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Lamivudine in Medical News

President Clinton and Mylan Chairman and CEO Robert J. Coury Announce New Agreement to Lower Price of Treatment for Patients with Drug-Resistant HIV in Developing Countries

...e all four drugs -- Atazanavir (ATV), Ritonavir (RTV), Tenofovir (TDF), and lamivudine (3TC) -- needed to enable once-daily treatment of patients who have develop...e ARVs. The four drugs will be available in three pills, with Tenofovir and lamivudine combined into a single pill. The three pills are being made available today...

New studies examine elimination of hepatitis B and C

...eated with peginterferon alfa-2a (21 percent) or peginterferon alfa-2a plus lamivudine (17 percent) achieved HBsAg levels under 100 IU/mL at the end of treatment compared with lamivudine (1 percent)," they report. "HBsAg clearance represents the best possible...

Medical research community needs to speak louder to prevent another Canadian brain drain

...Canada. T-cell receptors were cloned in Canada, the sequencing of the SARS virus genome was unveiled here and important medical treatments such as lamivudine for HIV/AIDS and montelukast for asthma have been developed in Canada. "Health professionals and scientists need to understand that Budget 2009 ca...

How to select anti-hepatitis B virus agents for drug-resistance patients?

... were transient transfected into Huh7 cells and antiviral susceptibility of lamivudine and adefovir were analyzed in vitro model system. Furthermore, the antivira...ould effectively replicate and be expressed in Huh7 cells. Adefovir but not lamivudine inhibited HBV replication both in vitro and in vivo. The novel method de...

The prevalence of hepatitis B virus infection in inflammatory bowel disease patients

...h these drugs. In patients with positive HBsAg, it would be recommended the lamivudine use before immunological suppression. After this study, it was recommende...ion for IBD patients that have never been infected by BV and also recommend lamivudine for patients with positive anti-HBc and needs to use steroids and immunomod...

A potential approach to treatment of hepatitis B virus infection

...nly approximately one-third of the patients and produces considerable side effects. Long-term treatment with the second-generation nucleoside analogue lamivudine (lam) efficiently inhibits HBV replication with frequent viral polymerase mutations. We found that HBV infection triggered an ATR-dependent DNA damage...

Head-to-Head 96-Week Study Shows EPZICOM(R) is Comparable to Truvada(R) in Efficacy and Safety Measures in HIV Treatment-Naive Patients

...f your liver does not function normally. Some patients infected with both hepatitis B virus (HBV) and HIV have worsening of hepatitis after stopping lamivudine (a component of EPZICOM). Discuss any change in treatment with your doctor. If you have both HBV and HIV and stop treatment with EPZICOM, you should b...

Analysis of Six Clinical Trials Finds EPZICOM(R) Effective in Treatment-Naive HIV Patients With Both High and Low Baseline Viral Loads

...f your liver does not function normally. Some patients infected with both hepatitis B virus (HBV) and HIV have worsening of hepatitis after stopping lamivudine (a component of EPZICOM). Discuss any change in treatment with your doctor. If you have both HBV and HIV and stop treatment with EPZICOM, you should b...

What is the more suitable for early detection of low abundant lamivudine-resistant mutants?

... lamivudine is an effective antiviral agent for treatment of p... B and advanced liver diseases. However, long-term lamivudine monotherapy leads to the emergence of lamivudine-r...ations in mixed plasmids and serum samples from 52 lamivudine treated patients. Time required and reagent cost f...

Standard Hepatitis B Treatment Bested by Newcomer

...itis B to receive either 600 milligrams of telbivudine or 100 milligrams of lamivudine once daily. After a year of treatment, 75.3 percent of HBeAg-positive pe...zed clinical trial. Entecavir has also been shown to be more effective than lamivudine and creates less resistance as well. More information To learn more...
Lamivudine in Medical Technology

Pharmasset Reports Fiscal Year End 2008 Financial Results

...ring 2008, new data from multiple investigator sponsored studies supported the potential of clevudine to treat hepatitis B (HBV), including its use in lamivudine resistant patients. Data from one study suggested that clevudine is as effective as entecavir (Baraclude(R)) and that it can be effectively used in co...

Ninety-Six Week Data on Tibotec Investigational NNRTI, TMC278, Presented at AIDS 2008

... three doses of TMC278 or EFV, and all patients received a background regimen of two nucleoside reverse transcriptase inhibitors (NRTIs), zidovudine + lamivudine (AZT/3TC) or tenofovir + emtricitabine (TDF/FTC). Safety Results Of patients in the TMC278 combined group compared with EFV, 9 percent vs. 21 perc...

