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Jak3 in Medical News

Researchers identify new cell targets for preventing growth of breast and other tumors

...e proteins encoded by the candidate genes. They found that seven of the genes encoded membrane or secreted proteins. Four of these namely FAP, SFRP2, jak3 and SMPD3 had not just increased gene expression, but also increased protein expression in breast tumor vessels, and thus could be good targets for t...

St. Jude researchers find key step in programmed cell death

...e to keeping cells alive. For example, they demonstrated earlier that most cytokines controlling hematopoietic cells require an enzyme called Jak2, or jak3 in lymphocytes, at the receptors where cytokines attached to the cell. In screening for components that are regulated by the Jak enzymes, the St. J...

Daniel Magilavy, M.D. Joins Rigel as Vice President of Clinical Research

...vanced Phase 2 clinical studies for RA and ITP this year, and also a Phase 2 clinical study in systemic lupus erythematosus. In addition, Rigel's oral jak3 inhibitor, R348, is currently in a Phase 1 study for the potential treatment of psoriasis and RA. "Dan comes to Rigel with solid clinical research l...

New Technique Identifies Unknown Genetic Mutations That Can Cause Cancer

...samples later identified two more mutations in the jak3 gene. Thomas Mercher, a postdoctoral fellow ... a mouse model. "It was important to show that the jak3 mutation, when introduced in mice, would lead to a...leukemia-like illness. It did, confirming that the jak3 mutations play a central role in leukemia," said G...
Jak3 in Medical Technology

Rigel Announces Initiation of Phase 1 Clinical Trial of R348 for Rheumatoid Arthritis, Psoriasis and Other Immune Disorders

...8 in young, healthy males using a double blind, placebo controlled, single dose and multiple rising doses of R348. Results are expected in mid-2008. jak3 in RA and Other Immune Disorders RA affects approximately 1% of the population worldwide -- approximately 2.1 million Americans -- and is a debilita...

Exelixis Presents Encouraging Phase 1 Data For XL019, A Novel Selective Inhibitor of JAK2

...es. XL019 is a potent JAK2 inhibitor (IC50 = 2 nM) with excellent selectivity versus the other members of the JAK kinase family (JAK1 IC50 = 130 nM, jak3 IC50 = 250 nM, TYK2 IC50 = 340 nM). It is active against both wild type and mutationally activated forms of JAK2, and in preclinical studies showed go...

Pharmacopeia Announces Third Quarter 2007 Financial Results

..., coupled with resources expended on the company's jak3 program. The expense for the jak3 program has been primarily classified as collabora...Prior to 2007, resources expended on the company's jak3 program were classified as proprietary research an...
Jak3 in Biological News

New strategy rapidly identifies cancer targets

...amples later identified two more mutations in the jak3 gene. Thomas Mercher, a postdoctoral fellow i...a mouse model. "It was important to show that the jak3 mutation, when introduced in mice, would lead to...eukemia-like illness. It did, confirming that the jak3 mutations play a central role in leukemia," said...
Jak3 in Biological Technology

Progen Shareholders Call Meeting to Spill Progen Board and Offer Merger or Full Cash Back to Shareholders

...considerable opportunity to unlock value in both stocks. "Cytopia is a world class drug development company with drug candidates ranging from the jak3 program partnered with global pharmaceutical company Novartis through to CYT997, a vascular disrupting agent which is now in Phase II clinical studies...

Rigel Announces Third Quarter 2008 Financial Results and Clinical Update

...igel plans to focus on psoriasis and possible topical applications with its jak3 inhibitor, R348, and to do so with a collaboration partner. Rigel will move...hibitor compound for transplant rejection. Rigel expects to select this new jak3 inhibitor compound by the end of 2008. Rigel will proceed on its own with t...

GlaxoSmithKline and Cellzome Announce Major Strategic Alliance

...logy to the discovery and development of innovative small-molecule kinase inhibitors targeting key inflammatory mediators such as PI3Kg and d, Zap-70, jak3 and mTOR, as potential oral therapeutics for rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, psoriasis and asthma. In addition...
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