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Liposomal in Medical News

MDOUTLOOK(R) Quick Polls Report on Clinical Integration of Key Oncology Developments Following ASCO 2009

... Breast Cancer Susceptibility Gene (BRCA) deficiencies. Gynecological Cancers: Combination of carboplatin + pegylated liposomal doxorubicin will be the new standard-of-care for relapsed, platinum-sensitive ovarian cancer For advanced cervical cancer, the combination of ...

Telik Presents Results at ASCO From ASSIST-5 Trial of TELCYTA in Platinum Refractory and Resistant Ovarian Cancer

... Orlando, Florida, of results from the ASSIST-5 Phase 3 randomized, multinational study of TELCYTA(R) (canfosfamide HCl) in combination with pegylated liposomal doxorubicin (PLD) vs. PLD alone in second-line therapy in platinum refractory or resistant ovarian cancer. Study Design : Patients with platinu...

Celator(R) Pharmaceuticals Initiates Research Agreement With Cephalon, Inc.

... "Celator has developed unique capabilities in liposomal and nano-particle encapsulation," said Jeffry Vaug...utcomes. The company pipeline includes: CPX-351 (a liposomal formulation of cytarabine:daunorubicin), currently... in patients with acute myeloid leukemia; CPX-1 (a liposomal formulation of irinotecan:floxuridine), currently ...

Celator(R) Pharmaceuticals to Present at 2009 BIO International Convention

...utcomes. The company pipeline includes: CPX-351 (a liposomal formulation of cytarabine:daunorubicin), currently... in patients with acute myeloid leukemia; CPX-1 (a liposomal formulation of irinotecan:floxuridine), currently ...e 2 in patients with colorectal cancer; CPX-571 (a liposomal formulation of irinotecan:cisplatin), a preclinica...

Celator(R) Pharmaceuticals Presents New Data on CPX-351 And CPX-1 at the American Association for Cancer Research

...utcomes. The company pipeline includes: CPX-351 (a liposomal formulation of cytarabine:daunorubicin), currently... in patients with acute myeloid leukemia; CPX-1 (a liposomal formulation of irinotecan:floxuridine), currently ...e 2 in patients with colorectal cancer; CPX-571 (a liposomal formulation of irinotecan:cisplatin), a preclinica...

Transave Completes Enrollment in Arikace(TM) Phase II Bronchiectasis Study

...y PARI Pharma GmbH. The Investigational eFlow Nebulizer System uses eFlow Technology to enable highly efficient aerosolization of medication including liposomal formulations via a vibrating, perforated membrane that includes thousands of laser-drilled holes. Compared to other nebulization technologies, eFlow T...

Celator(R) Pharmaceuticals to Present at Future Leaders in the Biotech Industry Conference

...utcomes. The company pipeline includes: CPX-351 (a liposomal formulation of cytarabine:daunorubicin), currently... in patients with acute myeloid leukemia; CPX-1 (a liposomal formulation of irinotecan:floxuridine), currently ...e 2 in patients with colorectal cancer; CPX-571 (a liposomal formulation of irinotecan:cisplatin), a preclinica...

Celator(R) Pharmaceuticals Enrolls First Patient in Its Phase 2 Study of CPX-351 in Acute Myeloid Leukemia in First Relapse

...tcomes. The company pipeline includes: CPX-351 (a liposomal formulation of cytarabine: daunorubicin), currentl... in patients with acute myeloid leukemia; CPX-1 (a liposomal formulation of irinotecan:floxuridine), currently ...e 2 in patients with colorectal cancer; CPX-571 (a liposomal formulation of irinotecan:cisplatin), a preclinica...

Telik Announces Fourth Quarter and 2008 Year End Financial Results and 2009 Financial Guidance

...d commercialization of TELINTRA. In the fourth quarter, the top-line results from the ASSIST-5 trial of TELCYTA(R), in combination with pegylated liposomal doxorubicin (PDL) versus PDL alone, as second line therapy in platinum refractory, primary or secondary platinum resistant ovarian cancer were announc...

Celator(R) Pharmaceuticals To Present at Biotech Showcase 2009

...outcomes. The company pipeline includes: CPX-1 (a liposomal formulation of irinotecan:floxuridine), currently ...e 2 in patients with colorectal cancer; CPX-351 (a liposomal formulation of cytarabine:daunorubicin), currently...n patients with acute myeloid leukemia; CPX-571 (a liposomal formulation of irinotecan:cisplatin), a preclinica...
Liposomal in Medical Technology

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

ZURICH, July 16 /PRNewswire/ -- An innovative treatment for infections of the respiratory tract in cystic fibrosis patients has received a second orphan drug designation in the US only weeks after a first designation was granted. The recent designation relates to Burkholderia cepacia pathogens...

PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine A and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans

MONTEREY, Calif., June 2 /PRNewswire/ -- This month's Journal of Aerosol Medicine and Pulmonary Drug Delivery features positive Phase Ib clinical trial results for PARI Pharma's L-CsA, inhaled liposomal cyclosporine A. In May, PARI Pharma received Orphan Drug Designation from the Food and Drug Ad...

Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM)

...stem developed by PARI Pharma GmbH. The eFlow Nebulizer System uses eFlow Technology to enable highly efficient aerosolization of medication including liposomal formulations via a vibrating, perforated membrane that includes thousands of laser drilled holes. Compared to other nebulization technologies, eFlow T...

Cancer Treatment Centers of America(R) Studies Treatment That Aims Chemotherapy Directly at Ovarian Cancer Cells

...rred within six months of a first or second treatment with a platinum-based chemotherapy drug. Those eligible will be treated with Doxil(R) (pegylated liposomal doxorubicin), an approved drug used to treat ovarian cancer, or with EC145, which combines Doxil with folate (vitamin B-9). The PRECEDENT study...

Telik Announces Presentation at ASCO Annual Meeting

...al study of canfosfamide (TELCYTA(R), TLK286) in combination with pegylated liposomal doxorubicin (PLD) vs. PLD will be presented at the 45th annual meeting of t...ed phase III study of canfosfamide (C, TLK286) plus pegylated liposomal doxorubicin (PLD) versus PLD as second-line therapy in platin...

Cystic Fibrosis - Orphan Drug Designation for Innovative Treatment Against Lung Infections by Axentis Pharma AG

...the US Food and Drug Administration (FDA) has granted the orphan drug designation to its lead product candidate Fluidosomes-tobramycin. This drug is a liposomal formulation of tobramycin, an innovative treatment for infections of the respiratory tract in patients with cystic fibrosis that is delivered directly...

The Leukemia & Lymphoma Society and Celator Pharmaceuticals Announce Partnership to Accelerate Development of CPX-351 for AML

...utcomes. The company pipeline includes: CPX-351 (a liposomal formulation of cytarabine:daunorubicin), currently... in patients with acute myeloid leukemia; CPX-1 (a liposomal formulation of irinotecan:floxuridine), currently ...e 2 in patients with colorectal cancer; CPX-571 (a liposomal formulation of irinotecan:cisplatin), a preclinica...

Phase III Studies of EXPAREL(TM) (DepoBupivacaine) from Pacira Complete Enrollment

...tions of widely used medications by enhancing their dosing and/or administration profile. It achieves this by encapsulating the drug in multivesicular liposomal particles which then release the drug over a desired period of time without altering the drug molecule. DepoFoam is a proven technology that is alread...

Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Hernia Repair Presented at the Postgraduate Assembly in Anesthesiology (PGA)

...tions of widely used medications by enhancing their dosing and/or administration profile. It achieves this by encapsulating the drug in multivesicular liposomal particles which then release the drug over a desired period of time without altering the drug molecule. DepoFoam is a proven technology that is alread...

Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Total Knee Arthroplasty Presented at International College of Surgeons World Congress

...s of widely known and used drugs by enhancing their dosing and/or administration profile. It achieves this by encapsulating the drug in multivesicular liposomal particles which then release the drug over a desired period of time without altering the drug molecule. DepoFoam is a proven technology that is alread...
Liposomal in Biological News

REGiMMUNE presents enhanced efficacy data in preclinical transplantation models

...presented today in a poster titled "Donor-Specific Tolerance Induction by a liposomal Formulation of KRN7000 (RGI-2001) Alone and in Combination with Low-Dose Si... potently activates natural killer T (NKT) cells. RGI-2001 is a proprietary liposomal formulation of KRN7000. RGI-2001 monotherapy has shown to induce antigen-s...

Scientists can predict nano drug outcome

...ched by liposomes loaded with a cancer drug called liposomal doxorubicin. The liposomes were administered intra...s had not substantially penetrated the tumor. When liposomal doxorubicin was administered, it was associated wi...rate, suggesting a better therapeutic outcome with liposomal doxorubicin, the authors wrote. A nanometer is a b...

New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome

... For the study, a long-circulating nanometer-scale liposomal capsule filled with iodinated contrast agent was i...cted with a clinically approved chemotherapy drug, liposomal doxorubicin. Results showed that the chemother...s, provided an accurate prognosis of the effect of liposomal doxorubicin on tumor growth rate. "When we plot...

Promising new treatment option for women with recurrent ovarian cancer

... Combining the new drug trabectedin with pegylated liposomal doxorubicin provides clinical benefit to women wit...st-line therapy. Half the women received pegylated liposomal doxorubicin 30 mg/m2 over 60 min plus trabectedin ...rs every 3 weeks, the remainder received pegylated liposomal doxorubicin 50 mg/m2 alone every 4 weeks. The ...

