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Lactate in Medical News

Mayo Clinic on the Summer Olympic Games: Better Athletes, the Physiology of Performance, the Lactate Threshold, the Aging Athlete and Much More

NOTE: Web video and audio for this news release are posted on the Mayo Clinic News Blog: http://newsblog.mayoclinic.org/ . The video and audio are also available in high resolution for TV broadcast upon request. ROCHESTER, Minn. July 31 /PRNewswire-USNewswire/ -- The world-record pace for t...

Horse Study: RBC Life Sciences' Antioxidant, Microhydrin, Reduced Lactic Acid Buildup and Improved Hydration During Strenuous Exercise

...enter at Rutgers , the horse trial measured blood lactate levels and weight loss of mares. During the week p...xidant in their feed had more than 13% lower blood lactate levels when they reached a fatigued state. The lactate levels were nearly 15% less up to 30-minutes after...

Could standard treatment for traumatic brain injury be wrong?

...he way glucose is used by the brain changes after a TBI, researchers believe other naturally used compounds, including pyruvate, beta-hydroxybutyrate, lactate and ketones, should be considered in treatment. Hovda and his colleagues think that each of these fuels may serve a different purpose, depending on th...

A new light on the mechanisms of early stage liver reperfusion injury

...er alterations including portal hepatitis, inflammation and the induction of apoptosis, were occurred. Biochemical analysis showed that the amounts of lactate dehydrogenase, alanine aminotransfrase and aspartate aminotransfrase, creatinine and urea were significantly increased in the serums obtained from the...

Lactate test made easy

... Performance athletes need to know their blood lactate level. It indicates how much lactic acid has colle... special device then measures the concentration of lactate in the blood. Such scenarios will soon be a thi...e athletes will in future be able to monitor their lactate readings themselves including during training. No...

Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome

... numbers (before and after treatment) and survival, along with other factors such as changes in levels of prostate-specific antigen (PSA) and baseline lactate dehydrogenase (LDH) in 164 prostate cancer patients starting first-line chemotherapy regimens. High values of CTC numbers and PSA levels before tre...

Nutritionist Investigates Claims of New Sports Nutritional Supplement

... his triathletes had never tested so high in their lactate threshold. Lactate threshold is a term used to describe an exercise level at which more lactate is being produced than cleared. The first group o...shold of 84%. The test also showed a reduction of lactate by 18%. By the time the crossover study was compl...

New Research Will Benefit Four Million Americans Suffering from Chronic Fatigue Syndrome

...eam will also investigate the reason for this phenomenon, exploring whether lactate levels are higher in CFS patients because their brains contain high levels ...tions in the production of brain energy. If this study is successful, brain lactate levels could provide an objective diagnostic biomarker for CFS. The...

New Approach Keeps Tumor Cells From Refueling

...d. "Using models of tumor cells, we found that well-oxygenated cells use lactate [lactic acid] as a preferential substrate to produce energy," said lead res... 1). "The same transporter is present in the muscle where it helps to clear lactate to prevent cramps," Sonveaux said. Tumors are famous for co-opting norma...

Inhibiting Protein May Keep Cancer Cells From Refueling

... findings were published in the Nov. 20 online issue of The Journal of Clinical Investigation . By inhibiting the protein MCT1, which takes in the lactate to convert it to fuel, in the well-oxygenated cells, they switched to using glucose. This upset the symbiotic relationship between the hypoxic and wel...
Lactate in Medical Technology

Alexion Reports Positive Results from AEGIS Registration Study of Soliris in Japanese Patients With PNH

...-- Hemolysis, the primary trial endpoint, was rapidly and significantly reduced with Soliris treatment. A standard measure of hemolysis, lactate dehydrogenase (LDH), decreased 86 percent from a median of 1,814 U/L at baseline to a median of 244 U/L following 12 weeks of treatment ...

Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

...e, Novato, CA and the MRC Dunn Human Nutrition Unit, Cambridge, UK comments, "I have been performing individual measurements of oxygen consumption and lactate production using cell suspensions for the greater part of my career and I trust Seahorse's XF technology, which allows us to make multiple simultaneou...

Embryo Viability Studies Support Utility of Novel, Metabolomic Profiling Technology

...h and IVF, neurodegenerative disease (e.g., Alzheimer's disease and Parkinson's disease), maternal fetal medicine, pulmonary metabolism and edema, and lactate metabolism. Molecular Biometrics is headquartered in Chester, NJ, with research and development facilities in New Haven, CT, and Montreal, Quebec. For...

