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Lamin in Medical News

Studies show LAM patients participate in clinical trials to help others, not themselves

...to do CT scan screening of non-smoking women, ages 25-54, who come to the emergency room for the first time with a collapsed lungan early predictor of lamin order to diagnose and treat those with the illness. "A major contributor to morbidity in patients with LAM is spontaneous pneumothorax, or a collap...

Turning down gene expression promotes nerve cell maintenance

...min, in maintaining myelin. They found that, while lamin is necessary in the initial stages of myelin formation, too much lamin promotes myelin breakdown. Further investigation ...chers to the discovery of a signal that fine-tunes lamin expression. This signal, a microRNA called miR-23,...

New Clues for Treatment of Disease That Causes Accelerated Aging

...any more bad copies of the gene's primary protein, lamin A, than progeria patients. Both infants di...hese cells, which had unusually high levels of bad lamin A, suggest that progeria treatment may not be as d...ology. "If physicians can reduce production of bad lamin A by as little as half in progeria patients, we mi...

New Clues for Treatment of Disease That Causes Accelerated Aging

...any more bad copies of the gene's primary protein, lamin A, than progeria patients. Both infants died...hese cells, which had unusually high levels of bad lamin A, suggest that progeria treatment may not be as d...ology. "If physicians can reduce production of bad lamin A by as little as half in progeria patients, we mi...

Gene is related to premature ageing disease

...gene responsible for the progeria syndrome, but they have developed a process to reverse the symptoms. The process will eliminate mutant LMNA mRNA and lamin A protein using splicing correction to the activated cryptic splice site. On doing this, the HGPS fibroblasts become like normal cell nuclei. This hel...
Lamin in Biological News

Lamin A/C deficiency is 'unnerving'

... Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss...ans the inner nuclear membrane, linking Nesprin to lamin A/C. Although lamin A/C is ubiquitously expressed, LMNA defects specif...

In just 5 years, gene discovery to clinical trial of potential treatment

...mal. The 2003 discovery of the HGPS gene, named lamin A (LMNA), laid the groundwork for the clinical tri...hromosome 1. This gene carries the DNA recipe for lamin A, the protein glue that holds together the cell's...leus. The mutated LMNA gene generates an abnormal lamin A protein (also called progerin) that disrupts the...

Stem cell nuclei are soft 'hard drives,' Penn study finds

...onal Academy of Sciences, supports the theory that lamin proteins are responsible for much of the genomic l...a set pattern of gene expression. To verify that lamin proteins were responsible for nuclear stiffness, t...uthors created a line of epithelial cells in which lamin filaments had been almost eliminated. Once as sti...

Anti-cancer drugs may hold promise for premature aging disorder

...ues discovered in April 2003 that mutations in the lamin A (LMNA) gene cause progeria, spurring renewed int...aging. The LMNA gene codes for a protein called lamin A, which constitutes a major component of the scaf...eria causes a section of 50 amino acids within the lamin A protein to be deleted, resulting in a mutated pr...

Cellular Defects in Premature Aging Disease are Reversible

...orrecting defects associated with the key protein, lamin A. By demonstrating that HGPS cellular characteris...for HGPS is a single mutation in the gene encoding lamin A. lamin A is a critical structural protein that acts as th...
Lamin in Biological Technology

More siRNA Vectors for RNA Interference

...ped by Sui and colleagues at Harvard Medical School and has been successfully used to knock down expression of cdk-2 and lamin A/C in HeLa, H1299, U-2 OS and C-33A (cdk-2 only) cells (Sui et al., 2002). Ambion's latest p Silencer siRNA expression...

siRNA transfection optimization with the Agilent 2100 bioanalyzer

...with the Agilent 2100 bioanalyzer. The kit includes dsDNA internal standards at 15 and 1500 bp for sample alignment (sizing) and quantitation. lamin A/C siRNA was analyzed after 1:10 dilution in PBS. Transfection and culture conditions Lipid based TransMe...

RNAi Gene Silencing System

...xtracts from transfected HeLa-S3 cells probed with lamin A/C monoclonal primary antibodies. Cells ...nts. siRNA: short interfering RNA duplex targeting lamin A/C at position 608630 relative to the st... Relative expression levels of lamin A/C after siRNA transfection. The value f...

Cancer siRNA Oligo Set Version 1.0

... Each Cancer siRNA Oligo Set includes 2 siRNAs to each of 139 cancer genes in addition to a positive control lamin A/C siRNA, 5 negative controls, and 4 fluorescein-labeled controls, all supplied at 1 nmol. Comprehensive information is also includ...

Custom and library siRNA for efficient gene silencing

...ansfected HeLa-S3 cells probed with lamin A/C monoclonal primary antibodies. ...rt interfering RNA duplex targeting lamin A/C at position 608630 relative to the start codon... Figure 2 Relative expression levels of lamin A/C after siRNA transfection. The v...

QIAGEN Instrument Service insist on the best in service and support

... In addition to 2 siRNAs to each of 139 cancer genes, the Cancer siRNA Oligo Set includes a positive control lamin A/C siRNA, 5 negative controls, and 4 fluorescein-labeled transfection controls, all supplied at 1 nmol. Comprehensive information i...

BioRobot MDx standardize your automated protocols in clinical laboratories

...ansfected HeLa-S3 cells probed with lamin A/C monoclonal primary antibodies. ...rt interfering RNA duplex targeting lamin A/C at position 608630 relative to ...ure 2 Relative expression levels of lamin A/C after siRNA transfection. The value for the mo...
Lamin in Biological Definition

Apoptosis

...rved by Kihlmark and colleagues, specialized caspases have already advanced in the degradation of nuclear pore proteins and have begun to degrade the lamin that underlies the nuclear envelope. It must be noted, also, that while the previous stage of initial chromatin condensation has been observed in non...

Cytoskeleton

...mmon structural support of many cells. made of keratin , found in skin cells, hair and nails . Neurofilaments of neural cells. made of lamin , giving structural support to the nuclear envelope. Microtubules Main article: microtubules They are hollow cylinders of about 25 nm., ...

Intermediate filament

...TocToggle("show","hide") 1 Types 1.1 lamin IFs 1.2 Keratin IFs 1.3 Type III IFs 1.4 ...stinguished by the protein each is made of. lamin IFs These form a network, the nuclear lamina , that supports the nuclear envelope. There are lamin A, B, and C filaments....
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