Transplanted fatty livers associated with worse prognosis for patients with HCV
A new study suggests that patients with hepatitis C (HCV) who need a liver transplant should not receive an organ with high levels of fatty deposits (a.k.a. hepatic steatosis). HCV recurrence was more frequent and earlier among those transplanted with such livers. These findings are in the January...
New System Improves Distribution of Donated Livers
Gains reported for blacks, but women lagging behind men, study finds
TUESDAY, Nov. 25 (HealthDay News) -- Thanks to a new liver transplant allocation system that gives preference to patients with the greatest need, rather than time spent on a waiting list, racial disparities among thos...
Artificial liver may extend lives
...stically higher in the ELAD group compared with the control.
have been attempted since the 1960s. Because previous designs didn't use hu...ng those with chronic liver diseases like hepatitis, as well as those whose livers
were damaged, such as by taking too much acetaminophen pain medicine. If no...
Some donor factors affect outcomes for HCV-positive liver transplant recipients
... as fatty liver disease, which is common in overweight individuals.
Researchers led by Patrizia Burra of Padova, Italy examined the impact of donor livers
with steatosis on recipients with and without HCV. They included 116 consecutive liver transplants on 56 HCV-positive and 60 HCV-negative recipients a...
Majority of doctors skeptical of organ transplantation practices in China
...rgan obtained in an unsafe or unethical manner.
In 2005, the World Health Organization (WHO) reported the transplantation of 66,000 kidneys, 21,000 livers
and 6,000 hearts. Approximately 10 percent of these procedures occurred via transplant tourism. Leading destination countries for transplant tourism i...
Transplanted liver cells function in older animals but do not proliferate as much as in younger ones
...odels, raising hopes that use of cells could overcome the shortage of donor livers
and the problems of surgery, but the procedure has not been as successful i...0 years in humans). These healthy liver cells were then implanted into the livers
of young rats (10 weeks, the equivalent of young adulthood) and "senescent"...
Fish in U.S. Rivers Tainted With Common Medications
...e diphenhydramine (Benadryl), an anticonvulsant and two types of antidepressants were among the seven types of pharmaceuticals found in the tissue and livers
of fish from waterways in or near Chicago, Dallas, Philadelphia, Phoenix and Orlando, Fla. Each river is considered "effluent-dominated," because they...
Researchers Use Gene to End High Blood Sugar in Mice
...ethod might someday help people awaits further study
WEDNESDAY, March 18 (HealthDay News) -- Delivering a gene called neurogenin3 into the livers
of diabetic mice activates adult stem cells that promote steady insulin production, say researchers at the Baylor College of Medicine in Houston.
American Chemical Society's Weekly PressPac -- March 4, 2009
... mannose or galactosamine, two sugars that accumulate selectively in the liver. The sugar-coated dots became three times more concentrated in the mice livers
than the regular dots, demonstrating their higher specificity, the researchers say. - MTS.
"In Vitro Imaging and in Vivo Liver targetin...
Technique may help stem cells generate solid organs, Stanford study shows
... hope to encourage the cells to become entire transplantable organs such as livers
Gurtner, who is also a member of Stanford's Cancer Center, ...ssels to a modified piece of equipment called a bioreactor designed to keep livers
and kidneys healthy outside the body. The modified bioreactor pumps an oxyg...
Livers in Medical Technology
Livers in Biological News
Resveratrol prevents fat accumulation in livers of 'alcoholic' mice
BETHESDA, Md. (Oct. 14, 2008) − The accumulation of fat in the liver as a result of chronic alcohol consumption could be prevented by consuming resveratrol, according to a new study with mice. The research found that resveratrol reduced the amount of fat produced in the liver of mice fed alc...
MIT: 'Micro' livers could aid drug screening
CAMBRIDGE, Mass.--MIT researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could allow better screening of new drugs that are potentially harmful to the liver and reduce the costs associated with their development.
Scientists link immune system's natural killer cells to infant liver disease
...still immature infant immune system, researchers in this study analyzed the livers
of infants diagnosed with biliary atresia. They discovered elevated populat...ound that active NK cells were the most abundant cells populating the mouse livers
and bile ducts at the time of obstruction. Furthermore, they discovered tha...
Scientists find a biological 'fountain of youth' in new world bat caves
...nter, San Antonio, Texas and the senior researcher involved in the work.
Asish and colleagues made their discovery by extracting proteins from the livers
of two long-lived bat species (Tadarida brasiliensis and Myotis velifer) and young adult mice and exposed them to chemicals known to cause protein mis...
The battle for CRTC2: How obesity increases the risk for diabetes
...goes on, which slows down the production of proteins," explains Montminy. "This process, which is known as ER stress response, is abnormally active in livers
of obese individuals, where it contributes to the development of hyperglycemia, or high blood glucose levels. We asked whether chronic ER stress in ob...
Liver disease 'shrunk' by blood-pressure drug
...t, the Newcastle University researchers discovered a biological marker, NF-kB, was crucial for the activities of scar-forming cells.
Tests on their livers
revealed that, before treatment with losartan, half of the patients had a high level of the biomarker NF-kB. After treatment, the level fell indicatin...
A biological basis for the 8-hour workday?
... see exactly this are the 12-hour and the 8-hour cycles.
To uncover these shorter oscillations, the Hogenesch and Salk team isolated RNA from the livers
of mice every hour for 48 hours. Microarray analysis showed that more than 3,000 genes were expressed on a circadian rhythm which account for approxi...
New link in liver cancer
... cancer. A new study by researchers at the National Institutes of Health and Osaka University reveals how one protein helps decide the fate of damaged livers
in mice. The study will be published online on March 30th in the Journal of Experimental Medicine .
Liver cells rely on signals triggered by growt...
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
...imals eating the high-fat diet, the fat tissue and livers
in the normal mice were larger than those in the PKC beta-deficient mice, as well. The livers
of the normal mice were on average about 50 percent larger than the livers
in mice lacking the gene. And the white fat tissue...
JCI online early table of contents: Jan. 19, 2009
...ernal diet is most important for the obesity-related health of a developing fetus.
TITLE: Maternal high-fat diet triggers lipotoxicity in the fetal livers
of nonhuman primates
Kevin L. Grove
Oregon Health and Science University, Beaverton, Oregon, USA.
Phone: (503) 690-5380; Fax: (5...
Livers in Biological Technology
Transplanted cells may hold the key to curing hemophilia A, Einstein scientists report
...e by the hepatocytescells that perform many of the livers
functions and comprise most of its bulk. But our r...ial endothelial cells that line the sinusoids, the livers
blood-filled spaces. We did this study to confirm ...her the liver endothelial cellsisolated from donor livers
and then injected into a vein leading into the liv...
Governors business-plan contest has a surprise ending
...ological tissues. The current system evolved out of bomb detector technology and the company is now using it to detect tumors. Initial tests using cow livers
and oatmeal plug tumors validated the technologys ability to detect foreign bodies in biological tissues.
Last August, NovaScan became the first co...