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LKB1 in Medical News

Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1

Scientists have uncovered an interesting connection between two important protein kinase signaling pathways that are associated with cancer. The research, published by Cell Press in the January 30th issue of the journal Molecular Cell , may direct new therapeutic strategies for multiple types of ...

'Innocent bystanders' can be the cause of tumor development

...covered that deletion of the tumor suppressor gene lkb1 leads to excessive proliferation of neighboring ep...tumor development. The results demonstrate that lkb1 deletion in smooth muscle cells disturbes the sign...n the Peutz-Jeghers polyposis caused by hereditary lkb1 mutations. ...
LKB1 in Medical Technology

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

...macokinetics and tumor distribution, efficacy in EGFR- and HER2-expressing xenograft models, activity in tumors harboring activated RAS or inactivated lkb1 mutations and activation of AMPK pathways in cardiac cells. -- Tyrosine kinase inhibitors, such as TAK-285, GW572016 or SU11248, protect or da...
LKB1 in Biological News

National Lung Cancer Partnership announces winner of 2007 Career Development Award

...le to invade surrounding tissues. He will focus on the how mutations of the lkb1 cellular protein cause lung cancer cells to move into other tissues and how...ivity of lung cancer cells to chemotherapy drugs. By understanding how lkb1 contributes to lung cancer invasion, our research could potentially impact ...

Cells united against cancer

...ition syndrome and it has also been suggested that lkb1 has tumor suppressor functions in several epitheli...rom's team found that epithelial cells missing the lkb1 protein are able to form only cancer-like disorgan...s malignant actions of cancer genes and identifies lkb1 tumor suppressor gene as an architect of this prol...

Energy management in cells may hold key to cancer defense

...(DMS) has demonstrated that cells lacking a tumor-suppressing kinase called lkb1 can still maintain healthy energy levels when they become stressed. This ...s LKB1." "We decided to work with cervical and lung cancer cells because lkb1 is absent from the cellular pathway," said Rebecca Hurley, lead author of t...
LKB1 in Biological Products

Mouse Anti-LKB1 Monoclonal Antibody, Unconjugated, Clone Ley 37D / G6 from Abcam

Description:... Mouse monoclonal [Ley 37D/G6] to lkb1 ( Abpromise for all tested applications). entrezGeneID: 6794 SwissProtID: Q15831...
Company:Abcam
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