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Ion in Medical News

Stanford researcher's discovery of ion channel turns ear on its head

STANFORD, Calif. Scientists thought they had a good model to explain how the inner ear translates vibrations in the air into sounds heard by the brain. Now, based on new research from the Stanford University School of Medicine, it looks like parts of the model are wrong. Anthony Ricci, PhD, as...

ChanTest to Highlight Expanded Ion Channel and GPCR Services and Cell Lines, Including FDA Critical Path Safety Profiling Tools at ToxExpo, Booth 3056

- Company to host seminar Tuesday, March 17, 2009, from 8:30 to 9:30 AM in Room 337 CLEVELAND, Ohio, March 10 /PRNewswire/ -- ChanTest, the leading expert in ion channels and GPCRs (G-protein coupled receptors) - key to drug discovery, development, and safety - will feature the latest in its...

Researchers identify proteins making up mechanosensitive ion channels

Researchers at Washington University in St. Louis are the first to identify two proteins responsible for mechanosensitive ion channel activities in plant roots. Scientists have long known that plant cells respond to physical forces. Until now, however, the proteins controlling the ion channel resp...

New Ion Trap Mass Spectrometers From Varian, Inc. Offer the Ultimate in Sensitive Detection and High Productivity

PALO ALTO, Calif., March 31, 2008 /PRNewswire-FirstCall/ -- Varian, Inc. (NasdaqGS: VARI) announced today its new 200-MS Series of ion trap mass spectrometers for GC/MS (gas chromatography/mass spectrometry). GC/MS is used by analytical chemists for the detection and characterization of compou...

Revolution in understanding of ion channel regulation

A study at Rush University Medical Center in Chicago published this week in the online version of Biophysical Journal proposes that bubbles may control the opening and closing of ion channels. This new understanding of the channels that control much of life in health and disease provides a vital p...

Boot Camp for New Dads Now Working with Renowned Katherine Stone - Educating Fathers about Postpartum Depression

In an effort to reach and educate more men about Postpartum Depression (PPD) and what they can do; Boot Camp for New Dads ( http://www.bcnd.org ), a non-profit orientation program for fathers-to-be, operating in more than 260 hospitals, clinics, schools, fire stations and churches around North Am...

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Ion in Medical Technology

Data Demonstrates Long-Term Reduction In Seizure Frequency With Novel Once Daily Anti-Epileptic Zebinix(R)

...nel blocker designed to selectively inhibit the rapid firing of nerve cells that causes seizures. It specifically targets the inactivated state of the ion channel, preventing its return to the active state, and thereby reduces repetitive neuronal firing. The efficacy of ESL has been demonstrated in three...

Pharmaxis Announces Positive Results of Phase 3 Cystic Fibrosis Trial

...low of mucus over the surfaces of the air passages in the lungs, removing debris and bacteria. In CF, an inherited disease, a defective gene disrupts ion transport across the epithelial membrane within cells. In the lungs, this leads to a depletion of the airway surface liquid that normally bathes the ...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

...ract (#1408), "Preclinical Evaluation of the TRPM8 ion Channel Agonist D-3263 for Benign Prostatic Hyperp...h Dendreon's in-house discovery efforts. It is an ion channel that is triggered by cold temperatures and...e agonists including D3263 that activate the TRPM8 ion channel and induce cell death. About Dendr...

Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer

...P8) was identified through Dendreon's in-house discovery efforts. It is an ion channel that is triggered by cold temperatures and small-molecule agonists ...synthesized small molecule agonists including D3263 that activate the TRPM8 ion channel and induce cell death. About Dendreon Dendreon Corporat...

Discovery's Edge Spring Issue - http://discoverysedge.mayo.edu

...ers are exploring ways to ensure breathing capability in SCI patients. http://discoverysedge.mayo.edu/de09-1-mssk-sieck-respsci/ Glitches in ion Transporters -- An Unlikely Link Between Kidney Diseases and Glaucoma A tale of coincidence and collaboration: the peculiar case of the kidney rese...

Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)

...Computational Biology at the University of Southern California . Professor Davies added: "Moreover, the so-called 'redox activity' of the bound metal ion can lead to the formation of soluble neurotoxic oligomers as well as fibrillar forms of the protein, which eventually deposit as plaques in the brains...

