Coming Soon: Lung-Cancer Spray?

... over more invasive modes of delivery." In the study, researchers used a lentiviral vector derived from a retrovirus able to infect non-dividing cells, causing lasting genetic changes. The lentiviral vector included a carboxyl-terminal modulator protein (CTMP), which inhibit...

Vaporized viral vector shows promise in anti-cancer gene therapy

...e associated with the activation of the Akt signaling pathway. They chose a lentiviral vector, derived from a retrovirus and known for its ability to infect nondividing cells and effect persistent genetic changes. They transfected the lentiviral vector with a negative regulator of Akt signaling, carboxyl-terminal modula...

The vulnerable cancer cell

...ning technology to assess about 5,000 shRNAs targeting about 1,000 human genes in a panel of eight human cancer cell lines. The shRNAs were carried in lentiviral vectors, which the researchers used to infect four cell lines carrying KRAS mutations and four lines carrying KRAS-wild-type genes. At the top of ...

UCSF creates fast, affordable tool for finding gene 'on-off' switches

...nome, the team will continue creating libraries for other species. McManus said he plans to make shRNA libraries available through the UCSF Sandler lentiviral RNAi Core, which he directs. The Core provides essential equipment, training, supervision, and monitoring for researchers working in lentiviral-based ...

Penn Medicine presents HIV gene therapy trial data at CROI 2009

... in a Phase I/II Open-label Clinical Trial Evaluative Multiple Infusions of lentiviral Vector-modified CD4+ T Cells Expressing Long env Antisense" was made by Pab... University of Pennsylvania School of Medicine. "The multiple infusions of lentiviral vector VRX496 with long antisense RNA appear to be safe, and no serious adv...

Converting adult somatic cells to pluripotent stem cells using a single virus

...er's Disease. Their research titled "iPS Cell Generation Using a Single lentiviral Stem Cell Cassette" appears on line in the journal Stem Cells . Prior... 10 times higher than previously reported studies. "The use of a single lentiviral vector for the derivation of iPS cells will help reduce the variability in ...

Open Biosystems Launches Decode RNAi Viral Screening Pools for Low-Cost Genome-Scale RNAi Screens

...ecode RNAi viral screening set has been created using Open Biosystems' GIPZ lentiviral shRNAmir library validated in its ability to produce effective knockdown ev...This pooled screening set targets the entire human genome in a ready-to-use lentiviral pool format, extending RNAi screening to primary and non-dividing cells. Th...

Open Biosystems' Open Access RNAi Program Continues to Gain Momentum Worldwide

...don and Hospital for Sick Kids purchase Open Access to lentiviral RNAi libraries HUNTSVILLE, Ala., March 26 /PRNewswire/ -- Open Biosystems...ing the entire human and mouse genomes, the RNAi Consortium human and mouse lentiviral shRNA libraries as well as RNAi collections targeting Drosophila, C. elegan...

Einstein researchers genetically engineer immune cells into potent weapons for battling HIV

...ce with both HIV-infected human cells and with reprogrammed nave CTLs into which the HIV-recognizing T-cell receptor genes had been inserted using the lentiviral delivery system. One week later, when the researchers looked for HIV-infected human cells in the animals, they found that the infected cells had virtu...

Cell Genesys Reports Fourth Quarter and Year-End 2007 Results

...nough events needed to trigger the final analysis of VITAL-1 in the second half of 2009. -- Announced in December 2007 the sale of Cell Genesys' lentiviral gene delivery technology to GBP IP, LLC, an affiliate of GBP Capital, the majority shareholder in privately held Lentigen Corporation, for $12...

Lentiviral in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

...vention strategies in organ transplantation. The rat is an important immunological model, and INSERM routinely generates transgenic rats using DNA or lentiviral vector microinjection. The generation of transgenic rats also is open to the scientific community through an open facility. More information is avai...

VIRxSYS to Host a Web Conference to Announce Clinical Trial Update

...udy of VRX1023, a new vaccine approach that uses a lentiviral vector expressing HIV antigens. In the study, VRX1... the likelihood of new infections. Conference on lentiviral Vectors (Evry, France) July 2008 VIRxSYS was inv... sponsor of the world's first clinical trial using lentiviral vectors, VIRxSYS has the most extensive data base ...

VIRxSYS Presents Data on HIV Vaccine at Keystone HIV Vaccine Symposia

... HIV-Based lentiviral vector VRX1023 Shows Promising Results GAITHERSB...s vector boost. VRX1023, an HIV antigen expressing lentiviral vector, has produced positive results in mice and ...ihood of new infections. "The use of a HIV-based lentiviral vector represents a truly innovative approach to a...

Thermo Fisher Scientific Advances Gene-Silencing Technology for Life Sciences Research

...ermo Scientific Dharmacon(R) SMARTvector(TM) shRNA lentiviral Particles, combines Thermo Scientific gene-silenci... officer of Lentigen, said, "By linking Lentigen's lentiviral technology and production capabilities with the RN...g." Thermo Scientific Dharmacon SMARTvector shRNA lentiviral Particles can be ordered at http://www.thermo.com...

