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Knockout in Medical News

President Obama's New Knockout Mother's Day Message from Champ

COLUMBUS, Ohio, May 8 /PRNewswire/ -- James "Buster" Douglas, former World Heavyweight Boxing Champion, delivers a message to President Obama in his brand new inspirational diabetic diet cookbook. "Take a moment to grieve," Douglas said, in "Buster's Backyard Bar-B-Q Knockout Diabetes Diet,"...

Hit Hard by the Economy, Americans Risk Knockout Without Disability Insurance

LIFE Urges Americans to Think About Income Protection, Offers Tips for Obtaining Coverage ARLINGTON, Va., May 1 /PRNewswire/ -- The results of a new survey show the historic recession has left many Americans with less in savings and investments -- and as a consequence, they are more vuln...

Dealing Cervical Cancer a Knockout Blow

Doctors step up efforts to vaccinate young women against virus that causes the disease FRIDAY, April 18 (HealthDay News) -- For the first time, a doctor's arsenal now includes a vaccine that can actually prevent cancer. Gardasil targets human papillomavirus, or HPV, which causes ...

Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis

...abetes, glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 Second Quarter Financial Results

...rome, diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Gene's novel role may provide key to treating liver and neurodegenerative diseases

...e human immune system responsible for fighting viruses and other pathogens that invade the body, the two scientists began developing the first in vivo knockout mouse model to closely examine FAIM's role in preventing programmed cell death. BTI Executive Director Miranda Yap, Ph.D., said, "The Immunology Gr...

AGA Institute presents cutting-edge research during DDW

...teractions at the Epithelial Cell Interface. D. Polk (8:39 a.m.) Changes in Mucosal Homeostasis Leading to Hypersensitivity to Mucosal Injury in NHE3 knockout Mice. D. Laubitz et al. (9:04 a.m.) Colitis-associated variant of TLR2 causes impaired mucosal repair due to TFF3 deficiency. A. Eyking et al. (9:21 ...

VARI researcher chosen for highly competitive Scholar-in-Training Award

...evements in cancer research and reaches an audience of thousands of the world's top scientists." Chen's research, entitled Proximal tubule-specific knockout of BHD in mouse kidney causes multicystic kidney disease and renal cancer pertains to a cancer called Birt-Hogg-Dub ( BHD) syndrome that affects the s...

U of I study shows benefits of hormone found in fat tissue

...," he said. "And, when we gave non-obese mice leptin injections, they recovered three times faster. Leptin did not hasten recovery though in IL-1RA knockout mice," Sherry said. That earlier work was published in a recent issue of Brain, Behavior, and Immunity . In the Endocrinology study, one group o...

Pacquiao Hosts Post-Christmas/Post-Birthday Victory Celebration

...dified his claim to being the best boxer in the world today, pound-for-pound, after he capped his grand slam and record-breaking year with a technical knockout win over the legendary Oscar Dela Hoya. Pacquiao also won the 130-pound World Boxing Council title and the 135-pound WBC version, on his way to becomi...
Knockout in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

MILWAUKEE, RICHMOND, Calif., ST LOUIS, PALO ALTO, Calif., and PARIS, July 23 /PRNewswire-FirstCall/ -- Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., (Nasdaq: SGMO ), Sigma-Aldrich Corporation (Nasdaq: SIAL ), Open Monoclonal Technology...

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

...abetes, glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

...ction purposes using Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN) technology. Genentech scientists demonstrated the successful knockout of two preselected genes in a Chinese hamster ovary (CHO) cell line. The milestone achievement triggered a payment from Genentech to Sangamo. "Ac...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... new research titled "Antisense inhibition of apolipoproteinC-III mitigated features of metabolic syndrome and reduced atherosclerosis in LDL receptor knockout mice" showing the ability of antisense drugs in a late-stage research program targeting apoC-III to selectively reduce triglycerides in both liver and...

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 First Quarter Results

...rome, diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Lexicon Presents Clinical Data on LX1032 for Carcinoid Syndrome at European Neuroendocrine Tumor Society Meeting

...abetes, glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Inverseon's Founder and SAB Member Published in PNAS

...rtive commentary on this essential asthma signaling pathway by Raymond Penn of the University of Maryland School of Medicine . "This work using knockout mice confirms prior results from Bond and collaborators using inverse agonists, a subset of beta blockers, in mice and patients (Callaerts-Vegh PNAS 2...

Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives

...e Biotechnology publication establishing the utility of ZFNs in the generation of transgenic animals and the potential broadening of the production of knockout transgenic models beyond mouse models (Doyon et al., 2008, Nat. Biotechnol. 26: 702). -- Publication of data in the journal Proceedings of the...

Stem Cell Regeneration Repairs Congenital Heart Defect

... of patients with heritable dilated cardiomyopathy. Researchers transplanted 200,000 embryonic stem cells into the wall of the left ventricle of the knockout mice. After one month the treatment improved heart performance, synchronized electrical impulses and stopped heart deterioration, ultimately saving th...

