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Lipase in Medical News

Solvay Pharmaceuticals, Inc. Announces Commercial Availability of CREON(R) (Pancrelipase) Delayed-Release Capsules

...available in three prescription strengths dosed by lipase units. As of today, the new FDA-approved dosage strengths are CREON (R) 6,000 lipase units, CREON (R) 12,000 lipase units, and CREON(R) 24,000...

Video: CREON(R) (Pancrelipase) Delayed-Release Capsules First and Only Pancreatic Enzyme Product to Receive FDA Approval Under New Guidelines

... patients. Caution should be exercised when doses of CREON(R) exceed 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day). Care should be taken to ensure that CREON...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

...ntributed to their occurrence. Elevated serum lipase Caution is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality Se...hrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated pha...

How to manage Chinese obese children with non-alcoholic fatty liver disease?

...be the hepatic aspect of the metabolic syndrome. Multiple therapeutic agents such as vitamin E, -carotene, metformin, PPAR-gamma agonists, and the lipase inhibitor orlistat have been demonstrated to be useful in NAFLD in a small series of cases. Lifestyle intervention (dietary restriction and exercise) ...

Amsterdam Molecular Therapeutics Initiates Program for Late Stage Liver Cirrhosis and Reports Strong Progress in AMT-011 With Trial Fully Recruited and European and US Submission On Track for First Half of 2008

...hat address unmet medical needs." Clinical Program AMT-011 The clinical development of AMT's lead product AMT-011 for the treatment of Lipoprotein lipase Deficiency is proceeding according to plan. All patients have been recruited in the Canadian study. A total of 6 patients have been injected with AMT-...

JCI table of contents: Nov. 21, 2007

...s in which blood clots form inappropriately inside blood vessels, such as occurs in individuals with pancreatic cancer. TITLE: Bile saltdependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans AUTHOR CONTACT: Laurence Panicot-Dubois Universit de la Mdit...

Is it pancreatitis in acute abdominal pain in acute viral hepatitis?

...nd sequelae on mean follow-up of 12 (range 8-24) months. Patients with acute viral hepatitis with severe abdomen pain should undergo serum amylase, lipase and ultrasonography or contrast-enhanced computed tomography of the abdomen to prove acute pancreatitis as a cause of abdomen pain. Hepatitis E vir...

Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies

...aution is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality: Tasigna may result in elevations...eumonia, febrile neutropenia, leukopenia, intracranial hemorrhage, elevated lipase and pyrexia. Tasigna may need to be withheld and/or dose reduced for QT in...

Baby with white blood!

...ood in stool. On detection the baby, a boy child, was found to have lipemic blood. Doctors said that this condition could be either due to// ‘familial lipase deficiency syndrome’ or ‘familial apolypoprotein C-2’. However, clinical tests conducted have shown that the reason was more likely to be that of a fa...
Lipase in Medical Technology

Glybera(TM) Shows Long-Term Health Benefits

...ant reduction in acute pancreatitis in lipoprotein lipase deficient patients. Recurrent acute pancreatitis i... the most debilitating complication of lipoprotein lipase deficiency (LPLD) and is associated with significa...for patients with the genetic disorder lipoprotein lipase deficiency. LPLD is an orphan disease for which no...

AMT: Glybera(R) Lowers Pancreatitis Incidence Significantly

...ence of acute pancreatitis in Lipoprotein Lipase Deficient patients. Recurrent acute pancreatitis is the most debilitating complication of Lipoprotein lipase Deficiency (LPLD) and is associated with significant morbidity and mortality. To date only one patient from the two clinical trials had an acut...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

...uted to their occurrence. Elevated serum lipase Caution is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality...hrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated pha...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...ted to their occurrence. Elevated serum lipase Caution is recommended in patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality...hrombocytopenia (28%), neutropenia (28%), elevated lipase (15%) and hyperglycemia (11%). In accelerated phas...

Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO

..., vomiting, hair hypopigmentation, and palmar-plantar erythema. Dose-limiting toxicities included palmar-plantar erythema, elevation of liver enzymes, lipase elevation, and mucositis. Pharmacokinetic analyses indicate that the half-life of XL184 was approximately 100 hours (range 59-136 hours), with expos...

Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting

...patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality Serum bil...hrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated pha...7%), neutropenia (37%), anemia (23%), and elevated lipase (17%). Other serious adverse reactions included pn...

Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer

...s (DLTs) have been reported, including Grade 3 palmar/plantar erythema (hand-foot syndrome), Grade 3 AST elevation, Grade 3 ALT elevation, and Grade 3 lipase elevation in patients dosed at 11.52 mg/kg (intermittent dosing schedule), as well as a DLT of Grade 2 mucositis in a patient dosed at 265 mg (daily d...

Updated Phase 1 Data for Exelixis' XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity

...se-limiting toxicities (DLTs) have been reported, including Grade 3 palmar/plantar erythema, Grade 3 AST elevation, Grade 3 ALT elevation, and Grade 3 lipase elevation in patients dosed at 11.52 mg/kg, as well as a DLT of Grade 2 mucositis in a patient dosed at 265 mg. Serious adverse events (AEs) considere...

Amsterdam Molecular Therapeutics BV to present preclinical proof-of-concept data on its gene therapy AMT-020 to treat acute intermittent porphyria

...ed a unique, stable and scalable GMP production platform. Its lead product, AMT-011, is in phase II for the first indication: treatment of lipoprotein lipase deficiency type I. The company's Management, Supervisory and Scientific Advisory Board bring together an extensive know-how from both gene science a...