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Ion in Medical Products

pH 1.07 Buffer Solution

Description:... Buffer solution is needed to calibrate pH catheters. The specific chloride ion concentration in the Medtronic buffers is required for proper function of your Medtronic pH measurement system. Buffer solutions are in plastic safety...
Company:Medtronic Gastroenterology

pH 7.01 Buffer Solution

Description:... Buffer solution is needed to calibrate pH catheters. The specific chloride ion concentration in the Medtronic buffers is required for proper function of your Medtronic pH measurement system. Buffer solutions are in plastic safety...
Company:Medtronic Gastroenterology

Hellige Electrode Gel

Description:... The proper gel is essential in preparing the reference electrode when working with pH catheters with an external reference. The specific chloride ion concentration in the hellige electrode gel is required for proper function of your Medtronic pH measurement system....
Company:Medtronic Gastroenterology

Impact2 EXP 8-Channel Electronic Pipettor, 0.5-12.5L

Description:...me with a power supply adapter and one set of NiCad batteries rated for 1200 cycles before recharging. (16-channel pipettors are provided with lithium ion batteriessee Accessories for details.) You have the option of continuing to use the pipettor while its rechargingjust plug it into the power supply an...
Company:Matrix Technologies Corporation

Impact2 EXP 8-Channel Electronic Pipettor, 15-1250L

Description:...me with a power supply adapter and one set of NiCad batteries rated for 1200 cycles before recharging. (16-channel pipettors are provided with lithium ion batteriessee Accessories for details.) You have the option of continuing to use the pipettor while its rechargingjust plug it into the power supply an...
Company:Matrix Technologies Corporation

Impact2 EXP 8-Channel Electronic Pipettor, 5-250L

Description:...me with a power supply adapter and one set of NiCad batteries rated for 1200 cycles before recharging. (16-channel pipettors are provided with lithium ion batteriessee Accessories for details.) You have the option of continuing to use the pipettor while its rechargingjust plug it into the power supply an...
Company:Matrix Technologies Corporation

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Ion in Medical Dictionary

Zinc

...f the periodic table. Zinc is chemically similar to magnesium because its ion is of similar size and its only common oxidation state is +2. Zinc ... ...xidants such as zinc can neutralize free radicals ... The free zinc ion is also a powerful Lewis acid up to the point of being corrosive. ... Chr...

Toxin

...have demonstrated that a bacterial toxin from the common bacterium Staphylococcus aureus shuts down the control mechanism of the tunnel, called an ion ... Physician reviewed botulinum toxin type A patient information - includes botulinum toxin type A description, dosage and directions. Pl...

Sodium

... This WebElements periodic table page contains Essential information for the element sodium ... The chemistry of sodium is dominated by the +1 ion Na ... Sodium (chemical symbol Na, atomic number 11) is a member of a group of chemical ... Given its reactivity, sodium is not found as a fre...

Respiratory alkalosis

...d plasma carbon dioxide concentration. This leads to decreased hydrogen ion and freely ionized blood calcium concentrations. Alkalosis refers to a condition reducing hydrogen ion concentration of arterial blood plasma (alkalemia). Generally alkalosi...

Protein

...s have put together a comprehensive list of proteins including benefits of each form, ... The catabolism of dietary protein generates ammonium ion and sulfates from ... The effects of a protein on urinary calcium and bone metabolism are modified by ... Protein is a long chain molecule...

Osmolality

...e blood, allowing the blood osmolality to fall back to normal. ... Conclusions: The authors investigated the role of tissue osmolality and ion concentrations in contusion-induced edema formation in both clinical and experimental ... ...

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Ion in Biological News

International collaboration by scientists culminates in novel ion channels database

An important resource consolidating understanding of the roles played by Ion channels in drug action is now available for scientists and students. The International Union of Basic and Clinical Pharmacology (IUPHAR) announce the publication of a new ion channels database, covering both the voltag...

GOCE's electric ion propulsion engine switched on

GOCE's sophisticated electric ion propulsion system has been switched on and confirmed to be operating normally, marking another crucial milestone in the satellite's post-launch commissioning phase. The success of GOCE's ultra-sensitive gravity measurements depends on finely controlling the sat...

