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LEADseeker in Biological Technology

Integration of the LEADseeker Multimodality Imaging System with automated plate loading and incubation using Overlord Instrument software

Key words: LEADseeker • imagin g • automatio n • integratio n The LEADseeker™ Multimodality Imaging System is a CCD-based optical imaging instrument that efficiently detects and quantitates light from a range of radiometric, lum...

Development of a CRF1 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System

Key words: CRF 1 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads In the mammalian brain, the corticotrophin-releasing factor (CRF) system comprises four CRF-related peptides (CRF and urocortin 1, 2, and 3...

Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: α 2c receptor • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads The α 2 -adrenergic receptors are G protein-coupled receptors that play a key role in the control of numerous physiol...

The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System

Key words: serotonin • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads In mammals, serotonin (5-hydroxytryptamine, 5-HT) is a regulator of neural transmission which induces its biological effect by binding to ...

The development of a somatostatin sst4 receptor-binding assay using the LEADseeker Multimodality Imaging System

Key words: somatostatin • receptor binding assay • LEADseeker • SPA Imaging Beads Somatostatin (SS) is a neurotransmitter/hormone with a wide range of biological actions (1–3) and a reduction in cortical SS levels has been re...

Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System

Key words: NK2 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads Neurokinins, also known as tackykinins, are a family of small neuropeptides. Members of this family include peptides, substance P (SP), neurokin...

Use of BRET2 luminescence cell-based assays with LEADseeker Multimodality Imaging System

Key words: luminescence • BRET 2 • LEADseeker • DeepBlueC• cell-based assays Competitive pressure is forcing organizations to continually increase screening throughput. Yet accuracy and sensitivity remain vital concerns, par...

Use of the HitHunter EFC Chemiluminescent Detection Kits with LEADseeker Multimodality Imaging System

Key words: EFC chemiluminescence • HitHunter • LEADseeker Competitive pressure is forcing organizations to continually increase screening throughput. Yet accuracy and sensitivity remain vital concerns, particularly for common screens such...

Performance of fluorescent dyes with LEADseeker Multimodality Imaging System

Key words: fluorescence • LEADseeker • Cy • Alexa Fluor • TAMRA • Brij Flexible and scalable uHTS programs demand that organizations be able to select the most appropriate or cost-effective fluorescent reagents for t...

Development of a histamine H1 receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: H 1 receptor • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads Histamine is a biogenic amine that plays important pathophysiological roles in central and peripheral tissues. Generally released from stimul...

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LEADseeker in Biological Products

Wheat Germ Agglutinin (WGA) PS SPA Imaging Bead from GE Healthcare, formerly Amersham Biosciences

Description:... Wheat Germ Agglutinin (WGA) PS SPA Imaging Bead, 2 g. Category: leadseeker Beads....
Company:GE Healthcare, formerly Amersham Biosciences
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