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Liposomes in Medical News

Scientists Test New Way to Get Drugs to Cancer Cells

... can be manipulated to control how long they remain in the bloodstream. Johns Hopkins University researchers attached cancer-specific antibodies to liposomes to create immunoliposomes that travel through the bloodstream and seek out tumors. When they come in contact with tumors, the immunoliposomes deliver ...

Potential for noninvasive brain tumor treatment

...this system in conjunction with chemotherapy drugs encased in heat-sensitive microbubbles called liposomes. "Physicians would inject drug-carrying liposomes into a patient's bloodstream, and then insert a catheter via a blood vessel to the site of the brain tumor," said Carl Herickhoff, fourth-year graduat...

Capsules encapsulated

...andte Chemie , these are polymer capsules in which liposomes have been embedded to form subcompartments. Cur...nsport of small molecules because they can escape. liposomes are good at protecting small drug molecules; howev...ontains building blocks modified with cholesterol. liposomes that have been loaded with an enzyme can be secure...

Transave Completes Enrollment in Arikace(TM) Phase II Bronchiectasis Study

...izing systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 micron), neutrally-charged liposomes that enable penetration of the biofilm and are highly efficient, with a very low lipid-to-drug ratio (0.65). Arikace can be delivered through ne...

Nanomedicine system engineered to enhance therapeutic effects of injectable drugs

...began with tiny drug-encapsulated fat bubbles called liposomes, now commonly used in cancer clinics worldwide. Targeting molecules were later added to liposomes and other nanovectors to assist in directing them to diseased cells, Ferrari said. Getting intravenous agents to their intended targets is no easy ...

AGI Dermatics Data Indicates 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1, Increases Collagen and Enhances DNA Repair

...oxo-guanine DNA glycosylase (OGG1) encapsulated in liposomes is an effective agent in treating photodamaged ski...hese studies demonstrate that OGG1 encapsulated in liposomes has a profound effect on repairing the cellular da...ermis. Treatment of ssUV-irradiated NHEK with OGG1 liposomes for 24 hours suppressed the induction of MMP-1 sec...

ImmunoVaccine Technologies Receives $3 Million From ACOA

...accine Technologies Inc. (IVT) has developed a breakthrough vaccine-enhancement technology - the VacciMax(R) platform. It is comprised of a mixture of liposomes and adjuvants. The VacciMax(R) platform is able to stimulate an earlier, more powerful, long lasting immune response that could provide a new way to t...

Collegiate Inventors Competition announces winners for 2007

...ighting drug in lipid particles and injected those liposomes into a subject. The germinated bacterial spores also secrete a protein that makes liposomes fall apart when the drug-containing liposomes are in the proximity of the tumors, and the drug i...

Collegiate Inventors Competition(R) Announces Winners for 2007

...ighting drug in lipid particles and injected those liposomes into a subject. The germinated bacterial spores also secrete a protein that makes liposomes fall apart when the drug-containing liposomes are in the proximity of the tumors, and the drug i...

Smart insulin nanostructures pass feasibility test, UT study reports

...protein named concanavalin A (Con A) and bundles of tiny fat bubbles called liposomes that are loaded with insulin. Con A binds insulin-containing liposomes that are coated with sugars, to each other, to form the inhaled particles, ...
Liposomes in Medical Technology

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

...ntis Pharma explains: "Once at the site of infection, tobramycin-containing liposomes seem to fuse with the cell membrane of the pathogen. In this way, the entir...interaction between tobramycin and the microbial cell is triggered when the liposomes undergo a fusion process with the outer membrane of the bacterial cell wall...

Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM)

...hile minimizing systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 micron), neutral liposomes that enable penetration of the biofilm and are highly efficient, with a very low lipid-to-drug ratio (0.65). ARIKACE can be delivered through nebuli...

PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine A and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans

... It is free of any irritating organic solvents and consists of unilamellar liposomes of about 100nm. The unilamellar liposomes are obtained via a high-pressure homogenization process using standard phar...

Cystic Fibrosis - Orphan Drug Designation for Innovative Treatment Against Lung Infections by Axentis Pharma AG

...logy with the well-established generic drug tobramycin. Utilising synthetic liposomes containing tobramycin, a standard nebulizer delivers the drug directly to t...interaction between tobramycin and the microbial cell is triggered when the liposomes attach to the outer cell membrane. Tobramycin then leaches into the inner c...

Optigenex Inc. Signs New License and Distribution Agreement With Itochu Corporation of Japan

... sun, stress, environmental pollution and other toxins. In its standard bulk powder form, AC-11(R) supplement may be consumed orally or combined with liposomes and other delivery mechanisms for topical application on the skin. The increase in demand for AC-11(R)-based products follows the issuance of a r...

