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Islet in Medical News

LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth

New Orleans, LA Michael Lan, PhD, Professor of Pediatrics and Genetics at LSU Health Sciences Center New Orleans, is the senior author of a paper revealing the molecular mechanism of how a protein determines the fate of the cells that make and release insulin. Zinc Finger Transcription Factor I...

UIC in NIH-funded islet transplantation study for type 1 diabetes

The University of Illinois at Chicago is one of 11 centers in the United States, Canada, Sweden and Norway to participate in the Clinical Islet Transplant Consortium funded by the National Institutes of Health. Consortium researchers have begun clinical studies to test new approaches to islet t...

Promising advances in islet cell transplants for diabetes

University of Illinois at Chicago researchers have modified the procedure for islet cell transplantation and achieved insulin independence in diabetes patients with fewer but better-functioning pancreatic islet cells. The study results are published in the June issue of the American Journal of...

Studies test new approaches to islet transplantation

Researchers from 11 medical centers in the United States, Canada, Sweden, and Norway have begun testing new approaches to transplanting clusters of insulin-producing islets in adults with difficult-to-control type 1 diabetes. The clinical studies, funded by the National Institutes of Health (NIH)...

The new source of islet cells

The shortage of islet cells limits the development of islet transplantation. One new approach was reported in the October 21 issue of the World Journal of Gastroenterology because of its great significance in enhancing the output of islet cells. This article will undoubtedly bring benefit to diabe...

LCT Reports Major Step for Islet Transplantation in Diabetes Patient

A research published by Living Cell Technologies Limited outlines the survival and identification of live porcine islet cells and insulin production// in a human patient 10 years after receiving a pig islet cell transplant. The scientific paper outlines how LCT has demonstrated the long-term...

Successful Islet Cell Transplant in Mice With Type 1 Diabetes

Researchers have determined a way to pre-screen cancer patients to see if they are suitable candidates for proteasome inhibitors, a promising class of anti-cancer drugs// . They propose to test for p53, a well-known tumor-suppressor protein that is broken down by cellular machinery called proteasom...

New role discovered for molecule important in development of the pancreas

...al and previously unknown regulatory role in the development of cells in the immature endocrine system. These cells ultimately give rise to pancreatic islet cells, which include beta cells. By carefully defining the developmental steps and genetic circuits that lead to mature beta cells, researchers ma...

Master Stem Cell for Human Heart Identified

...t are used are not from the heart and it's not yet clear how effective the approach really is. Chien and his team used antibodies directed against islet progenitor cells in human fetal hearts to identify the presence of the cells. They then purified the cells, cloned them and tracked their journey from...

Curing Diabetes, Pigs Turn to Lions

... organization developing pig donors for pancreatic islet transplantation to cure diabetes, is attending the...Lions organization." Type 1 diabetes destroys islet cells, which requires people with this disease to ...e Diabetes Research and Wellness Foundation (DRWF) islet Resource Facility where high-health, 'medical-grad...

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Islet in Medical Technology

Senesco Expands on Recently Announced Preclinical Pancreatic Islet Data

NEW BRUNSWICK, N.J., April 15 /PRNewswire-FirstCall/ -- Senesco Technologies, Inc. ("Senesco" or the "Company") (Amex: SNT ) announced today further details of Dr. Raghavendra Mirmira's preclinical pancreatic islet cell research that was funded by the Company. Using a small interfering RNA (s...

Senesco's Preclinical Pancreatic Islet Data to be Presented at Upcoming Conferences

NEW BRUNSWICK, N.J., April 2, 2008 /PRNewswire-FirstCall/ -- Senesco Technologies, Inc. ("Senesco" or the "Company") (Amex: SNT ) announced today that Dr. Raghavendra Mirmira, one of the Company's funded researchers, will be presenting his findings regarding preclinical pancreatic islet cell ...

Opexa Advances Monocyte Derived Islet Technology to Proof of Principle in stz-induced NOD/SCID Mice

THE WOODLANDS, Texas--(BUSINESS WIRE)--Jun 27, 2007 - Opexa Therapeutics, Inc. (NASDAQ:OPXA), a company involved in the development and commercialization of cell therapies, presented poster presentations at the 5th International Society for Stem Cell Research Annual Meeting (ISSCR) in Cairns, Queen...