Site used by sodium to control sensitivity of certain potassium ion channels

RICHMOND, Va. (Sept. 18, 2008) Virginia Commonwealth University School of Medicine researchers have uncovered how sodium is able to control specific potassium ion channels in cells, according to new study findings published online this week in Nature Chemical Biology . These findings, publish...

Researchers catch ion channels in their opening act

Each thought or action sends a million electrical signals pulsing through your body. At the heart of the process of generating these electrical impulses is the ion channel. A new study by researchers from the University of Illinois measures movements smaller than one-billionth of a meter in ion...

Researchers 'see' structure of open nicotinic acetylcholine ion channels

The neurotransmitter acetylcholine is an essential chemical communicator, carrying impulses from neurons to skeletal muscle cells and many parts of the nervous system. Now researchers at the University of Illinois have painstakingly mapped the interior of a key component of the relay system that a...

Brain networks strengthened by closing ion channels

Yale School of Medicine and University of Crete School of Medicine researchers report in Cell April 20 the first evidence of a molecular mechanism that dynamically alters the strength of higher brain network connections. This discovery may help the development of drug therapies for the cognitive ...

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Ion in Biological Technology

Cellectricon and BioFocus DPI Advance High Throughput ion Channel Drug Discovery

GOTHENBURG, Sweden, April 27 /PRNewswire/ -- Cellectricon, a leading provider of automated screening solutions for drug discovery, today announced its collaboration with BioFocus DPI, a contract research organization with leading expertise in ion channel screening. BioFocus DPI will utilize Ce...

Prosolia to Introduce Omni Spray(R) Ion Source in 2-D Format

INDIANAPOLIS, Dec. 8 /PRNewswire/ -- Prosolia, Inc. introduces a new advanced Omni Spray Ion Source model based on the Desorption Electrospray Ionization (DESI) technology. The Omni Spray 2-D Ion Source has an automated surface platform which enables rapid sampling and surface imaging. The platfor...

Cellectricon Partners With The Automation Partnership - Bringing Next Generation Ion Channel Screening System to Market.

GOTHENBURG, Sweden, December 3 /PRNewswire/ -- Cellectricon, a leading provider of screening solutions for drug discovery, today announced the signing of a collaborative agreement with The Automation Partnership (TAP) in the UK, manufacturers of advanced automated systems for cell culture, sample ...

Cold atoms could replace hot gallium in focused ion beams

Scientists at the National Institute of Standards and Technology (NIST) have developed a radical new method of focusing a stream of ions into a point as small as one nanometer (one billionth of a meter).* Because of the versatility of their approachit can be used with a wide range of ions tailored...

ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Assays & Cellular Targets Conference, Booth 11

Company CEO is featured speaker: "Case Study - Screening Ion Channels for Safety and Efficacy" on Friday, September 26 at 11:30 CLEVELAND, Sept. 18 /PRNewswire/ -- ChanTest will feature its expanding line of ion channel services and cell lines for drug-discovery and development applicat...

ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Ion Channel Targets, Booth 5

Company CEO is featured speaker: 'Ion Channel Panels for Safety Assessment and Drug Discovery' on Tuesday, September 9th at 2:30 CLEVELAND, Sept. 8 /PRNewswire/ -- ChanTest, the preeminent provider of validated ion channel-expressing cell lines and services for drug-discovery and develo...

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Ion in Biological Products

Varian 4000 Ion Trap GC/MS from Varian, Inc.

Description: The Varian 4000 GC/MS system offers three easily switchable ionization configurations: internal ionization (II), external ionization (EI) or hybrid chemical ionization (CI)...
Company:Varian, Inc.

LTQ XL Linear Ion Trap from Thermo Scientific

Description: ...
Company:Thermo Scientific

Adept HPLC System 8: Ion Chromatography from Cecil Instruments Ltd.

Description: An excellent ion chromatography system . The sensitive conductivity detector CE 4710, with twelve ranges from 0.01S to 5000S, houses the measuring cell in a thermostatted environment. The suppressor module CE 4715, is available. Data processing is provided by the CE 4900 interface and software....
Company:Cecil Instruments Ltd.

