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JNK3 in Medical News

Why Huntington's Shows Up in Midlife

...e mutated huntingtin gene, long known to cause the disease, switches on the jnk3 enzyme produced by neurons, the cells that process and carry signals through the nervous system. jnk3 weakens the ability of neurons to carry these messages. When a person is...
JNK3 in Biological News

Huntington's disease deciphered

...smissions, more dying back and eventual neuronal cell death. This mechanism also explains the late onset of the disease, Brady said. Activation of jnk3 reduces transport but does not eliminate it. Young neurons have a robust transport system, but transport gradually declines with age. "If you take ...
JNK3 in other areas

MAPK10 - Wikipedia, the free encyclopedia

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases. ... Crystal structure of JNK3: a kinase implicated in neuronal apoptosis. ...

JNK3 (55A8) Rabbit mAb #2305

JNK3 (55A8) Rabbit Monoclonal Antibody detects endogenous levels of total JNK3 protein. ... rabbits with a synthetic peptide (KLH-coupled) derived from human JNK3. ...

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.

Knockout mice lacking JNK3 showed reduced apoptosis of hippocampal neurons and ... Thus, JNK3 may be important in the pathology of neurological disorders and is of ...

Jnk3

Jnk3. Resistance to the excitotoxic glutamate-receptor agonist kainic acid ... Absence of excitotoxicity-induced apoptosis in the hippocampus. ...

beta -Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation ...

Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3 ... c-Jun amino-terminal kinase 3 (JNK3) as a binding partner of -arrestin ...

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 ...

Nature Neuroscience offers a unique mix of opinion and reviews alongside top ... These data identify JNK3 as a critical mediator of polyQ-Htt toxicity and ...
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