company:Dynal Biotech, LLC
Locus in Medical Definition

Autoimmune regulator

... Entrez 326 HUGO 360 OMIM *607358 RefSeq NM_000383.1 UniProt CAA08759 Other data locus Chr. 21 q22.3 The Autoimmune Regulator, abbreviated AIRE , is a human gene which is expressed in the thymus . It causes transcriptio...
Locus in Medical Dictionary

Pseudoxanthoma Elasticum

...tures were consistent with pseudoxanthoma elasticum . ... Pseudoxanthoma elasticum , or Gronblad-Strandberg syndrome, is a systemic, ... The locus of pseudoxanthoma elasticum has been mapped to an approximately 500-kb ... National Association for Pseudoxanthoma Elasticum (NAPE) PiXiE ...

Pedal

...l in Wiktionary, ... pedal curve ( ′pedəl ′kərv ) ( mathematics ) The pedal curve of a given curve C with respect to a fixed point P is the locus of the foot of the Definition of pedal from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and wor...

Muscular dystrophy

...LAR DYSTROPHY . Age of onset: Teens or early adulthood ... Duchenne muscular dystrophy is caused by a mutation of the dystrophin gene at locus Xp21. ... United Parent Project Muscular Dystrophy : United Parent Projects ... Information about neuromuscular conditions, facts, current rese...

Albinism

... has albinism ? ... The Albinism Database is edited by William Oetting (Institute of Human Genetics, ... The Albinism Database is part of the locus Specific Mutation Databases of the ... Albinism refers to a group of related conditions. ... Albinism results when the body is unable to produ...
Locus in Biological News

Mapping the genetic locus for triglycerides

Researchers have mapped out a region on human chromosome 1 that contributes to genetically elevated blood triglyceride levels, a major risk factor for heart disease. Triglycerides (TG), the main form of dietary fat, continuously circulate in the blood, but if their concentration elevates the r...

UBC researchers help push for standard DNA barcodes for plants

...ntre for Plant Research, and the Department of Botany. "Particular research projects with special needs could augment the system by adding a third DNA locus to their barcode if required." Theoretically, any DNA barcoding standard would have to accommodate over 400,000 species of plants, and would be a k...

Did the North Atlantic fisheries collapse due to fisheries-induced evolution?

...ors reports steep changes in the frequency of genotypes at a single genetic locus with depth: a gradient of nearly one half percent drop in frequency per meter. The genotypes at the locus are directly related to behavioral types that select deep vs shallow water ...

Study finds genetic links to age of first menstrual period and menopause

... collaboration of the WGHS and the NHS represents a great example of how large cohorts with genome-wide data can complement each other. While only one locus reached near genome-wide significance in the NHS alone, the meta-analysis of combined data had much more statistical power and revealed a total of two...

Genetic irregularities linked to higher risk of COPD among smokers

...reinforcing the notion that these variants influence risk independent of smoking behavior. The findings represent the discovery of the first major locus contributing to COPD in the general population. While Goldstein says the discovery may well open new therapeutic windows, it may also prompt clinicia...

Easton honored with inaugural AACR Outstanding Investigator Award in Breast Cancer Research

...hromosome which impact breast cancer susceptibility, none of which had previously been associated with breast cancer: FGFR2, TNRC9, MAP3K1, LSP1 and a locus on 8q. Subsequently, he demonstrated how variations in these loci are associated with increased risk of breast cancer in BRCA mutation carriers. These...
Locus in Biological Technology

China Medical Technologies Receives SFDA Approval for Its Bladder Cancer FISH Probe

...ion and monitoring the course of bladder cancer. It is designed to detect and identify whether aneuploidy for chromosomes 3, 7, 17 and loss of the p16 locus are present in the human bladder cells. A number of hospitals in China have applied the Probe for diagnosing patients with hematuria and have diagnose...

Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

...the sequence context of the mutation. The library can be sequenced directly via standard or massively parallel systems, queried at any desired genetic locus by PCR amplification or archived for subsequent multi-query analysis. About Transgenomic Transgenomic is a global biotechnology compan...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

...the sequence context of the mutation. The library can be sequenced directly via standard or massively parallel systems, queried at any desired genetic locus by PCR amplification or archived for subsequent multi-query analysis. About SURVEYOR SURVEYOR Mutation Detection Kits and the SURVEYOR Check-It Ki...

