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Leukemias in Medical News

Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas

A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood. The research, published by Cell Press in the September issue of the journal Cancer Cell, may be useful for identifying tumor-specific ...

Sorafenib Slows Growth of Some Leukemias

Drug shows potential for patients with specific gene mutations, researchers find FRIDAY, Feb. 1 (HealthDay News) -- The drug sorafenib shows promise in the treatment of people with acute myeloid leukemia who have specific gene mutations, say U.S. researchers. Previous research has s...

S*BIO Expands Pipeline With the Development of a Unique Flt3 -CDK Inhibitor as a Targeted Therapy for Acute Leukemias

SINGAPORE, Nov. 27 /PRNewswire/ -- S*BIO Pte Ltd today announced the expansion of its proprietary pipeline, with its third development candidate, SB1317. This is a novel orally-available small molecule compound targeted for the treatment of acute leukemias. SB1317 is designed to selectively ...

Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias

According to the investigators at St. Jude Children's Research Hospital it was found that a gene responsible for regulating the normal mammary gland function during nursing can also initiate leukemias. // This gene results in leukemia only if it undergoes mutation and fuses with another gene. Th...

Janet Rowley, MD, A Researcher Funded by The Leukemia & Lymphoma Society, Receives Presidential Medal of Freedom

... Rowley and 15 others at a ceremony Aug. 12, 2009. Dr. Rowley is being recognized for her discoveries of recurring chromosomal abnormalities in leukemias and lymphomas -- findings that have revolutionized how cancer is understood and treated. Since 1984, LLS has awarded Dr. Rowley's lab eight grants, in...

The vulnerable cancer cell

...s, Claudia Scholl and Stefan Frhling, as well as HHMI investigator Tyler Jacks at MIT, began their studies about two years ago. The team's interest in leukemias informed their decision to focus on using short hairpin RNAs (shRNAs) -- single strands of RNA that fold back on themselves -- to selectively knock do...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

...ing translocations during V(D)J recombination that might ultimately lead to leukemias and lymphomas," says Skok. "It also helps us understand why individuals wi...eficiency in ATM suffer more cancers arising from such translocations." leukemias and lymphomas are very common cancers, especially in children. Chromosomal ...

The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer

...y of Michigan , For Radical Improvements of Bone Marrow Transplant Safety Bone marrow transplantation is frequently used to treat cancer, mainly leukemias and lymphomas. When successful, bone marrow transplants literally offer a new lease on life for patients. However, despite close matching of donors ...

Childhood Leukemia Subtype Resists Treatment

...d online Jan. 9 and will appear in the February print issue of The Lancet Oncology . Although success rates for treating and curing many childhood leukemias are high, some with certain subtypes of ALL tend to fair poorly. About a quarter have genetically unclassified strains of the disease in which relapse...

Novel treatments show improvements in survival and response rates for leukemia and lymphoma

...lymphoma are two of the most common blood cancers. leukemias are categorized based on the speed at which the cancer grows acute leukemias grow quickly while chronic leukemias develop at a slower rate....
Leukemias in Medical Technology

Mutant Genes in High-Risk Childhood Leukemias Identified

Results of collaborative study could lead to development of new diagnostic tools and a new therapeutic target in high-risk disease MEMPHIS, Tenn., May 19 /PRNewswire-USNewswire/ -- A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblas...

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

...thers in the field. To assess whether cranial irradiation would have made a difference in CNS relapse, they compared the outcomes of 71 patients whose leukemias would have qualified them for irradiation with the outcomes of 56 patients who had received such irradiation in the past. The researchers found that t...

Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-CXCR4 Antibody, MDX-1338

... potential activity in multiple cancers. Our first Phase 1 study will be conducted in AML and future studies are expected to target a variety of other leukemias and solid tumors and may involve monotherapy and combination therapy." The American Cancer Society estimates that in 2008, approximately 13,290...

EntreMed Presents Initial Clinical Results for ENMD-2076

...r to a United States Investigational New Drug (IND) application. The Company plans to commence a Phase 1 study in patients with relapsed or refractory leukemias in Canada later this year. In addition, the U.S. Food and Drug Administration (FDA) granted orphan drug designation for ENMD-2076 for the treat...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

...atients with non-Hodgkin's lymphoma and prostate cancer, and plans to initiate a second phase I trial of SGI-1776 in patients with relapsed/refractory leukemias in 2009. Copies of the poster presentations at the ASH Annual Meeting are available in the pipeline section of SuperGen's Web site www.super...