CureDM's Diabetes Therapy Achieves Major Development Milestone

... present in the adult pancreas, into new insulin-producing islets. Each new islet contains pools of beta cells which make insulin. It is hypothesized that tr...ific team to determine the proteins involved in, and probable mechanisms of islet neogenesis in humans. For more information about CureDM, visit http://www....

Rigel's R788 Shows Preclinical Activity in Type 1 Diabetes Model

...., assistant professor in Medicine and Microbiology at Columbia University's College of Physician's and Surgeons. "In diabetes, autoantibodies against islet cells appear before the actual onset of disease providing the opportunity to intervene and disable these early events prior to immune destruction of t...

Siemens Preclinical Imaging System Helps The Methodist Hospital in Houston Further Its Research Mission

...ear legacy of medical breakthroughs, such as the world's first multiple-organ transplant in the 1960s, gene therapy for prostate cancer, and the first islet cell transplants in Texas. Methodist is ranked among the country's top centers in 14 specialties in U.S News & World Report's 2007 America's Best Hos...

Diabetes Research Institute Invention Promotes Growth of Stem Cells into Insulin-Producing Cells

...ent, and this means another donor pancreas is needed to provide the fragile islet cells for transplant. New findings by researchers at the Diabetes Research ...o the field of diabetes research, pioneering many of the techniques used in islet transplantation. From innovations in islet isolation and transplant procedu...

MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus

...g is evaluating the use of teplizumab as an induction therapy in pancreatic islet cell transplantation. Additional information regarding the studies is list...Pancreatic Led by Dr. Bernhard http://www.clinicaltrials.gov islet cell Hering of the University (search for NCT00265473) transplanta...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...via(TM) (sitagliptin) and metformin demonstrated significant improvement in markers of beta cell function in patients with type 2 diabetes. Pancreatic islet beta cell function determines the ability of the body to produce insulin, a hormone which plays a central role in the regulation of blood sugar levels...
Islet in Medical Products

GAD/IA-2 Autoantibody Screen

Description:...ntual onset of overt diabetes mellitus. During this extended pre-clinical phase, the characteristic circulation of autoantibodies against a variety of islet cell antigens including glutamic acid decarboxylase (GAD65), IA-2 (a tyrosine phosphatase-like protein), and insulin provides early markers of autoimm...
Company:KRONUS

Glutamic Acid Decarboxylase (GAD65) Autoantibody RIA

Description:...ntual onset of overt diabetes mellitus. During this extended pre-clinical phase, the characteristic circulation of autoantibodies against a variety of islet cell antigens including glutamic acid decarboxylase (GAD65), IA-2 (a tyrosine phosphatase-like protein), and insulin provides early markers of autoimm...
Company:KRONUS
Islet in Medical Definition

Proteopathy

... chains AH (heavy chain) amyloidosis Immunoglobulin heavy chains AA (secondary) amyloidosis Amyloid A protein Type II diabetes islet amyloid polypeptide (IAPP; amylin) Aortic medial amyloidosis Medin (lactadherin) ApoAI amyloidosis Apolipoprotein AI ApoAII amyl...
Islet in Medical Dictionary

VIPoma

.... What is VIPoma ? Meaning of VIPoma medical term. What does VIPoma mean? ... VIPoma /VIP·oma/ (vĭ-po'mah) an endocrine tumor, usually an islet cell tumor, ... Vipoma /diarrheogenic syndrome: a statistical evaluation of 241 reported cases. Soga J, Yakuwa Y. ... the present status of vi...

Transplantation

...sue and organs has become ... The mission of WHO on transplantation is carried out by the Clinical Procedure ... Studies Test New Approaches to islet Transplantation —May 2, 2008 ... All Transplantation News Releases. Volunteer for NIAID-funded clinical studies related to ... Infection and Ma...

Pancreas

... Pancreas Multidisciplinary Cancer Clinic. Participating in ... islet Cell Tumors & Endocrine Neoplasms of the Pancreas . Research Presentat...s an organ located near the lower part of the stomach. ... Pancreas and islet transplantation are two forms of beta cell replacement ... Intern...

Pancreas transplant

...ct before, during and after the ... In people with type 1 diabetes, the islet cells in the pancreas no longer produce insulin. So it seems logical that..... ... in diabetes treatment and research, including pancreas and islet transplants . ... Pancreas -only transplant for people with type 1 dia...

