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Islets in Medical News

Pancreatic Islets in Forefront of Diabetes Research

Cells could play major role in treatment, if supply is adequate, study finds TUESDAY, April 14 (HealthDay News) -- Pancreatic islets, which are hormone-producing cells, are becoming more prominent in diabetes research and could play a major role in future treatments, according to U.S....

Living donors may be best source of insulin-producing islets for diabetes treatment

Seoul, Korea November 26, 2007 - According to a new study in Clinical Transplantation, obtaining islet cells (clusters of pancreatic cells that create insulin) from living donors may be a solution to the shortage of islets available for transplantation. In samples taken from living donors, 94 per...

MRI Can Monitor Transplanted Islets

Magnetic resonance imaging (MRI) could be a safe way to monitor the fate of transplanted pancreatic islets, says a new study in the September issue of the journal Diabetes. // Researchers from the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) said that they were abl...

Diabetes cure can be achieved using pig islets

Bernhard J. Hering, M.D., associate professor of surgery and researchers at the University of Minnesota's Diabetes Institute for Immunology and Transplantation has successfully reversed diabetes in monkeys using transplanted islet cells from pigs. // Suppression of graft rejection was possible...

Curing Diabetes, Pigs Turn to Lions

...bilitating conditions such as blindness, stroke and heart attack. Replacing islets is the basis for the potential diabetes cure. Spring Point Project operates...re high-health, 'medical-grade' pig donors are produced as a source for the islets suitable for human transplantation. The Lions Clubs, www.lionsclubs....

Popular diabetes treatment could trigger pancreatitis, pancreatic cancer

...n the pancreas particularly how they affected beta cells in the pancreas's islets of Langerhans. Beta cells are responsible for releasing insulin in people w...n in sufficient amounts in diabetes patients. HIP rats approximate both the islets and metabolism of people with Type 2 diabetes. The drugs were tested in 40 ...

Stem Cells Buy Freedom From Insulin for Type 1 Diabetics

... Richard Burt, of Northwestern University Feinberg School of Medicine in Chicago. "Why new onset? Because we wanted to make sure there were still some islets there. We don't believe stem cells form islet cells, but if the islet cells are still there, there might be regeneration if we stop the attack soon en...

LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth

...nsulin. Beta cells are located in islet cell clusters throughout the pancreas. Diabetes mellitus type 1 results from the destruction or dysfunction of islets and their beta cells. Type 2 diabetes results from the body's inability to use insulin properly and a gradual decrease in the pancreas's ability to ma...

FDA OKs 1st Embryonic Stem Cell Trial

...research that was funded by Geron Corp. Geron is also working on using embryonic stem cells to treat failing hearts and to create insulin-producing islets for type 1 diabetics, Okarma said. "Embryonic stem cells are really nature's own way of making more of ourselves," Okarma said. "We are simply harn...

Cell transplantation and diabetes: New sites, new devices

...fore perhaps most supportive, microenvironment for islets - is the pancreas itself," said Van der Windt and ...rtunities for selecting a donor at an age when the islets have favorable properties, when islet-like cell cl...ine islet cells can provide an unlimited source of islets and in quantities that may satisfy the metabolic r...
Islets in Medical Technology

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

...ized monoclonal antibody engineered to alter the function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic re...

CureDM's Diabetes Therapy Achieves Major Development Milestone

...ntially reverse both type 1 and type 2 diabetes. Patients with type 1 diabetes will require pretreatment with an immune tolerance agent to protect new islets formed by HIP. CureDM, Inc., located at the Lankenau Institute for Medical Research on the Lankenau Hospital campus in Wynnewood, PA, is developing pe...

Senesco Expands on Recently Announced Preclinical Pancreatic Islet Data

...livered intraperitoneally, but was still shown to have significant penetration into isolated islets, meaning that difficult delivery directly into the islets may be avoided. Once delivered, the siRNA allowed treated islet cells to produce 30-40% more insulin than untreated cells. This increased insulin prod...

