Leukaemia

Funding boost in fight against leukaemia

University of Manchester researchers have been awarded 1.6 million to study a group of genes identified as playing a key role in leukaemia. The grant, by Leukaemia Research, will fund work analysing a wide range of cancer-causing genes in the hope of targeting their common mechanisms of action ...

Stem cells give clues to understanding cancer and make breakthrough in childhood leukaemia

Scientists in Switzerland are uncovering new clues about how cancer cells grow and how they can be killed by studying stem cells, blank cells that have the potential to develop into fully mature or differentiated cells and other scientists in UK have made a breakthrough in understanding the caus...

Gene Mutation That Increases the Risk of Chronic Lymphocytic Leukaemia Found

Scientists at Ohio State University Comprehensive Cancer Center have discovered an inherited gene mutation that makes a person more vulnerable to chronic lymphocytic leukaemia (CLL). The study shows that the inherited mutation greatly reduces the gene's protective activity. Furthermore, a...

'Good' And 'Evil' Clones Of Acute Lymphoblastic Leukaemia cells

According to Australian scientists, there are two types of acute lymphoblastic leukaemia (ALL) cells, good and bad. //The latter type of cells are those that have a pre-existing immunity to drugs used to treat ALL, that is responsible for relapse after treatment. The discovery means that now re...

Southeast Asian Children With Leukaemia To Get New Treatment

According to experts a hospital in US is all set to use Singapore as a base in order to treat the children, who are suffering from leukaemia// , of the developing Southeast Asian countries. The breakthrough enables the bone marrow cells of the parents to be used in the transplants the children...

Mom's Stomach Bacteria Can Cause Leukaemia In Children

A bacterium strain known as Helicobacter pylori may raise the risk of childhood leukaemia, according to a new study.// Two-thirds of the world population carries H. pylori, which is responsible for ulcers. Leukaemia accounts for 25 percent of all childhood cancers worldwide. Acute lymphoblast...

New Treatment Boosts Survival Chances for Child Leukaemia

A prototype method of treating infants with a form of leukaemia boosts their chances of survival compared with the standard drug regimen, according to a paper published in next Saturday's Lancet. In general, children with acute lymphoblastic leukaemia have a good chance of survival -- abou...

New Engineered Drug Shows Promise in Treating Lymphocytic Leukaemia

A recent research has found that a new type of engineered drug may have the potential to treat chronic lymphocytic leukaemia. The study by researchers at the Ohio State University Comprehensive Cancer Center was published online in the journal Blood. The research has established t...

Artificial sweetener, Aspartame, may be the potential cause of lymphoma, leukaemia

It has been found through an animal study that Aspartame can cause lymphoma, leukaemia. The study points out that drinking four to five 20-ounce bottles of diet soda sweetened with aspartame each day would be the //cause of cancers. The study would be published in March issue of Environmental H...

Human sperm created from embryonic stem cells

...lly their own." "It will also allow scientists to study how cells involved in reproduction are affected by toxins, for example, why young boys with leukaemia who undergo chemotherapy can become infertile for life and possibly lead us to a solution." The team also believe that studying the process of for...

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Leukaemia in Medical Technology

Micromet Presents Safety and Efficacy Data from Primate Studies With Two New BiTE Antibodies Developed for Treatment of Leukaemia and Melanoma

BETHESDA, Md., April 14 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel antibodies for the treatment of cancer, inflammation and autoimmune diseases, today presented at the Annual Meeting of the American Association for Cancer Research (A...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

First RNA Antagonist Medicine to Be Tested in Patients Reduces Severity of Adult Leukaemia Copenhagen, 6th June 2007 - Santaris Pharma, the Danish biopharmaceutical company, announced today that SPC2996, the Company's new RNA Antagonist of Bcl-2, has shown early evidence of efficacy in an initia...

Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery

...ts with KIT (CD117)-positive GIST. In the EU, Glivec is also approved for the treatment of adult patients with newly diagnosed Ph+ acute lymphoblastic leukaemia (Ph+ ALL) in combination with chemotherapy and as a single agent for patients with relapsed or refractory Ph+ ALL. Glivec is also approved for the tre...

Launch of Highly Targeted Cancer Treatment Tasigna(R) (nilotinib) Offers Potential Lifeline to Ph+ CML Patients Intolerant or Resistant to Existing Therapies, Including Glivec(R) (imatinib)

...nt in the Chronic (Early) Phase of Chronic Myeloid leukaemia (CML)(1) - Highly Targeted Nature of Tasigna(R) ...adelphia chromosome positive (Ph+) chronic myeloid leukaemia (CML). The availability of Tasigna(R) means that t...n in Patients with Newly Diagnosed Chronic Myeloid leukaemia in Chronic Phase (CML-CP) Treated with Imatinib. O...