Celator(R) Pharmaceuticals Announces Enrollment of First Patient in Phase 2 Study with CPX-351

... Phase 1 Study of a Liposomal Carrier (CPX-351) Containing a Synergistic, Fixed Molar Ratio of Cytarabine (Ara-C) and Daunorubicin (DNR) in Advanced leukemias will be presented on Monday, December 8, 2008, 5:30PM to 7:30PM in the Moscone Center, Hall A. Synergistic Cytarabin...

Sunesis Pharmaceuticals Presents Clinical Trial Data of Voreloxin in Patients with Acute Myeloid Leukemia and Ovarian Cancer at the Chemotherapy Foundation Symposium

... Phase 1 and 1b/2 Studies of Voreloxin in AML Data presented from a completed Phase 1 dose escalation trial of voreloxin as a single agent in acute leukemias (N=73) showed that single agent voreloxin was generally well tolerated, with the most frequently observed dose limited toxicity (DLT) being reversible...

The Leukemia & Lymphoma Society and Memgen Collaborate on CLL Clinical Trial

...that causes malignant cells to become more sensitive to subsequent chemotherapy treatments. This targeted and active approach by ISF35 first makes the leukemias and lymphomas more "visible" to the human immune system. Then, ISF35 activates the immune system so that it can seek out and destroy the cancerous cel...

Vion Pharmaceuticals Announces Presentation of Data of Cloretazine(R) (VNP40101M) in Elderly Patients with High-Risk Myelodysplastic Syndromes at the EHA Annual Meeting

...refractory anemia with excess blasts (RAEB) and 9 patients were diagnosed with RAEB-t. Five patients were diagnosed with either chronic myelomonocytic leukemias (CMML) (3) or as unknown (2). Fifteen patients had intermediate cytogenetics and 11 had unfavorable cytogenetics. Sixteen of the patients were classif...

SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models

...) technology to identify and rapidly advance candidates into the clinic. We plan to initiate Phase 1 clinical trials with SGI-1776 in solid tumors and leukemias later this year. SGI-1776 may become the first drug in this class of inhibitors to enter the clinic." About SuperGen Based in Dublin, Calif., Supe...
Leukemias in Medical Products

ADVIA 120 Hematology System

Features:...enefit from technology which utilizes Peroxidase staining - the gold standard for differential testing. Detects abnormalities early and differentiate leukemias with cytochemical staining and nuclear complexity. Maximize the effectiveness of costly platelet transfusions with accurate results the first time, e...
Company:Siemens Medical Solutions Diagnostics

Advia 120

Features:... The Advia 120 system features patented proprietary clinical parameters. Detects abnormalities early and differentiate leukemias with cytochemical staining and nuclear complexity. Extensive linearity range, sensitive and specific result flagging, cross-checking WBC technologies ...
Company:Siemens Medical Solutions Diagnostics
Leukemias in Medical Definition

Hematopathology

... include chronic myeloproliferative disease , myelodysplastic syndromes , leukemias , lymphomas , plasma cell neoplasms , and histiocytic and mast cell neo... standard classification system, called the " WHO classification". [1] leukemias are mainly bone marrow and blood based and can be subclassified as ch...
Leukemias in Biological News

La Jolla Institute discovers novel tumor suppressor

...activity, which is similar to our findings in myeloproliferative disease," he said. "We also have done human cell testing in some other lymphomas and leukemias -- including myeloid leukemia -- indicating that these diseases also use this mechanism (low expression of PLC-beta 3 and high STAT5 activity)." D...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

...sensitive camera. Within weeks, the mice developed leukemias that showed the same genetic and pathological feat...have proved Lowe to be correct. Just as in humans, leukemias in mice that received the AML1/ETO oncogene were a...otherapy and soon regressed, whereas MLL-triggered leukemias remained resistant and eventually killed their hos...

2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research

...rsity of Michigan: for Radical Improvements of Bone Marrow Transplant Safety Bone marrow transplantation is frequently used to treat cancer, mainly leukemias and lymphomas. When successful, bone marrow transplants literally offer a new lease on life for patients. However, despite close matching of donors ...

Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution

...n disease. In particular, Justices lab focuses on the process of hematopoiesis, the development of blood cells. Mutations in these genes can lead to leukemias or lymphomas. The method is freely accessible on the website for Cold Spring Harbor Protocols ( http://www.cshprotocols.org/cgi/content/full/2008/5/...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young investigators

...rganization of chromosomes within the nucleus - a fundamental question that will provide insight into the causes of morphological changes in nuclei of leukemias and lymphomas. Dipali G. Sashital, PhD , with her sponsor Jennifer A. Doudna, PhD, at the University of California, Berkeley, California, is stud...

St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia

...es. This study strongly suggests that a widely held explanation for how leukemias arise is not universally applicable. This view holds that leukemias arise from rare cancer stem cells, which do not make up the bulk of the tum...

Mutating the entire genome

...ng a piece of each of the two old ones. The process, “translocation,” also can create new genes from two other genes. Many cancers – certain sarcomas, leukemias and lymphomas – start with translocation. Existing methods result in the desired translocation of two chromosomes in one of every 1 million to 1...

Lost in the labyrinth

...mmit themselves to the right developmental path at the right time, they're very likely to die or to begin an inappropriate type of reproduction. Acute leukemias and other forms of cancer cells derive from defects such as this. Understanding the processes by which they form will require pinpointing the forks in...

Can you hear me now? Scientists find previously unknown receptors on adult stem cells

...athogen is attacking the body. The findings, which appear in the June issue of the journal Immunity, could have important implications for treating leukemias and autoimmune diseases such as lupus and rheumatoid arthritis. "We have long known that so-called hematopoietic (blood) stem cells create the bloo...

Researchers map out networks that determine cell fate

...eutic use of stem cells to rejuvenate damaged tissues. Understanding of leukemias also could be aided by insight into this regulatory circuitry, Singh said. Many leukemias exhibit mixed-lineage patterns of gene expression, for example of both mac...
Leukemias in Biological Technology

Data Presented at ASH Annual Meeting Indicates the Potential of T-Cell Engaging BiTE Antibody Blinatumomab as a Consolidation Treatment for Aggressive Leukemias

Interim Data from a Phase 2 Clinical Trial in B-Precursor Acute Lymphoblastic Leukemia Show that Blinatumomab is Able to Eliminate Minimal Residual Disease BETHESDA, Md., Dec. 8 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, propr...

Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer

...nts with solid tumors and lymphomas. The second-generation proteasome inhibitor NPI-0052 is being evaluated in patients with solid tumors, lymphomas, leukemias and multiple myeloma. The company's discovery portfolio includes potential drug candidates for cancer, infectious diseases and inflammation. For mor...

In 2008, Ipsogen Reinforced its Leadership in Molecular Diagnosis and Monitoring of Leukemia

... its leukemia molecular diagnostic portfolio: - FusionQuant BCR-ABL IVD kit, used in the the detection and monitoring of chronic myeloid leukemias (CML), is a new CE marked expanded version of our existing product. The new IVD kit now provides all the necessary components in one packa...

SuperGen Receives Clearance to Begin Clinical Trials With SGI-1776, a PIM Inhibitor

...f Pim-1 kinase has been shown to be a marker of poor prognosis in these tumors. A second Phase I/II study is being planned in patients with refractory leukemias in which Pim kinases are also overexpressed, and correlated with poor prognosis and drug resistance. "We are pleased to acknowledge FDA's clea...

Lixte Biotechnology Holdings Announces New Appointment to Board of Directors

...er in animal models of these diseases and is also active against breast, colon, lung, prostate, ovary, stomach and liver cancer and the major types of leukemias in cell culture. Forward-Looking Statements This announcement contains certain forward-looking statements within the meaning of Section 27A of the...

Celator(R) Pharmaceuticals Announces Appointment of Scott Jackson as CEO

...at major medical conferences. Results from a Phase 1 study with CPX-351 (a liposomal formulation of cytarabine:daunorubicin) in patients with advanced leukemias will be submitted to a conference before the end of the year," said Mr. Jackson. "In addition, Celator's CombiPlex (TM) technology platform has the po...

Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data

... with solid tumors and lymphomas, and the second-generation proteasome inhibitor NPI-0052 is being developed in patients with solid tumors, lymphomas, leukemias and multiple myeloma. The Company's discovery portfolio includes potential drug candidates for cancer, infectious diseases and inflammation. For more ...
Leukemias in Biological Definition

Cancer

...e of peak incidence of cancer in children occurs during the first year of life. Neuroblastoma is the most common infant malignancy, followed by the leukemias and the central nervous system cancers. Female infants and male infants have essentially the same overall cancer incidence rates, but white infants h...
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