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Lethal in Medical News

Targeting the more lethal form of the cancer rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). Although ARMS is less common than ERMS, it is associated with a much higher rate of mortality. A therapy tail...

Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells

DENVER - A combination of two targeted therapies packs a powerful punch to kill pancreatic cancer cells in the laboratory, Mayo Clinic cancer researchers report. With further testing of these drugs that are from classes of pharmaceuticals already used in patients, the Mayo research may lead to new...

Data Published in Nature Medicine Highlights Ability of Peregrine Pharmaceuticals' Bavituximab to Cure Lethal Virus Infections

--PS-Targeting AntibodiesMay Represent a Completely New Class of Drugs with Broad Potential to Treat Life-Threatening Viral Infections-- --Peregrine's Clinical-Stage Anti-PS Agent Bavituximab and Equivalent Antibodies Cured Lethal Viral Infections in Preclinical Models-- --Data C...

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

WHO and CDC have stated that the predictive accuracy of their annual formulations for human influenza vaccines is "suboptimal" - often correct less than 50% of the time, especially for seniors. Perhaps in part because we are not yet accurate in our predictions of upcoming influenza stra...

Most lethal melanomas are on scalp and neck

CHAPEL HILL People with scalp or neck melanomas die at nearly twice the rate of people with melanoma elsewhere on the body, including the face or ears, researchers at the University of North Carolina at Chapel Hill have found. The analysis of 51,704 melanoma cases in the U.S. confirms that sur...

AMAS Test Measures Lethal Replikin Gene Activity in Lung and Other Cancers

BOSTON, Dec. 6 /PRNewswire/ -- A gene related to rapid replication and lethality has been found to be present in, and to contain some identical protein sequences in, tobacco mosaic virus and non-small cell lung cancer. The early detection diagnostic test for cancer, the AMAS(R) test, appears t...

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Lethal in Medical Technology

British Midlands University Announces Use of Gene Technology to Fight Lethal Hospital Acquired Infection

University of Nottingham Scientists Leading Major Study into Lethal 'Super' Strains of C.difficile CHICAGO, Jan. 28 /PRNewswire/ -- The British Midlands Development Corporation today announced that scientists at The University of Nottingham are leading a major European study to unravel the ...

Peramivir Protects Mice From Lethal H5N1 Infection

St. Jude study shows intramuscular injection of peramivir for eight days protected mice from lethal H5N1 influenza virus infection and inhibited virus replication, supporting the use of this drug to control influenza during a pandemic MEMPHIS, Tenn., May 01, 2007 /PRNewswire-USNewswire/ -- The ant...

Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections

DENVER--(BUSINESS WIRE)--Jul 2, 2007 - Ceragenix Pharmaceuticals, Inc. (OTCBB:CGXP), a biopharmaceutical company focused on infectious disease and dermatology, today announced that researchers at the University of Pennsylvania led by Dr. Paul Janmey and Dr. Robert Bucki, in collaboration with Dr. P...

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

...esignation in the US only weeks after a first designation was granted. The recent designation relates to Burkholderia cepacia pathogens that can cause lethal infections in cystic fibrosis patients. For Axentis Pharma AG of Zurich, Switzerland, both designations affirm the therapeutic potential of its produc...

DOR BioPharma Receives EMEA Agreement on the Design of its Confirmatory Phase 3 Clinical Trial of orBec(R) in GI GVHD

...rsuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunog...

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

...ainst and treat anthrax infection, including inhalational anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium. The i...get a protein component known as the anthrax Protective Antigen (PA) of the lethal and edema toxin complexes produced by the bacterium. Preclinical studies su...
Lethal in Medical Products

Malaria Antigen CELISA

Features:... Alternative to thick or thin smear microscopy Specific for potentially lethal P. falciparum 192 tests kit format ...
Company:Cellabs
Lethal in Medical Definition

Artificial induction of immunity

...tion , which is the controlled infection of a less lethal natural form of smallpox (known as Variola Minor) ...ke him or her immune to re-infection with the more lethal natural form, Variola Major. This was practiced in...erial production of a toxin . Tetanus toxin is so lethal that humans cannot develop immunity to a natural i...
Lethal in Medical Dictionary

Ventricular tachycardia

...t surgery. ... Ventricular tachycardia can occur in the absence of apparent heart disease. ... Ventricular tachycardia is a potentially lethal arrhythmia and may result in an ... Health Library > Health Encyclopedia > Ventricular tachycardia . Printable Version ... Long-term t...

Trisomy 13

...find the alternate ... In the cell, genetic material is contained in discrete units of deoxyribonucleic ... Trisomy 13 is a severe and often lethal genetic disorder that occurs in ... Research into the causes and risk factors for Trisomy 13 . ... A small proportion of trisomy 13 cases...