Lentiviral in Biological News

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

...llow stable integration of transgenes and propagation into daughter cells. lentiviral vectors are preferred because they can transduce non-proliferating cellular...rs. The article, "Hematopoietic Stem Cell Targeting with Surface-Engineered lentiviral Vectors," is freely available on the website for Cold Spring Harbor Protoc...

Salk researchers develop novel glioblastoma mouse model

...cher and co-author Dinorah Friedmann-Morvinski. To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mic...

Studies on imaging and tracking transplanted cells

...aluate via noninvasive monitoring the effectiveness of transplanted cells to engraft and repopulate the recipient liver. Using double or triple fusion lentiviral vectors in a mouse model transplanted with immortalized fetal hepatocytes, the researchers for the first time imaged in vivo human hepatic progenitor ...

Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods

...cificity of small interfering RNA (siRNA) silencing with the versatility of lentiviral vectors gives researchers a powerful tool for the investigation of gene fun...enes in a wide range of cell types. "Design and Cloning of an shRNA into a lentiviral Vector" is freely accessible on the website for Cold Spring Harbor Protoco...

U. Mass Medical School and Carnegie announce licensing agreements with Oxford BioMedica

...ene therapy applications of RNA interference using lentiviral vectors. A lentiviral vector is based on a type of virus that infects di...rug development opportunities presented by Oxfords lentiviral vector delivery technology is intriguing to us. W...

UMMS and CIW grant key RNAi rights to Oxford Biomedica

...ene therapy applications of RNA interference using lentiviral vectors. A lentiviral vector is based on a type of virus that infects di...rug development opportunities presented by Oxfords lentiviral vector delivery technology is intriguing to us. W...

New chimeric mouse model for human liver diseases, drug testing

...e liver is repopulated by human hepatocytes. But whats more, the transplanted cells keep producing a foreign protein slipped inside with the help of a lentiviral vector, the kind usually used for gene therapy. We are very excited about that aspect since very often cells shut off the production of proteins intro...

Penn Veterinary Medicine report new strategy to create genetically-modified animals

...animals. These inefficient and difficult methods also carry a risk of producing offspring with developmental abnormalities. The use of retroviral or lentiviral vectors has been reported in rodents, but it requires that animals be handled and maintained under higher biosafety precautions that render this appro...

Proteasome activator enhances survival of Huntington's disease neuronal model cells

... either non-ubiquitinated protein degradation pathways (PA28ƒ×) or subunits of PA700, the 26S proteasome ubiquitinated pathway (S5a) into transducible lentiviral vectors. To address the therapeutic hypothesis experimentally, we transduced UPS subunits into HD skin fibroblasts or HD mutant protein expressing str...

Can engineered immune cells stop AIDS?

...ect both dividing and nondividing cells. Wang says lentiviral vectors are very efficient delivery vehicles for h...nufactured recombinantly, this modified virus ?the lentiviral vector -- becomes a natural delivery system that c...e cells." Another problem seems to be making sure lentiviral vectors target only hematopoietic stem cells, and ...

Lentiviral in Biological Technology

Lentigen Licenses Fundamental Lentiviral Vector Technology Patent From the University of Cambridge

BALTIMORE, April 3, 2008 /PRNewswire/ -- Lentigen Corporation today announced an exclusive licensing agreement with Cambridge Enterprise, the organization responsible for licensing technologies from the University of Cambridge (U.K.), for a fundamental patent in the area of lentiviral vector t...

Cell Genesys Announces Sale of Lentiviral Gene Delivery Technology for $12 Million

SOUTH SAN FRANCISCO, Calif., and GREENWICH, Conn., Dec. 20 /PRNewswire- FirstCall/ -- Cell Genesys, Inc. (Nasdaq: CEGE ) and GBP IP, LLC, an affiliate of GBP Capital, the majority shareholder in privately held Lentigen Corporation, today announced that the two companies have entered into an a...

VIRxSYS Publishes New Study on RNA Therapy

... a private biotechnology company that focuses on the development of a novel lentiviral gene delivery platform technology for the treatment of serious diseases. The Company has exclusively licensed its patented, proprietary lentiviral technology platform from The Johns Hopkins University (JHU) in Baltimore,...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

...n clones; and 3) All-in-One(TM) miRNA RT-qPCR system. Constructed in a lentiviral vector system, miExpress(TM) precursor miRNA expression clone collections cover all known miRNAs for human (750), mouse (450), and rat (270). These lentiviral vector based expression constructs allow efficient transduction of miRNAs i...

