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Linezolid in Medical News

Skin and Skin Structure Infections Are the Second Most Common Diagnoses for Which an Antibiotic Is Used in the Hospital Setting

...d skin structure infections, vancomycin (45 percent of therapy courses) is used more often followed by clindamycin (17 percent of therapy courses) and linezolid (16 percent of therapy courses)," stated Joyce Wedemeyer, product director at AMR. The Hospital Antibiotic Market Guide now includes an execut...

Trius Presents New Data on Torezolid Antibiotic for Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infections

...nstrate that MRSA and MSSA strains exposed in vitro to torezolid developed spontaneous resistance at a 16-fold lower frequency than strains exposed to linezolid (Zyvox(R)), the only drug of the oxazolidinone class currently marketed. Poster presentations on TR-701 also highlighted data characterizing torezolid...

Rib-X Granted Key Antibiotic Patent in China

...CAP). This compound has been shown to be microbiologically more active than linezolid against Gram-positive organisms, including potent activity against linezolid resistant bacteria, in prior studies. About Rib-X Pharmaceuticals, I...

Mylan Announces Tentative FDA Approval for Generic Version of Antibiotic Zyvox(R) Tablets

...d tentative approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Linezolid Tablets, 600 mg. linezolid Tablets, an antibiotic, are the generic version of Pharmacia and Upjohn's Zyvox(R) Tablets, which had U.S. sales of approximately $422 million for the...

Researchers Discover How Antibiotic Inhibits Bacterial Growth

...zer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth. Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketpla... in the production of blood cells. By crosslinking linezolid to its target in human cells, the researchers show...

Johns Hopkins Begins Aggressive Screening for 'superbugs' in Children

...rch fellow at Hopkins who led the study. Vancomycin (Vancocin) is currently the only FDA-approved drug for MRSA in children, and only one drug, linezolid (Zyvox), is approved in pediatrics for VRE. Milstone says children admitted to Hopkins are increasingly identified as harboring MRSA or VRE, wi...

Oral use of ZYVOX (Linezolid) is better to Intravenous Vancomycin use for Skin Infections

...atment // of Intravenous Vancomycin. The results show that oral tablets of linezolid (ZYVOX), provides better treatment and significant savings of money spent t...inistration. This study offers further evidence of the cost savings of oral linezolid to the health care system.” USE of ZYVOX: ZYVOX was initially appr...

New antibiotic already developing resistance

...becoming stale as the bacteria are showing signs of resistance. The drug linezolid is used to treat Enterococcus faecium (E. faecium) infections that are resi... 10% of these infections acquired in hospitals were resistant to treatment. linezolid was approved in April 2000 for the treatment of vancomycin-resistant E. fae...
Linezolid in Medical Technology

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

...as comparable to placebo while the labeled dose of linezolid produced the expected depletion of platelets and o...d drug in this class. Advantages of torezolid over linezolid include: 4-8 fold greater potency than linezolid in vitro and in vivo In vivo bactericidal ...

Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases

... Clinical results and advantage over linezolid in resistance acquisition by Staph aureus among data to be presented at inf...aw P 1104 : Characterization of the novel oxazolidinone TR-700 and linezolid spontaneous mutation frequencies and resistance mechanisms in Staphylococc...

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Next Generation Oxazolidinone at 2008 ICAAC/IDSA Joint Meeting

... and Microbiologically As Effective As Twice-a-Day linezolid When Used to Treat a Variety of uSSSIs - NEW HAV...olid was approximately four times more potent than linezolid against bacteria cultured from subjects in the stu... Phase 2 Study Comparing Two Doses of Radezolid to linezolid in Adults with Uncomplicated Skin and Skin Structu...

Pivotal Phase III Data Confirm the Efficacy and Safety of Arpida's Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections

... 82.2 percent for iclaprim versus 85.3 percent for linezolid in the intent-to-treat population and cure rates w...SA (76.4 percent), which was comparable to that of linezolid (78.7 percent). Overall, iclaprim was found to b...he comparative clinical cure rates of iclaprim and linezolid at the TOC visit in the ITT and PP populations. ...

