Targeting the more lethal form of the cancer rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). Although ARMS is less common than ERMS, it is associated with a much higher rate of mortality. A therapy tail...Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells
DENVER - A combination of two targeted therapies packs a powerful punch to kill pancreatic cancer cells in the laboratory, Mayo Clinic cancer researchers report. With further testing of these drugs that are from classes of pharmaceuticals already used in patients, the Mayo research may lead to new...Most lethal melanomas are on scalp and neck
CHAPEL HILL People with scalp or neck melanomas die at nearly twice the rate of people with melanoma elsewhere on the body, including the face or ears, researchers at the University of North Carolina at Chapel Hill have found. The analysis of 51,704 melanoma cases in the U.S. confirms that sur...AMAS Test Measures Lethal Replikin Gene Activity in Lung and Other Cancers
BOSTON, Dec. 6 /PRNewswire/ -- A gene related to rapid replication and lethality has been found to be present in, and to contain some identical protein sequences in, tobacco mosaic virus and non-small cell lung cancer. The early detection diagnostic test for cancer, the AMAS(R) test, appears t...Peramivir Protects Mice From Lethal H5N1 Infection
St. Jude study shows intramuscular injection of peramivir for eight days protected mice from lethal H5N1 influenza virus infection and inhibited virus replication, supporting the use of this drug to control influenza during a pandemic MEMPHIS, Tenn., May 01, 2007 /PRNewswire-USNewswire/ -- The ant...Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
DENVER--(BUSINESS WIRE)--Jul 2, 2007 - Ceragenix Pharmaceuticals, Inc. (OTCBB:CGXP), a biopharmaceutical company focused on infectious disease and dermatology, today announced that researchers at the University of Pennsylvania led by Dr. Paul Janmey and Dr. Robert Bucki, in collaboration with Dr. P...Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks
...esignation in the US only weeks after a first designation was granted. The recent designation relates to Burkholderia cepacia pathogens that can cause lethal infections in cystic fibrosis patients. For Axentis Pharma AG of Zurich, Switzerland, both designations affirm the therapeutic potential of its produc...Artificial induction of immunity
...tion , which is the controlled infection of a less lethal natural form of smallpox (known as Variola Minor) ...ke him or her immune to re-infection with the more lethal natural form, Variola Major. This was practiced in...erial production of a toxin . Tetanus toxin is so lethal that humans cannot develop immunity to a natural i...Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
TUSTIN, Calif., November 23, 2008 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today reported publication of data in Nature Medicine that supports the broad anti-viral potential of the company's novel anti-phosphatidylserine (anti-PS) antibody platform, showing that its PS-targeting drug ba...Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination
Troy, N.Y. -- The mysterious death of patients around the world following a routine dosage of the common blood thinner, heparin, sent researchers on a frantic search to uncover what could make the standard drug so toxic. A researcher at Rensselaer Polytechnic Institute was among a small group of s...UC Davis researchers discover how HIV turns food-poisoning into lethal infection
(SACRAMENTO, Calif.) Nearly half of all HIV-positive African adults who become infected with Salmonella die from what otherwise would be a seven-day bout of diarrhea. Now, UC Davis School of Medicine scientists have discovered how salmonella becomes lethal for AIDS patients. Their findings also i...CSHL scientists identify cells that promote formation of lethal lung metastases
Cold Spring Harbor, NY Cancer patients usually ask what can be done after a primary tumor has already spread, or metastasized, to other organs. In many cases, they learn, little can be done. Hence the importance of a discovery by scientists at Cold Spring Harbor Laboratory (CSHL) of a type of cel...It's official: The carbon crisis is lethal for coral reefs
THE SITUATION: The largest living structures on Earth and the millions of livelihoods which depend upon them are at risk, the most definitive review yet of the impact of rising carbon emissions on coral reefs has concluded. In a paper published in the prestigious Science Magazine today, 1...Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
One of the new in vitro tests, called the Standard Scrapie Cell Assay, measures prion infectivity levels in a highly accurate and extremely rapid way, producing results in less than two weeks. The second test, called the Cell Panel Assay, allows researchers to quickly distinguish between several p...Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
TUSTIN, Calif., November 23, 2008 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today reported publication of data in Nature Medicine that supports the broad anti-viral potential of the company's novel anti-phosphatidylserine (anti-PS) antibody platform, showing that its PS-targeting drug ba...Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
TUSTIN, Calif., November 23, 2008 -- Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) today reported publication of data in Nature Medicine that supports the broad anti-viral potential of the company's novel anti-phosphatidylserine (anti-PS) antibody platform, showing that its PS-targeting drug ba...Replikins Oral Vaccine Synthesized in 7 Days Protects 91% of Shrimp Against a Lethal Virus
BOSTON, March 11 /PRNewswire/ -- Replikins, Ltd. has announced development of a chemically synthesized vaccine specific to a Taura Syndrome virus structure based on its patented Replikins(TM) technology. When the vaccine was administered orally to shrimp, 91% survived a challenge by the lethal...Massive reanalysis of genome data solves case of the lethal genes
WALNUT CREEK, CA It is better to be looked over than overlooked, Mae West supposedly said. These are words of wisdom for genome data-miners of today. Data that goes unnoticed, despite its widespread availability, can reveal extraordinary insights to the discerning eye. Such is the case of a syst...OpGen Creates Map of Worlds Most Lethal Fungus
Madison, Wis.-- The worlds most common lethal fungal infection is caused by a mold called Aspergillus fumigatus . Strains put transplant, leukemia and HIV/AIDS patients at serious risk. OpGen , a University of Wisconsin-Madison spinout, has created a whole genome map of this fungal pathogen that ...PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection
Description:...y delivery using PULSin may be superior to transfection in some applications. For example, unlike traditional transfection, with PULSin you can study lethal proteins and control the level and time course of proteins in cells. Likewise, delivery of blocking antibodies may provide more information than tradi...PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection
Description:...y delivery using PULSin may be superior to transfection in some applications. For example, unlike traditional transfection, with PULSin you can study lethal proteins and control the level and time course of proteins in cells. Likewise, delivery of blocking antibodies may provide more information than tradi...PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection
Description:... Unlike DNA transfection, with PULSin Protein & Antibody Delivery Reagent the amount and timing of exogenous proteins in cells can be controlled, even lethal proteins can now be studied. Real time function blocking and protein localization studies can now be easily performed using antibodies in living cell...Cleland’s Reagent from Calbiochem
Description:...so reaction is "driven" to completion. A protective agent for SH groups. Does not contain waxy surfactant found in many other preparations. Blocks the lethal and hypnotic effects of pentobarbitol. Purity: ≥97% by titration. Contaminants: Heavy metals: ≤1 ppm. Heavy metals: Oxidized dithiothreit...Cleland’s Reagent from Calbiochem
Description:...so reaction is "driven" to completion. A protective agent for SH groups. Does not contain waxy surfactant found in many other preparations. Blocks the lethal and hypnotic effects of pentobarbitol. Purity: ≥97% by titration. Contaminants: Heavy metals: ≤1 ppm. Heavy metals: Oxidized dithiothreit...