An AIDS-related virus reveals more ways to cause cancer, Penn researchers find

... subverts normal cell machinery to cause cancer. A kshv protein called latency-associated nuclear antigen,...iscovered by Robertson and his associates by which kshv subverts control of normal cell growth. Robertsons...the same strategies that we have found for LANA in kshv has not been determined, says Robertson. This ...

DNA damage response confers a barrier for viral tumorigenesis

...and an etiological agent for Kaposis sarcoma (KS). kshv infection is endemic in sub-Saharan Africa where K...ommon malignancy, due to widespread infection with kshv and human immunodeficiency virus (HIV). Important...eckpoint is activated during the initial stages of kshv infection and KS tumorigenesis and this can confer...

A Novel Treatment for KSHV-infected Lymphomas

...effective against the aggressive KSHV-induced PEL. kshv displays two patterns of infection: latent and lyt... a restricted set of viral genes is expressed. The kshv genome encodes several homologues of cellular prot...e results of this study demonstrate binding of the kshv latency associated antigen LANA to both p53 and MD...

Virus Causing Kaposi's Sarcoma Discovered

...cribe how the molecule xCT is a major gateway that kshv uses to enter human cells. The molecule may also p...ces. Of note, this sort of stress can be caused by kshv itself. This suggests that the virus may facilitat...nfections. Dr. Berger became interested in kshv because of his interest in how viruses enter cells...

Oral Sex may carry AIDS related Cancer Virus

...h man's individual sexual behavior and his risk of kshv infection. KSHV, also known as human herpesvirus...e HIV epidemic triggered the similar one seen with kshv infection. But in looking at blood samples from ho... late 1970s to the 1990s, Osmond's team found that kshv was prevalent when HIV infections were still "clos...

KSHV in Biological News

Research uncovers clues to virus-cancer link

...tain miRNAs were lost as the tumors progressed, effectively accelerating the cancer's growth. More aggressive tumor stages expressed higher levels of kshv miRNA. In second study, published June 4 in the journal Blood, the team looked for the presence of tumor suppressor mRNAs in primary effusion lymph...

Study proposes new theory of how viruses may contribute to cancer

...sly implicated in cancer development. Cells with low K13 expression allowed kshv to replicate, and these cells subsequently died off, the researchers noted. Cells with higher expression of K13 emerged after kshv replication and showed defective expression of two key proteins that are kn...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...effective against the aggressive KSHV-induced PEL. kshv displays two patterns of infection: latent and lyt... a restricted set of viral genes is expressed. The kshv genome encodes several homologues of cellular prot...e results of this study demonstrate binding of the kshv latency associated antigen LANA to both p53 and MD...

Mice lacking key immune component still control chronic viral infections

...2, which cause cold sores and genital herpes, and varicella zoster virus, which causes chickenpox. Infection with gamma herpes viruses such as EBV and kshv increases the risk of some cancers, especially in persons with weakened immune systems. Immune system cells known as CD8 or cytotoxic T cells are ...

Landmark discovery of a Kaposi's sarcoma-associated herpesvirus receptor

...cribe how the molecule xCT is a major gateway that kshv uses to enter human cells. The molecule may also p...ces. Of note, this sort of stress can be caused by kshv itself. This suggests that the virus may facilitat...ic infections. Dr. Berger became interested in kshv because of his interest in how viruses enter cells...

Touching Molecules With Your Bare Hands

...us-68 (MHV-68). Though MHV-68 infects mice, it behaves similarly to EBV and kshv infections in humans, producing an acute mononucleosis-like illness and a p...of latently infected B cells. The episome maintenance protein in MHV-68 and kshv is called ORF73. None of the viruses can maintain latent infections with de...

How A Latent Virus Eludes Immune Defenses

...us-68 (MHV-68). Though MHV-68 infects mice, it behaves similarly to EBV and kshv infections in humans, producing an acute mononucleosis-like illness and a p...of latently infected B cells. The episome maintenance protein in MHV-68 and kshv is called ORF73. None of the viruses can maintain latent infections with de...

KSHV in Biological Dictionary

Lytic cycle

...re amplified by PCR from B95.8 virus DNA and all genes ... Herpesviruses exist in two states, latency and a lytic productive cycle . ... Other kshv encoded lytic cycle transcripts, for example the virally encoded IL-6 ... They can have either lytic or lysogenic cycle , depending on the e...

Episome

...ic with that of ... In contrast, episome signals in BAC36-transfected cells remained relatively stable. ... One of LNA's potential functions is kshv episome persistence. ... ...