Membrane fusion at the synapse: Janus faced synaptotagmin-1 helps to keep the fast pace
Imagine a bathtub with two soap bubbles colliding but never fusing. Then you add detergent, and the surface of the water goes flat as the walls of the bubbles collapse and merge.
Dr. Christian Rosenmund, professor of neuroscience and molecular and human genetics at Baylor College of Medicine, a...
SpeechEasy Seeks Proposals For Future Research Studies
... Greenville, NC (PRWEB) July 25, 2009 -- janus
Development Group (Janus), the providers of Speech... product and its technology.
In November 2007, janus
assembled an independent research review panel to ...arolina University, and is marketed exclusively by janus
Development Group. SpeechEasy devices are availabl...
Onyx Pharmaceuticals Acquires Option to License Novel Highly Specific JAK2 Inhibitors From S*BIO
... (Nasdaq: ONXX ) today announced that it has acquired an option to license rights to SB1518, an orally available, potent, and selective inhibitor of janus
Kinase 2 (JAK2), and SB1578, also a JAK2 inhibitor, from S*BIO Pte Ltd based in Singapore. Under the terms of the agreement, Onyx has obtained option...
A new relationship between brain derived neurotrophic factor and inflammatory signaling
...a 1 containing GABA-A receptors, the main inhibitory neurotransmitter receptor in the brain, that may be dependent upon BDNF-induced activation of the janus
kinase (JAK)/signal transducers and activators of transcription (STAT) pathway. Activation of the JAK/STAT pathway has previously been shown to be dep...
Hamilton Medical, Inc. Welcomes New Vice President
...a financial background and strong technology
experience that has been utilized by such companies as Smith Barney,
Citigroup Private Bank, Vangaurd and janus
Funds, just to name a few. With
experience ranging from sales to financial analysis, Hamilton Medical is
looking forward to great things for the futur...
Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success
...L-13ralpha2); inosine monophosphate dehydrogenase (IMPDH); integrin
alpha2; interleukin 6 (IL-6); interleukin 8 (IL-8); placental growth factor
kinase 2 (JAK2); JAK3; kinesin-like spindle protein (KSP);
Lewis y antigen; lymphocyte-specific protein tyrosine kinase (Lck);
lymphotoxin (LT) beta r...
Anemia Drugs May Speed Tumor Growth in Some Cancer Patients
High levels of EpoR mRNA in patients who had undergone radiation but not surgery tended to signal a worse prognosis. There was a similar effect with janus
Kinase 2 (Jak2), the main intermediary of EpoR signaling, Blau added.
"These are preliminary findings, but they're very exciting," Gralow said. "If...
Hearing Loss in Children Leads to Substantial Meningitis Risk
...-Head and Neck Surgery Foundation (AAO-HNSF). The authors of the study are Erik Thorlund Parner, PhD, MSc; Jennita Reefhuis, PhD; Diana Schendel, PhD; janus
L. Thomsen, PhD; Therese Ovensen, PhD; and Poul Thorsen, PhD. Parner, Thomsen, and Thorsen are associated with the University of Aarhus, Denmark’s Ins...
Janus in Medical Technology
Cephalon Provides Clinical Update on Lestaurtinib in Relapsed Acute Myelogenous Leukemia
...erall cost of healthcare."
Developed by Cephalon scientists, lestaurtinib is a potent inhibitor of several tyrosine kinases including FLT3 and a janus
kinase (JAK2). In leukemic cells, lestaurtinib inhibits FLT3 activity and induces cell death (apoptosis). In myeloproliferative disorders, mutations i...
Portola Completes $60 Million Financing to Advance Its Therapeutic Programs
...al to expand the use of
anticoagulants. New investors, including D.E. Shaw group, Adage Capital
Management, BBT Capital Management/Apothecary Capital, janus
and PAC-LINK BioVentures, joined the company's existing investors to
complete the round.
"Raising funds from this outstanding group of...
Rigel Announces Initiation of Phase 1 Clinical Trial of R348 for Rheumatoid Arthritis, Psoriasis and Other Immune Disorders
...oday that it has begun
enrolling patients in a Phase 1 study to evaluate the safety and
tolerability of R348, an orally available, potent inhibitor of janus
3 (JAK3), as a potential treatment for patients with rheumatoid arthritis
(RA), psoriasis and other immune disorders. In preclinical studies, R...
Genoptix, Inc. Announces Availability of MPL W515 L/K Mutation Analysis for MPD at 49th Annual American Society of Hematology (ASH) Meeting
...ailability of molecular assays such as this one."
MPL mutations, which affect the thrombopoietin receptor and result in
the continuous activation of janus
2 kinase (JAK2) and other pathways, are
commonly associated with two myeloproliferative disorders, namely
idiopathic myelofibrosis (IMF) and essential...
Data Support use of SuperGen's CLIMB Technology in Lead Development and Optimization
... Poster C200 (Abstract No. 907) Effect of small molecule inhibitors of JAK2 kinase on modulating
signaling cascades downstream of cytokine receptors janus
kinases (JAKs) are critical to a number of intracellular
signaling pathways. Dysregulation of JAK2 signaling has been implicated in
Rigel to Present New Research Programs at AACR Meeting
...sts will be presenting three other poster
presentations at the AACR meeting highlighting drug discovery
efforts focused on significant cancer targets: janus
Kinase 2 (JAK 2), Polo-Like Kinase 1 (PLK 1) and Protein Kinase
C-related Kinase 1 (PRK-1). Rigel anticipates that small molecule
Janus in Biological News
Janus in Biological Technology
Cytopia Scientific Presentation on JAK2 Inhibitor Program at American Chemical Society Conference
...dnesday, March 25, 2009 from 7:00 PM to 9:00 PM (US ET), Salt Palace Convention Center, Hall 1.
The poster, entitled Small molecule inhibitors of janus
kinases describes preclinical data for a series of JAK2 inhibitors that lead to the identification of CYT387, the company's lead JAK2 drug candidate f...
'Two-Faced' Particles Act Like Tiny Submarines
...re physically or chemically
different -- so-called janus
particles -- will move like stealthy
submarines wh...round and
respond to changes in their environment. janus
particles could be used as
microscopic mixers, mol... applications.
"You can imagine other types of janus
particles comprising a 'smart
gel' that responds t...
'2-faced' particles act like tiny submarines
... are physically or chemically different so-called janus
particles will move like stealthy submarines when...round and respond to changes in their environment. janus
particles could be used as microscopic mixers, mol...f applications.
"You can imagine other types of janus
particles comprising a 'smart gel' that responds t...
49th Annual Meeting of the American Society of Hematology Will Feature the Latest Research in Blood Diseases
.... Dr. Skoda's lecture will focus on the
molecular basis of myeloproliferative disorders (MPDs). Recently, the
discovery of activating mutations in the janus
kinase 2 gene in the
majority of MPD patients has transformed and energized the field; however,
a number of questions still remain unanswered.
... stop-flow interference lithography, the team has even been able to produce janus
particles, microparticles with two chemically different hemispheres.
Our ... region around the boundary between the two liquids, the process results in janus
particles with two chemically different hemispheres.
Rigel to Present Research Programs at Scientific Conferences
...ll highlight drug discovery
efforts focused on significant cancer targets including Axl receptor
tyrosine kinase (Axl), Polo- like kinase 1 (PLK1) and janus
2 (JAK2). Axl kinase is a novel therapeutic target for solid tumors. Signaling
via Axl drives proliferation, migration and invasion o...
Janus in Biological Products