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JNK in Medical News

Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann

...h as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

...h as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals Inc. Regains Compliance With NASDAQ Listing Requirements

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. Receives Extension for Nasdaq Listing Compliance

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Targeting the more lethal form of the cancer rhabdomyosarcoma

...ry Hannigan, determined that the signaling protein jnk mediated these differing effects of ILK. Knocking ...ression of ILK in ERMS cells induced activation of jnk and promoted tumor cell growth both in vitro and w...own expression of ILK in ARMS cells abrogated both jnk signaling and tumor cell growth. Further analysis ...

Keryx Biopharmaceuticals, Inc. Announces First Quarter 2009 Financial Results

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. Requests an Appeal Hearing After Receiving Notice of Delisting From Nasdaq

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Grape Seed Extract Kills Leukemia Cells in Lab

...effective, though, when researchers added an agent to it that inhibited the jnk protein or used genetic engineering to shut down the jnk gene. More information The National Center for Complementary and Al...

Keryx Biopharmaceuticals Receives Nasdaq Notification

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2008 Financial Results

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...
JNK in Medical Technology

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

...INTRA has a novel mechanism of action that inhibits a target enzyme called glutathione S- transferase P1-1 which in turn facilitates the activation of jnk kinase, a key regulator of cellular growth and differentiation of blood. TELINTRA has been shown to stimulate normal multilineage differentiation of ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...tein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is current...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

...s Akt and a number of other key signal transduction pathways, including the jnk and MAPK pathways, all of which are pathways associated with programmed cel...modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death...

Keryx Biopharmaceuticals, Inc. Announces Phase 2 Results on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Waldenstroms Macroglobulinemia at the 44th Annual Meeting of the American Society of Clinical Oncology

...s Akt and a number of other key signal transduction pathways, including the jnk and MAPK pathways, all of which are pathways associated with programmed cel...modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois

...s Akt and a number of other key signal transduction pathways, including the jnk and MAPK pathways, all of which are pathways associated with programmed cel...modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death...

Keryx Biopharmaceuticals Announces Termination of SUN-MACRO Phase 4 Trial

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401, which is c...
JNK in Biological News

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

...tract induced apoptosis. They found that the extract strongly activated the jnk pathway, which then led to up-regulation of Cip/p21, which controls the cel...d that the extract was ineffective. Using a genetic approach silencing the jnk gene also disarmed grape seed extract's lethal attack in leukemia cells. ...

Identification of protein able to stimulate production of T-cells

...the Wnt family, i.e. stabilization of a signalling protein called -catenin, but rather through an alternative pathway involving members of the jnk family of proteins. The IRIC team is now investigating ways to capitalize on its discovery to develop new therapeutic agents. ...

Fruit flies show how salmonella escapes immune defenses

...t immune response for their own benefit. They found that one of these proteins, named AvrA, not only shuts down the key immune signaling pathways jnk and NF-kB, but also turns off the fail safe system organisms have evolved to respond to irreversible threats. This ultimate immune defense, called apo...

In mice, drug protects against diabetes and atherosclerosis

...- and significantly improved insulin sensitivity compared to control mice. Tests also showed that the drug reduced the activity of gene pathway called jnk that triggers the inflammatory and insulin-resistance responses to fatty diets. As an "added bonus," commented Hotamisligil, the drug also exerte...

Most important actors in the growth process of neurons identified

...s mediated by an interaction among three signal cascades: Wnt, FGF and JNK. jnk is necessary for stimulating the growth of axons. Wnt activates jnk and FGF inactivates JNK, so the right balance between Wnt and FGF provides ...

Diabetes research takes wing thanks to long-lived fruit fly

...boosting the amount of a molecular signal known as jnk in a fruit fly allows the fly to live 85 days inst...th by free radicals. While scientists knew that jnk in a fly cranks up the anti-oxidants, helping to k... had considered that simply boosting the amount of jnk could have such a broad impact on life span. Th...

Mechanism for neurodenegerative diseases linked to transport proteins

...MA, caused inhibition of fast axon transport by activating an enzyme called jnk that can inhibit these transport proteins. Brady said this is the first ...y the terminals die before the cell body. The link to the activation of the jnk enzyme suggests a new therapeutic target that might limit, delay or perhaps...

University of Minnesota researchers take new look at cellular suicide

...sly found that various forms of an enzyme known as jnk played a role in the development of the cancer. Wo...o damaging amounts of ultraviolet light, a form of jnk initiates both of the cellular processes that culminate in DNA destruction. In one process, jnk starts a chain reaction that leads to the activati...

Cycles of cell death, proliferation key to liver cancer

... the control of tissue renewal through the IKK and jnk pathways plays a key role in liver cancer in mouse...on of the gene that codes for the major isoform of jnk in liver cells, JNK1, prevented the development of... by ablation of IKKƒÒ. "We found that long-term jnk activation leads to cell death; if activated brief...

Researchers discover how tumor suppressor gene works

...oma cancer cells, the team found that p16 inactivates key enzymes -- called jnk 1 and jnk 2 -- in the process. The enzymes are normally activated by exposure to ultr...
JNK in Biological Technology

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2009 Financial Results

...h as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT

...h as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

AEterna Zentaris Partner, Keryx, Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial with Perifosine (KRX-0401) for the Treatment of Multiple Myeloma

...e Perifosine is a novel, first-in-class, oral anti-cancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and jnk that have been shown to be critical for the survival of cancer cells. Perifosine has demonstrated single agent anti-tumor activity in Phase 1 and Phas...

AEterna Zentaris Discloses Preliminary Phase 2 Trial Results for Perifosine in Combination with Radiotherapy for Non-Small Cell Lung Cancer

...e Perifosine is a novel, first-in-class, oral anti-cancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and jnk that have been shown to be critical for the survival of cancer cells. Perifosine has demonstrated single agent anti-tumor activity in Phase 1 and Phas...

Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals Announces Appointment of Ron Bentsur as Chief Executive Officer

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals Announces Poster Presentations Highlighting Clinical Activity of KRX-0401 (Perifosine) at the Upcoming Annual Meeting of the American Society of Clinical Oncology

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on First Quarter 2009 Financial Results on Thursday, May 14, 2009 at 8:30am EDT

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals, Inc. Announces Michael P. Tarnok as Interim Chairman and Chief Executive Officer

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

...otein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the jnk and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currentl...
JNK in Biological Dictionary

Sequential Epitope

... cell epitope spreading that follows a sequential cascade. ... They further demonstrate that the epitope MOG92–106 has the specific ... The jnk and p38 pathways function to modulate cell-cycle, apoptotic and ... Purification: Purified from rabbit serum by sequential epitope -specific chro...
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