Why Huntington's Shows Up in Midlife
...e mutated huntingtin gene, long known to cause the disease, switches on the jnk3
enzyme produced by neurons, the cells that process and carry signals through the nervous system. jnk3
weakens the ability of neurons to carry these messages.
When a person is...
Huntington's disease deciphered
...smissions, more dying back and eventual neuronal cell death.
This mechanism also explains the late onset of the disease, Brady said. Activation of jnk3
reduces transport but does not eliminate it. Young neurons have a robust transport system, but transport gradually declines with age.
"If you take ...