CU-Boulder study shows brain's immune system may cause chronic seizures
...ia called lipopolysaccharide, or LPS, to the brain, activating the micro-glial cells. The glial cells very rapidly clustered around the area where the lps
was applied and created an immune reaction in that locale.
The glial cells then released their cytokines, causing the neurons to become excitable e...
Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
...animal studies had shown that exposure to elevated lps
levels compromised the integrity of the BBB. "So w...combination of HIV-infected monocytes and elevated lps
levels would amplify the ability of HIV to cross t... team injected control mice with very low doses of lps
that were comparable to the levels in the bloodstr...
JCI online early table of contents: Feb. 7, 2008
... as IFN-gamma, which was shown to cause damage to the colonic mucosa. The upregulation of IFN-gamma expression was eliminated if the bacterial product lps
was removed from the explant cultures. As IFN-gamma expression could be restored by the addition of a bacterium that lives naturally in the human colo...
Who is the arch-criminal in the development of hepatopulmonary syndrome?
...ogression and severity of HPS were closely associated with increased plasma lps
level, and that there was a paralleling deterioration between the lung func...pment of hepatopulmonary syndrome. Therefore, the strategy directed against lps
will certainly be effective in the prevention and treatment of HPS.
JCI online early table of contents: Dec. 6, 2007
...ttempts to identify the mechanisms responsible for lps
removal during septic shock have been unsuccessful... an uncontrollable inflammatory response following lps
challenge, with a higher subsequent mortality rate...to foreign substances in the blood, in response to lps
challenge and infection with Gram-negative bacteri...
Evotec Reports Positive Top-Line Results in Phase II Study With EVT 201 in Elderly Insomniacs With Daytime Sleepiness
...ean WASO (mins) / % 101.4 86.2 / 15% 65.3 / 36% change from placebo p=0.0140 p= Adjusted mean lps
(mins) / % 46.5 30.5 / 34% 26.5 / 43% change from placebo p=0.0091 p=0.0014 The PSG analysi...
Pest Control research Leads to Pain Control Discovery
... enzyme inhibitors (a previously undescribed soluble epoxide hydrolase inhibitor or sEHIs) in lipopolysaccharide (LPS)-challenged mice.
'We used lps
as an inflammatory agent, which is a component of some bacterial cell walls,' said, co-author Steven Jinks. His laboratory examined the effects of the...
ROZEREM? Can Be A Better Option For Insomnia Patients
...howed that a statistically significantly greater percentage of adults with chronic insomnia treated with ROZEREM 8 mg demonstrated at least 50 percent lps
reduction compared to those who received placebo at week 1 (63 percent vs. 40 percent (P
Those results were sustained throughout the study (63 p...
LPS in Medical Technology
Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia
...the study if
symptoms of insomnia were chronic and lps
was greater than 30 minutes.
Significant Improve...r the 4 week duration of
the study. The results on lps
at night 1 (N1)/night 8 (N8), and night 22
(N22)/night 29 (N29) are as follows.
-- Mean lps
at baseline (before drug treatment) was 78.8 minut...
Neurogen Proprietary Insomnia Compound Data Presented at American
Psychiatric Association Annual Meeting
...bjects aged 24-63 with no self-reported sleep disorders were
was statistically significantly reduced, compared to
placebo, at all doses ...f NG2-73, and demonstrated a dose-response
relationship. The mean times for lps
were 30.8 minutes for the
Placebo group, and 17.8, 10.6, 7.8, and 6.6 minut...
Evotec Reports Positive Proof-of-Concept Top-Line Results with
Insomnia Drug Candidate EVT 201
...d the eligibility criteria included: a
diagnosis of primary insomnia according to DSM (Diagnostic and
Statistical Manual of Mental Disorders) IV; mean lps
minutes, mean WASO Ã?Â³ 40 minutes, mean TST
240-420 minutes, all determined during two consecutive nights PSG
Neurogen Proprietary Insomnia Compound Data for Two Studies
Presented at Associated Professional Sleep Societies Annual Meeting
...self-reported sleep disorders, were
was significantly reduced, compared to placebo, at...es
of NG2-73, in a dose-dependent manner with mean lps
of 30.8 minutes
for the placebo group, and 17.8, 1...tent sedative hypnotic
which significantly reduced lps
at all doses tested, which was
supported by subjec...
