Broccoli Compound May Help COPD Patients
...ere was a difference in the levels of NRF2 between people with and without COPD.
They also looked at levels of two biochemical regulators of NRF2, keap1
(which inhibits NRF2) and DJ-1 (which stabilizes it).
Biswal's team found that COPD patients had significantly lower levels of NRF2-dependent antio...
Fruit flies all aglow light the way to cancer prevention
...jor ways that the body defends itself against toxic assaults and threats like cigarette smoke, diesel exhaust, and dangerous microbes. A gene known as keap1
senses danger and then unleashes NRF2, which triggers rampant anti-oxidant activity in a cell.
Now scientists from the University of Rochester Medi...
COPD? Eat your veggies
..., a significant decrease in NRF2 protein with no change in NRF2 mRNA levels (indicating that it was expressed, but subsequently degraded), and similar keap1
levels, but a marked decrease in the level of DJ-1.
"NRF2-dependent antioxidants and DJ-1 expression was negatively associated with severity of COP...
Scripps Research study reveals new activation mechanism for pain sensing channel
... noted. Another signaling protein known as Kelch-like ECH-associated protein 1 (KEAP1) is activated by many of the same compounds that activate TRPA1; keap1
is a sensor for oxidative damage from free radicals and upregulates expression of antioxidant enzymes. Apparently, reactive compounds can activate at ...
Key to lung cancer chemo resistance revealed
...pumping them out of the cell. Another gene called keap1
encodes products that stop this cleansing process....hat lung cancer cells recruit and distort NRF2 and keap1
expression to help tumor cells evade the toxic eff...o halt the detox process, proteins manufactured by keap1
bind to the NRF2 triggers tagging them for destruc...