Nanoparticles for delivery of prostate cancer treatment

...y, which is critical for effective cancer therapy. With the Prostate Foundation funding Garen will test the efficacy and safety of using targeted liposomal nanoparticle vectors ?lipid-covered, gene delivery packets ?to deliver the therapy in animal models of human metastatic prostate cancer. "While ...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

...e FAK, which are difficult to target with a drug, can be attacked with this liposomal siRNA approach, which penetrates deeply into the tumor," Sood said. Mi...essor of Molecular Therapeutics Gabriel Lopez-Berestein, M.D., an expert in liposomal therapeutics, cite at least two factors for the success of the anti-FAK lip...
Liposomal in Biological Technology

Sopherion Therapeutics, LLC Announces Publication of Phase I/II Myocet(R) (Nonpegylated Liposomal Doxorubicin) Data in Advanced Breast Cancer Patients

PRINCETON, N.J., Feb. 5 /PRNewswire/ -- Sopherion Therapeutics, LLC, a biopharmaceutical company focused on the development and commercialization of anti-cancer therapies, today announced the publication of data from a phase I/II study of nonpegylated liposomal doxorubicin (Myocet(R)) in the Janua...

Telik Announces Top-Line Results From Assist-5 Trial of Telcyta(R) in Combination With Pegylated Liposomal Doxorubicin in Platinum Refractory and Resistant Ovarian Cancer

PALO ALTO, Calif., Oct. 29 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK ) today announced top-line results from an interrupted Phase 3 randomized study of Telcyta (canfosfamide HCL) in combination with pegylated liposomal doxorubicin (PLD) versus PLD alone in second-line therapy in pla...

Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria

... PARI Pharma GmbH. The investigational eFlow Nebulizer System uses eFlow Technology to enable highly efficient aerosolization of medication including liposomal formulations via a vibrating, perforated membrane that includes thousands of laser drilled holes. Compared to other nebulization technologies, eFlow T...

Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress

...officer, Celator Pharmaceuticals. "Our nano-scale liposomal encapsulation maintains the desired 5:1 molar rati...ination. The further observation that circulating liposomal drug could be detected in the plasma up to Day 12,...utcomes. The company pipeline includes: CPX-351 (a liposomal formulation of cytarabine:daunorubicin), currently...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...e 1b trials of the thioredoxin inhibitor PX-12 in advanced cancer patients. Stimuvax Data concerning the long-term safety of Stimuvax (BLP25 liposomal vaccine) were presented by Dr. Charles Butts, Cross Cancer Institute, Edmonton, Alberta. Sixteen patients who received Stimuvax for between 2 and 8.2 ...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...tein reduction to outcomes in a trial of pegylated liposomal doxorubicin (PLD) plus bortezomib (B) versus B alo... phase III study of trabectedin (T) with pegylated liposomal doxorubicin (PLD) versus PLD alone (Abstract 5550...alysis in the OVA-301 phase III study of pegylated liposomal doxorubicin (PLD) compared with trabectedin and PL...

Sopherion Therapeutics Announces Completion of Enrollment in Phase III Study of Myocet in Metastatic Breast Cancer

...that it completed enrollment in its pivotal Phase III study of nonpegylated liposomal doxorubicin (Myocet(TM)) in metastatic HER-2-overexpressing breast cancer. ...the required period of follow-up." A bout Myocet (TM) (Nonpegylated liposomal Doxorubicin) Myocet is a liposome-encapsulated doxorubicin-citrate co...

Quest PharmaTech Announces Strategic Alliance with IntelligentNano to Develop Nanotechnology-Based Next Generation SL052

...al applications of Quest's proprietary SonoLight technology platform. Current SonoLight photosensitizer and sonosensitizer formulations are based upon liposomal drug delivery systems which target the drug to the desired sites of photodynamic or sonodynamic therapies. Quest intends to initiate a series of precl...

Sopherion Therapeutics Secures $55 Million in Series C Funding

...he company will use the funding to complete the pivotal Phase III clinical development program for its lead product candidate, Myocet(TM). Myocet is a liposomal formulation of doxorubicin designed to reduce the risk of cardiotoxicity while preserving antitumor efficacy. In January 2008, Zoticon Bioventure...

Chronic Lung Disease - Axentis Pharma Attracts Investment Interest

...rapeutic formulation for treating chronic lung disease. "2008 was extremely successful for Axentis", explains Acklin. "Our lead product ARB-CF0223 - a liposomal formulation of tobramycin, delivered directly to the site of infection via standard nebulisers - produced very satisfying data from a phase I clinical...
Liposomal in Biological Products

AAIBiotech Solutions from AAIPharma Inc.

Description:...ct formulation and manufacturing for solutions, powders, emulsions and lyophilized injectables, oral liquids, oral capsules, modified release tablets, liposomal delivery systems, coatings and topicals Comprehensive analytical services Stability management and GMP storage in US and EU Formulation and ...
Company:AAIPharma Inc.
Liposomal in Biological Dictionary

Transfection

...ntroduction of exogenous molecules and ... Information on FuGene, FuGENE HD, X-tremeGENE siRNA, DOTAP, and DOSPER Transfection Reagents ... DOTAP liposomal Transfection Reagent ... Find a range of specialized transfection reagents that effectively deliver plasmid DNA, siRNA or duplex RNAi, oligon...

Liposomes

...Phospholipids are the basic building block of every cell membrane in the human body. ... Liposomes are lipid bubbles and are the foundation of liposomal ... Liposomes ... Liposomes are different from micelles structurally in that they have a bilayer ... Nano- liposomes and ... Investigating ...
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