Rigel's R788 Shows Preclinical Activity in Type 1 Diabetes Model

...diabetes, also called juvenile diabetes or insulin-dependent diabetes, occurs when the body's immune system attacks and destroys beta cells within the islets of the pancreas. Beta cells normally produce insulin, a hormone that helps the body move glucose from food into the body's cells to be used for energy...

New Data Shows Ranexa(R) Increases Glucose-Stimulated Insulin Secretion

...ege of Cardiology 57th Annual Scientific Session in Chicago showed that ranolazine increased glucose-stimulated insulin secretion (GSIS) in pancreatic islets isolated from animals and humans. The Company believes that the increase in GSIS seen with ranolazine may contribute to the statistically significan...

Metabolex Initiates Phase 1 Trial of MBX-2982

...lunteers in the 6-cohort ascending-dose study. MBX-2982 is an agonist of GPR119, a G-protein coupled receptor (GPCR) that is expressed in pancreatic islets and the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent insul...

MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus

...ized monoclonal antibody engineered to alter the function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic res...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

...r acute spinal cord injury, the functional characterization of hESC-derived islets for diabetes, and hESC-derived chondrocytes for arthritis and other orthope...ine cells. The endocrine cells appeared as bud-like clusters resembling the islets of Langerhans and included the major islet cell types that produce the horm...

New Data from Multiple Studies Show Galvus Delivers Consistent and Robust Blood Sugar Control in Patients with Type 2 Diabetes

...se, blindness, and vascular or neurological problems[1]. Galvus works through a novel mechanism of action, targeting a dysfunction in the pancreatic islets that causes high blood sugar levels in people with type 2 diabetes. In clinical studies, Galvus has demonstrated significant reductions in blood sugar...

Opexa Advances Monocyte Derived Islet Technology to Proof of Principle in stz-induced NOD/SCID Mice

...s) to generate pancreatic endocrine cell clusters known as monocyte-derived islets (MDIs). MDIs express pancreatic specific factors as well as hormones insuli...ulin, glucagon and somatostatin characteristic hormones found in pancreatic islets and function in a glucose responsive manner. Dr. Winnier commented, "The ...
Islets in Medical Products

Insulin EIA Diabetes and Obesity Markers 008-10-1113-01

Description:... Insulin is the principal hormone responsible for the control of glucose metabolism. It is synthesized in the b-cells of the islets of Langerhans as the precursor, proinsulin, which is processed to form C-peptide and insulin. Both are secreted in equimolar amounts into the portal ...
Company:ALPCO Diagnostics

Insulin Ultrasensitive EIA Diabetes and Obesity Markers 008-10-1132-01

Description:... Insulin is the principal hormone responsible for the control of glucose metabolism. It is synthesized in the b-cells of the islets of Langerhans as the precursor, proinsulin, which is processed to form C-peptide and insulin. Both are secreted in equimolar amounts into the portal ...
Company:ALPCO Diagnostics

Iso-Insulin EIA Diabetes and Obesity Markers 008-10-1128-01

Description:... Insulin is the principal hormone responsible for the control of glucose metabolism. It is synthesized in the b-cells of the islets of Langerhans as the precursor, proinsulin, which is processed to form C-peptide and insulin. Both are secreted in equimolar amounts into the portal ...
Company:ALPCO Diagnostics
Islets in Medical Dictionary

Hyperglycemia

..... Hyperglycemia — Find out what to do if your blood sugar level is too high. ... Still, hyperglycemia is nothing to take lightly. ... islets of Hope Diabetes Information for the newly diagnosed: What is hyperglycemia ? Symptoms, causes, treatment and prevention. Chronic hyperglycemi...
Islets in Biological News

LSUHSC student awarded top national honor for diabetes research

...nction. Beta cells are located in islet cell clusters throughout the pancreas. Diabetes mellitus type 1 results from the destruction or dysfunction of islets and their beta cells. Type 2 diabetes results from the body's inability to use insulin properly and a gradual decrease in the pancreas's ability to ma...

