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Knockout Mouse Project

Children's Hospital & Research Center Oakland is leading one of two teams in an international effort to produce thousands of genetically altered mice for a study to understand the role of individual genes in human health. Other members of the team represent the School of Veterinary Science at the University of California, Davis and the Wellcome Trust Sanger Institute in Hinxton, England. Th...

Knocking out survival protein could aid leukemia treatment

An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study shows. But such a drug used in combination with several existing drugs might also offer an effective one-two punch against drug-resistant f...

Dealing deadly cancers a knockout punch

New scientific evidence is helping to build a compelling case for oncolytic viruses as a first-line and adjunctive treatment for many cancers. Reovirus, a non-pathogenic virus under development at Calgary, Alberta-based Oncolytics Biotech, has shown powerful anti-cancer activity against cultured tumor cells, in animal models, and in human clinical trials. Oncolytics' proprietary reoviru...
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* Quick & Easy Conditional Knock Out Kit - loxP from Gene Bridges GmbH

Description:This kit is designed for the fast and simple integration of loxP-sites into large vector plasmids at any position (for the generation of transgenic mouse models). The included loxP-PGK-gb2-neo-loxP cassette is designed to allow neomycin / kanamycin selection in prokaryotic and eukaryotic cells. It combines a prokaryotic promoter (gb2) for expression of kanamycin resistance in with a...
Company:Gene Bridges GmbH

* Quick & Easy Conditional Knock Out Kit - FRT from Gene Bridges GmbH

Description:This kit is designed for the fast and simple integration of FRT-sites into large vector plasmids at any position (for the generation of transgenic mouse models). The included FRT-PGK-gb2-neo-FRT cassette is designed to allow neomycin / kanamycin selection in prokaryotic and eukaryotic cells. It combines a prokaryotic promoter (gb2) for expression of kanamycin resistance in with a eu...
Company:Gene Bridges GmbH

TargeTron Gene Knockout System from Sigma-Aldrich

Description:The TargeTron(TM) Gene Knockout System provides optimized reagents and protocols for the rapid and specific disruption of bacterial genes by insertion of group II introns. The method exploits the retrohoming ability of group II introns and utilizes a simple PCR step to re-target the TargeTron group II intron for specific insertion into the host genome. Utility of the technology has been demonstra...
Company:Sigma-Aldrich
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Measuring siRNA-mediated knockdown of IL-8 mRNA

By Genospectra, Inc., 6519 Dumbarton Circle, Fremont, CA 94555. A critical step in siRNA-mediated gene expression knockdown studies is the validation of expression inhibition. The QuantiGene Reagent System and the Molecular Devices LMax II microplate luminometer were used to measure IL-8 mRNA in PMA-induced HeLa cells, following siRNA t...

Housekeeping Genes: Universal Positive Controls in siRNA Knockdown Experiments

RNA interference is a powerful technique for geneknockdown experiments in academic research and animportant tool for target identification and target validationin therapeutic research. A growing number of different cell lines are us...

Who's that knocking at the door? Preparing for an FDA inspection

FDA enforces...
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Alcohol a potential carcinogen: knocking on the door: pay heed!

Alcohol consumption is related to liver malfunction and now it has another danger lurking behind it: cancer.According to a study by French scientists it has been found that alcohol consumption is // a major cancer-causing agent that is responsible for many types of cancer. Scientists found that excessive drinking raises risk of cancer of the mouth, larynx, oesophagus, liver, colon and...

Knock on the Head – No Small Thing After Al

A pick-up game of basketball often leaves you with a hit in the head with the ball. While the jolt would most likely leave you feeling a little dizzy and queasy// you often just continue playing. The question is, should you? Dizziness and nausea are two signs of concussion—one of the least understood sports injuries, says Ned Shannon, head athletic trainer and instructor at the Universi...

The Tech Savvy Patient Knocks on the Doors of Telemedicine and Virtual Clinics

Britain: Technology savvy patients are experimenting with medical consultations and patients are seen tapping the online medium// to seek solutions to many of their medial ailments, especially ones they would like to hide in the closet. Thrush, ringworm and urinary infections scored very high on the search list and back pain, stress and depression followed suit with its share of atten...

Lethal Hospital Bug Tough to Knock Down, Statistics Reveal

There is both good and bad news in the report released by the Health Protection Agency (HPA) of Britain.// The report looks at figures representing cases of infection by bugs including the potentially lethal hospital bug, Clostridium difficile and the ‘super bug’ MRSA. According to the released statistics the figures for Clostridium infections have risen drastically by 5.5 per...

Knocking Out Survival Protein Could Aid Leukemia Treatment

An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study// shows. The findings suggest that a drug that can block this 'survival protein' might on its own be an effective therapy. But such a drug used in combination with several existing drugs might also offer an effective one-two punch against drug-resist...

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Knockout

Description:With a large white surface and a black X in the center, knockout really makes you look the heavyweight....
Company:CIBA Vision
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