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

...erized Rats Treated with the Novel Oxazolidinone TR-701: Comparison to linezolid -- F1-2068: Quality Control Parameters for TR-700 Broth Microdilution ...teria -- F1-2069a ("Late Breaker"): Hematological Effects of TR-701, linezolid and Placebo Administered for 21 Days in Healthy Subjects (Poster Session 1...

Arpida Provides Further Comments on the Pivotal Phase III Trials

...d and importantly used the same comparator (i.e. linezolid) which could allow regulators to pool and further analyse the data. Noteworthy to say, that linezolid has been shown to be superior to vancomycin in cSSSI for patients with MRSA infections (Weigelt et al, AAC, June 2005, page 2260-2266). The aim of t...

Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria

...ime-kill studies were performed using oritavancin, linezolid and vancomycin on stationary-phase MSSA, methicill...EC) values between 0.5 and 2 microgram/mL, whereas linezolid and vancomycin were ineffective (MBEC greater than...bacteria tested than were vancomycin, teicoplanin, linezolid or daptomycin at their respective physiologically ...
Linezolid in Biological News

Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections

... 82.2 percent for iclaprim versus 85.3 percent for linezolid in the intent-to-treat population and cure rates w...SA (76.4 percent), which was comparable to that of linezolid (78.7 percent). Overall, iclaprim was found to...he comparative clinical cure rates of iclaprim and linezolid at the TOC visit in the ITT and PP populations. ...
Linezolid in Biological Technology

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Radezolid in Community-Acquired Pneumonia

...ed a Phase 2 trial in uncomplicated skin and skin structure infections (uSSSI). In in vitro studies, radezolid has demonstrated greater potency than linezolid against a variety of Gram-positive organisms; radezolid is also active against linezolid-resistant isolates. About Rib-X Pharmaceuticals, Inc...

Rib-X Pharmaceuticals to Present at the 2008 ICAAC/IDSA Joint Meeting

...sent a poster entitled "A Phase 2 Study Comparing Two Doses of Radezolid to linezolid in Adults with Uncomplicated Skin and Skin Structure Infections (uSSSI)" at... Phase 2 Study Comparing Two Doses of Radezolid to linezolid in Adults with Uncomplicated Skin and Skin Structu...

Rib-X Pharmaceuticals Initiates Two Phase 2 Studies for Novel Antibiotic Compound RX-1741

...d Skin Structure Infections (uSSSI). The study will assess the efficacy of a single dose of RX-1741 given either once daily or twice daily compared to linezolid given twice daily for five to ten days in the treatment of ambulatory patients with uSSSI. It will also evaluate the safety and tolerability profile o...

Astellas and Theravance Report Additional Telavancin Data at 47th Annual ICAAC

...ivity of telavancin against both enterococci and streptococci pathogens versus the commonly used drugs vancomycin, levofloxacin, daptomycin, linezolid and quinupristin/dalfopristin. In the more than 2,700 clinical isolates tested, telavancin was one of the most potent agents. When evaluat...
Linezolid in Biological Definition

Antibiotic

...ctams Penicillins Glycopeptide antibiotics Vancomycin Teicoplanin Ramoplanin Decaplanin Oxazolidinones linezolid Quinupristin/dalfopristin Polyketides Macrolides Erythromycin Azithromycin Clarithromycin Roxithromycin ...

Antibiotic resistance

...vailable in the 1990s, and the first commercially available oxazolidinone, linezolid , is comparable to vancomycin in effectiveness against MRSA. Linezolid-resi...illin resistance was seen in 1983, vancomycin resistance (VRE) in 1987 and linezolid resistance (LRE) in the late 1990s. Penicillin-resistant pneumonia (or...

Antibiotic resistance

...vailable in the 1990s, and the first commercially available oxazolidinone, linezolid , is comparable to vancomycin in effectiveness against MRSA. Linezolid-resi...illin resistance was seen in 1983, vancomycin resistance (VRE) in 1987 and linezolid resistance (LRE) in the late 1990s. Penicillin-resistant pneumonia (or...
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