St. Jude Finds 'Dancing' Hair Cells Are Key to Humans' Acute Hearing

...se mice showed exactly the same kinds of hearing deficiency as the previous knockout mice," Zuo said. "Therefore, we believe that these experiments eliminate criticism of our earlier experiments with the knockout mice." The new experiments, Zuo said, thus firmly establish that the "danci...
Knockout in Medical Products

Knockout

Description:... With a large white surface and a black X in the center, knockout really makes you look the heavyweight....
Company:CIBA Vision
Knockout in Medical Definition

Autoimmune regulator

...us candidiasis. [1] AIRE is expressed primarily in the thymus. A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients. [2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcri...
Knockout in Medical Dictionary

Amebic liver abscess

...Liver Abscess Is Dependent on Gamma ... Susceptibility of IFN-γ receptor knockout mice and iNOS knockout mice to amebic liver abscess ... Liver abscess . From Wikipedia...
Knockout in Biological News

URI researchers help score knockout punch on birch tree pest

KINGSTON, R.I. November 24, 2008 The United States has been under assault for decades by a wide variety of alien plants and animals, and it is not often that one of these aliens faces a counterpunch. But in a collaborative project with several other institutions, the University of Rhode Island ...

Insecticide combo delivers knockout punch

A cocktail of insecticides containing a plant protein and a common insecticide may be more lethal to crop pests than either ingredient used alone, according to biologists. The one-two punch also inhibits the insects' growth rate and reduces their chance of developing resistance. "We found a syn...

Dealing deadly cancers a knockout punch

New scientific evidence is helping to build a compelling case for oncolytic viruses as a first-line and adjunctive treatment for many cancers. Reovirus, a non-pathogenic virus under development at Calgary, Alberta-based Oncolytics Biotech, has shown powerful anti-cancer activity against cultur...

C. difficile spores spread superbug

...microbiota of the mouse. Although the majority of mice exhibited no visible symptoms of C. difficile , the team found that one particular group of knockout mice with mutations associated with impaired immune defence began to lose weight and became moribund. The similarity with the human manifestation of t...

Genetically engineered mice yield clues to 'knocking out' cancer

...neered mice without the neil1 gene (known as neil1 knockout mice). During their first 6-10 months of life, the... Jaruga and Gldal Kirkali found that both types of knockout mice exhibited significant accumulation of two les...ary and hepatocellular (liver cell) tumors. Double knockout mice had a higher incidence of tumors than the sin...

Mouse model provides clues to human language development

... supported and confirmed the findings. In a second step to further substantiate this hypothesis, the Helmholtz scientists analyzed the heterozygous knockout mouse model in which one of the normally two copies of the Foxp2 gene is missing. This loss leads to serious changes: The ability of the mice to hear ...

New findings in taste and smell

...l in human tears β1,3-N-Acetylglucosaminyltransferase 1 (β3GnT1) regulates signaling in olfactory neurons CNGA2 heterozygous mice with a knockout TRPM5 show fewer glomeruli targeted by OSNs with nonfunctional CNGA2 Copy-number variation map obtained by high-resolution genomics reflects human o...

Time (and PPAR-beta/delta) heals all wounds

...talk between layers of the skinthe epidermal hyperproliferation seen in the knockout mice could be due to faulty signals from the dermal cells. But this coul...blasts keep stimulating keratinocyte division. Similarly, PPARβ/δ knockout mice expressed less sIL-1ra after wounding and produced more growth factors...

200,000 rice mutants available worldwide for scientific investigation

...omputers the precise positions of mutations in the rice genome sequence, for each rice mutant plant. About 50 percent of the protein-coding genes have knockout mutations, which probably abolish their expression and can provide valuable information on the genes by virtue of their loss of function. This is a si...

200,000 rice mutants available worldwide for scientific investigation

...omputers the precise positions of mutations in the rice genome sequence, for each rice mutant plant. About 50 percent of the protein-coding genes have knockout mutations, which probably abolish their expression and can provide valuable information on the genes by virtue of their loss of function. This is a si...
Knockout in Biological Technology

Transposagen Creates a Rat Model of the Human Immune System

...ive worldwide licensing rights to create TKO(TM) knockout Rat Models using a variety of mobile DNA technologies. knockout rats are pharmaceutical research models with singl...s. Transposagen's goal is to produce 30,000 unique knockout rat lines to represent each gene in the rat genome...

Sangamo BioSciences Reports Second Quarter 2009 Financial Results

...member of the Roche Group. Genentech scientists demonstrated the successful knockout of two pre-selected genes in a Chinese hamster ovary (CHO) cell line using ...eleted or knocked out. The technology opens the door for the production of knockout animals in species other than mouse and broadens the possibilities for new ...