Tick fever

... It should not be confused with the bacterial tick -borne infection, Rocky Mountain Spotted Fever . Rocky Mountain spotted fever is the most lethal and most frequently reported rickettsial illness in the United States. It has been diagnosed throughout the Americas. Some synonyms for Rocky Mountain...

Spores

... ... ranchers picked up the anthrax spores through cuts or sores on their ... But none have inhaled enough spores to develop the potentially lethal form of anthrax. ... Remove Mold to Keep Your Home Healthy -- health effects of mold, where to ... Because some mold spores are very small and...

Septic shock

...ondition that occurs when an overwhelming infection ... Any type of bacteria can cause septic shock . ... Septic shock is a potentially lethal drop in blood pressure due to the presence of bacteria in the blood. ... Septic shock can lead to multiple organ failure ... Septic ...

Microcephaly

... most often occurs because of failure of the brain to grow at ... Amish lethal microcephaly is a disorder in which infants ... Infants with Amish lethal microcephaly have a sloping forehead and an extremely small head size. .....
Lethal in Biological News

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

TUSTIN, Calif., November 23, 2008 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today reported publication of data in Nature Medicine that supports the broad anti-viral potential of the company's novel anti-phosphatidylserine (anti-PS) antibody platform, showing that its PS-targeting drug ba...

Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination

Troy, N.Y. -- The mysterious death of patients around the world following a routine dosage of the common blood thinner, heparin, sent researchers on a frantic search to uncover what could make the standard drug so toxic. A researcher at Rensselaer Polytechnic Institute was among a small group of s...

UC Davis researchers discover how HIV turns food-poisoning into lethal infection

(SACRAMENTO, Calif.) Nearly half of all HIV-positive African adults who become infected with Salmonella die from what otherwise would be a seven-day bout of diarrhea. Now, UC Davis School of Medicine scientists have discovered how salmonella becomes lethal for AIDS patients. Their findings also i...

CSHL scientists identify cells that promote formation of lethal lung metastases

Cold Spring Harbor, NY Cancer patients usually ask what can be done after a primary tumor has already spread, or metastasized, to other organs. In many cases, they learn, little can be done. Hence the importance of a discovery by scientists at Cold Spring Harbor Laboratory (CSHL) of a type of cel...

It's official: The carbon crisis is lethal for coral reefs

THE SITUATION: The largest living structures on Earth and the millions of livelihoods which depend upon them are at risk, the most definitive review yet of the impact of rising carbon emissions on coral reefs has concluded. In a paper published in the prestigious Science Magazine today, 1...

Scripps scientists develop new tests that identify lethal prion strains quickly and accurately

One of the new in vitro tests, called the Standard Scrapie Cell Assay, measures prion infectivity levels in a highly accurate and extremely rapid way, producing results in less than two weeks. The second test, called the Cell Panel Assay, allows researchers to quickly distinguish between several p...

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Lethal in Biological Technology

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

TUSTIN, Calif., November 23, 2008 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today reported publication of data in Nature Medicine that supports the broad anti-viral potential of the company's novel anti-phosphatidylserine (anti-PS) antibody platform, showing that its PS-targeting drug ba...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

TUSTIN, Calif., November 23, 2008 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today reported publication of data in Nature Medicine that supports the broad anti-viral potential of the company's novel anti-phosphatidylserine (anti-PS) antibody platform, showing that its PS-targeting drug ba...

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

BOSTON, Nov. 12 /PRNewswire/ -- WHO and CDC have stated that the predictive accuracy of their annual formulations for human influenza vaccines is "suboptimal" -- often correct less than 50% of the time, especially for seniors. Perhaps in part because we are not yet accurate in our predictions ...

Replikins Oral Vaccine Synthesized in 7 Days Protects 91% of Shrimp Against a Lethal Virus

BOSTON, March 11 /PRNewswire/ -- Replikins, Ltd. has announced development of a chemically synthesized vaccine specific to a Taura Syndrome virus structure based on its patented Replikins(TM) technology. When the vaccine was administered orally to shrimp, 91% survived a challenge by the lethal...

Massive reanalysis of genome data solves case of the lethal genes

WALNUT CREEK, CA It is better to be looked over than overlooked, Mae West supposedly said. These are words of wisdom for genome data-miners of today. Data that goes unnoticed, despite its widespread availability, can reveal extraordinary insights to the discerning eye. Such is the case of a syst...