Insulinoma

... insulinoma n. , pl. -mas or insulinomata . An islet cell adenoma that secretes insulin. ... Insul...ulinoma tumor. ... insulinoma is usually an islet cell carcinoma of the pancreas ... insulino...oendocrine tumor deriving mainly from pancreatic islet ... In patients with insulinoma , the ratio rises...

Glucagonoma

..... Glucagonoma is a very rare tumor of the islet cells of the pancreas, which ... Glucagonoma is ...rview, Glucagonoma is a very rare tumor of the islet cells of the pancreas, which release the hormones ...ation, Glucagonoma is a very rare tumor of the islet cells of the pancreas, which release the hormones ...
Islet in Biological News

Stem cell infusion and hyperbaric oxygen treatment improve islet function in diabetes

Tampa, Fla. (Mar. 12, 2009) A study to determine if patients with type 2 diabetes can benefit from a combination of autologous (patient self-donated) stem cell infusions (ASC) and hyperbaric (above the normal air pressure of ) oxygen treatment (HBO) before and after ASC has found "significant ben...

High blood sugar's impact on immune system holds clues to improving islet cell transplants

AUGUSTA, Ga. A biological tit for tat may hold clues to improving the success of islet cell transplants intended to cure type 1 diabetes, according to a Medical College of Georgia scientist. In type 1, the immune system attacks insulin-producing cells causing high blood glucose levels that ma...

New technique eliminates toxic drugs in islet transplant in diabetic mice

CHICAGO -- The body's immune system hates strangers. When its security patrol spots a foreign cell, it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the r...

Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes

Scientists at Joslin Diabetes Center have discovered that a surprisingly high percentage of people with type 1 diabetes (insulin-dependent) who have had the disease for 50 years or longer (The Joslin Medalists) may still have residual functioning, insulin-producing islet cells and/or islet cell ant...

Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice

Researchers at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins have invented a cost-effective and highly efficient way of analyzing what many have termed "junk" DNA and identified regions critical for controlling gene function. And they have found that these control regions from...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising int...

Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes

Patients with type 1 diabetes who received islet transplantation from a single donor pancreas were insulin independent one year later, according to a study in the February 16 issue of JAMA, a theme issue on medical applications of biotechnology. Type 1 diabetes remains a therapeutic challenge, a...

First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes

Biologists at the University of Liverpool have discovered how the plagues of the Middle Ages have made around 10% of Europeans resistant to HIV. Scientists have known for some time that these individuals carry a genetic mutation (known as CCR5-delta32) that prevents the virus from entering the cell...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

A University of Alberta and Capital Health surgeon, well known for his pioneering work in developing the Edmonton Protocol treatment for diabetes, has taken another important step in the fight against diabetes. On January 19, at Kyoto University Hospital, Dr. Koichi Tanaka and Dr. James Shapiro,...

Stem cell research: From molecular physiology to therapeutic applications

...fessor Deng has written a summary of recent progress in human embryonic and inducible pluripotent stem cell differentiation into functional pancreatic islet cells and discusses the challenges for future work[3]. Professor Qi Zhou is assistant Director of the Institute of Zoology at the Chinese Academy of...

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Islet in Biological Technology

Pigs to Be Genotyped to Improve Selection and Breeding for Pancreatic Islet Cell Research

Cutting-edge DNA testing technology provided by GeneSeek Inc. LINCOLN, Neb., Feb. 13 /PRNewswire/ -- A privately held biotechnology company, will be used for medical-grade source pigs which are being developed by Spring Point Project, a Minnesota non-profit organization providing pig islet ce...

BioLife Solutions HypoThermosol(R) Adopted by MicroIslet for Processing Pancreatic Islet Cells to Treat Diabetes

Preservation with BioLife's Proprietary, Next Generation, Biopreservation Media Resulted in Increased Yield and Quality of Insulin-Producing Islet Cells BOTHELL, Wash., Oct. 24 /PRNewswire-FirstCall/ -- BioLife Solutions Inc. (OTC Bulletin Board: BLFS), a leadi...

iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming

... the pancreas, are formed during organogenesis, how their function is regulated in the mature organism, and how changes in gene expression might allow islet regeneration. Dr. Amy Wagers, assistant professor in the Section on Developmental and Stem Cell Biology at Joslin Diabetes Center and the Depa...