OMT announces a breakthrough in the development of a novel human antibody platform

...today announced the creation of the first targeted knockout rats as detailed in "Knockout Rats Produced via Em...human monoclonal antibody platform. "Creating a knockout rat was the biggest challenge OMT faced", said Dr....sed ZFNs developed by Sangamo BioSciences, Inc. to knockout a gene encoding rat immunoglobulin. The mutations ...

Lexicon to Provide Clinical Pipeline Update and Report Second Quarter 2009 Financial Results on July 28, 2009

...rome, diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction

...ormone produced by the stomach and acting in the brain. Compelling evidence obtained with the administration of AEZS-123, and a ghrelin receptor mouse knockout model, highlights the role of ghrelin to regulate the rewarding value of alcohol in a mouse model of alcohol dependence. When ghrelin's actions are bl...

Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome

...abetes, glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Lexicon Names Ajay Bansal Executive Vice President and Chief Financial Officer

...rome, diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Lexicon to Present Clinical Data for LX1031 and LX1032 at Digestive Disease Week

...abetes, glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Lexicon to Provide Clinical Pipeline Update and Report First Quarter 2009 Financial Results on April 28, 2009

...rome, diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...

Lexicon Pharmaceuticals 2008 Annual Report to Stockholders Available Online

...abetes, glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. The company has used its proprietary gene knockout technology to identify more than 100 promising drug targets. Lexicon has focused drug discovery efforts on these biologically-validated targets to cr...
Knockout in Biological Products

TargeTron Gene Knockout System from Sigma-Aldrich

Description: The TargeTron(TM) Gene Knockout System provides optimized reagents and protocols for the rapid and specific disruption of bacterial genes by insertion of group II introns. The method exploits the retrohoming ability of group II introns and utilizes a simple PCR step to re-target the TargeTron group...
Company:Sigma-Aldrich

* Quick & Easy E. coli Gene Deletion Kit from Gene Bridges GmbH

Description:... This kit is designed to knockout or alter genes on the E.coli chromosome in less than one week. Red/ET recombination allows the exchange of genetic information in a base pair precis...
Company:Gene Bridges GmbH
Knockout in Biological Definition

Long-term potentiation

...):774-6. PMID 2869411 McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA. "Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice." Cell . 1996 Dec 27;87(7):1147-8. PMID 8980239 Tang YP, Wang H, Feng R, Kyin M, Tsien JZ. "Differential effects of enrichment on learnin...

Molecular genetics

...t is possible to induce the deletion of a particular gene, creating a gene knockout . Alternatives include the random induction of DNA deletions and subsequent...tance forward and reverse genetics screens RNA interference gene knockout transgenics and overexpression mapping, cloning, and sequencing ...

Reverse genetics

...by site-directed mutagenesis , for example, by deletion of a gene by gene knockout (as can be done in some organisms, such as yeast and mice ) -- and only a...technique is the application of RNA interference . RNAi creates a specific knockout effect without actually mutating the DNA of interest. In C. elegans , RNAi...
Knockout in Biological Dictionary

Gene knockout

A gene knockout is a genetic technique in which an organism is engineered to carry genes that have been made inoperative . This is done for research purposes. Also known as knockout organisms or simply knockouts, they are used in learning about a gene that has been sequenced, but which has an...

Transgenic mouse

... transgenic . ... CWRU Transgenic Mice and knockout Mice : Transgenic Core Facility ... Strategies:...l pay for the maintenance of foster mothers ... knockout & Transgenic Research Portal - articles, job.... of transgenic organism used in research is the knockout ... The mouse core facility at Boston Univers...

Transgenic

...s laboratory models to study ... The technology for creating transgenic animals is constantly improving and will ... CWRU Transgenic Mice and knockout Mice: Transgenic Core Facility ... The Roth lab developed transgenic mice in which activity of specific neuronal ... [ANDi, the first transgen...

Recombination

...to the variation ... More technically put, genetic recombination is the transmission-genetic process ... Homologous Recombination Method (and knockout Mouse) ... To perform homolgous recombination , you must know the DNA sequence of the gene ... A creation science resource megasite where you ...

Knock-Out

... A knockout is a winning criterion in several full-contact combat sports, such as boxin...ay Thai, mixed martial arts, Karate and others sports involving striking. A knockout is usually awarded when one... ... out rondje ... Er is een nieuwe so...

Gene targeting

...sue,... Specializes in providing mouse gene knockout and DNA sequencing services to academic and comm...s. ... iTL uses gene targeting technologies to knockout or knockin genes ... What is gene targeting ... Sciences: The creation of standard or conditional knockout mice, or knockin mice, utilizes some proprietary ...

Gene expression

...ts and integrates the gene expression information in MGI. ... Gene Expression Notebook (GEN) Mouse Phenome Database (MPD) Deltagen and Lexicon knockout Mice ... long oligonucleotide arrays for gene expression analysis including tiling expression , mutiplex expression for a broad range of p...
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