OpGen Creates Map of Worlds Most Lethal Fungus

Madison, Wis.-- The worlds most common lethal fungal infection is caused by a mold called Aspergillus fumigatus . Strains put transplant, leukemia and HIV/AIDS patients at serious risk. OpGen , a University of Wisconsin-Madison spinout, has created a whole genome map of this fungal pathogen that ...
Lethal in Biological Products

PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection

Description:...y delivery using PULSin may be superior to transfection in some applications. For example, unlike traditional transfection, with PULSin you can study lethal proteins and control the level and time course of proteins in cells. Likewise, delivery of blocking antibodies may provide more information than tradi...
Company:Polyplus Transfection

PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection

Description:...y delivery using PULSin may be superior to transfection in some applications. For example, unlike traditional transfection, with PULSin you can study lethal proteins and control the level and time course of proteins in cells. Likewise, delivery of blocking antibodies may provide more information than tradi...
Company:Polyplus Transfection

PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection

Description:... Unlike DNA transfection, with PULSin Protein & Antibody Delivery Reagent the amount and timing of exogenous proteins in cells can be controlled, even lethal proteins can now be studied. Real time function blocking and protein localization studies can now be easily performed using antibodies in living cell...
Company:Polyplus Transfection

Cleland’s Reagent from Calbiochem

Description:...so reaction is "driven" to completion. A protective agent for SH groups. Does not contain waxy surfactant found in many other preparations. Blocks the lethal and hypnotic effects of pentobarbitol. Purity: ≥97% by titration. Contaminants: Heavy metals: ≤1 ppm. Heavy metals: Oxidized dithiothreit...
Company:Calbiochem

Cleland’s Reagent from Calbiochem

Description:...so reaction is "driven" to completion. A protective agent for SH groups. Does not contain waxy surfactant found in many other preparations. Blocks the lethal and hypnotic effects of pentobarbitol. Purity: ≥97% by titration. Contaminants: Heavy metals: ≤1 ppm. Heavy metals: Oxidized dithiothreit...
Company:Calbiochem
Lethal in Biological Definition

Apoptosis

...sis, is incompletely understood. But it has been found that a mitochondrial outer-membrane protein, VDAC2, interacts with BAK to keep this potentially lethal apoptotic effector under control. When the death signal is received, products of the activation cascade - such as tBID, BIM or BAD - displace VDAC2: B...

Avian influenza

...the avian influenza virus undergoes antigenic shift with a human influenza virus, the new subtype created could be both highly contagious and highly lethal in humans. Such a subtype could cause a global influenza pandemic , similar to the Spanish Flu that killed over 20 million people in 1918 (though a...

Barbiturate

...pment of tolerance, the margin of safety between the effective dose and the lethal dose becomes very narrow. That is, in order to obtain the same level of int...with a muscle relaxant , for euthanasia and for capital punishment by lethal injection . References Text partially derived from public domain...

Chromosome

...it may lead to a higher chance of having a child with an chromosome disorder. Abnormal numbers of chromosomes or chromosome sets, Aneuploidy , may be lethal or give rise to genetic disorders. Genetic counseling is offered for families that may carry a chromosome rearrangement. The gain or loss of chromos...

Enzyme

...ssential to living organisms, and a malfunction of even a single enzyme out of approximately 2,000 types present in our bodies can lead to severe or lethal illness. An example of a disease caused by an enzyme malfunction in humans is phenylketonuria (PKU). The enzyme phenylalanine hydroxylase , which u...
Lethal in Biological Dictionary

Skin cell

...l trace back to the mutilation of melanin cells. Skin ... The modified skin cells added to cultured skin substitutes might fight potentially lethal infections in patients with severe burns. Skin Cell Types. Keratinocytes. The most abundant cell type of the epidermis is the keratinocyte....

RNA virus

...heir RNA into ... Double-stranded RNA viruses -- which include the rotavirus that kills about one ... RNA viruses : constant annoyance and lethal disease ... These viruses must do many things inside the cell using only RNA as an invading genetic code. ... Viruses consist basically of ...

Mutagenesis

... Mutagenesis Kit (Academic Use Only) ... Here, we propose a theory of lethal mutagenesis . ... To detect lethal mutagenesis , accurate measurements of the genome-wide mutation ... H...

Homozygous

...Homozygous Black (EE) can only pass on ... HancockHorses.com, portal website for Hancock bred horses. ... This is consistent with the homozygous lethal roan gene theory. ... law of segregation principle of heredity seed shape nbsp nbsp nbsp nbsp nbsp independent assortment: Definition of h...

Genetic interactions

... in the genetic etiology of complex ... ... similar patterns of genetic interactions often encode products that tend to work ... of synthetic lethal genetic interaction networks between distantly ... A highly successful approach is the use of genetic interactions . Genetic interactions...

Gene splicing

...tension of conventional plant breeding ... intron usually contains a clear signal for splicing (e.g., the beta globin gene ) ... g., the sex lethal gene of fruit fly), a splicing signal may be masked ... Alternative gene transcript splicing has increasingly become more common-forcing ...
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