Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
Scientists have uncovered an interesting connection between two important protein kinase signaling pathways that are associated with cancer. The research, published by Cell Press in the January 30th issue of the journal Molecular Cell , may direct new therapeutic strategies for multiple types of ...
'Innocent bystanders' can be the cause of tumor development
...covered that deletion of the tumor suppressor gene lkb1
leads to excessive proliferation of neighboring ep...tumor development.
The results demonstrate that lkb1
deletion in smooth muscle cells disturbes the sign...n the Peutz-Jeghers polyposis caused by hereditary lkb1
LKB1 in Medical Technology
LKB1 in Biological News
National Lung Cancer Partnership announces winner of 2007 Career Development Award
...le to invade surrounding tissues. He will focus on the how mutations of the lkb1
cellular protein cause lung cancer cells to move into other tissues and how...ivity of lung cancer cells to chemotherapy drugs.
By understanding how lkb1
contributes to lung cancer invasion, our research could potentially impact ...
Cells united against cancer
...ition syndrome and it has also been suggested that lkb1
suppressor functions in several epitheli...rom's team found
that epithelial cells missing the lkb1
protein are able to form only
malignant actions of cancer genes and identifies lkb1
tumor suppressor gene
as an architect of this prol...
Energy management in cells may hold key to cancer defense
...(DMS) has demonstrated that cells lacking a tumor-suppressing kinase called lkb1
can still maintain healthy energy levels when they become stressed. This ...s LKB1."
"We decided to work with cervical and lung cancer cells because lkb1
is absent from the cellular pathway," said Rebecca Hurley, lead author of t...
LKB1 in Biological Products