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Laminin in Medical News

Carbohydrate acts as tumor suppressor

...vity. The research was published in the journal Proceedings of the National Academy of Sciences . The specialized glycans are capable of binding to laminin and are attached to the α-DG cell surface protein. This binding facilitates adhesion between epithelial and basement membrane cells and prevents ...

Investigational drug tested for preventing muscle fiber death in muscular dystrophy

... of two structural proteins, delta-sarcoglycan and laminin alpha2. Similar to deleting the gene encoding c...d the experiment with mice lacking a gene encoding laminin alpha2, which causes a more severe dystrophy, swol... two months of age. In contrast, mice lacking both laminin alpha2 and cyclophilin D showed much healthier mus...

Neurotransmitters in biopolymers stimulate nerve regeneration

...ty percent acetylcholine also led to a neurite growth rate of up to 0.7 millimeters per day, or approximately half the thickness of a compact disc. laminin is a natural protein present in the nervous tissues, but it dissolves in water, making it difficult to incorporate into a conduit that needs to suppor...

An eye for an eye: using stem cells to treat damaged eyes and a rare skin disorder

...f the disease there is a mutation in one of these anchoring proteins called laminin 5. The Italian researchers obtained consent to carry out a small-scale tria...hem from a biopsy. The team then used gene therapy to insert the correct laminin gene into the growing cells and grafted the new tissue onto the patients bo...

New Technique Dissects Stem Cells' Picky Likes, Dislikes

...major protein component of the ECM called laminin. laminin also makes up about 60 percent of Matrigel, an ext...faces - each displaying just a single peptide from laminin - did as well as the mixture Matrigel at growing h...he researchers don't yet know why these particular laminin peptides promote human ES cell growth. But with th...

Suitable Culturing Medium, essential for Stem Cell Development

... a stem cell, but in early stages it seems nurture is very important.’ In experiments, scientists confirmed a cell culture surface molecule called laminin activates a common developmental pathway that is crucial for the generation and survival of particular types of brain cells. The laminin-influence...

Integrin helps healing process in cells

...bbed on to that sticky layer of proteins, which included a substance called laminin 5. Without interfering with the initial cell movement started by t...he first round of chemical signals, the second integrin essentially blocked laminin 5 by turning off the first integrin. These findings are reported in the Apr...
Laminin in Biological News

Potential therapy for congenital muscular dystrophy

...rom Rooney et al "indicate a critical role for the alpha7beta1 integrin and laminin in muscle repair and suggest direct muscle injections of laminin may serve as an exciting novel therapy for patients with alpha 7 integrin c...

Laminin builds the neuromuscular synapse

...eveals that an extracellular matrix protein called laminin shapes both sides of the junction to ensure they f...forming part of the sheath that covers muscle, the laminin protein has different domains called alpha, beta, ...s. Previous work had shown that the beta2 chain of laminin spurs differentiation of the nerve terminal. The t...

Birds going extinct faster due to human activities

...a stem cell, but in early stages it seems nurture is very important." In experiments, scientists confirmed a cell culture surface molecule called laminin activates a common developmental pathway that is crucial for the generation and survival of particular types of brain cells. The laminin-influen...

Medium is the message for stem cells in search of identities

...a stem cell, but in early stages it seems nurture is very important." In experiments, scientists confirmed a cell culture surface molecule called laminin activates a common developmental pathway that is crucial for the generation and survival of particular types of brain cells. The laminin-influen...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...f the most severe, is due to a genetic mutation of laminin alpha-2, a protein that is essential for maintaini... Simply replacing the defective gene with a good laminin alpha-2 gene is not possible because its size make...i-agrin protein functionally took the place of the laminin alpha-2 protein by binding to the key proteins on ...

UCSD researchers maintain stem cells without contaminated animal feeder layers

... animal products. In the Hayek study, the animal-derived feeder layers are completely eliminated. However, the petri dishes themselves are coated with laminin (an animal-derived product), and the UCSD team is continuing studies to determine if contamination occurs from this source. For a proposed animal-f...
Laminin in Biological Technology

Significant Milestone Marks the Beginning of FDA-Authorized Breast Cancer Trial

...essful trial outcome." The clinical trials involve the use of dendritic cell therapy using the oncofetal antigen ("OFA"), or iLRP -- immature laminin Receptor Protein, as a cancer antigen (a protein found on cancer cells that can be targeted by the body's own immune system) found in many tumor cell ...

Cynvec to Present at The 2009 New York Venture Summit

... oncolytic viral vector, a novel technology that targets the over expressed laminin receptor on the surface of many solid tumors without affecting normal cells... screening program is underway to identify small molecules that bind to the laminin receptor, which is implicated in Alzheimer's disease, multiple sclerosis an...

Cynvec to Present at the 11th Annual Shanghai International Forum on Biotechnology and Pharmaceutical Industry

... oncolytic viral vector, a novel technology that targets the over expressed laminin receptor on the surface of many solid tumors without affecting normal cells... screening program is underway to identify small molecules that bind to the laminin receptor, which is implicated in Alzheimer's disease, multiple sclerosis an...