Soliris(R) Improved Fatigue Independent of Changes in Anemia in Patients with PNH by Controlling Hemolysis

...onal Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale. Anemia was measured by levels of hemoglobin, and hemolysis was measured by levels of lactate dehydrogenase (LDH). Key findings included the following: * While intravascular hemolysis reduction (decreased LDH) and anemia improvement (inc...

Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells

...ovements in secondary endpoints, including the percentage of dense RBCs (-2.41 vs. -0.08, high-dose vs. placebo), reticulocytes (-4.12 vs. -0.46), and lactate dehydrogenase (-121 vs. -15), a marker of hemolysis. There were no differences among the treatment groups in the overall frequency of painful crises, ...

PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity

...molysis, mild anemia and minimal transfusion requirements. Data were analyzed by levels of baseline hemolysis (as indicated by baseline quartiles of lactate dehydrogenase, LDH), anemia (Hgb < 10.5 g/L vs greater than or equal to 10.5 g/L), and transfusion requirements (transfusion episodes in prior year gr...

Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH

... long- term clinical improvements for patients with PNH: -- Soliris significantly and consistently reduced hemolysis, as assessed by levels of lactate dehydrogenase, from a mean of 2286 +/- 87 U/L at baseline to 300 +/- 15 U/L in patients after 2 years of therapy (P -- Soliris significantly ...

Wyeth's TORISEL Receives European Commission Approval for the Treatment of Advanced Kidney Cancer

...o randomization, Karnofsky performance status of 60 or 70, hemoglobin less than the lower limit of normal, corrected calcium of greater than 10 mg/dL, lactate dehydrogenase > 1.5 times the upper limit of normal, and more than one metastatic organ site. In the United States, TORISEL is indicated for the treat...
Lactate in Medical Products

QC 463 EQUIL® Plus with Glucose and Lactate Control

Description: QC 463 is a quality control material that, once tonometered, is used for monitoring the performance of blood gas, electrolyte, metabolite, and CO-Oximeter instrumentation. It provides a practical alternative to the use of human blood in tonometry. QC 463 is available in three (3) levels for monitor...
Company:RNA Medical

LD Lactate –> Pyruvate

Description: For the quantitative in vitro determination of Lactate Dehydrogenase (LD) in serum and plasma....
Company:Randox Laboratories Ltd.

LDH

Description:... The LDH method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of lactate dehydrogenase activity in serum or plasma...
Company:Randox Laboratories Ltd.

OptiMAL-IT Individual Rapid Malaria Test

Description:... DiaMed OptiMAL-IT is an immuno-chromatographic test, using monoclonal antibodies against the metabolic enzyme pLDH (parasite lactate dehydrogenase) of Plasmodium spp. These Mabs are classified in two groups....
Company:DiaMed

VACUETTE Glucose tubes - Non-ridged (pull cap)

Description:... Glucose tubes contain an anti-coagulant and a stabiliser. The tubes are ideal for glucose and lactate determinations....
Company:Greiner Bio-One

VACUETTE Glucose tubes - Ridged (safety screw cap)

Description:... Glucose tubes contain an anti-coagulant and a stabiliser. The tubes are ideal for glucose and lactate determinations....
Company:Greiner Bio-One

Liquichek Blood Gas Plus EGL Control

Description:... Liquichek Blood Gas Plus EGL Control is an aqueous product used to monitor the measurement of pH, pCO2, pO2, electrolytes, glucose and lactate (lactic acid)....
Company:Bio-Rad Laboratories

ABL700 Blood gas analyzer

Description:...te parameters. Unique technology reduces to a minimum the interfering effect some substances have on the accuracy of blood gas, oximetry, glucose, and lactate measurements....
Company:Radiometer America Inc.

OptiMAL Malaria Test

Features:... The DiaMed OptiMAL detects the presence of Plasmodium lactate dehydrogenase (pLDH), an enzyme produced by all forms of the parasite The presence of pLDH is revealed using monoclonal antibodies directed against ...
Company:DiaMed

ABL555 Blood gas analyzer

Features:...ysate and cerebrospinal fluid Improve accuracy Proven technology platform secures highly accurate measurements Interference free glucose and lactate measurements Save time and reduce costs Minimal maintenance and sturdy construction reduce overall operating costs Remote management of ...
Company:Radiometer America Inc.

More>>

Lactate in Medical Dictionary

Muscle Soreness

... or discomfort often felt 24 to 72 hours after exercising and subsides generally within 2 to 3 days. It is commonly thought to be caused by increased lactate concentrations; however, this is a misconception as it has been shown elevated levels of lactic acid rarely persist... Muscle pain and musc...