Micromet Announces Presentation of Five Posters Related to Its Proprietary BiTE Antibody Platform at Annual Meeting of American Association for Cancer Research

...man BiTE antibodies to CD33 and MCSP for the treatment of acute myelogenous leukaemia and melanoma, respectively (abstract no. 2404). A fifth poster explores t... CD33- and MCSP-specific BiTE Antibodies for the Treatment of Acute Myeloid leukaemia and Melanoma, Respectively, that Are Fully Human in Sequence. Annual Meetin...

Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future

...t platform. The most advanced BiTE antibody is MT103 (MEDI-538) targeting CD19, and is being tested in a phase 2 clinical trial in acute lymphoblastic leukaemia patients and in an ongoing phase 1 clinical study in advanced non- Hodgkin's lymphoma patients. Three other BiTE antibodies, targeting EpCAM (CD326), ...

Preclinical Studies Show Promise for Novel Antibody Therapy to Treat Acute Myeloid Leukemia (AML)

...arch, Australia, its key collaborators in this important project. For further information please contact: Associate Professor Richard Lock Head, leukaemia Biology Program Children's Cancer Institute Australia for Medical Research Phone: +61 414 769 194 Dr. Darryl Maher Medical Director CSL Bioplasm...

CuraGen and TopoTarget Announce Presentations on Belinostat at the Upcoming American Society of Hematology 49th Annual Meeting

...cacy of PXD101 (Belinostat) on Primary Leukaemic Cells and Cell Lines as a Novel Agent for Childhood Acute Lymphoblastic leukaemia (ALL) Date/Time: Monday, December 10, 2007, 5:00 - 7:00 PM EST Session: Acute Lymphocytic Leukemia: Biology and Pathophysiology Poster boar...

Data supporting three Antisoma programmes presented at AACR

... to be very well-tolerated and produced two objective responses in late-stage renal cancer patients. Phase II trials in renal cancer and acute myeloid leukaemia (AML) are now planned and the drug may ultimately have potential against a variety of solid and blood cancers. Preclinical support for AS1409 trial ...

Santaris Pharma presents positive preclinical data on SPC2996 at the American Association for Cancer Research

... effective in a mouse model of Chronic Lymphocytic leukaemia COPENHAGEN, 18 April 2007 - Santaris Pharma, the...n a preclinical model of human Chronic Lymphocytic leukaemia (CLL). In collaboration with scientists at the U...7268 3002 Notes to editors Chronic Lymphocytic leukaemia Chronic lymphocytic...

Leukaemia in Medical Definition

Hematopathology

... e Pathology : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , CLL , HCL ) • Lymphoma ( Hodgkin's disease , NHL ) • LPD • Myeloma ( Multiple myeloma , Extramedullary plasmacytoma ) Myeloid : ...

Pathology

... e Pathology : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , CLL , HCL ) • Lymphoma ( Hodgkin's disease , NHL ) • LPD • Myeloma ( Multiple myeloma , Extramedullary plasmacytoma ) Myeloid : ...

Personalized medicine

...em eligible. Herceptin sales have grown from $30.5 million in 1998, its year of introduction, to $764 million in 2005. Gleevec treats chronic myeloid leukaemia (CML) arrived in 2004 and it is known as a targeted cancer drug. In addition because of new molecular testing for c-kit, tumors such as GIST GastroIn...

Leukaemia in Biological News

The quest for specific anti-inflammatory treatment

...i-inflammatory drugs, creating synthetic analogues of the C1P (ceramide-1-phosphate) molecule. This molecule was discovered in 1990 in a case of human leukaemia After synthesising it in the laboratory, it was observed that it was an important mytogenic agent (provoking cell growth and blocking the natural deat...

Development of gene therapy

...ficiency and chronic granulomatous disease. There are also initial indicators that point to the efficacy of gene therapy in treating chronic lymphatic leukaemia and haemophilia B. But successes in clinical testing come with their share of setbacks, such as the currently slight margin of therapeutic effectivene...

Honey helps problem wounds

...ealing process of wounds. 'Normally a skin injury heals in a week, with our children it often takes a month or more,' he says. Moreover, children with leukaemia have a weakened immune system. If a germ enters their bloodstream via a wound, the result may be a fatal case of blood poisoning. For several years...

Infections could contribute to adult brain tumours

...ith earlier research led by Dr McNally into childhood cancer in North West England. This discovered patterns in the diagnosis of two types of cancer - leukaemia and brain tumours - in that they tended to occur together at similar times and geographical locations. Dr McNally, who also works with Newcastle ...