Histogen Aesthetics Launches ReGenica Rejuvenation System

...growth factors such as Keratinocyte Growth Factor and Vascular Endothelial Growth Factor, and soluble extracellular matrix proteins such as collagens, laminin and decorin, which are associated with skin renewal and scarless healing. In addition, factors associated with scarring, such as TGFbeta, are decrease...

Cynvec to Present at New York Biotechnology Association 18th Annual Meeting

... oncolytic viral vector, a novel technology that targets the over expressed laminin receptor on the surface of many solid tumors without affecting normal cells... screening program is underway to identify small molecules that bind to the laminin receptor, which is implicated in Alzheimer's disease, multiple sclerosis an...

Immunotherapy-Based Provisional Patents Mark Significant Discovery

...rk in cancer immunotherapy. The company's research is focused on the use of the oncofetal antigen ("OFA"), or more specifically, iLRP - immature laminin Receptor Protein, as a cancer immunogen (a cancer target against which the immune system is directed) found in many tumor cell lines or fetal tissue, ...

Cynvec to Present at the BIO National Venture Conference

... oncolytic viral vector, a novel technology that targets the over expressed laminin receptor on the surface of many solid tumors without affecting normal cells... screening program is underway to identify small molecules that bind to the laminin receptor, which is implicated in Alzheimer's disease, multiple sclerosis an...

Cynvec LLC(SM) to Present at the Cowen and Company 29th Annual Health Care Conference

...ndbis oncolytic viral vector, a novel technology that targets overexpressed laminin receptors on the surface of many solid tumors without affecting normal cell... screening program is underway to identify small molecules that bind to the laminin receptor, which is implicated in Alzheimer's disease, multiple sclerosis an...

Cynvec LLC(SM) to Present at the Rodman & Renshaw 10th Annual Healthcare Conference on November 11, 2008

...he company is developing therapies to treat a number of tumor types, including ovarian, pancreatic, GI, liver, colorectal, and other cancers where the laminin receptor is overexpressed. The Company's lead product, CYN 101, is in late pre-clinical development, and has shown statistically significant survival ...

Cynvec LLC(SM) Appoints Former Johnson & Johnson Executive Frank D. Stonebanks as President and Chief Executive Officer

...ancreatic, gastrointestinal, liver, colorectal, and other cancers where the laminin receptor is over-expressed. Its lead product, CYN 101, is in late-stage pre...ing ovarian, pancreatic, GI, liver, colorectal, and other cancers where the laminin receptor is overexpressed. The Company's lead product, CYN 101, is in late ...
Laminin in Biological Products

Mouse Anti-67kD Laminin Receptor Prediluted Monoclonal Antibody, Unconjugated, SPM278 from GeneTex

Description: Product Mouse monoclonal [SPM278] to 67kD Laminin Receptor, prediluted Immunogen Small cell lung carcinoma N592 live cells (Human). Reactivity / Specificity Cross-reacts with Human. Not yet tested in other species. Background Information Laminin, one of the major glycoproteins of basement m...
Company:GeneTex

Mouse Laminin from Invitrogen

Description: Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
Company:Invitrogen

Cultrex 3D Culture Matrix Laminin I from R&D Systems

Description: Cultrex 3D Culture Matrix Laminin I....
Company:R&D Systems

Rat Anti-Mouse Laminin B2 gamma 1 Monoclonal Antibody, Unconjugated, Clone SPM277 from ABR-Affinity BioReagents

Description: Immunogen: Tissue / cell preparation. (Murine EHS laminin preparation) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents

Mouse Anti-Human Laminin beta-1 / gamma-1 complex Monoclonal Antibody, Unconjugated, Clone 612C10 from Santa Cruz Biotechnology, Inc.

Description: Laminin beta-1/gamma-1 (612C10)...
Company:Santa Cruz Biotechnology, Inc.

Human Laminin ELISA Kit, QuantiMatrix from Upstate

Description: ...
Company:Upstate

BD BioCoat Laminin 35 mm Culture Dishes from BD Biosciences - Discovery Labware

Description: BD BioCoat Laminin 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
Company:BD Biosciences - Discovery Labware

BD BioCoat Laminin 150 mm Culture Dishes from BD Biosciences - Discovery Labware

Description: BD BioCoat Laminin 150 mm Culture Dishes...
Company:BD Biosciences - Discovery Labware

BD Laminin 60 mm Culture Dishes from BD Biosciences - Discovery Labware

Description: BD BioCoat Laminin 60 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
Company:BD Biosciences - Discovery Labware

BD BioCoat Laminin 100 mm Culture Dishes from BD Biosciences - Discovery Labware

Description: BD BioCoat Laminin 100 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse laminin....
Company:BD Biosciences - Discovery Labware

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