500-MS LC Ion Trap from Varian, Inc.

Description: The Varian 500-MS LC Ion Trap is the instrument of choice for high-throughput LC/MS analysis where sensitivity, reliability and productivity are essential. The Varian 500-MS provides a robust platform for demanding LC/MS/MS applications. The system sensitivity, mass resolution, and mass stabi...
Company:Varian, Inc.

Varian 2200 Ion Trap GC/MS from Varian, Inc.

Description: The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver unequaled performance a Saturn tradition...
Company:Varian, Inc.

LTQ XL Linear Ion Trap from Thermo Scientific

Description: The LTQ XL extends the MSn performance of the LTQ linear ion trap with powerful new tools to generate extensive structural information for the most demanding proteomics and metabolism applications. Multiple dissociation techniques (PQD, ETD, CID) Extensive coverage for predicted and unp...
Company:Thermo Scientific

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Ion in Biological Definition

Active transport

...er-transport In counter-transport two species of ion or other solute are pumped in opposite directions ...s rapid recovery. This shows that a single type of ion can be transported by several enzymes, which need ...lucose it imports into the cell. See also ion channel ...

Adenosine triphosphate

...of the cell. Also, the hydrolysis yields free inorganic phosphate and adenosine diphosphate , which can be broken down further to another phosphate ion and adenosine monophosphate . ATP can also be broken down to adenosine monophosphate directly, with the formation of pyrophosphate . This last rea...

Alcohol

...s upon oxidation, while secondary alcohols give ketones . Tertiary alcohols resist oxidation. Traditionally strong oxidants such as dichromate ion or potassium permanganate are used, under acidic conditions, for example: 3 CH 3 -CH(-OH)-CH 3 + K 2 Cr 2 O 7 + 4 H 2 SO 4 → 3...

Amine

...e nitrogen atom has a lone electron pair available which can accept a H + ion to bond to the nitrogen forming a positive substituted ammonium ion. The p...ll be formed along with a negative halide ion. These sort of paired ion compounds are called quaternary ammonium salts . The X shown in the abo...

Andrew Huxley

...red the prize that year with John Carew Eccles , who was cited for research on synapses . Hodgkin and Huxley's findings led the pair to hypothesize ion channels , which were confirmed only decades later. The experimental measurements on which the pair based their action potential theory represent on...

ATPase

... a class of enzymes that catalyze the decomposition of adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and a free phosphate ion . This dephosphorylation reaction releases energy , which the enzyme (in most cases) harnesses to drive other chemical reactions that would not ...

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Ion in Biological Dictionary

Phosphate ion

The phosphate ion carries a negative three formal charge and is the conjugate ... In weakly-acid conditions, the dihydrogen phosphate ion (H2PO4) is most common. ... phosphate ( ) n. A salt or ester of phosphoric acid. ... The phosphate ion carries a negative three formal c...

Zinc finger

...ochemistry ) A small structural domain that is organized around a zinc ion and is found in many Zinc finger protein 165 edit Zinc finger ..... ... DNA to RNA: a finger -shaped fold of amino acids plus a zinc ion that is found in ... See all search results in Photos & more (5) Books ...

Transmembrane receptor

...ymes (may involve receptor tyrosine kinases) ... The Worldwide Intensivist ... Types of Receptor ... Receptors that activate transmembrane ion channels. ... ...

Transferrin receptor

...iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Transferrin is a blood plasma protein for iron ion delivery that, in humans, is encoded by the TF gene. Transferrin is a glycoprotein that binds iron very tightly but reversibly. Although iron boun...

Transduction

...tions graph.jpeg ... International Bio pharmaceutical Association Medical Terms ... 3.1.3 Signal transduction of transmembrane receptors that are ion channels ... Transduction summary with 12 pages of encyclopedia entries, essays, summaries, research information, and more. ... Transduction is...

Sequence homology

...al ... EBI Tools: Homology and Similarity: blast, fasta, MPsrch, scanps ... Nucleotide sequence similarity searching against the Ligand Gated ion Channel ... sitive and fast sequence homology search algorithms outside of the relational ... present new challenges for sequence homology ...

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