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Leptin in Medical News

UT Southwestern scientists discover leptin can also aid type 1 diabetics

DALLAS Aug. 25, 2008 Terminally ill rodents with type 1 diabetes have been restored to full health with a single injection of a substance other than insulin by scientists at UT Southwestern Medical Center. Since the discovery of insulin in 1922, type 1 diabetes (insulin-dependent diabetes) i...

Cardiac stent patients with diabetes may benefit from drug that counteracts the effects of leptin

NEW YORK (Dec. 17, 2008) The naturally high levels of leptin in diabetic patients may reduce the effectiveness of drug-eluting stents used to treat heart blockages, but using a chemical that differs from the one commonly used to coat stents could counteract this effect. The work by researchers...

How Does Leptin Work?

Leptin is a wonder hormone which is discovered around 1994 which has the ability to perform multi tasks such as to controls appetite, burns calories// and performs other crucial physiological activities. But the actual mechanism or mode of action through which Leptin carries out these metabol...

Hormone Leptin Found To Be Effective In Treating Women With Infertility Problems

A new study reveals women suffering from extremely low body fat whether due to strenuous exercise, eating disorders, or other factors may benefit from treatment with the appetite-and-weight-regulation hormone leptin.// The study also indicates leptin may be useful in treating some instances of inf...

Estrogen Curbs Appetite In Same Way as the Hormone Leptin

Estrogen regulates the brain’s energy metabolism in the same way as the hormone leptin, leading the way to a viable approach to tackling obesity in people resistant to leptin//, researchers at Yale School of Medicine report in the online issue of Nature Medicine. “We found that estrogen suppr...

Weight gain following smoking cessation not linked to Leptin

Smoking cessation has often been connected to gaining excess weight. It has been debated for long that this weight gain could be related to the hormone leptin, which regulates appetite and controls// weight. These arguments were based on assumptions that leptin levels were high during smoking perio...

Fish rich diet lowers leptin

According to a recent study, studied on African tribe, most of the things being equal including one's genes eating a diet rich in fish appears to be healthier for the heart than eating a vegetarian diet. The findings suggest a diet high in fish helps the body control blood levels of leptin,// a sub...

Making Obese Mice Slim, Without Diet or Exercise

...r activity levels. The mice in the study lacked leptin and receptors in the brain for leptin, a hormone t...idly obese and diabetic. When researchers added leptin receptors to a particular type of neuron (pro-opio...Harvard Medical School. Figuring out how to use leptin to help humans struggling with obesity has proven ...

Study further expands understanding of leptin's role in brain neurocircuitry

...se control, scientists have known that the hormone leptin plays a key role in the process. But within the my...ll Metabolism , the findings demonstrate that when leptin sensitivity is restored to a tiny area of POMC neu...1994 as an appetite and weight-regulation hormone, leptin plays a key role in energy homeostasis through its...

Cancer-obesity link discovery by MSU researchers could aid prevention efforts

...clusions are published in a study today in the journal Carcinogenesis . leptin a fat cell-derived hormone regulating body energy is higher in obese indi...viduals. Fenton's study is the first to demonstrate that, at higher levels, leptin induces precancerous colon cells to produce more of a growth factor that ca...

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Leptin in Medical Technology

Genaera Presents Preliminary Phase 1b Data for Trodusquemine (MSI-1436)

...squemine is the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), an enzyme central to controlling the function of both the leptin and insulin pathways. By inhibiting both central and peripheral PTP1B, MSI-1436 is expected to decrease appetite and normalize blood sugar. Initial cl...

Genaera Presents Promising Preclinical Data for Trodusquemine (MSI-1436) at Keystone Symposia

...squemine is the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), an enzyme central to controlling the function of both the leptin and insulin pathways. By inhibiting both central and peripheral PTP1B, MSI-1436 is expected to decrease appetite and normalize blood sugar. Initial cl...

Genaera Begins Phase 1b Trial of Trodusquemine (MSI-1436) in Overweight and Obese Type 2 Diabetics

... and obesity which works centrally and peripherally to regulate insulin and leptin pathways through the highly selective inhibition of its novel target enzyme...atase 1B (PTP1B), an enzyme central to controlling the function of both the leptin and insulin pathways. By inhibiting PTP1B, MSI-1436 is expected to decrease...

Genaera Corporation Reports Phase 1 Data for Trodusquemine (MSI-1436) at the North American Association for the Study of Obesity Annual Meeting

... PTP1B, a validated molecular target that controls the function of both the leptin and insulin pathways to normalize glucose and decrease appetite. In the stu...hatase 1B (PTP1B). PTP1B is central to controlling the function of both the leptin and insulin pathways. By inhibiting PTP1B, MSI-1436 is expected to decrease...

Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society

... symposium presentation: "Therapeutic Potential of leptin in General Obesity: A New, Integrated Neuroho... the weight-reducing effects of amylin and/or leptin in diet-induced obese (DIO) rats" will be pre...on treatment with neurohormones such as amylin and leptin can produce additive and synergistic weight loss i...