National Nanotechnology Initiative releases new strategic plan

...oordinate Federal nanotechnology R&D. The NNI provides a vision of the long-term opportunities and benefits of nanotechnology. By serving as a central locus for communication, cooperation, and collaboration for all Federal agencies that wish to participate, the NNI brings together the expertise needed to g...

The Changing Face of Work (and Play)

...t seat of your car, the family room of your home, the Red Carpet Room at the airport, or Aisle 6 of the Safeway. When work is about communicating, the locus of work is at the ends of the connection, which for many purposes can be anywhere. In time, Always On People will change the nature of the working ...

Device Computing: The Wave Is Building

...st incorporate this new modality into the desktop, server, and networked environments from which it came. It is driving change in the structure and locus of the workday. No longer are we tied to our desks -- or for that matter to the traditional workday. It is driving change in behaviors, attitudes,...
Locus in Biological Products

Custom Oligo Assay Single Locus 1920 samples from Illumina

Description: ...
Company:

Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

Description:... The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression....ain of p14^ARF^ and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53...
Company:Lab Vision

SNP Scoring Service from Polymorphic DNA Technologies, Inc.

Description:...lidated Sanger dideoxy DNA sequencing, the gold standard in DNA analysis. We use high throughput capillary sequencing instrumentation. The polymorphic locus can be confirmed by sequencing in both directions. The use of DNA sequencing also provides sequence context information, further confirming the locati...
Company:Polymorphic DNA Technologies, Inc.
Locus in Biological Definition

Locus

The word locus (plural loci ) is Latin for "place". In biology and evolutionary computation , a locus is the position of a gene (or other significant sequence) on a chromosome . A locus can be occupied by any of the alleles of the gene. Diploid or polyploid cells are ei...

Allele

... An allele is any one of a number of alternative forms of the same gene occupying a given locus (position) on a chromosome . An example is the gene for blossom color in many species of flower - a single gene controls the color of the petals, ...

Allele frequency

...lele frequency is defined as follows: Given a) a particular chromosome locus , b) a gene occupying that locus, c) a population of individuals carrying... Example If there are ten individuals in a population and at a given locus there are two possible alleles, A and a , then if the genotypes of the...

Bacterial conjugation

...Among other genetic information, the F-plasmid carries a tra and a trb locus , which together are about 33 kb long and consist of about 40 genes . The tra locus includes the pilin gene and controlling genes, which together form pili ...

Chromosomal crossover

...rmally two homologous instances of the same chromosome, break and then reconnect but to the different end piece. If they break at the same place or locus in the sequence of base pairs, the result is an exchange of genes . This outcome is the normal way for crossover to occur. If they break at slightl...

Evolutionary developmental biology

...llows fixation of a particular cellular or biochemical function at one locus , leaving the duplicated locus free to fulfill a new function. In contrast, changes in gene regulation , ...
Locus in Biological Dictionary

Locus

Locus (mathematics), the set of points satisfying a particular condition, often ... Retrieved from "http://en.wikipedia.org /wiki/ Locus " ... In the fields of genetics and evolutionary computation, a locus (plural loci) is a fixed position on a chromosome such as the pos...

VNTR

...etic profiles of any two individuals (other than ... molecular weight of a given VNTR by the molecular weight of the. repeated sequence. ... Multi locus VNTR Analysis (MLVA) is a method to sub-type microbial isolates ... A VNTR typically exhibits a large range of copy numbers, even among highly ......

True-breeding

... a true breeding strain, we are in fact trying to make all ... A true - breeding population is one that contains only one allele for the locus in ... act of selection will create a true - breeding pink population (Figure 9) ... Find Breeding's True Value and search our online di...

Splicing

...he coupling of alternative splicing with NMD is intriguing and could provide a ... Alternative splicing is the process whereby a single genetic locus can be ... Compare prices for Splicing . Become.com searches billions of web pages to find the most relevant information on splicing , and allow...

Single locus probe

... A single locus probe is a DNA or RNA sequence that is able t....e. ... has been developed for the first single locus probe , the radioactivity on the ... DNA Fore...s Problem Set 2. Problem 5: Alleles in a single - locus probe ... individual with a specific single -...

Revertant

...otic Gene Conversion ... Revertant flagellin is antigenically distinct from wild-type ... revertant flagellin (referred to as FlaAB to dis ... locus of each revertant is lacking a ... When reversion was compared, the revertant proportion (RP), defined as the ... The transmission of these r...
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