Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer
Findings from one of the largest studies in hormone receptor positive women with first-line oral treatment regimen
PHILADELPHIA, Dec. 11 /PRNewswire-USNewswire/ -- New results from a study evaluated the combination of TYKERB(R) (lapatinib) plus Femara(R) (letrozole) versus letrozole
Late treatment with letrozole can reduce breast cancer recurrence risk
Treatment with the aromatase inhibitor letrozole
(Femara) can reduce the risk of breast cancer recurrence even when initiated one to seven years after a course of tamoxifen therapy. The results of a study involving women originally in the placebo arm of an international trial of letrozole
Justifying the use of letrozole for inducing ovulation Letrozole
used for the treatment of advanced/metastatic breast cancer in postmenopausal women is also being used by // infertility specialists as a second line of treatment for infertility for inducing ovulation. Studies indicate that letrozole
was used not on an experimental basis, but as an accep...
Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer
...abine or capecitabine in the first- or second-line setting following progression on bevacizumab, and a trial to evaluate Nexavar plus docetaxel and/or letrozole
in the first-line setting.
About Breast Cancer
Breast cancer was the most commonly diagnosed cancer among women worldwide in 2007-200...
Some Antidepressants May Thwart Tamoxifen's Effect on Breast Cancer
...s while trying to sort this out."
Marcom agreed. He also noted that breast cancer-inhibiting medications called aromatase inhibitors, which include letrozole
(Femara) and exemestane (Aromasin), "are one possible alternative to tamoxifen. There are also genotyping issues -- how different individuals metaboli...
GSK Submits TYVERB(R)/TYKERB(R) (lapatinib) for First-Line Treatment of Metastatic Breast Cancer in Europe, US
...ent study, EGF30008. This study evaluated TYVERB/TYKERB in combination with letrozole
in women whose breast cancer expressed was hormone receptor positive (HR+) ...east cancer tumors which initially respond to anti-hormonal therapy such as letrozole
can become resistant to treatment, leading to disease progression and ultim...
Patient management: Quality of life and beyond
...mplete data to be presented at the meeting.
following breast cancer surgery may provide surviv....D.
Embargo: 9:45 a.m. CST, December 11, 2008
may improve overall survival in patients with primary breast cancer. A four-arm comparison study of letrozole
and tamoxifen shows...
HRT Users Who Get Breast Cancer Less Likely to Die
...-life issues can generally be treated and improved, Vogel said.
The drug letrozole
may beat out tamoxifen in improving overall survival in patients with primary breast cancer. A comparison study of the two found that letrozole
reduces breast cancer recurrence and may decrease the risk of breast cancer...
Osteoporosis Drug Seems to Shrink Breast Tumors
...another HER2 inhibitor, with an aromatase inhibitor (in this case, letrozole) prolonged progression-free survival from three months among those taking letrozole
(Femara) alone to 8.2 months in women taking both drugs. These patients had HER-2-positive metastatic breast cancer. "The combination shows benefits i...
Cancer drugs in the pipeline
...that also co-expressed HER2, combining lapatinib with an aromatase inhibitor significantly improved progression-free survival from three months in the letrozole
alone group to 8.2 months in the combination group. Overall clinical benefit rate increased from 28.7 percent to 48.7 percent. Involving 1,286 patient...
Letrozole in Medical Technology
Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types
...RI_2_4_3X_How_is_liver_cancer_staged_25.asp . Accessed May 2009.
Ribi K, et al. Cognitive function in postmenopausal women receiving adjuvant letrozole
or tamoxifen in the Breast International Group (BIG) 1-98 trial. Abstract # 510. American Society of Clinical Oncology 2009 Annual Meeting, Orlando, F...
Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery
...rial. "The potential reduction in the risk of death that we are seeing with letrozole
in the adjuvant setting may be a positive result of letrozole's early and s... References
1. Mouridsen H for the BIG 1-98 Collaborative Group, letrozole
Alone or in Sequence with Tamoxifen for Postmenopausal Women with Early Bre...
Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments
... show RAD001 significantly increased efficacy of
tablets in women with newly diagnosed hormone-posi...ces tumor
shrinkage when given in combination with letrozole
tablets (Femara(R)) to
postmenopausal women with n... show that adding RAD001
to initial treatment with letrozole
tablets may improve outcomes for
VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy
...ss PE, Ingle JN, Pater JL, et al. Late extended adjuvant treatment with letrozole
improves outcome in women with early-stage breast cancer completing 5 y...JL , et al. Intent-to-treat analysis of the placebo-controlled trial of letrozole
for extended adjuvant therapy in early breast cancer: NCIC CTG MA.17. A...
Newly Published Study Reveals Femara Improves Chances for Harder to
Treat Early Breast Cancer Relapse in Postmenopausal Women
...maginis.com/breasthealth/metastatic.asp">http://www.imaginis.com/breasthealth/metastatic.asp . Accessed 23.04.07
(5). Thurlimann B et al. Adjuvant letrozole
reduces the risk of
relapse in postmenopausal women with receptor positive early breast
cancer compared with tamoxifen: first results of the BIG 1-98
Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal
Women with Early Breast Cancer Receiving Treatment with Tamoxifen
...vant treatment of early breast cancer in hormone
receptor positive postmenopausal women who have received 2 to 3
years of adjuvant tamoxifen. · letrozole
Adjuvant treatment of postmenopausal women with hormone receptor
positive invasive early breast cancer. Treatment of early invasiv...
First single breast cancer study to show significant survival
benefit for women switching from tamoxifen to Arimidex
...nt treatment of early breast cancer
in hormone receptor positive postmenopausal women who have received
2 to 3 years of adjuvant tamoxifen.
(Femara), Novartis: Adjuvant treatment of
postmenopausal women with hormone receptor positive invasive early
breast cancer. Treatment of early invasiv...
Letrozole in Biological News
CTRC-AACR San Antonio Breast Cancer Symposium
...est is as important as physical activity in breast cancer prevention
Recurrence rates among patients with small HER2-positive tumors
Evaluation of letrozole
as adjuvant endocrine therapy
Phase III trials of new, paradigm-shifting clinical agents like topoisomerase
December 10-14, 2008
New research shows no link between aromatase inhibitors and cardiovascular problems
...n total cholesterol levels between different AIs. In a second trial (MAP.1) letrozole
was associated with a transient decrease in cholesterol levels.
In tria...seen in heart-related problems, but in another trial (MA17), which compared letrozole
with placebo, there were no differences in hypercholesterolaemia or other c...
Fertility drugs given 'all-clear' in new study
...showed that babies whose mothers were treated with letrozole
had the same rate of birth defects as those whose ...ur findings indicate concerns about a link between letrozole
and birth defects are unfounded. This is significant because it confirms that letrozole
can indeed be used in the treatment of infertility...