Motor proteins may be vehicles for drug delivery
...ins to the rest of the molecule is longer in kinesin-2 motors than in other kinesin
proteins, which prevents efficient mechanical coordination between the two ...hereby slow the growth of tumors."
The researchers also believe that the kinesin
transport system could in the future be engineered onto microchips.
NYP/Columbia physician-scientists present at ASCO 44th annual meeting
...risk AML or following reduced-intensity AlloSCT in standard-risk AML.
Spindle Protein (KSP) for Hodgkin's Lymphoma
Dr. Owen O'Connor
Director ...y College of Physicians and Surgeons
A Phase 1 dose-escalation trial of kinesin
Spindle Protein (KSP), a drug that targets a unique aspect of cancer cell d...
Research shines spotlight on a key player in the dance of chromosomes
...It turns out its like a little person it walks with its two feet, one in front of the other. I was interested to know whether the normal rules of how kinesin
walks apply to these different kinds of kinesins.
In vivo studies are hampered by the presence of lots of other proteins, making it hard to study h...
Tug of war in the cells
...e always involved in the tug-of-war over a cargo - for example, some of the kinesin
type and some of the dynein type. The kinesin
motors move to the end of the microtubule that biologists call the positive...
Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway
...portant role in Alzheimers disease.
Dynein and kinesin
proteins transport cellular cargo towards opposite...oes awry.
The transport performed by dynein and kinesin
is required for continuously providing new protein...ules are abundantly decorated with tau. Dynein and kinesin
encounter the tau molecules on their travels along...
Protein-dependent 'switch' regulates intracellular trafficking in epithelial cells
... family of "motor proteins," called kinesins. Each kinesin
facilitates the transport of specific surface mark...nderstanding of processes directed by the specific kinesin
family members marks a big step forward in develop... its environment," Dr. Kreitzer explains.
"trains" work by moving their cargoes along filame...
Experimental cancer pharmaceuticals under trial
... A potent and selective inhibitor of the mitotic kinesin
CENP-E (GSK923295A) demonstrates a novel mechanism of inhibiting tumor cell...apy, they say.
The experimental drug, GSK923295A, inhibits the mitotic kinesin
centromere-associated protein E (CENP-E), which is required during mitosis,...
Kinesin in Medical Technology
Cytokinetics Announces Non-clinical Data to be Presented at the
2007 AACR Annual Meeting
...nt data evaluating
ispinesib, a novel inhibitor of kinesin
Spindle Protein (KSP), in
models of multiple myelo...l Meeting
Abstract #1435: kinesin
Spindle Protein Inhibition for the Treatment of
...rative research activities directed to the
centromere-associated protein E (CENP-E).
Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
kinesin spindle protein (KSP), a mitotic kinesin
proper cell division. Ispinesib has...rial are expected
Background on Mitotic kinesin
Since their introduction over 40 year...ispinesib
and SB-743921, each a novel inhibitor of kinesin
(KSP), a mitotic kinesin. Ispines...
Kinesin in Biological News
Dartmouth researchers find new protein function
...his study on NOD provided evidence for a new way a kinesin
motor could function," said Jared Cochran, a postd...ir paper is titled, "ATPase Cycle of the Nonmotile kinesin
NOD Allows Microtubule End Tracking and Drives Chr...nt."
"Before this study, it had been shown that kinesin
motors either walked along their microtubule track...
Media highlights in the January issues of Biophysical Journal
...ing their phosphorylation status. Likewise numerous biophysical studies have explored the mechanics of single motor proteins of the myosin, dynein and kinesin
Here, a biomechanical approach is taken, where in living cells the tension of the cytoskeletal network is monitored by atomic f...
Biophysical Society announces winners of 2008 Student Travel Awards
...Known to Cause Familial Hypertrophic Cardiomyopathy.
Nicholas R. Guydosh, Stanford University, Direct Observation of Individual Head Motions in kinesin
Sejin Han, University of Maryland, College Park, Abnormal Formation and Remodeling of Fibers Containing Type I Collagen Homotrimers. ...
Researchers image molecular motor structural changes
...s. For the study, Endow and her colleagues chose a kinesin
found in baker's yeast that closely resembles kine...resolution models and combined them with models of kinesin
and microtubule structures rendered using another ... defects in kinesins. Finding methods to stimulate kinesin
activity might help in the treatment of these huma...
Biological motors sort molecules one by one on a chip
... 15 micrometers in length) were then transported over the 'carpet' of motors. The microtubules are, as it were, 'crowd surfing' over the sea of small kinesin
motors. A particular challenge of the research was to ensure beforehand that the microtubule tubes could be transported in a determined direction and ...
A new way of looking at molecular motors
...dness and kidney disease to neurodegenerative disorders and parasitic diseases such as malaria.
All complex organisms use myosin and its relatives, kinesin
and dynein, to move substances around inside cells and to help cells move from one place to the other. Myosins also help parasites enter and infect ho...
Marathon of nano-sprinters
...ded by the hydrolysis of ATP, which can be considered the fuel of the cell. kinesin
and dynein motors move along microtubules and myosins move along actin fila... function of the maximum number of motors that can pull this par-ticle. For kinesin
motors, for example, calculations show that only seven or eight motors are ...
Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
...discovered that two molecular motors -- dynein and kinesin
-- do not compete for control, even though they wa...l motors measured outside the cell."
Dynein and kinesin
are biomolecular motors that haul cargo from one p...es material from the cell membrane to the nucleus; kinesin
moves material from the cell nucleus to the cell m...
Kinesin in Biological Definition
...ing within flagellar microtubules , whereas the cytoplasmic dynein is implicated in moving toward the negative end of a microtubule.
See also: kinesin
How Cilia and Flagella Work (axonemal dynein)
Microtubule Based Movement (cytoplasmic dynein)
List of gene families
...g immune system proteins
Major histocompatibility complex (MHC)
Related protein families
Signal transducing proteins
Receptor tyrosine kinases
Kinesin in Biological Dictionary
... protein . From Wikipedia, the free encyclopedia. Jump to: navigation, search ... Categories: Disambiguation pages | Transport proteins ... kinesin
accomplishes transport by essentially "walking" along a ... Biology Proteins Vesicles Carrier Protein Transport Cytoskeleton M...
...orkshop 2009 have been announced! ... Cytoplasmic dynein is a protein complex responsible for the transport of a large ... Dynein , along with kinesin
(see previous ALS highlight, "Kinesin Action ... AAA+ Ring and Linker Swing Mechanism in the Dynein Motor ... Single-Molecule Analysis of Dynein...
...copy. Interactive... Cell Models. Mitosis ... Funding opportunities for students & fellows. Postdoc Job Opportunities. Confocal Reservations. kinesin
Home. 2009 Stem Cell Symposium Registration ... Cell structures and functions. A visual tour inside the cell that highlights each organelle. ...