Hana Biosciences Announces New Positive Interim Efficacy Results in Pivotal rALLy Clinical Trial of Marqibo in Acute Lymphoblastic Leukemia

...ing pivotal rALLy clinical trial evaluating Marqibo(R) (vincristine sulfate liposomes injection) for the treatment of adult acute lymphoblastic leukemia (ALL) in...uation Agency in adult ALL. About Marqibo (R) (vincristine sulfate liposomes injection) Marqibo is a novel, targeted, Optisomal(TM) formulation of...

Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound

...the ongoing pivotal rALLy clinical trial of Marqibo(R) (vincristine sulfate liposomes injection) for the treatment of adult acute lymphoblastic leukemia (ALL) in...aluation Agency in adult ALL. About Marqibo(R) (vincristine sulfate liposomes injection) Marqibo is a novel, targeted, Optisomal(TM) formulation o...

Cystic Fibrosis Axentis Pharma Initiates Clinical Trial for Lung Infections

...ogy is based on the well characterised drug tobramycin. Utilising synthetic liposomes containing tobramycin, a standard nebulizer delivers the drug directly to t...interaction between tobramycin and the microbial cell is triggered when the liposomes attach to the outer cell membrane. Tobramycin then leaches into the inner c...

Transave Announces Positive Phase II Results for Once-Daily Arikace(TM) in the Treatment of Cystic Fibrosis Patients Who Have Pseudomonas Lung Infections

...tment. Arikace was designed with small (0.3 micrometers), neutrally-charged liposomes that enable penetration of the biofilm, which may be an important advantage...he lung that are formulated into small (0.3 micrometers), neutrally-charged liposomes that enable penetration of the biofilm and are highly efficient, with a ver...

Celator(R) Pharmaceuticals Successfully Uses Nanoparticles to Administer Hydrophobic Drug Combinations

...th the goal of improving clinical outcomes. To date, Celator has utilized liposomes to deliver synergistic drug combinations to treat cancer. Hydrophobic drugs...clitaxel are not amenable to this form of delivery because they detach from liposomes almost immediately after injection. Celator scientists reported that they w...
Liposomes in Medical Products

Murad® Firm and Tone Serum For Cellulite and Stretch Mark Management

Features:... and elasticity while masking imperfections helping reduce the appearance of cellulite by up to 69%*. Breakthrough serum containing encapsulated liposomes delivers active ingredients to skin, reducing the appearence of cellulite and stretch marks. Cayenne Pepper invigorates circulation within skin Ho...
Company:Murad, Inc.
Liposomes in Biological News

New cancer drug delivery system is effective and reversible

...o molecules that target receptors on cancer cells, liposomes can enter and dump their cancer-killing contents i...sts have spent more than a decade trying to direct liposomes to specific cancer cells, with limited success. A ...ing, however, and the process of attaching them to liposomes is difficult to control. Antibodies spur an immune...

Potential for non-invasive brain tumor treatment

...this system in conjunction with chemotherapy drugs encased in heat-sensitive microbubbles called liposomes. "Physicians would inject drug-carrying liposomes into a patient's bloodstream, and then insert a catheter via a blood vessel to the site of the brain tumor," said Carl Herickhoff, fourth-year graduat...

Nanotechnology holds promise for STD drug delivery

...While past work has focused on delivery of siRNAs with liposomes, bubble-like carriers made of phospholipids similar to those found in cell membranes, liposomes are potentially more toxic to the mucosal tissues and are unable to provide sustained release. In the current work, the researchers demonstrated that ...

Long-lasting nerve block could change pain management

...used specially designed fat-based particles called liposomes to package saxitoxin, a potent anesthetic, and pro...evaluated various formulations -- various types of liposomes containing saxitoxin with or without dexamethasone...t the action of encapsulated anesthetics. The best liposomes produced nerve blocks lasting two days if they con...

Scientists can predict nano drug outcome

...ast agents encapsulated in tiny fat bubbles called liposomes to determine if breast tumors in rodents could be breached by liposomes loaded with a cancer drug called liposomal doxorubicin. The liposomes were administered intravenously. When scientis...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

...sible for chemotherapy resistance. In collaboration with the University of the Basque Country and the Swiss firm Merk Serono International, a model in liposomes simulating the composition of the mitochondrial membrane was developed in order to check the effects of cholesterol on its fluidity and response to se...

Cells get sprayed

... way into the cell through a cell membrane that has been made porous, through treatment with electrical current or UV lasers, for example. Viruses and liposomes can be used as genetic transporters and the genetic material can be injected or shot into the cell with a particle gun. These methods all have the dis...

Nanoengineers mine tiny diamonds for drug delivery

...nearly five times the amount of drug carried by conventional materials. liposomes and polymersomes, both spherical nanoparticles, currently are used for drug...ls, even healthy cells that are encountered as they travel to their target. liposomes and polymersomes also are very large, about 100 times the size of nanodiamo...