LDH

... lactate dehydrogenase ( LDH ) is an enzyme (EC 1.1.1.27)...e interconversion of pyruvate and lactate. ... lactate dehydrogenase test - Overview, The lactate dehydrogenase ( LDH ) test measures the amount of ...

LDH isoenzymes

... LDH isoenzymes is a test to check how much lactate dehydrogenase ( LDH ) is in the ... Measurement of...... LDH isoenzymes is a test to check how much lactate dehydrogenase ... Measurement of LDH isoenzymes... LDH isoenzymes is a test to check how much lactate dehydrogenase ( LDH ) is in the ... Measurement of...

Lactic acidosis

...ic acidosis results from an increase in blood lactate levels when lactate ... Overview: By the turn of the 20th century,...sociated with lactic acidosis include: ... lactate accumulation and lactic acidosis results becau...

Anaerobic

...ly attractive ... The Anaerobic Process ... There are several methods used to determine an athlete's anaerobic threshold. ... How To Determine lactate / Anaerobic Threshold ... An overview of ... Anaerobic digester systems can reduce fecal coliform bacteria in ... Controlled anaerobic di...
Lactate in Biological News

Mental fatigue can affect physical endurance

...umption, heart rate, cardiac output, blood pressure, ventilation, and blood lactate levels. The participants completed surveys to measure their motivation and ... However, because the non-fatigued trials went longer, heart rate and blood lactate levels were higher at the end of those trials. Motivation was the same in ...

During exercise, the human brain shifts into high gear on 'alternative energy'

...o speak, future studies should show us when to use lactate as part of a treatment," said Gerald Weissmann, MD...n its way to the brain contained considerably more lactate than blood flowing from the brain. Further investigation showed that the brain was not storing the lactate which had come from the muscles during exercise, b...

Photosynthesizing bacteria with a day-night cycle contain rare chromosome

... unexpected linear chromosome was more than just a pretty face. It contained the only copy of a key protein that lets the bugs produce lactate, called lactate dehydrogenase, during fermentation. DNA sequencing revealed the linear chromosome to be 430 kilobases long and contain a cluster of nine genes that...

Cyanobacterium sequenced features rare linear chromosome

... proteins on the linear chromosome are hypothetical. But the gene cluster is a major find. "The linear chromosome contains the only gene copy for lactate dehydrogenase, which facilitates one of the organism's fermenting capabilities, "said Jana Stckel, Ph.D., WUSTL postdoctoral researcher who worked wit...

July 2008 highlights

...lic enzymes and ATP production in sperm function, it is now shown that one lactate dehydrogenase family member, LDHC, is required for male fertility. Several...ung, Edward M. Eddy, and Erwin Goldberg. Expression of the Gene for Mouse lactate Dehydrogenase C ( Ldhc ) Is Required for Male Fertility. Biol Reprod 20...

Research cautions to catch-and-release in less than 4 minutes

...ulation in order to monitor the levels of calcium, lactate and glucose during recovery. "We found that it ...es' physiological changes when being caught to the lactate that builds up in a runner's muscles after running...thing may return to normal fairly quickly, but the lactate build-up can take a much longer time to return to ...

Hearts of male and female rainbow trout are different

...yers and analyzed for layer cross-sectional areas. lactate concentration and net lactate release from cardiac tissue was also examined. ...emales had similar rates of oxygen consumption and lactate release under resting conditions; the inhib...

Seals protect brain, conserve oxygen by turning off shivering response on icy dives

...horter than their maximum capacity, and only occasionally perform very long dives. By limiting dive duration, seals maintain aerobic metabolism, avoid lactate buildup that occurs in the face of insufficient oxygen and require little time to recover, Folkow explained. Seals often spend 80-90% of their time at...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

...ined whether blocking the conversion of glucose to lactate in mammary tumor cells might help shed light on th...ophisticated genetic technique to reduce levels of lactate dehydrogenase A (LDH-A), an enzyme required for the glucose to lactate pathway that is elevated in human breast and lung ...

Lactic acid not athlete's poison, but an energy source - if you know how to use it

... use of lactic acid, or lactate, not only prevents lactate build-up, but ekes out more energy from the body's...aboratory add one of the last puzzle pieces to the lactate story and also link for the first time two metabol...about metabolism," Brooks said. "This shows us how lactate is the link between oxidative and glycolytic, or a...
Lactate in Biological Technology

Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology

... "Effect of ipilimumab at 10 mg/kg on disease control in patients (pts) with M1c-stage melanoma in relation to baseline lactate dehydrogenase (LDH) levels" (Abstract #9041, Melanoma Session) M. Smylie - General poster from 8:00 a.m. to 12:00 p.m. local time on Monday, June 1, 2...

