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Liposome in Medical News

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

...y, the U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) recommended that the combination of DOXIL(R) (doxorubicin HCI liposome injection) and docetaxel did not provide a sufficient benefit-risk profile for the treatment of women with locally advanced or metastatic breast c...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding Trabectedin for Relapsed Ovarian Cancer

...ation (FDA) Oncologic Drugs Advisory Committee (ODAC) recommended that the combination of trabectedin when administered with DOXIL(R) (doxorubicin HCI liposome injection) did not provide a sufficient benefit-risk profile for the treatment of relapsed ovarian cancer. Ovarian cancer is difficult to tre...

Potential for noninvasive brain tumor treatment

...d then direct a higher-power beam to generate heat at the site, melting the liposome shells and releasing the chemotherapy directly to the tumor. "The temper...scopes for real-time imaging of tissues throughout the body. Much of the liposome research was carried out at Duke by David Needham, professor of mechanical ...

Capsules encapsulated

...yme in a functional state. By means of the enzymatic reaction, which causes a color change of the solution, it was possible to determine the number of liposome compartments to be about 8000 per polymer capsule. "Because the capsosomes are biodegradable and nontoxic", says Brigitte Staedler, a senior resear...

Celator(R) Pharmaceuticals Presents New Data on CPX-351 And CPX-1 at the American Association for Cancer Research

...nimal studies of CPX-351 (Cytarabine:Daunorubicin) liposome Injection in consolidation treatment for leukemia and of CPX-1 (Irinotecan HCl:Floxuridine) liposome Injection in combination with biological agents fo...di P, Harasym T, Dos Santos N, et. al. CPX-351, a liposome formulation containing a synergistic 5:1 molar rat...

Transave Completes Enrollment in Arikace(TM) Phase II Bronchiectasis Study

...enclosed in nanocapsules of lipid called liposomes. This advanced pulmonary liposome technology prolongs the release of amikacin in the lungs while minimizing s... developing antibiotic therapy delivered via proprietary advanced pulmonary liposome technology in areas of high unmet need in lung diseases. The Transave te...

Celator(R) Pharmaceuticals Enrolls First Patient in Its Phase 2 Study of CPX-351 in Acute Myeloid Leukemia in First Relapse

...nounced that the first patient has been treated in its Phase 2 multicenter, randomized, open-label clinical trial of CPX-351 (Cytarabine:Daunorubicin) liposome Injection versus intensive salvage therapy in adult patients (up to 60 years old) with acute myeloid leukemia in first relapse. As previously announc...

Data on VELCADE(R) (Bortezomib) for Injection Based Therapies to be Presented at the International Myeloma Workshop

...day rest period in 1163 patients with previously treated multiple myeloma (N=1008, not including the Phase III, VELCADE plus DOXIL(R) [doxorubicin HCl liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulated. In these studies, the safety profile of VELCADE w...

Better MRI scans of cancers made possible by TU Delft

... of a tumour cell. Mice Finally, Djanashvili has managed to incorporate the compound into so-called thermosensitive liposomes. A thermosensitive liposome forms a sort of protective ball, which opens (releasing the active compound) only when heated to roughly 42 degrees. This means that, by localised hea...

Celator(R) Pharmaceuticals Presents Phase 1 Results With CPX-351 in Patients With Advanced Leukemia at the American Society of Hematology Meeting

...NCETON, N.J., Dec. 9 /PRNewswire/ -- Celator Pharmaceuticals today announced that a Phase 1 dose escalating study of CPX-351 (cytarabine:daunorubicin) liposome Injection established the recommended dose for Phase 2 studies and confirmed preliminary observations of safety, enhanced pharmacokinetics and promisi...
Liposome in Medical Technology

Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM)

...the drug in nanocapsules of lipid called liposomes. This advanced pulmonary liposome technology prolongs the release of amikacin in the lungs while minimizing s... developing antibiotic therapy delivered via proprietary advanced pulmonary liposome technology in areas of high unmet need in lung diseases. The Transave te...

The Leukemia & Lymphoma Society and Celator Pharmaceuticals Announce Partnership to Accelerate Development of CPX-351 for AML

...armaceuticals, Inc. today announced a partnership to support Phase 2 development of Celator's lead product candidate CPX-351 (Cytarabine:Daunorubicin) liposome Injection for treatment of adults with acute myeloid leukemia (AML). Through the partnership, LLS will provide $3.7 million to support Celator's ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

...d a significant improvement in time to disease progression (TTP) and overall response rates after receiving a combination of DOXIL(R) (doxorubicin HCl liposome injection) and docetaxel as compared to docetaxel alone. Results from this randomized, parallel-group, open-label, multi-center study were pre...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

...day rest period in 1163 patients with previously treated multiple myeloma (N=1008, not including the Phase III, VELCADE plus DOXIL(R) [doxorubicin HCl liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulated. In these studies, the safety profile of VELCADE w...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

...day rest period in 1163 patients with previously treated multiple myeloma (N=1008, not including the Phase III, VELCADE plus DOXIL(R) [doxorubicin HCl liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulated. In these studies, the safety profile of VELCADE w...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

...day rest period in 1163 patients with previously treated multiple myeloma (N=1008, not including the Phase III, VELCADE plus DOXIL(R) [doxorubicin HCl liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulated. In these studies, the safety profile of VELCADE w...

