Metastasis-promoting protein identified; could provide a prognostic test or target for breast cancer
...w, for the first time, that a small protein called lipocalin
2 triggers the EMT in human breast cancer and tha...human breast cancer cells to make large amounts of lipocalin
2, and showed that cell motility and invasiveness ... cells from aggressive breast cancers and silenced lipocalin
2, and found that cell migration was significantly...
Technique May Let More Women Use Tamoxifen
...rch, another study in the same issue of PNAS found that a protein called lipocalin
2 can indicate how invasive a breast cancer is likely to be. Better yet, levels of the protein can be measured in urine.
2 decreases estrogen receptor levels, which indicates the presence of more ...
New Test Predicts Risk of Post-Surgery Kidney Injury
...d lead to earlier treatment and better patient outcomes, the researchers say.
The test measures a biomarker called neutrophil gelatinase-associated lipocalin
(NGAL) in urine.
"Urine NGAL represents a powerful early predictive marker of AKI, preceding the increase in serum creatinine -- the current gold s...
JCI online early table of contents: March 3, 2008
... expression in human sebaceous glands might provide a new approach to treating individuals with acne.
TITLE: Neutrophil gelatinase–associated lipocalin
mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells
Diane M. Thiboutot
Pennsylvania State University...
$4 million award to improve detection of acute kidney injury after cardiac surgery
...earchers, led by nephrologist Chirag Parikh, M.D., are studying three biomarkers: urine interleuken 18 (IL-18), urine neutrophil gelatinase associated lipocalin
(NGAL), and serum cystatin C. Parikh and his colleagues are doing the work in conjunction with a clinical consortium called Translational Research Inv...
Early test to detect kidney failure
...en successful in developing an early test for detecting kidney failure.//
Their research had led to finding of neutrophil gelatinase-associated lipocalin
(NGAL) as an early biomarker to detect ischemic renal injury after the patient had a cardiopulmonary bypass surgery.
Of the 71 children surveye...
Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
...meterol compared to those who were given the placebo. Salmeterol, compared with fluticasone propionate, reduced neutrophil number and human neutrophil lipocalin
level in bronchial lavage fluid, and intercellular adhesion molecule-1 level in bronchoalveolar lavage fluid. It was also observed that the numbers of...