Pillows - a hot bed of fungal spores

...y found in the pillows, is most likely to cause disease; and the resulting condition Aspergillosis has become the leading infectious cause of death in leukaemia and bone marrow transplant patients. Fungi also exacerbate asthma in adults. The researchers dissected both feather and synthetic samples and ident...

Chernobyl: The true scale of the accident

...rgency workers from 1986-1987, evacuees and residents of the most contaminated areas. This number contains both the known radiation-induced cancer and leukaemia deaths and a statistical prediction, based on estimates of the radiation doses received by these populations. As about quarter of people die from spon...

Leukaemia in Biological Technology

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

OSLO, Norway, June 17 /PRNewswire-FirstCall/ -- - New Investigational Drug Also Shown to Improve Remission Rates and Reduce Short-Term Mortality Compared to Previous Treatments Clavis Pharma ASA (OSE: CLAVIS) today announces positive final results from a Phase II trial of its nov...

Clavis Pharma Raises NOK 129 Million (USD 20 Million) in a Private Placement to Fund Further Development of its Pipeline of Novel Anticancer Drug Candidates

...sed data from clinical studies for lead products a. Complete first part of a Phase II/III registration study for elacytarabine in leukaemia (AML) b. Complete a randomised Phase II study with IV CP-4126 in pancreatic cancer c. Complete Phase I study for Oral CP...

Cepheid Announces Symposium Speakers and Program Highlights for 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

...l carriage of Group B Streptococcus Xpert(R) BCR-ABL Monitor Monitoring test for patients with Chronic Myeloid leukaemia (CML) Congress attendees can also look forward to a wide variety of insightful presentations, based on recent ...

ERYtech Pharma Signs an Agreement With the Penn Jersey Region of American Red Cross

... fields of Haematology, Oncology and Metabolic Diseases. ERYtech Pharma's most advanced product, GRASPA(R), has completed a Phase II clinical trial in leukaemia and is currently being evaluated in the indication of several solid tumours. Beyond GRASPA(R), ERYtech has several investigational compounds addressin...

Rigel Announces Third Quarter 2008 Financial Results and Clinical Update

... 2 lymphoma clinical trial is continuing and is focused on diffuse large B-cell, follicular and other B- cell lymphomas, including chronic lymphocytic leukaemia and small lymphocytic lymphoma (CLL/SLL). Rigel plans to present further results from this ongoing clinical trial at the American Society of Hematolog...

Genmab Announces Results for the First Nine Months of 2008

...nced positive top-line results from a Phase III pivotal study evaluating ofatumumab (HuMax-CD20(R)) in two groups of patients with chronic lymphocytic leukaemia (CLL). The study met the primary endpoint in both patient populations and the results from the secondary endpoints also supported the primary endpoint...

Ipsogen Launches MapQuant Dx(TM) Genomic Grade Test to Identify Breast Cancer Patients who Benefit From Chemotherapy

...CHICAGO, May 30 /PRNewswire/ -- Ipsogen SA (Marseilles, France and New Haven, CT, USA), a cancer profiler that markets molecular diagnostic assays for leukaemia announced today that it is entering the breast cancer diagnostic market with the European launch of MapQuant Dx(TM) Genomic Grade. MapQuant Dx(TM) Gen...

Leukaemia in Biological Definition

Blood

... inconsequential wounds to be life-threatening, but more commonly results in hemarthrosis , or bleeding into joint spaces, which can be crippling. leukaemia (more often called leukemia) is a group of cancers of the blood-forming tissues. Major blood loss, whether traumatic or not (e.g. during surgery...

Full blood count

...tes - May indicate bacterial infection. Lymphocytes - Higher with some viral infections such as glandular fever . Also raised in lymphocytic leukaemia CLL . Monocytes - May be raised in bacterial infection Eosinophil granulocytes - Increased in parasitic infections. Basophil granulocyte...

Retrovirus

... Feline leukemia virus Genus Deltaretrovirus ; type species: Bovine leukaemia virus ; others include Human T-lymphotropic virus Genus Epsilonretr...viruses, this is no longer appropriate. See also sarcoma and leukaemia HIV External links Retroviruses NCBI retrovirus book o...

Stem cell

... cells. Since 1988 these cord blood stem cells have been used to treat Gunther's disease , Hunter syndrome , Hurler syndrome , Acute lymphocytic leukaemia and many more problems occurring mostly in children. It is collected by removing the umbilical cord, cleansing it and withdrawing blood from the umbi...