Genaera Releases Phase 1 Data and New Preclinical Data on the CNS Function of Trodusquemine (MSI-1436) at CBI Obesity Summit

...pressant and the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B is central to controlling the function of both the leptin and insulin pathways. By inhibiting PTP1B, MSI-1436 is expected to decrease appetite and normalize blood sugar. Trodusquemine has produced consistent,...

Genaera Corporation Presents Data on Mechanism of Inhibition of PTP-1B for Trodusquemine (MSI-1436) at Federation of American Societies for Experimental Biology (FASEB) Meeting

...essant and the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP-1B is central to controlling the function of both the leptin and insulin pathways. By inhibiting PTP-1B, MSI-1436 is expected to decrease appetite and normalize blood sugar. Trodusquemine has produced consistent...

Genaera Corporation Presents Additional Promising Preclinical Type 2 Diabetes Data for Trodusquemine (MSI-1436) at American Diabetes Association

...essant and the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP-1B is central to controlling the function of both the leptin and insulin pathways. By inhibiting PTP-1B, MSI-1436 is expected to decrease appetite and normalize blood sugar. Trodusquemine has produced consistent...

Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity

... the natural hormone amylin, and recombinant human leptin (r-metHuLeptin; metreleptin) for the treatment of ...ed hope of harnessing the therapeutic potential of leptin as part of an integrated neurohormonal approach to...ion provide preclinical and clinical evidence that leptin responsiveness is at least partially restored by a...

Genaera Corporation Presents Promising Preclinical Type 2 Diabetes Data for Trodusquemine (MSI-1436) at Keystone Symposia

...essant and the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP-1B is central to controlling the function of both the leptin and insulin pathways. By inhibiting PTP-1B, MSI-1436 is expected to decrease appetite and normalize blood sugar. Trodusquemine has produced consistent...
Leptin in Medical Products

Ghrelin, Total ELISA Test

Description:...l state of Ghrelin resistance analogous to that of leptin resistance in obesity remains to be elucidated. In... that is analogous to the elucidation of a role of leptin in the control of reproductive function (4). K...000. Henson, M.C. & Castracane, V.D., eds. (2003) leptin and Reproduction. Kluwer Academic Publishers, New ...
Company:Diagnostic Systems Laboratories, Inc.

Leptin IRMA Test

Description:... leptin is a proteohormone with a molecular weight of 16 kDa. leptin is a protein encoded by the ob gene and produced by adipocytes [1,2]. leptin is thought to play a key role in the regulation of...
Company:Diagnostic Systems Laboratories, Inc.

Leptin Soluble Receptor ELISA Test

Description:... leptin is a 16kDa peptide encoded by the ob gene and is p...y influencing energy intake and expenditure [1,2]. leptin functions as a lipostat and is produced by adipocy...response to increasing fat stores. Increased serum leptin levels signal the brain to stop eating and increas...
Company:Diagnostic Systems Laboratories, Inc.

Leptin ELISA Test

Description:... leptin is a proteohormone with a molecular weight of 16 kDa. leptin is a protein encoded by the ob gene and produced by adipocytes [1,2]. leptin is thought to play a key role in the regulation of...
Company:Diagnostic Systems Laboratories, Inc.
Leptin in Biological News

Joslin researchers uncover potential role of leptin in diabetes

BOSTONOctober 1, 2007A new Joslin-led study has shown that leptin, a hormone known mainly for regulating appetite control and energy metabolism, plays a major role in islet cell growth and insulin secretion. This finding opens up new avenues for studying leptin and its role in islet cell biology,...

NIH funds research center for women's reproductive health at Einstein

...Perry, M.D., Ph.D., assistant professor of obstetrics & gynecology and women's health and of neuroscience. "Antagonistic actions of melanocortins and leptin on reproductive competence"Streamson Chua, Jr., M.D., Ph.D., professor of medicine and of neuroscience. ...

Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover

...n leptin," Dr. Yanagisawa said. "They have tons of leptin floating around. The problem is that their brain i...ad lower blood levels of leptin, implying that the leptin was more effective in controlling weight in these ...ce. In addition, when the researchers administered leptin to the high-orexin mice, the animals responded wit...

Disabling enzyme allows mice to gorge without becoming obese, new study finds

...n average of 5 grams of food per day, while mice that lacked both AdPLA and leptin ate 7.5 grams. Typically, normal mice will eat only 2-3 grams per day. By 1...ting the scales at 75 grams. In comparison, mice that lacked both AdPLA and leptin weighed just under 35 grams. The researchers found that levels of AdPLA ...

Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect

...rlying the different reaction of people to lifestyle and environmental conditions." With the exception of the SH2B1 gene, which plays a role in the leptin signalling and thus in the regulation of appetite, none of the other five genes was hitherto discussed as obesity genes. Iris Heid and her collegue Cl...