JDRF-funded researchers discover proteins regulating human beta cell replication

...) alone or with cyclin D, when injected into human islets by viral delivery methods, triggered the beta cells to replicate. These transduced islets were then transplanted into diabetic mice for six ...performed better than control (non-modified) human islets as measured by blood glucose levels and glucose to...

Human beta cells can be easily induced to replicate, according to study in Diabetes

...gene, the cells replicated. Stimulation was further enhanced by increasing production of another cell cycle molecule called cyclin D1. Untreated human islets did not replicate. "After we transplanted some of these engineered human beta cells under the outer layer of a kidney in a diabetic mouse, we saw t...

Researcher tricks immune system in diabetic mice

... a way to trick the immune system of mice into believing those transplanted islets are its own cells. This new technique eliminated the need for the immunosup...done without pre-treated cells, the immune system rejected the transplanted islets within 15 days. In an upcoming study, Miller and Luo will work with mice...

New technique eliminates toxic drugs in islet transplant in diabetic mice

... a way to trick the immune system of mice into believing those transplanted islets are its own cells. This new technique eliminated the need for the immunosup...done without pre-treated cells, the immune system rejected the transplanted islets within 15 days. In an upcoming study, Miller and Luo will work with mice...

American Chemical Society's Weekly PressPac -- July 2, 2008

... United States. In the new study, Yuji Teramura and Hiroo Iwata point out that transplantation of the pancreas's insulin producing cells, so-called islets of Langerhans, is a promising experimental technique for treating patients with insulin-dependent diabetes. However, the procedure is not sufficiently...

Type 1 diabetes triggered by 'lazy' regulatory T-cells: McGill researchers

... including blindness, heart attack and stroke. The genetic and cellular mechanisms by which the immune system goes out of control and destroys the islets has been an enigma and an area of great interest over the last few decades, said Dr. Piccirillo, Canada Research Chair in Regulatory Lymphocytes of th...

NIBIB invests in quantum research

...a replacement strategy for treating diabetes. Transplantation of pancreatic islets to restore insulin production is promising; however, the donor pancreata ar...y and do not meet medical needs. The development of these tissue engineered islets will provide a new source of insulin-producing cells and help realize the f...

Breakthrough research identifies how cells from pigs may cure diabetes

...immunosuppression issues, researchers are now working to transplant porcine islets in an engineered pre-vascularized, cytoprotective and immune-privileged imp...s will be able to provide unlimited islet tissue in a few years. Pig islets from young disease-free donors are superior to cadaver human islets. ...

Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin

... in the laboratory into billions of cells, Denner explained. Then, for a person with type 1 diabetes, researchers might engineer these cells to become islets of Langerhans, the cellular masses that produce the hormone insulin, which allows the body to utilize sugar, synthesize proteins and store neutral fat...
Islets in Biological Technology

iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming

... Research, is professor of Medicine and associate director for research at the Diabetes Center at UCSF. The main focus of his lab is to understand how islets of Langerhans, the endocrine component of the pancreas, are formed during organogenesis, how their function is regulated in the mature organism, and h...

Pigs to Be Genotyped to Improve Selection and Breeding for Pancreatic Islet Cell Research

...h quality DNA information to link DNA profiles with characteristics of islet tissue. The information will help Spring Point Project supply the optimum islets for transplantation. "We are thrilled to donate our genotyping services in support of Spring Point Project's charitable efforts to improve care a...

Novel Diabetes Drug Discovery Has Potential to Reverse Disease

...at triggers islet neogenesis. Restoring functional islets as a therapeutic approach is fundamental to curing... restoration as a therapeutic approach. Pancreatic islets contain four primary cell types and are responsibl...new insulin-producing beta cells by generating new islets that contain alpha, beta, gamma and delta cells, a...