Tibotec Conducts Two Pivotal Phase III Clinical Trials Studying TMC278 in Treatment-Naive Adults with HIV

...5 mg) once daily versus EFV (600 mg) once daily, when combined with an investigator-selected background regimen consisting of two N[t]RTIs (abacavir + lamivudine or tenofovir disoproxil fumarate + emtricitabine or zidovudine + lamivudine). Each study will be conducted at more than 100 sites in over 20 countri...

BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients

... - Data Indicate Pre-existing lamivudine Resistance Predisposes Patients to Higher Rates of BARACLUD... lamivudine-refractory patients who received BARACLUDE after treatment with lamivudine failed, the cumulative probability of genotypic BARACLUDE resistance was 51...

Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART

...masset.com/pipeline . Clevudine was Superior to lamivudine in the Patients with HBeAg(+) Chronic Hepatitis B....ompare the efficacy and safety of clevudine versus lamivudine for 48 weeks in chronic hepatitis B (CHB) e-antige...levudine 30mg showed superior viral suppression to lamivudine 100mg without the emergence of viral breakthrough ...

Avexa Reports Positive Phase IIb Result

...he viral load of patients with drug-resistant HIV with the effectiveness of lamivudine (3TC), a leading NRTI in widespread use. A total of 47 patients completed 2...AVX-201 is a randomised, double blind study of two doses of ATC compared to lamivudine (3TC) in treatment-experienced HIV-1 infected patients with the M184V mutat...

Baraclude (entecavir) Therapy Resulted in Undetectable Levels of Hepatitis B Virus in Cohort of Patients Who Re-Started Treatment

...ap between end of treatment in study ETV-027 and start of treatment in study ETV-901. -- ETV-027 compared 0.5 mg of BARACLUDE vs. 100 mg of lamivudine in nucleoside-naive chronic HBeAg-negative chronic hepatitis B patients. -- Rollover study ETV-901 was established as an open-label, follow-up protoco...

Idenix Announces Data Presentations at the 2007 Digestive Disease Week Meeting

... Dr. Yuming Wang, Professor of Infectious Disease, Southwest Hospital, Chongqing, China, will present "A Phase III Comparative Trial of Telbivudine vs lamivudine in Chinese Patients with Chronic Hepatitis B: Two- Year Results" in a poster session beginning on Sunday, May 20, 2007 at 8:00 a.m. EDT. Dr. Vinod R...

Pharmasset Presents Clevudine and Racivir Data at the International HIV Drug Resistance Workshop

... of a 600 mg dose of Racivir head-to- head against lamivudine in HIV-infected, treatment-experienced patients with the M184V mutation who have been on lamivudine therapy. Racivir demonstrated antiviral activity in patients harboring HIV with the M184V mutation and less than three thymidine analog mutations. The...
Lamivudine in Biological News

BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients

...acific Association for the Study of the Liver (APASL) in Seoul, Korea. In lamivudine-refractory patients who received BARACLUDE after treatment with lamivudine failed, the cumulative probability of genotypic BARACLUDE resistance was 51 percent through the fifth year. This finding is consistent with prior obse...

Widely used hepatitis B drug spurs HIV drug resistance

...a medication that prevents HIV replication and "is a cornerstone of most drug-combination therapies used to fight the immune system disease." Because lamivudine is in the same category of HIV therapies as another widely used drug, emtricitabine, its effectiveness is also compromised by entecavir, she says. ...

UCLA study assesses cost-effectiveness of Hepatitis B drugs

...s B: 1) No treatment at all 2) Interferon alone 3) lamivudine alone 4) Adefovir alone 5) Beginning therapy with ...e agent in people who develop viral resistance for lamivudine ?a therapy that has been available for over 15 yea...thcare System. "The combined treatment strategy of lamivudine and adefovir is also a very viable option. This is...
Lamivudine in Biological Technology

Shire plc: IFRS Results for the Year Ending December 31, 2007

...mbivir, Zeffix and Epzicom in the US. Pursuant to the GSK/Shire license for lamivudine products, GSK has the right to enforce the licensed patents. In November 20...s relating to Combivir. The patent, which covers the combination of AZT and lamivudine to treat HIV, expires in May 2012. Teva had filed an ANDA with the FDA with...

Shire plc: Excellent Performance Across All Areas of the Business and Accelerating New Product Sales Drive Revenue Growth of 36%

...MBIVIR, ZEFFIX and EPZICOM in the US. Pursuant to the GSK/Shire license for lamivudine products, GSK has the right to enforce the licensed patents. In November 20...s relating to COMBIVIR. The patent, which covers the combination of AZT and lamivudine to treat HIV, expires in May 2012. Teva had filed an ANDA with the FDA with...
Lamivudine in Biological Definition

Hepatitis B

... for chronic hepatitis B that can increase a person's chance of clearing the infection. Treatments are available in the form of antivirals such as lamivudine and adefovir and immune system modulators such as interferon alpha . There are several other antivirals under investigation. Roughly, all of the cu...
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