Sigma-Aldrich Introduces MISSION(R) LentiPlex(TM) Pooled shRNA Libraries to Enable Rapid Whole Genome Screening in Primary Cells, Stem Cells or Tumor Cells

...nch-top level in a convenient and powerful, pooled lentiviral format. As a member of both TRC-1 and TRC-2 colla...ercial source for access to TRC shRNA libraries in lentiviral format. The MISSION LentiPlex Pooled shRNA ...e genes. Combining Sigma-Aldrich's high-throughput lentiviral production methodologies with the pooled library f...

Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement

...specializing in the development and manufacture of lentiviral gene delivery technologies, and Expression Therape...iotechnology company focused on the development of lentiviral vector technology for a wide range of therapeutic,...search applications in biotechnology and medicine. lentiviral vectors are the most efficient vehicles for the de...

Lentigen Corporation and PATH Announce Partnership on Innovative Vaccine for Pandemic Influenza

...development and commercialization of breakthrough treatments for human disease. The company's development programs, which are based on its proprietary lentiviral RNA delivery technology, include novel cell, vaccine, and protein therapeutics. Lentigen manufactures and supplies research products based on this tec...

Lentigen Corporation Announces Relocation to New Facility

...needs as the leading developer and manufacturer of lentiviral vectors (LVs) and proteins for a wide range of cli...anufacturing to the clinic. We plan to manufacture lentiviral products for clinical trials during 2009 and we wi...uring projects for collaborators as the market for lentiviral products expands." About Lentigen Corporation ...

Lentigen Appoints Jim Meade as Vice President of Corporate Development

...iotechnology company focused on the development of lentiviral vector technology for a wide range of therapeutic,...search applications in biotechnology and medicine. lentiviral vectors are the most efficient vehicles for the de...n is a highly collaborative company, co-developing lentiviral vector-based products across a broad spectrum of b...

AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response

...n addition, a primary goal of TIGET research is to improve the efficiency and safety of gene transfer by advancing the development and applications of lentiviral vector technology. For this research TIGET also received funding from the European Union (VIth Framework Program: Project RIGHT). Certain statements...

Lentiviral in Biological Products

ViraPower UbC Lentiviral Gateway Expression Kit from Invitrogen

Description: Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient...
Company:Invitrogen

ViraPower Lentiviral Packaging Mix from Invitrogen

Description: Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient viral deliver...
Company:Invitrogen

Lentiviral Vector Manufacture from Lentigen

Description:... Lentigen's manufacturing platform is sufficiently versatile for use in the manufacture of any HIV-based lentiviral vector. Lentigen will manufacture your LV of choice to the highest possible titer and purity. • Starting at $2,450...
Company:Lentigen

293FT Cell Line from Invitrogen

Description:...ng 2;Many mammalian cell types and experimental situations create challenges for standard transfection and other viral transduction systems. ViraPower lentiviral Expression System overcomes these challenges by efficiently transduci...
Company:Invitrogen

pLenti6/V5 Directional TOPO Cloning Kit from Invitrogen

Description:...ng 2;Many mammalian cell types and experimental situations create challenges for standard transfection and other viral transduction systems. ViraPower lentiviral Expression System overcomes these challenges by efficiently transduci...
Company:Invitrogen

Lentiviral in Biological Dictionary

SiRNA

...ifically inhibit MEK1 expression using RNA interference, a method in which ... siRNA Products ... Chromosome DBase siRNA shRNA Plasmids shRNA lentiviral Transfected Lysates Flow ... Biotechnology now offers siRNA gene silencers targeted ... Small interfering RNA Mediating RNA interference in c...

RNAi

...Related to RNAi ... Decode RNAi viral screening pools. miR-express lentiviral ... pLKO.1 lentiviral shRNA Libraries from the RNAi Consortium (TRC) RNAintro shRNA Starter Kit...

MicroRNA

... suite of analytical services to advance your microRNA research. These comprehensive services are designed to be one-stop and get ... miR-express lentiviral microRNA - for over-expression of human pri-miRNA transcripts ... microRNA biogenesis ... A uniform system for microRNA annotation. ... A...

Gene family

...otated Genes . Cancer Genes . Druggable Genes ... Human TRC gene families and pathways - defined by Gene Ontology ... Human Apoptosis TRC lentiviral shRNA gene family -Glycerol. call. call. Search: ... For Low Income Families . Healthy Families . Retinoblastoma Gene . Human Resources Jobs ...

Gene families

... Expression. Human. Human Full-Length Expression ... Human TRC gene families and pathways - defined by Gene Ontology ... Human Apoptosis TRC lentiviral shRNA gene family -Glycerol. call. call. Search: ... The evolution of gene families has been studied for over 50 years. ... Mammalian Gen...

Expression clone

...tructural genomics and functional genomics ... design tool for designing expression cloning experiments ... OmicsLink™ Expression Clones. lentiviral Packaging Kits and Cells ... MicroRNA Expression Clones. MicroRNA 3'UTR Target ... Expression Clone Construction ... MiRNA & Target Clone...