Celator(R) Pharmaceuticals Announces Enrollment of First Patient in Phase 2 Study with CPX-351

...or Pharmaceuticals today announced that the first patient has been treated in a randomized Phase 2 clinical study of CPX-351 (Cytarabine:Daunorubicin) liposome Injection in patients with newly diagnosed acute myeloid leukemia (AML). The first patient was enrolled by Eric Feldman, MD at the Weill Med...

Celator Pharmaceuticals Receives Orphan Drug Designation for Anticancer Agent CPX-351

...harmaceuticals today announced that the U.S. Food & Drug Administration (FDA) has granted orphan drug designation to CPX-351 (Cytarabine:Daunorubicin) liposome Injection for the treatment of Acute Myeloid Leukemia (AML). Celator is currently preparing to conduct two randomized Phase 2 studies with CPX-351. ...

Sunesis Pharmaceuticals Presents Updated Clinical Data From Ongoing Phase 2 Trial of Voreloxin (Formerly SNS-595) in Ovarian Cancer Patients at the 44th ASCO Annual Meeting

...in the trial have previously failed treatment with platinum-containing regimens, and 26 patients have also failed prior treatment with doxorubicin HCl liposome injection (Doxil(R)). Both platinum-resistant and Doxil-resistant patients in the Phase 2 clinical trial have responded to voreloxin therapy. In Mar...

Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting

... ATLANTA, Dec. 7 /PRNewswire/ -- Ortho Biotech today announced that 12 clinical studies of DOXIL(R) (doxorubicin HCl pegylated liposome injection) will be presented at the 49th annual meeting of the American Society of Hematology (ASH) at the Georgia World Congress Center on December 8...
Liposome in Biological News

New cancer drug delivery system is effective and reversible

...mon approach involves attaching an antibody to the liposome membrane. Ideally the antibody will bind to a cancer cell receptor so that it can deliver the liposome and the cancer drug into the cell. Developin...an effective method for attaching the aptamer to a liposome loaded with cisplatin, a drug that effectively kil...

Potential for non-invasive brain tumor treatment

...d then direct a higher-power beam to generate heat at the site, melting the liposome shells and releasing the chemotherapy directly to the tumor. "The temper...scopes for real-time imaging of tissues throughout the body. Much of the liposome research was carried out at Duke by David Needham, professor of mechanical ...

Scientists can predict nano drug outcome

...wrote. A nanometer is a billionth of a meter and a liposome is about 100 nanometers. Nano drugs for cancer ...the size of these miniaturized drug carriers. If a liposome with contrast agents can penetrate a tumor and be detected by X-rays, there is a good chance that a liposome with anti-cancer agents can enter the tumor, too. ...

TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer

...packaging the gene-silencing strips of RNA in a fatty nanoparticle called a liposome and delivering it intravenously. TG2 is the third protein they have target...ophagy. In a separate paper, they showed that silencing TG2 with the siRNA liposome reduced tumor size, slowed metastasis and enhanced the effect of gemcitabin...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

...a large dose of radiation to the entire body. In the study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation. The researchers found that in a control group of mice that received an initi...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

...large dose of radiation to the entire body. In the study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation. The researchers found that in a control group of mice that received an initi...

Sandia researchers discover way to see how a drug attaches to a cell

...up grew large continuous nanosheets of platinum on liposome templates, forming foam-like platinum nanostructur...ge in the shape of the spherical liposome. The liposome that Shelnutt and his team used as a blueprint con...nd thus the number of platinum clumps - within the liposome double layer is very high," Shelnutt says. "The re...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

...ncer cells survive and spread and rolled it into a liposome -- a lipid ball so small that its dimensions are m...py docetaxel. Mice receiving the FAK-silencing liposome had reductions in mean tumor weight ranging from 4...n the control groups. Combining the FAK-silencing liposome with docetaxel boosted tumor weight reduction to t...

Scientists design potent anthrax toxin inhibitor

...in at multiple sites and is orders of magnitude more potent than an inhibitor that binds at a single site. The multiple peptides on the functionalized liposome are arranged with the same average spacing as the binding sites of the PA molecule, which permits a firmer bond between the two, explains Dr. Kane. Wh...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...ocomplex" consisting of a microscopic, lipid-based liposome and an antibody along with gene therapy is enterin...ocomplex" consisting of a microscopic, lipid-based liposome and an antibody along with gene therapy in an appr...ashington, D.C., and her co-workers have created a liposome nanoparticle roughly one millionth of an inch acro...
Liposome in Biological Technology

Burrill & Company Invests in Taiwan Liposome Company

SAN FRANCISCO and TAIPEI, Taiwan, July 7 /PRNewswire/ -- US Venture Capital firm Burrill & Company has invested in Taiwan Liposome Company ( http://www.tlcbio.com ), a Taiwan based company with operations in Taipei and South San Francisco. Taiwan Liposome Company ("TLC"), is a specialty ph...

Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria

...he drug in nanocapsules of lipid called liposomes. This advanced pulmonary liposome technology prolongs the release of amikacin in the lungs while minimizing s... developing antibiotic therapy delivered via proprietary advanced pulmonary liposome technology in areas of high unmet need in lung diseases. The Transave te...

Chimerix, Inc. Appoints Kenneth I. Moch Chief Operating Officer

...therapy company that pioneered the collection and commercial application of cord blood stem cells. Prior, he was co-founder and Vice President of The liposome Company, Inc. Earlier in his career, Mr. Moch was a management consultant with McKinsey & Company, Inc. Mr. Moch holds a degree in biochemistry ...

Oncothyreon announces initiation of Phase 3 trial of Stimuvax in breast cancer

...: ONTY ) (TSX:ONY) (the "Company") today announced that Merck KGaA of Darmstadt, Germany, has initiated a global Phase 3 trial of Stimuvax(R) (BLP25 liposome vaccine, L-BLP25) in patients with hormone receptor-positive, locally advanced, recurrent or metastatic breast cancer. Stimuvax is an investigational ...

Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress

...vailability and tumor cell selectivity of CPX-351 (Cytarabine:Daunorubicin) liposome Injection in leukemia were presented at the 14th Congress of the European H...tive uptake of cytarabine (Cyt) and daunorubicin (Daun) mediated by CPX-351 liposome injection in the bone marrow compartment. EHA Abstract #383 ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...r SAU, Madrid, Spain; Johnson & Johnson, Raritan, NJ; Royal Marsden Hospital, Sutton, United Kingdom About DOXIL (R) (doxorubicin HCl liposome injection) DOXIL is indicated for the treatment of patients with ovarian cancer whose disease has progressed or recurred after prior platinum b...

Oncothyreon announces presentations at American Society of Clinical Oncology (ASCO) Annual Meeting

...are now available to the public online at the ASCO Web site, www.abstract.asco.org . Abstracts include: - "Long-term safety of BLP25 liposome vaccine (L-BLP25) in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC)" - Abstract No: 3055 Poster session: Develo...

Sopherion Therapeutics Announces Completion of Enrollment in Phase III Study of Myocet in Metastatic Breast Cancer

...ocet (TM) (Nonpegylated Liposomal Doxorubicin) Myocet is a liposome-encapsulated doxorubicin-citrate complex. By encapsulating doxorubicin in a liposome -- a manufactured, microscopic, vesicle consisting of discreet aqueous compartments surrounded by membranes composed of naturally occurring fats -- it...

Sopherion Therapeutics, LLC Announces Publication of Phase I/II Myocet(R) (Nonpegylated Liposomal Doxorubicin) Data in Advanced Breast Cancer Patients

... Myocet (TM) (Nonpegylated Liposomal Doxorubicin) Myocet is a liposome-encapsulated doxorubicin-citrate complex. By encapsulating doxorubicin in a liposome - a manufactured, microscopic, vesicle consisting of discreet aqueous compartments surrounded by membranes composed of naturally occurring fats - its ...

Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology

...ample of such diseases is cystic fibrosis (mucoviscidosis). The company is in final preparation to initiate a phase II clinical trial using tobramycin liposome formulation against lung infections in Cystic Fibrosis patients. About the patent families The inventions which have now been acquired by Axentis ...
Liposome in Biological Definition

Molecular biology

...lls, such as animal cells, is called transfection. Several different transfection techniques are available, including calcium phosphate transfection, liposome transfection , and proprietary transfection reagents such as Fugene. DNA can also be introduced into cells using viruses as a carrier. In such cases, ...
Liposome in Biological Dictionary

Vesicle

...id-filled cavity under the epidermis, commonly called a ... Information about vesicle in the free online English dictionary and encyclopedia. ... liposome - an artificially made microscopic vesicle into which nucleic acids can ... List of 18 disease causes of Vesicle , patient stories, diagnostic...

Phospholipid

...olecules into a bilayer in an ... Supplies GMP grade phospholipids for worldwide drug manufacturers and develops new types of phospholipids and liposome formulations. Compare Cheap Prices for Phospholipid Cell at NexTag.com. Shop for Bargain Sporting Goods, Toys, Collectibles, Car Parts, Food, and...

Liposomes

... A liposome is a tiny bubble (vesicle), made out of the same m...ctures called liposomes . ... The development of liposome technology offers the potential for many beneficial ... liposome n. An artificial microscopic vesicle consisting...
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