AMT Presents Positive Results of Phase I/II Study with Lead Product at Annual Meeting of American Society of Gene Therapy

...n gene therapy, reported positive Phase I/II clinical trial results with its lead product AMT-010 (now referred to as AMT-011) in Complete Lipoprotein lipase (LPL) deficient patients at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle. The study's lead investigator is Erik S...
Lipase in Medical Products

Lipase (Liquid)

Description:... For the quantitative in vitro determination of lipase in human serum and plasma....
Company:Randox Laboratories Ltd.
Lipase in Medical Dictionary

Lipoprotein

...of lipid than protein, that transports cholesterol in lipoprotein lipase An enzyme produced in fat cells (adipocytes) and bound to the walls of capillaries ... Lipoprotein lipase deficiency leads to ... Lp(a) has a lipoprotein structure nearly id...

Acute pancreatitis

...ally improves on its ... Practice guidelines in acute pancreatitis " ... UK Working Party on Acute Pancreatitis (2005) ... of amylase and lipase in the diagnosis of acute pancreatitis " ... Acute pancreatitis is a sudden inflammation of the pancreas, the large gland ... Your do...
Lipase in Biological News

Key to 'curing' obesity may lie in worms that destroy their own fat: McGill researchers

...p within a few days. This is because they lack an enzyme that blocks the activity of a very important triglyceride lipase. Without this regulation the lipase burns up all the fat it encounters and destroys the worm's energy reserves." This discovery was a near-accidental by-product of Roy's regular line ...

Scripps research team defines new painkilling chemical pathway

... have remained largely unknown. Teasing out 2-AG's specific impacts have proven challenging. Comparable to FAAH, an enzyme called monoacylglycerol lipase (MAGL) breaks down 2-AG. But, despite numerous attempts, no group had been able to develop a chemical that inhibits MAGL specifically. "The toolss...

New bacteria discovered in raw milk

...id so they are unlikely to cause disease. Some bacteria produce extracellular enzymes that are remarkably heat tolerant and can resist pasteurisation. lipase enzymes cause flavour defects and proteases can lead to bitterness and reduced yields of soft cheese. Raw milk is consumed in rural areas of Europe...

Link found between immune system and high plasma lipid levels

...ed into the blood where it plays a key role in lipid metabolism. The livers of mice with T cells expressing LIGHT made and secreted much less hepatic lipase ?and consequently, had higher plasma lipid levels. The authors write: "Our data may help to explain the long time dogma that chronic inflammati...

Gene linked to rare disease activates fat breakdown

...sts the activity of so-called adipose triglyceride lipase (ATGL) up to 20-fold. "We knew that the enzyme ...es the first fatty acid from triglyceride. A third lipase finishes the job, Zechner said. The researcher...er study will examine how CGI-58 activation of the lipase affects energy metabolism in various tissues. As d...

Baby's genes affect mom's cholesterol levels

...proteins involved in lipid metabolism, lipoprotein lipase and apolipoprotein E. "Apolipoprotein E and lipoprotein lipase play important roles in the degradation of triglyc...tions (also known as polymorphisms) of lipoprotein lipase and apolipoprotein E that are known to influence t...
Lipase in Biological Technology

AMT Starts Preregistration Trial for Glybera(TM)

...announced today the treatment of the first patient in a preregistration clinical trial with Glybera(TM). This gene therapy product targets lipoprotein lipase deficiency (LPLD), a seriously debilitating and potentially lethal disease. The randomized controlled trial has been designed to gather additio...

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

...patients with history of pancreatitis. Check serum lipase periodically. Liver function abnormality Serum...hrombocytopenia (28%), neutropenia (28%), elevated lipase (15%), and hyperglycemia (11%). In accelerated pha...7%), neutropenia (37%), anemia (23%), and elevated lipase (17%). Other serious adverse reactions included pn...

AMT's Lead Product Poised to Address Major Liver Disease

...d. AMT-011, NAFLD, NASH and the metabolic syndrome AMT-011 is currently in its last phase of clinical development for the treatment of lipoprotein lipase (LPL) deficiency that is associated with very high circulating triglyceride (fat) levels. The product consists of an AAV-based vector that delivers th...

Preparation of PCR Quality Template DNA from a Wide Range of Tissues Using InstaGene Matrix

...ned to amplify a 120 base pair fragment of the Canine Pancreatic lipase Gene (Mickel et al., 1989). Amplification was carried out using ...ge, K. S. and Scheele, G. A., Structure of the Canine Pancreatic lipase Gene, J.Biol.Chem., 264 , 12895-12901 (1989). ...
Lipase in Biological Definition

Lipase

A Lipase is a water - soluble enzyme that catalyzes the hydrolysis of ester bonds in waterinsoluble, lipid substrates. Most lipases act at a specific position on the glycerol backbone of a lipid substrate (A1, A2 or A3). In the example of human pancreatic lipase (HPL), which is th...
Lipase in Biological Dictionary

Lipase

A lipase is a water-soluble enzyme that catalyzes the hydrolysis of ester bonds in water–insoluble, lipid substrates. Lipases thus comprise a subclass of the esterases. Lipase is an enzyme necessary for the absorption and digestion of nutrients in the intestines. ... Most people ...
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