University of Minnesota Receives $40 Million for Type 1 Diabetes Research

...y in stem cell, transplantation and immunology research. These synergies will help us find the best cure faster. Stem cells provide another source of islets for transplantation and offer us tremendous potential to conquer this complicated disease," said Firpo. Internal and external advisory boards ...

Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982

...evelopment of treatments for serious unmet medical needs." About MBX-2982 MBX-2982 is an agonist of GPR119, a GPCR that is expressed in pancreatic islets and the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent insul...

Two Metabolex Projects Recognized in Windhover's Top 10 Lists for Partnering Opportunities

...rtnerships conference in Philadelphia, PA. MBX-2982 MBX-2982 is an agonist of GPR119, a G protein-coupled receptor that is expressed in pancreatic islets and the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent insul...

BioLife Solutions HypoThermosol(R) Adopted by MicroIslet for Processing Pancreatic Islet Cells to Treat Diabetes

...ported to BioLife that with HypoThermosol, quality islets could still be successfully isolated from the stor...ost important criteria tested. The recovery of the islets processed after using HypoThermosol as a cold stor... the necrotic and apoptotic cell death profiles of islets from pancreata stored in HypoThermosol were simila...

Spring Point Project Names New Members to Board of Directors

...im's experience in finance and business will be invaluable not only in providing direction for daily operations but also in further development of pig islets to a clinical entity." Currently, there are about 25 million people in the United States with diabetes, representing approximately eight percent of ...

A New Era in Cell Biology: German Company Develops Groundbreaking Alternative to Stem Cell Therapy

...patented procedure we can 'reprogram' these programmable cells into the desired target cells, for example liver or muscle cells or cells in pancreatic islets of Langerhans." The therapeutic possibilities lie in replacing defective or missing cells (regenerative medicine) or producing cells that regulate the...

Novocell Reports Successful Use of Stem Cells to Generate Insulin in Mice

... is performed by transplanting donor-derived human islets combined with chronic immunosuppression. While thi...py, the limited availability of donated pancreatic islets and the adverse side effects of long-term immunosu...sfully tested in human clinical trials using human islets isolated from donor organs. "By developing propr...
Islets in Biological Products

Dog Anti-Pig Pancreatic Islets of Langerhans Cells Polyclonal Antibody, Unconjugated from Abcam

Description: Dog polyclonal to Porcine Pancreatic Islets of Langerhans Cells ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Pig): Sonicated crude membrane fraction of porcine pancreatic islets of langerhans cells....
Company:Abcam

COPAS 500 from Union Biometrica

Description:...phila embryos to first instar larvae, other like-sized model organisms, cells, pollen, seeds and beads even delicate cell clusters such as pancreatic islets and embryoid bodies. Analysis is performed based on up to five parameters size, optical density, and three fluorescent spectra. Sorting is based on...
Company:Union Biometrica
Islets in Biological Definition

Diabetes mellitus

...er , in which the body's own immune system attacks the beta cells in the islets of Langerhans of the pancreas , destroying them or damaging them sufficie...the induced diabetes in dogs by giving them an extract from the pancreatic islets of Langerhans of healthy dogs 8 . They went on to isolate the hormone insu...

Insulin

...tin insula , "island", as it is produced in the islets of Langerhans in the pancreas ) is a polypeptid...the "little heaps of cells", later known as the islets of Langerhans , was unknown, but Edouard Laguesse ...attempts were made to isolate the secretion of the islets as a potential treatment. In 1906 Georg Ludwig Zue...
Islets in Biological Dictionary

Islets of Langerhans

... The islets of Langerhans are the regions of the pancreas ...man pathological anatomist Paul Langerhans , the islets of Langerhans constitute approximately 1 to 2% o...ormal human pancreas contains about 1,000,000 islets . The ...

Insulin

...ulin n. A polypeptide hormone secreted by the islets of Langerhans and functioning in the regulation of...n is made specifically by the beta cells in the islets of ... Insulin lowers the level of glucose ... (Latin insula, "island", as it is produced in the islets of Langerhans) ... Insulin is used medically in ...
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