Neurogen Announces Positive Results for Proprietary Insomnia Drug
in Two Chronic Insomnia Clinical Trials
...imary endpoint of
sleep onset (measured by Latency to Persistent Sleep - or lps
the first two nights of treatment). Study 203 included two
immediate rel...t arms were tested in addition to
The following table shows mean lps
difference from baseline in
LPS in Medical Products
LPS in Medical Dictionary
... also demonstrated macrophage variability in the pattern of TNF ... Further, the macrophage responses observed were clearly due to P8 PGLC, as lps
... WT L. pifanoi-infected macrophages at the same amastigote/ macrophage ratio. ... Rac1 and Rac2 regulate macrophage morphology but are not...
LPS in Biological News
For fats, longer may not be better
...versity of Kentucky wondered whether some unwanted lps
particles, routinely shed by the bacteria that inh... oleic acid they observed significant secretion of lps
together with the chylomicron particles, a phenome...t butyric acid, promoted significant absorption of lps
into the blood and lymph nodes and subsequent expr...
Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo
...ced, or the control saline solution.
Samples treated with hydro-Cy3 and lps
showed fluorescence intensity almost four times greater than explants treat...o-Cy3 and saline. Once more, adding TEMPOL to the sample with hydro-Cy3 and lps
decreased the fluorescence to a level comparable to the control saline expl...
Researchers identify new weapon to fight deadly bacterial sepsis
...mp blood normally and allowed mice injected with otherwise lethal levels of lps
Other experiments conducted in cell cultures traced the specific biochemical pathways by which lps
triggers an inflammatory cycle that damages the cells of the heart. By bloc...
Pest control research leads to pain control discovery
...nd enzyme inhibitors (a previously undescribed soluble epoxide hydrolase inhibitor or sEHIs) in lipopolysaccharide (LPS)-challenged mice.
"We used lps
as an inflammatory agent, which is a component of some bacterial cell walls," said, co-author Steven Jinks. His laboratory examined the effects of the...
A step forward in the fight against bacterial infections
... of the bacterial cell wall is LPS. The binding of lps
with its specific receptor in our immune system ...the process of inflammation following contact with lps
is a profuse production of type 1 interferons. The...searchers administered 10 times the lethal dose of lps
to the mutant mice, without deadly consequences. T...
Scripps research scientists solve structure of a critical innate immune system protein
... the innate immune system works something like this. Certain cells have the ability to recognize foreign molecules such as components of membrane like lps
or other protein molecules unique to microorganisms . The presence of these pathogen-specific molecules activates the immune system, which responds wi...
Protein prevents detrimental immune effects of bacterial sepsis
...ct by analyzing the effects of the bacterial toxin lps
on normal and annexin 1 knockout mice. Annexin 1 w...ne was activated as early as 1.5 and 6 hours after lps
administration, with levels returning to normal by...ombinant annexin 1 in the first 24 hours following lps
treatment, survival increased to 60%.
Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
...immune response. Because it spurs an immune response without live bacteria, lps
helps to reveal how the immune system works on its own, without the complic...e effects.
The team found that E. coli-infected pups later injected with lps
had significantly lower concentrations of cytokines called interleukins tha...
Scientists solve structure of key protein in innate immune response
...r membrane of certain bacteria. Once CD14 binds to lps
or another ligand, it presents the molecule to oth...pose that this pocket is the main binding site for lps
because previous biochemical studies demonstrate t...id residues comprising the pocket are critical for lps
binding. Most, if not all, of the CD14 ligands com...
Dysentery uses 'sword and shield' to cause infection
...oteins into human cells. This causes the cells to become inflamed, resulting in symptoms of dysentery, such as bloody diarrhoea. At the same time, the lps
chains on the surface of the bacteria are shortened. This allows the needles to inject proteins, while protecting the bacteria from being destroyed by...
LPS in Biological Products
LPS in Biological Dictionary
...rom time to time, Tilth Producers will send you important and timely email ... 'The Producers ' and 'You Make The Heat' were reissued on CD as 2 lps
on 1 CD! ... Ask Sony to reissue the Producers in MP3 format through this form on Sony's site. ... Offers new and used equipment. BAVC is a no...