Sandia researchers discover way to see how a drug attaches to a cell

...rous, nanoscopic, hollow platinum spheres by using liposomes as blueprints. (Liposomes are microscopic, fluid-f...a double layer of lipid (detergent) molecules. The liposomes are placed in a solution containing a platinum salt. When these liposomes are irradiated with light, photocatalysts located ...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

... cancer were treated for 3-5 weeks. They received liposomes that contained either the FAK siRNA, a control siRNA, or were empty. Some mice received siRNA liposomes plus the chemotherapy docetaxel. Mice receivin...an advantage over positively or negatively charged liposomes when it comes to binding with and penetrating cell...
Liposomes in Biological Technology

Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria

...ile minimizing systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 micron), neutral liposomes that enable penetration of the biofilm and are highly efficient, with a very low lipid-to-drug ratio (0.65). ARIKACE can be delivered through nebul...

Burrill & Company Invests in Taiwan Liposome Company

... and infectious diseases. TLC founded and led by renowned scientist, Dr. Keelung Hong, who has over 30 years of research and development experience in liposomes with over 100 publications. TLC also has a team of researchers, management, production experts, and advisors who are building the company into an orga...

Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress

...up to 70 days (saline-treated controls all died by Day 42). In several additional experiments, investigators confirmed the presence of intact CPX-351 liposomes inside the leukemia cells, allowing the release of the synergistic 5:1 molar ratio of the active agents intracellularly, and demonstrated that CPX-351...

ImmunoVaccine Technologies Partners with FIT Biotech to advance a therapeutic HIV vaccine

...ch demonstrates that DepoVax(TM) effectively delivers DNA plasmids into draining lymph nodes with as little as one dose. The DepoVax(TM) platform uses liposomes to encapsulate a target antigen, like GTU(R) MultiHIV, and adjuvant. DepoVax(TM) also relies on a hydrophobic carrier to create a depot effect that si...

Chronic Lung Disease - Axentis Pharma Attracts Investment Interest

...d other respiratory diseases. In the case of Fluidosome(R) tobramycin, the interaction between tobramycin and the microbial cell is triggered when the liposomes attach to the outer cell membrane. Tobramycin then penetrates into the inner cell compartment of the microbial cell, which leads to rapid cell death. ...

Transave, Inc. Secures $12.5 Million in New Financing

... systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 micrometers), neutrally-charged liposomes that enable biofilm penetration and are highly efficient, with very low lipid-to-drug ratio (0.65). Arikace can be effectively delivered through nebul...

ImmunoVaccine Technologies Broadens Its Patent Protection to Japan

...s in the world; including the US, Europe, Canada, Australia and Japan. The company's VacciMax(R) technology is based on a novel approach to the use of liposomes in an oil emulsion. IVT has discovered that liposomes, stabilized in the VacciMax(R) technology, significantly enhance antibody production, creating a...

Transave, Inc. Raises $35 Million Through Series D Convertible Preferred Stock Financing

...minimizing systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 mm) neutrally charged liposomes that enable biofilm penetration and are highly efficient with very low lipid to drug ratio (0.6). ARIKACE can be effectively delivered through nebuliz...

Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients

...es. The study evaluated the ability of the ARIKACE liposomes to pass through patient mucus (sputum) ex vivo and...el to microscopically visualize the penetration of liposomes into Pseudomonas biofilms. Separate studies show...s, the investigators were able to see that Arikace liposomes effectively penetrated and lodged into the spaces ...

Cystic Fibrosis: License Agreement Boosts Development of Therapy Against Lung Infections

...uke Tokoro, President and CEO of aRigen Pharmaceuticals, Inc. adds: "ARB-CF0223 is based on a well-characterised drug, Tobramycin. Utilising synthetic liposomes that contain Tobramycin, a proprietary nebulizer delivers the drug directly to the endobronchial sites of infection in Cystic Fibrosis patients. This ...
Liposomes in Biological Definition

Diffusion

...anck equation Gel permeation chromatography Hydrothermal circulation Isotope separation Kirkendall effect Laminar flow liposomes List of biochemistry topics List of biology topics List of physics topics Mass transfer Materials science Mechanical v...

Phospholipid

...e up against each other, and forms a membrane with hydrophilic heads on both sides extending out into the water. This allows it spontaneously to form liposomes , or small lipid vesicles , which can then be used to transport materials into living organisms and study diffusion rates into or out of a cell membr...
Liposomes in Biological Dictionary

Liposomes

A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. www.avantilipids.com/images / Liposomes /vesicle.jpg - endocytosed phagocytosed - adjuvants. Zeta Potential....
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