Leptin's long-distance call to the pancreas

...B ). In the fight against obesity and diabetes, leptin is one of the good guys. Mice lacking the hormone ...y-high insulin levels eventually lead to diabetes. leptin can curtail insulin release directly. But there's ...ill trying to piece together. Scientists knew that leptin nudges osteoblasts, cells known for building bone ...

Fructose sets table for weight gain without warning

... 2008) − Eating too much fructose can induce leptin resistance, a condition that can easily lead to be... Although previous studies have shown that being leptin resistant can lead to rapid weight gain on a high-...calorie diet, this is the first study to show that leptin resistance can develop as a result of high fructos...

New master switch found in the brain that regulates appetite and reproduction

...star regulator of appetite, Montminy says, because leptin turns on TORC1, which in turn activates a number o...esity results when the brain becomes "deaf" to the leptin signal, so one goal of Montminy's research is to "...ut we put two and two together," he says. "We knew leptin is the critical hormone for regulating body weight...

Mom's obesity during conception phase may set the stage for offspring's obesity risk

...at feeding significantly increased serum glucose, triglyceride, insulin and leptin levels in both groups. Strikingly, the serum insulin and leptin levels increased by 2.2 and 2.3 fold in obese offspring compared to lean of...

Cheaper drugs now closer to realization with new DropArray technology

... of samples and reagents required provides similar advantages for protein-based assays such as ELISA with limited human and animal serum such as Human leptin and Endostatin assays. This DropArray was realized through the efforts of an interdisciplinary team of researchers, which is typical of the projec...
Leptin in Biological Technology

Amylin Pharmaceuticals Announces Positive Results from Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment for Obesity

... p<0.01) than those receiving placebo (1.8%; 4 pounds) or either agent alone (approximately 5%; 10 pounds). Consistent with the physiologic role of leptin in regulating body fat, the weight loss in these patients was predominantly due to a reduction in fat mass (approximately 18 of the 22 pounds lost). T...

Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008

...tion Treatment in Obese Subjects: Clinical Evidence for Restoration of leptin Responsiveness by Amylin Agonism" will be presented by Christian Weyer...0 PM PT (8:00 PM ET). 3. Oral: "Triple Peptide Administration of Amylin, leptin and PYY (3-36) in Diet-Induced Obese Rats: Magnitude and Mechanism of ...

A week in UW research: fusion, racing and sleep

...egulated the production of hormones related to appetite. People who slept less tended to want to eat more. Sleep deprivation led to lower levels of leptin and higher levels of ghrelin, the study found. The combined effect is likely to increase appetite. The project, named the Wisconsin Sleep Cohort St...

The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System

...nked to the regulation of appetite (1). Evidence has suggested that melanocortins are involved in mediating appetite regulation through the effects of leptin and controlling the expression of neuropeptide Y. Thus, the MC 4 receptor is a potential target for anti-obesity agents (2).

This applic...

RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater

...iple genes. As shown in Figure 1, the long form of leptin receptor mRNA was detected in arcuate b...A) was performed for 40 cycles for both leptin receptor and glucokinase. A lower C t value indic...t gene (it is detected more quickly). P leptin receptor was not detected (ND) in the thalamus RNA...
Leptin in Biological Products

Human Leptin Receptor, soluble (Ob sR) ELISA Kit from R&D Systems

Description: ...
Company:R&D Systems

Rat Leptin from BioVision

Description: rat Leptin...
Company:BioVision

Rat Leptin from Cell Sciences

Description: Recombinant Rat Leptin, Ultra Pure...
Company:Cell Sciences

Rat Leptin Assay Kit from Immuno-Biological Laboratories, Inc.

Description: This kit #27295 has improved stability and convenience from the former kit #17295. However, the improved kit not only has overcome this problem but also produced some advantages as follows. At first, we have changed the formulation of HRP conjugated antibody from lyophilized product to liquid (0.4m...
Company:Immuno-Biological Laboratories, Inc.

Porcine Leptin ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description: Leptin is a proteohormone with a molecular weight of 16 kDa. Leptin is a protein encoded by the ob gene and produced by adipocytes [1,2]. Leptin is thought to play a key role in the regulation of body weight [1-3]. In the human, leptin levels are elevated with increasing adiposity in both men an...
Company:Diagnostic Systems Laboratories, Inc.

Rabbit Anti-Leptin Receptor Polyclonal Antibody, Unconjugated from BioVision

Description:... leptin Receptor Polyclonal Ab 100 ug purified rabbit anti-mouse leptin Receptor. Tested in Western blotting....
Company:BioVision

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Leptin in Biological Definition

Hormone

... hGH) insulin insulin-like growth factor (IGF, also somatomedin) leptin luteinizing hormone (LH) melanocyte stimulating hormone (MSH or &#...mones" - ghrelin , orexin and PYY 3-36 - and their antagonists - e.g. leptin . Spelling note Current North American and international usage is es...
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