Molecular Biometrics Announces Results of Parkinson's Disease Research and Receipt of Grant From Michael J. Fox Foundation to Advance Diagnostic Technology

...h and IVF, neurodegenerative disease (e.g., Alzheimer's disease and Parkinson's disease), maternal fetal medicine, pulmonary metabolism and edema, and lactate metabolism. Molecular Biometrics is privately held and headquartered in Chester, NJ, with research and development facilities in New Haven, CT, and Mo...

JCI table of contents: April 22, 2008

...DF of this article at: https://www.the-jci.org/article.php?id=34928 ACCOMPANYING COMMENTARY TITLE: One-stop-shop tumor imaging: buy hypoxia, get lactate free AUTHOR CONTACT: Mark W. Dewhirst Duke University, Durham, North Carolina, USA. Phone: (919) 684-4180; Fax: (919) 684-8718; Email: dewhi001...

Inoculation, Growth & Harvesting in a New Easy-to-Use Disposable Cell Culture System

... and metabolite concentrations including glucose, glutamine, ammonia and lactate once a day. Media and glucose should be added as required. ...the Up/Down Speed and Bottom Hold Time will help to expel CO 2 , reduce lactate production, and thus further stabilize pH in culture medium. Mea...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

...Quattro, University of South Carolina, pers. comm.), with a 15 nt GC clamp attached to LDHA6F1, were used to amplify muscle-type lactate dehydrogenase intron six. Oligonucleotides were prepared by commercial manufacturers (Genosys, Life Technologies) without additi...

Cell Proliferation and Viability Measurement

... however, in these assays, molecules are released from dying cells with leaky cytoplasmic membranes, and are measured in cell populations (e.g., lactate dehydrogenase or [51Cr] release). Assay Procedures for Cell Proliferation ...

Chemical Stability of the Brinkmann Bottletop Dispenser and the Brinkmann Bottletop Buret

... 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1 Lactic acid / lactate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1 Magnesium ...
Lactate in Biological Products

Rabbit Anti-Porcine LACTATE DEHYDROGENASE H4 Polyclonal Antibody, Unconjugated from AbD Serotec

Description: ANTI PIG LDH H4...
Company:AbD Serotec

YSI 2300 STAT Plus Glucose & Lactate Analyzer from YSI Incorporated

Description: The gold standard for whole-blood clinical diagnostic work in hospitals and laboratories. In 60 seconds or less, this analyzer makes precise glucose measurements of whole blood, plasma, or serum and precise lactate measurements of whole blood, plasma, or cerebrospinal fluid. The analyzer's hematocr...
Company:YSI Incorporated
Lactate in Biological Definition

Fermentation

... zymnosis ) is the energy-yielding anaerobic metabolic breakdown of a nutrient molecule, such as glucose, without net oxidation. Fermentation yields lactate , acetic acid , ethanol , or some other simple product. Fermentation is also used much more broadly to refer to the bulk growth of microorganis...

Liver

.... The liver performs several roles in carbohydrate metabolism : Gluconeogenesis (the formation of glucose from certain amino acids , lactate or glycerol ) Glycogenolysis (the formation of glucose from glycogen ) Glycogenesis (the formation of glycogen from glucose) Th...

Redox

...H and NADP + /NADPH in a biological system such as a cell or organ. The redox state is reflected in the balance of several sets of metabolites (e.g., lactate and pyruvate , beta-hydroxybutyrate and acetoacetate ) whose interconversion is dependent on these ratios. An abnormal redox state can develop in ...

Redox

...H and NADP + /NADPH in a biological system such as a cell or organ. The redox state is reflected in the balance of several sets of metabolites (e.g., lactate and pyruvate , beta-hydroxybutyrate and acetoacetate ) whose interconversion is dependent on these ratios. An abnormal redox state can develop in ...
Lactate in Biological Dictionary

Isoenzyme

...oenzyme usage examples and isoenzyme quotes. ... isoenzyme definition. iso·enzyme (ī′sō en′zīm) noun ... Manufacturer of Highest Quality Human lactate DEHYDROGENASE ISOENZYME from LEE BIOSOLUTIONS specializing in developing high purity, stable enzymes, antigens and ... (Redirected from Isoenz...
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