American Transplant Congress 2009

...dress - Philip Sharp, M.I.T., Boston, MA Special Interactive Sessions "What's Hot, What's New" Presentation Stem Cell & islet Cell Research Infectious Diseases Cardiac Risks Living Donation Ethics, Economics & Regulatory Issues ...

Calvert Research and CureDM Sign Collaborative Agreement

...HIP) targeted for the treatment of type 1 and 2 diabetes patients. HIP has a novel mechanism of action that works by stimulating the generation of new islet structures which secrete key hormones like insulin to normalize glucose levels in the blood. "We appreciate that Calvert has recognized the poten...

Novel Diabetes Drug Discovery Has Potential to Reverse Disease

...rating pancreatic islets, a process also known as islet neogenesis. "Utilizing an innovative and proprieta...hly conserved bioactive gene product that triggers islet neogenesis. Restoring functional islets as a thera...id of islets. HIP was also shown to stimulate new islet formation with a 3-fold increase in...

University of Minnesota Receives $40 Million for Type 1 Diabetes Research

...e system mistakenly destroys all insulin-producing islet beta cells in the pancreas. To stay alive and to ...ising conceptual cures have been identified: human islet transplantation, pig islet transplantation and stem cell-derived islet cells. The Schulze gift will focus on specific ef...

Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982

...t. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health. The Phase 1a study was a randomized, placebo-controlled, double-blind, ascending-dose clinical trial in 60 healthy male and female volunteer...

Spring Point Project Welcomes Second Generation 'Medical-Grade' Piglets

...created to expedite the widespread availability of islet tissue (insulin-producing cells of the pancreas), ...e Diabetes Research and Wellness Foundation (DRWF) islet Resource Facility, a biosecure animal facility in ...hese are the first pigs that can serve as donor of islet cells suitable for transplantation in diabetes pat...

Spring Point Project Gains Support of Lions Clubs

...dable and widespread availability of pig donors of islet tissue for diabetes care. (Logo: http://www.new...e Diabetes Research and Wellness Foundation (DRWF) islet Resource Facility, where high-health source pig do..., including a $6.2 million grant to build the DRWF islet Resource Facility. The Ryan Companies U.S., a le...
Islet in Biological Products

Streptozotocin from Calbiochem

Description:...ic oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells. Purity: ≥95% by HPLC. Soluble in H 2 O. RTECS LZ5775000, CAS 18883-66-4, M.W. 265.2....
Company:Calbiochem

Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen

Description:... in the immune response, cellular proliferation, oncogenic transformation, morphogenesis, and apoptosis.JIP1 (JNK-interacting protein-1, also known as islet Brain-1 and mitogen-activated protein kinase 8-interacting protein-1,) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a ...
Company:Invitrogen
Islet in Biological Definition

Insulin

... If blood glucose levels drop lower than this, especially to dangerously low levels, release of hyperglycemic hormones (most prominently glucagon from islet alpha cells) forces release of glucose into the blood from cellular stores. The release of insulin is strongly inhibited by the stress hormone adren...
Islet in Biological Dictionary

Polypeptide

...de -related peptides. 4.4 Opioid peptides. 4.5 Calcitonin peptides ... A polypeptide is a single linear chain of amino acids. ... Amylin, or islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic β-cells at the same time as insulin . What is a(n) poly...

Pancreas

..... The pancreas ' exocrine function involves the secretion of bicarbonate and ... Pancreas Multidisciplinary Cancer Clinic. Participating in ... islet Cell Tumors & Endocrine Neoplasms of the Pancreas . Research Presentations. Bibliography ... IOH - definition and description of the pancreas...

Islets of Langerhans

... of Langerhans contain cells that produce and ... Definition of islet of Langerhans in the Online Dictionary. Meaning of islet of Langerhans . ... islets of Langerhans (lts v längr-häns) ... ...

Insulin

...work about 15 minutes ... Location of the PancreasInsulin is a hormone. ... Insulin is secreted by groups of cells within the pancreas called islet cells. ... Provides an easy-to-read guide about the variety of diabetes ... Alternative Devices for Taking Insulin . Pills for Type 2 Diabetes: ...

Chaperone Proteins

...ly effective in their abilities ... Purification of Tumor-derived Chaperone Proteins . ... Chaperone Proteins Hsp70 and BiP Fold and Traffic islet Amyloid Polypeptide in ... common polymorphisms in these chaperone proteins on IAPP folding and trafficking ... ...
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